Croakers and Swift Croakers

As readers of John G. Fuller\u27s Games for Insomniacs (Doubleday, 1966) recall, Tom Swifties are sentences in which the adverb echoes the subject-matter of the quotation: I can\u27t drink any more pineapple juice, said Tom dolefully. In a February 1972 Word Ways article, J. A. Lindon showed several ways in which the classic Tom Swiftie could be generalized, all within the adverbial format

Primary schools’ development in Somaliland – The role of Community Education Committees

The study sought to determine the methods used to participate the community in school infrastructure projects. It also examined the extent and effectiveness of the community education committee participation process. Done as a cross-sectional survey using mixed methods of inquiry, the study targeted 1002 respondents consisting of 920 headteachers and 82 officers in charge of District Education (DEOs) in Somaliland. The sample comprised 257 headteachers and 22 DEOs. Multi stage sampling was used. Purposive sampling was used to draw a sample of regions, stratified random sampling to draw a sample of headteachers while simple random sampling was used to draw a sample of DEOs. Pilot testing of the questionnaire was done on 28 headteachers. DEOs were interviewed while Headteachers filled questionnaires. Reliability of the questionnaire was ensured using Cronbach alpha. Empirical literature review, peer review and pilot testing were used to ensure validity. The response was received from 20 DEOs and 247 headteachers. Thematic analysis was used to analyse interview data collected from DEOs. Headteachers data collected by questionnaire were analysed using descriptive statistics. Participating the community in decision-making, offering free labour and and fundraising were the leading methods of participating communities in school infrastructure projects. Communities perceived full ownership of completed school infrastructure projects. Community members were satisfied with the schools‘ participation process. Most schools had realized their community participation goals. The CEC process was just one of the numerous ways the community participated in school infrastructure projects. The CEC participation method was largely working and realising its goals. More school development could be realised if the CEC participation process was further strengthened

Harnessing Social Capital for School Development: Community Participation in School Construction Projects

The study examined how communities participate in school construction projects in primary schools in Somaliland and how community participation in school construction projects influences the performance of those projects. The study used a correlational design and was undertaken as a cross-sectional survey. The target population was 920 primary school headteachers in all the 13 regions of Somaliland and 82 District Education Officers. A sample of 257 headteachers was drawn using multistage sampling where purposive sampling and stratified random sampling with replacement were used to sample headteachers while 22 DEOs were sampled using simple random sampling. Data was collected from headteachers using questionnaires and from DEOs using semi-structured interviews. The questionnaire was pilot tested on 28 headteachers. The response was received from 247 headteachers and 20 DEOs. Variables relationships were analyzed using path analysis and tested using t-tests at α = 5%. The main methods used to involve the community in primary schools’ construction projects were: involving them in decision-making processes, volunteering labour and fundraising. The study found that community participation had no significant influence on the performance of construction projects. Community participation in public primary schools in postwar Somaliland is a policy-driven initiative and a fill-gap measure of deficiencies left by the government’s low and inadequate capitation to schools. Low social capital in the communities participated in projects coupled with the costs and the downsides of the community participation process can result in a negative impact on the performance of those projects. Urban schools tend to benefit more from community participation than rural schools due to higher social capital stocks in urban communities as compared to rural communities

Solution structure of deglycosylated human IgG1 shows the role of CH2 glycans in its conformation

The human immunoglobulin G (IgG) class is the most prevalent antibody in serum, with the IgG1 subclass being the most abundant. IgG1 is composed of two Fab regions connected to a Fc region through a 15-residue hinge peptide. Two glycan chains are conserved in the Fc region in IgG; however, their importance for the structure of intact IgG1 has remained unclear. Here, we subjected glycosylated and deglycosylated monoclonal human IgG1 (designated as A33) to a comparative multidisciplinary structural study of both forms. After deglycosylation using peptide:N-glycosidase F, analytical ultracentrifugation showed that IgG1 remained monomeric and the sedimentation coefficients s020,w of IgG1 decreased from 6.45 S by 0.16–0.27 S. This change was attributed to the reduction in mass after glycan removal. X-ray and neutron scattering revealed changes in the Guinier structural parameters after deglycosylation. Although the radius of gyration (RG) was unchanged, the cross-sectional radius of gyration (RXS-1) increased by 0.1 nm, and the commonly occurring distance peak M2 of the distance distribution curve P(r) increased by 0.4 nm. These changes revealed that the Fab-Fc separation in IgG1 was perturbed after deglycosylation. To explain these changes, atomistic scattering modeling based on Monte Carlo simulations resulted in 123,284 and 119,191 trial structures for glycosylated and deglycosylated IgG1 respectively. From these, 100 x-ray and neutron best-fit models were determined. For these, principal component analyses identified five groups of structural conformations that were different for glycosylated and deglycosylated IgG1. The Fc region in glycosylated IgG1 showed a restricted range of conformations relative to the Fab regions, whereas the Fc region in deglycosylated IgG1 showed a broader conformational spectrum. These more variable Fc conformations account for the loss of binding to the Fcγ receptor in deglycosylated IgG1

Solution structures of human myeloma IgG3 antibody reveal extended Fab and Fc regions relative to the other IgG subclasses

Human immunoglobulin IgG3 possesses a uniquely long hinge region that separates its Fab antigen-binding and Fc receptor-binding regions. Owing to this hinge length, the molecular structure of full-length IgG3 remains elusive, and the role of the two conserved glycosylation sites in the Fc region is unknown. To address these issues, we subjected glycosylated and deglycosylated human myeloma IgG3 to multidisciplinary solution structure studies. Using analytical ultracentrifugation, the elongated structure of IgG3 was determined from the reduced sedimentation coefficients s020,w of 5.82-6.29 S for both glycosylated and deglycosylated IgG3. X-ray and neutron scattering showed that the Guinier RG values were 6.95 nm for glycosylated IgG3 and were unchanged after deglycosylation, again indicating an elongated structure. The distance distribution function P(r) of both forms of IgG3 showed a maximum length of 25-28 nm and three distinct maxima. The molecular structure of IgG3 was determined using atomistic modelling based on molecular dynamics simulations of the IgG3 hinge and Monte Carlo simulations to identify physically-realistic arrangements of the Fab and Fc regions. This resulted in libraries containing 135,135 and 73,905 glycosylated and deglycosylated IgG3 structures respectively. Comparisons with the X-ray and neutron scattering curves gave 100 best-fit models for each of the two forms of IgG3 that accounted for the experimental scattering curves. These models revealed the first molecular structures for full-length IgG3. The structures exhibited relatively-restricted Fab and Fc conformations joined by an extended semi-rigid hinge, which explains the potent effector functions of IgG3 relative to the other subclasses IgG1, IgG2 and IgG4

Laser-Induced Spall Of Aluminum And Aluminum Alloys At High Strain Rates

We conducted laser-induced spall experiments aimed at studying how a material's microstructure affects the tensile fracture characteristics at high strain rates (> 10(6) s(-1)). We used the Z-Beamlet Laser at Sandia National Laboratory to drive shocks and to measure the spall strength of aluminum targets with various microstructures. The targets were recrystallized, high-purity aluminum (Al-HP RX), recrystallized aluminum + 3 wt.% magnesium (Al-3Mg RX), and cold-worked aluminum + 3 wt.% magnesium (Al-3Mg CW). The Al-3Mg RX and Al-3Mg CW are used to explore the roles that solid-solution alloying and cold-work strengthening play in the spall process. Using a line-VISAR (Velocity Interferometer System for Any Reflector) and analysis of recovered samples, we were able to measure spall strength and determine failure morphology in these targets. We find that the spall strength is highest for Al-HP RX. Analysis reveals that material grain size plays a vital role in the fracture morphology and spall strength results.Mechanical Engineerin

Implementation and performance of SIBYLS: a dual endstation small-angle X-ray scattering and macromolecular crystallography beamline at the Advanced Light Source.

The SIBYLS beamline (12.3.1) of the Advanced Light Source at Lawrence Berkeley National Laboratory, supported by the US Department of Energy and the National Institutes of Health, is optimized for both small-angle X-ray scattering (SAXS) and macromolecular crystallography (MX), making it unique among the world's mostly SAXS or MX dedicated beamlines. Since SIBYLS was commissioned, assessments of the limitations and advantages of a combined SAXS and MX beamline have suggested new strategies for integration and optimal data collection methods and have led to additional hardware and software enhancements. Features described include a dual mode monochromator [containing both Si(111) crystals and Mo/B(4)C multilayer elements], rapid beamline optics conversion between SAXS and MX modes, active beam stabilization, sample-loading robotics, and mail-in and remote data collection. These features allow users to gain valuable insights from both dynamic solution scattering and high-resolution atomic diffraction experiments performed at a single synchrotron beamline. Key practical issues considered for data collection and analysis include radiation damage, structural ensembles, alternative conformers and flexibility. SIBYLS develops and applies efficient combined MX and SAXS methods that deliver high-impact results by providing robust cost-effective routes to connect structures to biology and by performing experiments that aid beamline designs for next generation light sources

Spall And Dynamic Yielding Of Aluminum And Aluminum Alloys At Strain Rates Of 3X10(6) S(-1)

We have explored the role that grain size, impurity particles and alloying in aluminum play in dynamic yielding and spall fracture at tensile strain rates of similar to 3x10(6) We achieved these strain rates shocking the aluminum specimens via laser ablation using the Z-Beamlet Laser at Sandia National Laboratories. The high purity aluminum and 1100 series aluminum alloy produced very different spall strengths and nearly the same yield strengths. In contrast, various grain-sized Al + 3 wt. % Mg specimens presented the lowest spall strength, but the greatest dynamic yield strength. Fracture morphology results and particle analysis are presented along with hydrodynamic simulations to put these results in context. Impurity particles appeared to play a vital role in spall fracture at these fast strain rates. Alloying elements such as Mg seem to be the dominant factor in the dynamic yield results.Mechanical Engineerin

Discutindo agricultura de precisão - aspectos gerais.

bitstream/CNPT-2010/40660/1/p-do42.pd

Exclusive measurement of coherent eta photoproduction from the deuteron

Coherent photoproduction of eta mesons from the deuteron has been measured from threshold up to incident photon energies of 750 MeV using the photon spectrometer TAPS at the tagged photon facility at the Mainz microtron MAMI. For the first time, differential coherent cross sections have been deduced from the coincident detection of the eta meson and the recoil deuteron. A missing energy analysis was used for the suppression of background events so that a very clean identification of coherent eta-photoproduction was achieved. The resulting cross sections agree with previous experimental results except for angles around 90 deg in the photon-deuteron cm-system where they are smaller. They are compared to various model calculations.Comment: 4 pages, 4 figure