The development of a structured approach to the design for economic manufacture of engineering products

The present work has been concerned with establishing a rationalapproach to product design for economic manufacture. This hasinvloved the de velopment of an organised design approach togetherwith proposals for a structure for an ideal organisational system tosupport a design for economic manufacture activity.Surveys of relevant literature and industry have been conducted toreview practices and techniques which are currently available to theindustry to aid the processed of design for economic manufacture. Asa result of the survey it was possible to define analyse the majorareas of activities in relation to product design and manufacture toidentify where maximum attention should be given by the managementand designers to effect economy of product manufacture.It was concluded that although the mangement in several companieshave adopted certain policies towards designing for economic 'manufacture, a more structure and organised approach is required tomeet the growing need to apply design of economic manufacture as ameans of reducing manufacturing costs.As a result of the analysis, it has been POSBible to identify theactions which must be taken at the different stages of product designand devleopment to ensure economy of manufacture. These findings aresupported by two design case studies which individually demostratethe type Of Cost savings which can be achieved by givingconsideration to the product concept at an early stage of design, inaddition to optimising the component desine for manfacture. The abovecase studies highlighted the fundamental factors which influence theproduct manufacuring COBtSTheabove work has allowed proposals to be made for an overallintegrated organisational system which should aid the process. ofdesign for economic manufacture in most engineering companies

Hazards of sea level rise and dams built on the River Nile on water budget and salinity of the Nile Delta aquifer

Data availability: No data was used for the research described in the article.Code availability: Upon request.Supplementary material is available online at: https://www.sciencedirect.com/science/article/pii/S2214581823002872#sec0135 .Copyright © 2023 The Authors. Study region: The Nile Delta region consists of flat, low-lying areas, where most areas are used for agriculture. It covers an area of 22,000 km2, which is 2.20% of the total area of Egypt. Study focus: This study evaluates the water budget and the salinity due to the Sea Level Rise (SLR) and the reduction in the river water flow caused by the Grand Ethiopian Renaissance Dam (GERD) using the numerical code SEAWAT. Three filling scenarios were considered for the GERD reservoir at elevations 600 m, 621 m, and 645 m above mean sea level (AMSL) for the storage volumes of 17 billion cubic meters (BCM) (scenarios #1), 37.30 BCM (scenarios #2), and 74 BCM (scenarios #3). The impact of these fillings scenarios was combined with SLR of 25 cm, and increasing the abstraction rates from the Nile Delta aquifer by 25%, 50%, and 100%, respectively. New hydrological insights for the region: The study findings indicated that the SLR and the GERD reservoir filling with increasing pumping rates, especially during the filling periods, would influence the groundwater resources in the Nile Delta. The GERD reservoir filling could alter the freshwater, in which the aquifer salinity increased by 4.47%, 11.48%, and 29.99% for the three scenarios, respectively. The methodology and findings presented in this study might be useful for investing and comparing the impact of SLR and upstream dam projects on the downstream water budget and salinity at other coastal regions.Alban Kuriqi is grateful for the Foundation for Science and Technology's support through funding UIDB/04625/2020 from the research unit CERIS

Association between vitamin D receptor gene polymorphisms and chronic periodontitis among Libyans

Background: Chronic periodontitis (CP) is a common oral disease characterized by inflammation in the supporting tissue of the teeth ‘the periodontium’, periodontal attachment loss, and alveolar bone loss. The disease has a microbial etiology; however, recent findings suggest that the genetic factors, such as vitamin D receptor (VDR) gene polymorphisms, have also been included.Aim: Investigation of the relationship between VDR gene polymorphisms and CP among Libyans.Materials and methods: In this study, we examined 196 unrelated Libyans between the ages of 25 and 65 years, including 99 patients and 97 controls. An oral examination based on Ramfjord Index was performed at different dental clinics in Tripoli and information were collected using a self-reported questionnaire. DNA was extracted from buccal swabs; the VDR ApaI, BsmI, and FokI polymorphisms were genotyped using polymerase chain reaction and were sequenced using Sanger Method.Results: A significant difference in the newly detected ApaI SNP C/T rs#731236 was found (p0.022), whereas no significant differences were found in ApaI SNP G/T rs#7975232, BsmI SNPA/G rs#1544410, and FokI SNP A/G rs#2228570 between patients and controls (p0.939, 0.466, 0.239), respectively.Conclusion: VDR ApaI SNP C/T rs#731236 may be related to the risk of CP in the Libyan population.Keywords: chronic periodontitis; vitamin D receptor; gene; polymorphisms; variations; SN

A Spotlight on the Egyptian Honeybee (Apis mellifera lamarckii)

Egypt has an ongoing long history with beekeeping, which started with the ancient Egyptians making various reliefs and inscriptions of beekeeping on their tombs and temples. The Egyptian honeybee (Apis mellifera lamarckii) is an authentic Egyptian honeybee subspecies utilized in apiculture. A. m. lamarckii is a distinct honeybee subspecies that has a particular body color, size, and high levels of hygienic behavior. Additionally, it has distinctive characteristics; including the presenceof the half-queens, an excessive number of swarm cells, high adaptability to climatic conditions, good resistance to specific bee diseases, including the Varro disorder, and continuous breeding during the whole year despite low productivity, using very little propolis, and tending to abscond readily. This review discusses the history of beekeeping in Egypt and its current situation in addition to its morphology, genetic analysis, and distinctive characters, and the defensive behaviors of native A. m.lamarckii subspecies.publishersversionPeer reviewe

The 21st Century Paradigm in Supporting Sustainable Development

This book chapter was prepared with the theme "21st century paradigm in supporting sustainable development", with the aim of describing the efforts that have been made to support sustainable development from various fields, not only in the field of education. The material contained in this book chapter illustrates that literacy is very important to apply, so that students are able to face the challenges of a rapidly changing world that requires students to be able to solve every existing problem. In fact, it's not just literacy, but numeracy literacy is also one of the things that must be considered in the learning process. Considering the low level of scientific literacy, if not immediately addressed, it will have an impact on the low quality of human resources and will hinder the progress of science and technology in Indonesia. Literacy in schools is implemented through various learning components that must be designed or prepared by teachers. The application of scientific literacy in science learning should be carried out using scientific inquiry to foster the ability to think, work and behave scientifically and communicate it as an important aspect of life skills

Perspectives of the Apiaceae Hepatoprotective Effects - A Review

The liver has the crucial role in the regulation of various physiological processes and in the excretion of endogenous waste metabolites and xenobiotics. Liver structure impairment can be caused by various factors including microorganisms, autoimmune diseases, chemicals, alcohol and drugs. The plant kingdom is full of liver protective chemicals such as phenols, coumarins, lignans, essential oils, monoterpenes, carotenoids, glycosides, flavonoids, organic acids, lipids, alkaloids and xanthenes. Apiaceae plants are usually used as a vegetable or as a spice, but their other functional properties are also very important. This review highlights the significance of caraway, dill, cumin, aniseed, fennel, coriander, celery, lovage, angelica, parsley and carrot, which are popular vegetables and spices, but possess hepatoprotective potential. These plants can be used for medicinal applications to patients who suffer from liver damage

Desert Farming Benefits from Microbial Potential in Arid Soils and Promotes Diversity and Plant Health

BACKGROUND: To convert deserts into arable, green landscapes is a global vision, and desert farming is a strong growing area of agriculture world-wide. However, its effect on diversity of soil microbial communities, which are responsible for important ecosystem services like plant health, is still not known. METHODOLOGY/PRINCIPAL FINDINGS: We studied the impact of long-term agriculture on desert soil in one of the most prominent examples for organic desert farming in Sekem (Egypt). Using a polyphasic methodological approach to analyse microbial communities in soil as well as associated with cultivated plants, drastic effects caused by 30 years of agriculture were detected. Analysing bacterial fingerprints, we found statistically significant differences between agricultural and native desert soil of about 60%. A pyrosequencing-based analysis of the 16S rRNA gene regions showed higher diversity in agricultural than in desert soil (Shannon diversity indices: 11.21/7.90), and displayed structural differences. The proportion of Firmicutes in field soil was significantly higher (37%) than in the desert (11%). Bacillus and Paenibacillus play the key role: they represented 96% of the antagonists towards phytopathogens, and identical 16S rRNA sequences in the amplicon library and for isolates were detected. The proportion of antagonistic strains was doubled in field in comparison to desert soil (21.6%/12.4%); disease-suppressive bacteria were especially enriched in plant roots. On the opposite, several extremophilic bacterial groups, e.g., Acidimicrobium, Rubellimicrobium and Deinococcus-Thermus, disappeared from soil after agricultural use. The N-fixing Herbaspirillum group only occurred in desert soil. Soil bacterial communities were strongly driven by the a-biotic factors water supply and pH. CONCLUSIONS/SIGNIFICANCE: After long-term farming, a drastic shift in the bacterial communities in desert soil was observed. Bacterial communities in agricultural soil showed a higher diversity and a better ecosystem function for plant health but a loss of extremophilic bacteria. Interestingly, we detected that indigenous desert microorganisms promoted plant health in desert agro-ecosystems

Investigation of Gamma-aminobutyric acid (GABA) A receptors genes and migraine susceptibility

Background Migraine is a neurological disorder characterized by recurrent attacks of severe headache, affecting around 12% of Caucasian populations. It is well known that migraine has a strong genetic component, although the number and type of genes involved is still unclear. Prior linkage studies have reported mapping of a migraine gene to chromosome Xq 24–28, a region containing a cluster of genes for GABA A receptors (GABRE, GABRA3, GABRQ), which are potential candidate genes for migraine. The GABA neurotransmitter has been implicated in migraine pathophysiology previously; however its exact role has not yet been established, although GABA receptors agonists have been the target of therapeutic developments. The aim of the present research is to investigate the role of the potential candidate genes reported on chromosome Xq 24–28 region in migraine susceptibility. In this study, we have focused on the subunit GABA A receptors type ε (GABRE) and type θ (GABRQ) genes and their involvement in migraine. Methods We have performed an association analysis in a large population of case-controls (275 unrelated Caucasian migraineurs versus 275 controls) examining a set of 3 single nucleotide polymorphisms (SNPs) in the coding region (exons 3, 5 and 9) of the GABRE gene and also the I478F coding variant of the GABRQ gene. Results Our study did not show any association between the examined SNPs in our test population (P > 0.05). Conclusion Although these particular GABA receptor genes did not show positive association, further studies are necessary to consider the role of other GABA receptor genes in migraine susceptibility