43 research outputs found

    Solidification of Al alloys under electromagnetic pulses and characterization of the 3D microstructures under synchrotron x-ray tomography

    Get PDF
    A novel programmable electromagnetic pulse device was developed and used to study the solidification of Al-15 pct Cu and Al-35 pct Cu alloys. The pulsed magnetic fluxes and Lorentz forces generated inside the solidifying melts were simulated using finite element methods, and their effects on the solidification microstructures were characterized using electron microscopy and synchrotron X-ray tomography. Using a discharging voltage of 120 V, a pulsed magnetic field with the peak Lorentz force of ~1.6 N was generated inside the solidifying Al-Cu melts which were showed sufficiently enough to disrupt the growth of the primary Al dendrites and the Al2Cu intermetallic phases. The microstructures exhibit a strong correlation to the characteristics of the applied pulse, forming a periodical pattern that resonates the frequency of the applied electromagnetic field

    Bio-analytical Assay Methods used in Therapeutic Drug Monitoring of Antiretroviral Drugs-A Review

    Get PDF

    Review of the techniques used in motor‐cognitive human‐robot skill transfer

    Get PDF
    Abstract A conventional robot programming method extensively limits the reusability of skills in the developmental aspect. Engineers programme a robot in a targeted manner for the realisation of predefined skills. The low reusability of general‐purpose robot skills is mainly reflected in inability in novel and complex scenarios. Skill transfer aims to transfer human skills to general‐purpose manipulators or mobile robots to replicate human‐like behaviours. Skill transfer methods that are commonly used at present, such as learning from demonstrated (LfD) or imitation learning, endow the robot with the expert's low‐level motor and high‐level decision‐making ability, so that skills can be reproduced and generalised according to perceived context. The improvement of robot cognition usually relates to an improvement in the autonomous high‐level decision‐making ability. Based on the idea of establishing a generic or specialised robot skill library, robots are expected to autonomously reason about the needs for using skills and plan compound movements according to sensory input. In recent years, in this area, many successful studies have demonstrated their effectiveness. Herein, a detailed review is provided on the transferring techniques of skills, applications, advancements, and limitations, especially in the LfD. Future research directions are also suggested

    A century of trends in adult human height

    No full text
    Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5-22.7) and 16.5 cm (13.3-19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8-144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries

    Dissemination of cooking energy alternatives in India--a review

    No full text
    Energy requirements for cooking account for 36% of total primary energy consumption in India. The rural and urban populaces, depend mainly, on non-commercial fuels to meet their energy needs. Diverse urban growth patterns have led to structural changes in economy, and have important ramifications on energy consumption in household sector. It is observed that India follows income-based ladder starting with fuelwood and ending with sophisticated fuels like liquefied petroleum gas (LPG) and electricity. This paper discusses cooking energy dissemination in the country with an objective of understanding the underlying socioeconomic factors governing the utilization of various fuels/energy carriers in cooking. The diffusion of renewable energy devices is observed to be far below their estimated potential. Policy interventions required for better dissemination of renewable energy based devices are also discussed.Cooking energy Dissemination Solar cookers Renewable energy

    A review of wind energy developments in India

    No full text
    Climate change, dwindling reserves of fossil fuels and shortage of electricity have prompted the government to give an impetus to renewable energy sources. Wind energy, with an average growth rate of 30%, is the fastest growing source of renewable energy in the world. India has a potential capacity of over 45,000 MW out of which 1869 MW has been extracted from this eco-friendly source. India stands at fifth position in the world in wind energy development. Policy initiatives and fiscal initiatives for realisation of the estimated potential already exist. This paper discusses an overview of wind assessment, monitoring, development and environmental impact in India. Financial interventions and state policies on commercialisation are also presented with a view to identifying the barriers for further commercialisation.wind monitoring; commercialisation; renewable energy; grid interaction; wind energy; wind power; India; environmental impact.

    {}

    No full text

    Long-term culture and expansion of primary human hepatocytes

    No full text
    Item does not contain fulltextHepatocytes have a critical role in metabolism, but their study is limited by the inability to expand primary hepatocytes in vitro while maintaining proliferative capacity and metabolic function. Here we describe the oncostatin M (OSM)-dependent expansion of primary human hepatocytes by low expression of the human papilloma virus (HPV) genes E6 and E7 coupled with inhibition of epithelial-to-mesenchymal transition. We show that E6 and E7 expression upregulates the OSM receptor gp130 and that OSM stimulation induces hepatocytes to expand for up to 40 population doublings, producing 1013 to 1016 cells from a single human hepatocyte isolate. OSM removal induces differentiation into metabolically functional, polarized hepatocytes with functional bile canaliculi. Differentiated hepatocytes show transcriptional and toxicity profiles and cytochrome P450 induction similar to those of primary human hepatocytes. Replication and infectivity of hepatitis C virus (HCV) in differentiated hepatocytes are similar to those of Huh7.5.1 human hepatoma cells. These results offer a means of expanding human hepatocytes of different genetic backgrounds for research, clinical applications and pharmaceutical development
    corecore