Increased Metabolic Rate in X-linked Hypophosphatemic Mice

Hyp mice are a model for human X-linked hypophosphatemia, the most common form of vitamin D-resistant rickets. It has previously been observed that Hyp mice have a greater food consumption per gram body weight than do normal mice. This led to the search for some alteration in metabolism in Hyp mice. We found that oxygen consumption was significantly higher in Hyp mice than in normal C57BL/6J mice and this was accompanied by an increased percentage of cardiac output being delivered to organs of heat production (liver and skeletal muscle), to the skin, and to bone and a decreased percentage to the gastrointestinal tract of Hyp mice. The increased oxygen consumption in Hyp mice was not associated with increased plasma free T4 levels and was not affected by alterations in plasma phosphate produced by a low phosphate diet. The cause of the increased oxygen consumption is not known, and the role that this change and reported changes in distribution of cardiac output may play in the development of X-linked hypophosphatemia is also unknown. Study of the cardiovascular and thermoregulatory systems in Hyp mice should help increase understanding of the underlying mechanisms of this disease

Design of Optimum Ducts Using an Efficient 3-D Viscous Computational Flow Analysis

Design of fluid dynamically efficient ducts is addressed through the combination of an optimization analysis with a three-dimensional viscous fluid dynamic analysis code. For efficiency, a parabolic fluid dynamic analysis was used. Since each function evaluation in an optimization analysis is a full three-dimensional viscous flow analysis requiring 200,000 grid points, it is important to use both an efficient fluid dynamic analysis and an efficient optimization technique. Three optimization techniques are evaluated on a series of test functions. The Quasi-Newton (BFGS, eta = .9) technique was selected as the preferred technique. A series of basic duct design problems are performed. On a two-parameter optimization problem, the BFGS technique is demonstrated to require half as many function evaluations as a steepest descent technique

Scaling laws for light weight optics, studies of light weight mirrors mounting and dynamic mirror stress, and light weight mirror and mount designs

Scaling laws for light-weight optical systems are examined. A cubic relationship between mirror diameter and weight has been suggested and used by many designers of optical systems as the best description for all light-weight mirrors. A survey of existing light-weight systems in the open literature was made to clarify this issue. Fifty existing optical systems were surveyed with all varieties of light-weight mirrors including glass and beryllium structured mirrors, contoured mirrors, and very thin solid mirrors. These mirrors were then categorized and weight to diameter ratio was plotted to find a best curve for each case. A best fitting curve program tests nineteen different equations and ranks a goodness-to-fit for each of these equations. The resulting relationship found for each light-weight mirror category helps to quantify light-weight optical systems and methods of fabrication and provides comparisons between mirror types

Efficient Toffoli Gates Using Qudits

The simplest decomposition of a Toffoli gate acting on three qubits requires {\em five} 2-qubit gates. If we restrict ourselves to controlled-sign (or controlled-NOT) gates this number climbs to six. We show that the number of controlled-sign gates required to implement a Toffoli gate can be reduced to just {\em three} if one of the three quantum systems has a third state that is accessible during the computation, i.e. is actually a qutrit. Such a requirement is not unreasonable or even atypical since we often artificially enforce a qubit structure on multilevel quantums systems (eg. atoms, photonic polarization and spatial modes). We explore the implementation of these techniques in optical quantum processing and show that linear optical circuits could operate with much higher probabilities of success

Phenomenological Modeling of Photoemission Spectra in Strongly Correlated Electron Systems

A phenomenological approach is presented that allows one to model, and thereby interpret, photoemission spectra of strongly correlated electron systems. A simple analytical formula for the self-energy is proposed. This self-energy describes both coherent and incoherent parts of the spectrum (quasiparticle and Hubbard peaks, respectively). Free parameters in the expression are determined by fitting the density of states to experimental photoemission data. An explicit fitting is presented for the La$_{1-x}$Sr$_x$TiO$_3$ system with $0.08 \le x \le 0.38$. In general, our phenomenological approach provides information on the effective mass, the Hubbard interaction, and the spectral weight distribution in different parts of the spectrum. Limitations of this approach are also discussed.Comment: 13 pages, 4 figures, IJMPB style (included

Rapid purification of quantum systems by measuring in a feedback-controlled unbiased basis

Rapid-purification by feedback --- specifically, reducing the mean impurity faster than by measurement alone --- can be achieved by making the eigenbasis of the density matrix to be unbiased relative to the measurement basis. Here we further examine the protocol introduced by Combes and Jacobs [Phys.Rev.Lett. {\bf 96}, 010504 (2006)] involving continuous measurement of the observable $J_z$ for a $D$-dimensional system. We rigorously re-derive the lower bound $(2/3)(D+1)$ on the achievable speed-up factor, and also an upper bound, namely $D^2/2$, for all feedback protocols that use measurements in unbiased bases. Finally we extend our results to $n$ independent measurements on a register of $n$ qubits, and derive an upper bound on the achievable speed-up factor that scales linearly with $n$.Comment: v2: published versio

Biased EPR entanglement and its application to teleportation

We consider pure continuous variable entanglement with non-equal correlations between orthogonal quadratures. We introduce a simple protocol which equates these correlations and in the process transforms the entanglement onto a state with the minimum allowed number of photons. As an example we show that our protocol transforms, through unitary local operations, a single squeezed beam split on a beam splitter into the same entanglement that is produced when two squeezed beams are mixed orthogonally. We demonstrate that this technique can in principle facilitate perfect teleportation utilising only one squeezed beam.Comment: 8 pages, 5 figure

Scattering Theory of Charge-Current Induced Magnetization Dynamics

In ferromagnets, charge currents can excite magnons via the spin-orbit coupling. We develop a novel and general scattering theory of charge current induced macrospin magnetization torques in normal metal$|$ferromagnet$|$normal metal layers. We apply the formalism to a dirty GaAs$|$(Ga,Mn)As$|$GaAs system. By computing the charge current induced magnetization torques and solving the Landau-Lifshitz-Gilbert equation, we find magnetization switching for current densities as low as $5\times 10^{6}$~A/cm$^2$. Our results are in agreement with a recent experimental observation of charge-current induced magnetization switching in (Ga,Mn)As.Comment: Final version accepted by EP

Entanglement conditions for two-mode states: Applications

We examine the implications of several recently derived conditions [Hillery and Zubairy, Phys. Rev. Lett. 96, 050503 (2006)] for determining when a two-mode state is entangled. We first find examples of non-Gaussian states that satisfy these conditions. We then apply the entanglement conditions to the study of several linear devices, the beam splitter, the parametric amplifier, and the linear phase-insensitive amplifier. For the first two, we find conditions on the input states that guarantee that the output states are entangled. For the linear amplifier, we determine in the limit of high and no gain, when an entangled input leads to an entangled output. Finally, we show how application of two two-mode entanglement conditions to a three-mode state can serve as a test of genuine three-mode entanglement.Comment: 7 pages, no figures, replaced with published versio

Laboratory Accident Liability: Academic and Industrial

Educational institutions are not expected to be insurers of a student\u27s safety; however, schools must exercise that degree of care required to avoid a negligent disregard of the potential dangers inherent in academic chemical experimentation. Industry must likewise exert due care to avoid unnecessary exposure of the industrial chemist to unreasonable dangers. Injuries sustained in the industrial research laboratory may be recoverable under workmen\u27s compensation statutes or under tort law. The industrial chemist assumes a limited risk, but he does not assume the perils of his employer\u27s negligence