Adaptive Mesh Fluid Simulations on GPU

We describe an implementation of compressible inviscid fluid solvers with block-structured adaptive mesh refinement on Graphics Processing Units using NVIDIA's CUDA. We show that a class of high resolution shock capturing schemes can be mapped naturally on this architecture. Using the method of lines approach with the second order total variation diminishing Runge-Kutta time integration scheme, piecewise linear reconstruction, and a Harten-Lax-van Leer Riemann solver, we achieve an overall speedup of approximately 10 times faster execution on one graphics card as compared to a single core on the host computer. We attain this speedup in uniform grid runs as well as in problems with deep AMR hierarchies. Our framework can readily be applied to more general systems of conservation laws and extended to higher order shock capturing schemes. This is shown directly by an implementation of a magneto-hydrodynamic solver and comparing its performance to the pure hydrodynamic case. Finally, we also combined our CUDA parallel scheme with MPI to make the code run on GPU clusters. Close to ideal speedup is observed on up to four GPUs.Comment: Submitted to New Astronom

Tracing the Dark Matter Sheet in Phase Space

The primordial velocity dispersion of dark matter is small compared to the velocities attained during structure formation. The initial density distribution is close to uniform and it occupies an initial sheet in phase space that is single valued in velocity space. Because of gravitational forces this three dimensional manifold evolves in phase space without ever tearing, conserving phase-space volume and preserving the connectivity of nearby points. N-body simulations already follow the motion of this sheet in phase space. This fact can be used to extract full fine-grained phase-space-structure information from existing cosmological N-body simulations. Particles are considered as the vertices of an unstructured three dimensional mesh, moving in six dimensional phase-space. On this mesh, mass density and momentum are uniquely defined. We show how to obtain the space density of the fluid, detect caustics, and count the number of streams as well as their individual contributions to any point in configuration-space. We calculate the bulk velocity, local velocity dispersions, and densities from the sheet - all without averaging over control volumes. This gives a wealth of new information about dark matter fluid flow which had previously been thought of as inaccessible to N-body simulations. We outline how this mapping may be used to create new accurate collisionless fluid simulation codes that may be able to overcome the sparse sampling and unphysical two-body effects that plague current N-body techniques.Comment: MNRAS submitted; 17 pages, 19 figures; revised in line with referee's comments, results unchange

The price of tumor control

Ipilimumab, a cytotoxic T-lymphocyte antigen-4 (CTLA-4) blocking antibody, has been approved for the treatment of metastatic melanoma and induces adverse events (AE) in up to 64% of patients. Treatment algorithms for the management of common ipilimumab-induced AEs have lead to a reduction of morbidity, e.g. due to bowel perforations. However, the spectrum of less common AEs is expanding as ipilimumab is increasingly applied. Stringent recognition and management of AEs will reduce drug-induced morbidity and costs, and thus, positively impact the cost-benefit ratio of the drug. To facilitate timely identification and adequate management data on rare AEs were analyzed at 19 skin cancer centers. Patient files (n = 752) were screened for rare ipilimumab-associated AEs. A total of 120 AEs, some of which were life-threatening or even fatal, were reported and summarized by organ system describing the most instructive cases in detail. Previously unreported AEs like drug rash with eosinophilia and systemic symptoms (DRESS), granulomatous inflammation of the central nervous system, and aseptic meningitis, were documented. Obstacles included patientś delay in reporting symptoms and the differentiation of steroid-induced from ipilimumab-induced AEs under steroid treatment. Importantly, response rate was high in this patient population with tumor regression in 30.9% and a tumor control rate of 61.8% in stage IV melanoma patients despite the fact that some patients received only two of four recommended ipilimumab infusions. This suggests that ipilimumab-induced antitumor responses can have an early onset and that severe autoimmune reactions may reflect overtreatment. The wide spectrum of ipilimumab-induced AEs demands doctor and patient awareness to reduce morbidity and treatment costs and true ipilimumab success is dictated by both objective tumor responses and controlling severe side effects

The price of tumor control: an analysis of rare side effects of anti-CTLA-4 therapy in metastatic melanoma from the ipilimumab network

Background: Ipilimumab, a cytotoxic T-lymphocyte antigen-4 (CTLA-4) blocking antibody, has been approved for the treatment of metastatic melanoma and induces adverse events (AE) in up to 64% of patients. Treatment algorithms for the management of common ipilimumab-induced AEs have lead to a reduction of morbidity, e.g. due to bowel perforations. However, the spectrum of less common AEs is expanding as ipilimumab is increasingly applied. Stringent recognition and management of AEs will reduce drug-induced morbidity and costs, and thus, positively impact the cost-benefit ratio of the drug. To facilitate timely identification and adequate management data on rare AEs were analyzed at 19 skin cancer centers. Methods and Findings: Patient files (n = 752) were screened for rare ipilimumab-associated AEs. A total of 120 AEs, some of which were life-threatening or even fatal, were reported and summarized by organ system describing the most instructive cases in detail. Previously unreported AEs like drug rash with eosinophilia and systemic symptoms (DRESS), granulomatous inflammation of the central nervous system, and aseptic meningitis, were documented. Obstacles included patientś delay in reporting symptoms and the differentiation of steroid-induced from ipilimumab-induced AEs under steroid treatment. Importantly, response rate was high in this patient population with tumor regression in 30.9% and a tumor control rate of 61.8% in stage IV melanoma patients despite the fact that some patients received only two of four recommended ipilimumab infusions. This suggests that ipilimumab-induced antitumor responses can have an early onset and that severe autoimmune reactions may reflect overtreatment. Conclusion: The wide spectrum of ipilimumab-induced AEs demands doctor and patient awareness to reduce morbidity and treatment costs and true ipilimumab success is dictated by both objective tumor responses and controlling severe side effects

Dünenmonitoring bei Sturmflutereignissen

Das Forschungsvorhaben PADO (Prozesse und Auswirkungen von Dünendurchbrüchen an der deutschen Ostseeküste) hat es sich zur Aufgabe gemacht, wesentliche Erkenntnisse zur Dünendynamik und dem Verhalten von Dünen in Durchbruchsituationen zu generieren. Damit soll das Bemessungskonzept für Dünen und kombinierte Küstenschutzsysteme verbessert werden.Hierfür wurde ein für ein jährliches Sturmflutereignis bemessenes großmaßstäbliches Dünenbauwerk am Strand von Rostock Warnemünde errichtet. Das Bauwerk wurde durch ein auftretendes Hochwasser bis zum Versagen (Dünendurchbruch) belastet und dabei durch eine umfangreiche Instrumentierung überwacht. Mit einem 3D-Messkonzept konnte die Dünenoberfläche kontinuierlich vermessen und die stattgefundenen Prozesse, wie die Breschenbildung, erfasst werden. Die gewonnenen Daten dienen unter anderem als Grundlage für die Kalibrierung numerischer Modelle sowie für weiterführende Untersuchungen langfristiger Folgen eines Dünendurchbruchs auf das Hinterland. Hierbei wird das Hauptaugenmerk auf die damit verbundene Versalzung und den möglichen Aussüÿungsprozess gelegt. Darüber hinaus nden auf Basis der überschwemmten Gebiete sozioökonomische Auswertungen statt, bei denen technische, hydrologische und ökonomische Bewertungen der durch Dünen geschützten Küstenregionen durchgeführt werden