6,931 research outputs found
Compressive force generation by a bundle of living biofilaments
To study the compressional forces exerted by a bundle of living stiff
filaments pressing on a surface, akin to the case of an actin bundle in
filopodia structures, we have performed particulate Molecular Dynamics
simulations of a grafted bundle of parallel living (self-assembling) filaments,
in chemical equilibrium with a solution of their constitutive monomers.
Equilibrium is established as these filaments, grafted at one end to a wall of
the simulation box, grow at their chemically active free end and encounter the
opposite confining wall of the simulation box. Further growth of filaments
requires bending and thus energy, which automatically limit the populations of
longer filaments. The resulting filament sizes distribution and the force
exerted by the bundle on the obstacle are analyzed for different grafting
densities and different sub- or supercritical conditions, these properties
being compared with the predictions of the corresponding ideal confined bundle
model. In this analysis, non-ideal effects due to interactions between
filaments and confinement effects are singled out. For all state points
considered at the same temperature and at the same gap width between the two
surfaces, the force per filament exerted on the opposite wall appears to be a
function of a rescaled free monomer density . This
quantity can be estimated directly from the characteristic length of the
exponential filament size distribution observed in the size domain where
these grafted filaments are not in direct contact with the wall. We also
analyze the dynamics of the filament contour length fluctuations in terms of
effective polymerization () and depolymerization () rates, where again it
is possible to disentangle non-ideal and confinement effects.Comment: 24 pages, 7 figure
Le défi de la mécanisation : mécaniser la coupe sur 20 000 hectares
In this thesis we investigate some problems in set theoretical topology related to the concepts of
the group of homeomorphisms and order. Many problems considered are directly or indirectly related to the concept of the group of homeomorphisms of a topological space onto itself. Order theoretic methods are used extensively. Chapter-l deals with the group of homeomorphisms.
This concept has been investigated by several authors for many years from different angles. It was observed that nonhomeomorphic topological spaces can have isomorphic groups of homeomorphisms. Many problems relating the topological properties of a space and the algebraic properties of its group of homeomorphisms were investigated. The group of isomorphisms of several algebraic, geometric, order theoretic and topological structures had also been investigated. A related concept of the semigroup of continuous functions of a topological space also received attentionCochin University of Science and TechnologyDepartment of Mathematics and Statistics, Cochin University of Science and Technolog
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Case report: targeted whole exome sequencing enables the first prenatal diagnosis of the lethal skeletal dysplasia Osteocraniostenosis.
BACKGROUND: Osteocraniostenosis (OCS) is a rare genetic disorder characterised by premature closure of cranial sutures, gracile bones and perinatal lethality. Previously, diagnosis has only been possible postnatally on clinical and radiological features. This study describes the first prenatal diagnosis of OCS. CASE PRESENTATION: In this case prenatal ultrasound images were suggestive of a serious but non-lethal skeletal dysplasia. Due to the uncertain prognosis the parents were offered Whole Exome Sequencing (WES), which identified a specific gene mutation in the FAMIIIa gene. This mutation had previously been detected in two cases and was lethal in both perinatally. This established the diagnosis, a clear prognosis and allowed informed parental choice regarding ongoing pregnancy management. CONCLUSIONS: This case report supports the use of targeted WES prenatally to confirm the underlying cause and prognosis of sonographically suspected abnormalities
The conjectures of Artin-Tate and Birch-Swinnerton-Dyer
We provide two proofs that the conjecture of Artin-Tate for a fibered surface
is equivalent to the conjecture of Birch-Swinnerton-Dyer for the Jacobian of
the generic fibre. As a byproduct, we obtain a new proof of a theorem of
Geisser relating the orders of the Brauer group and the Tate-Shafarevich group.Comment: 13 pages, Takashi Suzuki has joined as author, new version has two
proofs (second proof by Takashi Suzuki
Multiloop divergences in the closed bosonic string theory
The structure of the divergences in the multiloop vacuum diagrams for the closed bosonic strings in the framework of the Polyakov covariant formalism is discussed. It is found, by an explicit computation, that all the divergences in the theory may be interpreted as due to tadpole diagrams in which the dilaton goes into the vacuum
Short-course chemotherapy in neuro-tuberculosis - Brief review of clinical trials undertaken at the Tuberculosis Research Centre, Madras
Tuberculosis of the nervous system can present as tuberculous meningitis,
tuberculoma of brain, Potts paraplegia, tuberculosis of spine and rarely as arachnoiditis
and vasculitis.
Tuberculosis is conventionally treated for 12 to 18 months to ensure adequate cure,
stabilise quiescence and prevent relapses. With the introduction of rifampicin and
pyrazinamide it became feasible to shorten the duration of chemotherapy to 6 to 9
months. Many controlled clinical trials conducted all over the world have confirmed the
success of this approach in pulmonary tuberculosis by evolving 100% effective SCC
regimens 1-5. In a few studies especially tuberculous lymphadenitis, tuberculous abdomen
and pericarditis SCC has also been used and found to be as effective as conventional
regimens6,7. However, only recently has SCC been tried for neurotuberculosis. This
presentation briefly highlights some of the chemotherapy trials conducted at the
Tuberculosis Research Centre in some areas of CNS tuberculosis8-10.
What is SCC? SCC refers to chemotherapeutic regimens containing powerful
bactericidal drugs like INH, Rifampicin and Pyrazinamide, by the use of which the
duration of treatment of TB is reduced from the conventional 12 to 18 months to 6 to 9
months
A neuromorphic approach to auditory pattern recognition in cricket phonotaxis
Rost T, Ramachandran H, Nawrot MP, Chicca E. A neuromorphic approach to auditory pattern recognition in cricket phonotaxis. In: 2013 European Conference on Circuit Theory and Design (ECCTD). IEEE; 2013: 1-4.Developing neuromorphic computing paradigms that mimic nervous system function is an emerging field of research with high potential for technical applications. In the present study we take inspiration from the cricket auditory system and propose a biologically plausible neural network architecture that can explain how acoustic pattern recognition is achieved in the cricket central brain. Our circuit model combines two key features of neural processing dynamics: Spike Frequency Adaptation (SFA) and synaptic short term plasticity. We developed and extensively tested the model function in software simulations. Furthermore, the feasibility of an analogue VLSI implementation is demonstrated using a multi-neuron chip comprising Integrate-and-Fire (IF) neurons and adaptive synapses
On the Enhanced Interstellar Scattering Toward B1849+005
(Abridged) This paper reports new Very Large Array (VLA) and Very Long
Baseline Array (VLBA) observations of the extragalactic source B1849+005 at
frequencies between 0.33 and 15 GHz and the re-analysis of archival VLA
observations at 0.33, 1.5, and 4.9 GHz. The structure of this source is complex
but interstellar scattering dominates the structure of the central component at
least to 15 GHz. An analysis of the phase structure functions of the
interferometric visibilities shows the density fluctuations along this line of
sight to be anisotropic (axial ratio = 1.3) with a frequency-independent
position angle, and having an inner scale of roughly a few hundred kilometers.
The anisotropies occur on length scales of order 10^{15} cm (D/5 kpc), which
within the context of certain magnetohydrodynamic turbulence theories indicates
the length scale on which the kinetic and magnetic energy densities are
comparable. A conservative upper limit on the velocity of the scattering
material is 1800 km/s. In the 0.33 GHz field of view, there are a number of
other sources that might also be heavily scattered. Both B1849+005 and PSR
B1849+00 are highly scattered, and they are separated by only 13'. If the lines
of sight are affected by the same ``clump'' of scattering material, it must be
at least 2.3 kpc distant. However, a detailed attempt to account for the
scattering observables toward these sources does not produce a self-consistent
set of parameters for such a clump. A clump of H\alpha emission, possibly
associated with the H II region G33.418-0.004, lies between these two lines of
sight, but it seems unable to account for all of the required excess
scattering.Comment: 23 pages, LaTeX2e AASTeX, 13 figures in 14 PostScript files, accepted
for publication in Ap
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