Introduction to Dynamic Financial Analysis

In the last few years we have witnessed growing interest in Dynamic Financial Analysis (DFA) in the nonlife insurance industry. DFA combines many economic and mathematical concepts and methods. It is almost impossible to identify and describe a unique DFA methodology. There are some DFA software products for nonlife companies available in the market, each of them relying on its own approach to DFA. Our goal is to give an introduction into this field by presenting a model framework comprising those components many DFA models have in common. By explicit reference to mathematical language we introduce an up-and-running model that can easily be implemented and adjusted to individual needs. An application of this model is presented as wel

A square planar silylene nickel four-membered ring

Herein the new nickel silylene [PhC(NtBu)2SiNi(C5Me5)]2, which features a square planar central ring motif consisting of two silicon and two nickel atoms is presented. The title compound was obtained by an insertion of the Ni(0) precursor [Ni(cod)2] (cod = 1,5-cyclooctadiene) in the Si–C bond of the silylene [PhC(NtBu)2Si(C5Me5)]. Analytic characterisation including mass spectrometry as well as IR and Raman spectroscopies was combined with quantum chemical calculations to get an insight on the bonding situation within the four-membered Si–Ni-ring

Evaluierung des Programms Klima- und Energie-Modellregionen

Klima- und Energie-Modellregionen (KEM) ist ein Programm des österreichischen Klima- und Energiefonds, das Gemeinden und Regionen bei der Umsetzung von Klimaschutzmaßnahmen unterstützt. KEM folgt dabei der Leitvorgabe des Fonds, die Senkung der Treibhausgasemissionen Österreichs so schnell und nachhaltig wie möglich umzusetzen und dabei regionale Wertschöpfung und Arbeitsplätze zu generieren. Eine Evaluierung des Programms wurde durch das Wuppertal Institut und der KMU Forschung Austria zwischen Oktober 2018 und Juni 2019 durchgeführt. Ein breites Spektrum von Erhebungsmethoden kam darin zur Anwendung, durch die das Konzept und die Ziele des Programms, die Qualität des Programmmanagements und dessen Wirkungen evaluiert wurden. Insbesondere über zahlreiche Interviews mit Experten und Expertinnen, eine Online-Befragung der KEM-Managerinnen und -Manager und quantitative Wirkungsberechnungen getätigter Investförderungen konnten eine Fülle von Informationen gewonnen werden, anhand derer Vorschläge zur Weiterentwicklung und Verbesserung des Programms formuliert wurden

Omega-3 polyunsaturated fatty acids and bronchial inflammation in grass pollen allergy after allergen challenge

SummaryRatioAsthma is a major public health problem, with bronchial inflammation as the therapeutic target. The role of dietary fish oil derived polyunsaturated fatty acids (PUFAs) in allergic inflammation is controversial. Most asthmatics suffer from mild disease and non-pharmacologic interventions are attractive. This study investigates the anti-inflammatory potential of nutritional PUFAs in an experimentally induced bronchial inflammation.MethodsWe examined 38 grass pollen allergic asthmatics and 19 controls. History of dietary PUFA intake was compared with levels of PUFAs in erythrocyte membranes, and stratified according to low (25th quartile; Q25) and high (75th quartile; Q75) ratios of omega-3 (n-3) to omega-6 (n-6) PUFAs as a surrogate for anti-inflammatory (Q75) or proinflammatory (Q25) effects. Bronchial inflammation was simulated with one-step inhalation of grass pollen. Bronchial response (exhaled nitric monoxide, eNO as surrogate for inflammation, decrease of FEV1) was correlated with levels of PUFAs in erythrocyte membranes.ResultsRatios of n-3/n-6 PUFA were significantly lower in asthmatics than in healthy controls. Levels of eNO were significantly higher in Q25 asthmatics than in Q75 asthmatics (p = 0.040). There was a trend of higher bronchial hyperreactivity in Q25 asthmatics (median PD20 0.27 vs. 0.14; n.s.), induced by specific bronchial challenge with grass pollen (FEV1 decrease 16.7 vs. 23.1%; n.s.).ConclusionWhen stratifying for erythrocyte membrane PUFA content as a surrogate for alimentary intake, we found mild effects on bronchial allergic inflammation. Future intervention studies with pharmacological PUFA doses appear suitable to clarify dietary PUFA role as an adjunctive intervention to the established treatment of asthma.ClinicalTrials.gov No. NCT00519740

Engagement Effects of Player Rating System-Based Matchmaking for Level Ordering in Human Computation Games

Human computation games lack established ways of balancing the difficulty of tasks or levels served to players, potentially contributing to their low engagement rates. Traditional player rating systems have been suggested as a potential solution: using them to rate both players and tasks could estimate player skill and task difficulty and fuel player-task matchmaking. However, neither the effect of difficulty balancing on engagement in human computation games nor the use of player rating systems for this purpose has been empirically tested. We therefore examined the engagement effects of using the Glicko-2 player rating system to order tasks in the human computation game Paradox. An online experiment (n=294) found that both matchmaking-based and pure difficulty-based ordering of tasks led to significantly more attempted and completed levels than random ordering. Additionally, both matchmaking and random ordering led to significantly more di cult tasks being completed than pure difficulty-based ordering. We conclude that poor balancing contributes to poor engagement in human computation games, and that player rating system-based difficulty rating may be a viable and efficient way of improving both

Effect of Fouling on the Performance of an Instream Turbine

As the tidal energy industry starts to mature towards commercial projects a key focus is on reliable power performance. As for any marine application, fouling poses a potential performance reduction risk for instream turbine deployments. SCHOTTEL HYDRO have developed their current commercial SCHOTTEL Instream Turbines. Four drivetrains with 6.3m rotors were deployed on the surface platform PLAT-I by Sustainable Marine Energy. One of PLAT-Is key features is access to the turbines for inspection and maintenance in situ. The system has undergone sea testing from 2017 to 2021 in Scotland and Nova Scotia (Canada). This paper presents the hydrodynamic rotor performance reduction due to fouling based on full-scale experimental results. An in-house blade element momentum model is used to quantify the changes of the hydrodynamic forces in terms of lift and drag for the hydrofoils used. Furthermore, the effect of fouling on the downstream wake was quantified in the field. The performance reduction due to fouling is significant and leads to a power drop of up to 43%, whereas the thrust is reduced by 25%. This is also reflected in a reduction of the turbine’s downstream wake as a “fouled” rotor extracts less energy from the flow. Modifications of the polar data, used for semi-empirical performance predictions, are able to predict the effect of fouling on the rotor performance. In general, the results derived from the testing prove the significance of access to the turbines in order to avoid reduction in the turbines’ performance due to fouling

Critical Role of Methylglyoxal and AGE in Mycobacteria-Induced Macrophage Apoptosis and Activation

Apoptosis and activation of macrophages play an important role in the host response to mycobacterial infection involving TNF-α as a critical autocrine mediator. The underlying mechanisms are still ill-defined. Here, we demonstrate elevated levels of methylglyoxal (MG), a small and reactive molecule that is usually a physiological product of various metabolic pathways, and advanced glycation end products (AGE) during mycobacterial infection of macrophages, leading to apoptosis and activation of macrophages. Moreover, we demonstrate abundant AGE in pulmonary lesions of tuberculosis (TB) patients. Global gene expression profiling of MG-treated macrophages revealed a diverse spectrum of functions induced by MG, including apoptosis and immune response. Our results not only provide first evidence for the involvement of MG and AGE in TB, but also form a basis for novel intervention strategies against infectious diseases in which MG and AGE play critical roles

Cyclic stretch increases splicing noise rate in cultured human fibroblasts

BACKGROUND: Mechanical forces are known to alter the expression of genes, but it has so far not been reported whether they may influence the fidelity of nucleus-based processes. One experimental approach permitting to address this question is the application of cyclic stretch to cultured human fibroblasts. As a marker for the precision of nucleus-based processes, the number of errors that occur during co-transcriptional splicing can then be measured. This so-called splicing noise is found at low frequency in pre-mRNA splicing. FINDINGS: The amount of splicing noise was measured by RT-qPCR of seven exon skips from the test genes AATF, MAP3K11, NF1, PCGF2, POLR2A and RABAC1. In cells treated by altered uniaxial cyclic stretching for 18 h, a uniform and significant increase of splicing noise was found for all detectable exon skips. CONCLUSION: Our data demonstrate that application of cyclic stretch to cultured fibroblasts correlates with a reduced transcriptional fidelity caused by increasing splicing noise