Designing an Adversarial Model Against Reactive and Proactive Routing Protocols in MANETS: A Comparative Performance Study

Mobile ad-hoc networks are self-organized infrastructure less networks that consists of mobile nodes, which are capable of maintaining and forming the network by themselves. Recently, researchers are designed several routing protocols on these networks. However, these routing protocols are more vulnerable to attacks from the intruders, which can easily paralyze the operation of the network due to its inherited characteristics of MANETS. One such type of attack is wormhole attack. Because of its severity, the wormhole attack has attracted a great deal of attention in the research community. This paper compares reactive and proactive routing protocols in adversarial environment. Specifically, wormhole attack is applied to these routing protocols to evaluate its performance through simulation. Comprehensively the results shows the comparative performance of these protocols against wormhole attack is hard to detect and easy to implement

5-Chloro­spiro­[indoline-3,7′-6H,7H,8H-pyrano[3,2-c:5,6-c′]di[1]benzopyran]-2,6′,8′-trione

The asymmetric unit of the title compound, C26H12ClNO6, consists of two independent mol­ecules. The central pyran rings and both the 1-benzopyran ring systems are nearly planar in both mol­ecules [r.m.s. deviations of pyan rings = 0.0264 (1) and 0.0326 (1) Å for molecules A and B, respectively; r.m.s. deviations of benzopyran rings = 0.0439 (1) and 0.0105 (1) for molecule A, 0.0146 (1) and 0.0262 (1) Å for molecule B]. In the crystal, the molecules are linked by C—H⋯O, N—H⋯O and C—H⋯π inter­actions

5-[(E)-4-Fluoro­benzyl­idene]-8-(4-fluoro­phen­yl)-2-hy­droxy-9-phenyl-3,10-diaza­hexa­cyclo­[10.7.1.13,7.02,11.07,11.016,20]henicosa-1(20),12,14,16,18-pentaen-6-one

In the title compound, C38H28F2N2O2, the piperidine ring adopts a chair conformation and the pyrrolidine ring adopts an envelope conformation with the spiro C atom as the flap atom. The naphthalene ring system makes dihedral angles of 39.89 (8), 35.33 (8) and 46.45 (8)° with the two fluoro-substituted benzene rings and the phenyl ring, respectively, while the dihedral angle between the two fluoro-substituted benzene rings is 75.21 (10)°. An intra­molecular O—H⋯N hydrogen bond generates an S(5) ring. In the crystal, mol­ecules are connected by C—H⋯O hydrogen bonds, forming supra­molecular chains propagating along the c-axis direction. Weak C—H⋯π inter­actions further consolidate the structure

14-Hy­droxy-11-[(E)-4-meth­oxy­benzyl­idene]-8-(4-meth­oxy­phen­yl)-5-thia-3,13-diaza­hepta­cyclo­[13.7.1.19,13.02,9.02,14.03,7.019,23]tetra­cosa-1(22),15(23),16,18,20-pentaen-10-one

In the title compound, C36H32N2O4S, the piperidine ring adopts a chair conformation, while the five-membered pyrrolidine (with a C atom as the flap atom) and thia­zolidine (with the S atom as the flap atom) rings adopt envelope conformations. The naphthalene ring system makes dihedral angles of 18.82 (5) and 40.92 (5)° with the two meth­oxy-substituted benzene rings. In the crystal, centrosymmetrically-related mol­ecules are linked into dimers via pairs of C—H⋯O and C—H⋯N hydrogen bonds. An intra­molecular O—H⋯N hydrogen bond is also observed. The crystal structure is further stabilized by C—H⋯π inter­actions

Analysis of COVID-19 Pandemic - Origin, Global Impact and Indian Therapeutic Solutions for infectious diseases

The first case of COVID-19 was reported in China on December 2019[1] and almost 213 countries has reported around 5,350,000 COVID-19 cases all over the world with the mortality rate up to 3.4% as of May 23,2020. On March 11, 2020 WHO (World Health Organization) declared COVID-19 as global pandemic. Moving towards from epidemic to global pandemic situation just in two months, COVID-19 has caused tremendous negative effects on people's wellbeing and the economy all over the world. Scientists and researchers all over the world have a vested interest in researching and mitigating to handle the dire situation. This paper covers the COVID-19's origin, characteristics of the virus, and reasons behind the outbreak and precautionary measures that have to be followed to handle the critical situation. Several therapeutic solutions in Indian healing tradition have been discussed to improve the immune system in order to equip ourselves to deal with the outbreak of COVID-19.

Role of copper and alumina for heat transfer in hybrid nanofluid by using Fourier sine transform

The convection, thermal conductivity, and heat transfer of hybrid nanofluid through nanoparticles has become integral part of several natural and industrial processes. In this manuscript, a new fractionalized model based on hybrid nanofluid is proposed and investigated by employing singular verses and non-singular kernels. The mathematical modeling of hybrid nanofluid is handled via modern fractional definitions of differentiations. The combined Laplace and Fourier Sine transforms have been configurated on the governing equations of hybrid nanofluid. The analytical expression of the governing temperature and velocity equations of hybrid nanofluid have been solved via special functions. For the sake of thermal performance, dimensional analysis of governing equations and suitable boundary conditions based on Mittage-Leffler function have been invoked for the first time in literature. The comparative analysis of heat transfer from hybrid nanofluid has been observed through Caputo-Fabrizio and Atangana-Baleanu differential operators. Finally, our results suggest that volume fraction has the decelerated and accelerated trends of temperature distribution and inclined and declined profile of heat transfer is observed copper and alumina nanoparticles

Effect of Magnetic Baffles and Magnetic Nanofluid on Thermo-Hydraulic Characteristics of Dimple Mini Channel for Thermal Energy Applications

The combined effect of a magnetic baffle and a dimple turbulator on the heat transfer and pressure drop is investigated computationally in a mini channel. Fe3O4 magnetic nanofluid is used as a working fluid. The Reynolds number (Re) is varied from 150 to 210 and the magnetic field intensities range from 1200 G to 2000 G. Finite-volume based commercial computational fluid dynamics (CFD) solver ANSYS-Fluent 18.1 was used for the numerical simulations. A laminar viscous model is used with pressure-velocity coupling along with second-order upwind discretization and QUICK scheme for discretizing the momentum and energy equations. The results show that there is an increase of 3.53%, 10.77%, and 25.39% in the Nusselt numbers when the magnetic fields of 1200 G, 1500 G and 2000 G, respectively, are applied at x = 15 mm, as compared to the flow without a magnetic field when the pitch = 10 mm. These values change to 1.51%, 6.14% and 18.47% for a pitch = 5 mm and 0.85%, 4.33%, and 15.25% for a pitch = 2.5 mm, when compared to the flow without a magnetic field in the respective geometries. When the two sources are placed at x = 7.5 mm and 15 mm, there is an increase of 4.52%, 13.93%, and 33.08% in the Nusselt numbers when magnetic fields of 1200 G, 1500 G, and 2000 G are applied when the pitch = 10 mm. The increment changed to 1.82%, 8.16%, and 22.31% for a pitch = 5 mm and 1.01%, 5.96%, and 21.38% for a pitch = 2.5 mm. This clearly shows that the two sources at the front have a higher increment in the Nusselt numbers compared to one source, due to higher turbulence. In addition, there is a decrease in the pressure drop of 10.82%, 16.778%, and 26.75% when magnetic fields of 1200 G, 1500 G, and 2000 G, respectively, are applied at x = 15 mm, as compared to flow without magnetic field when the pitch = 10 mm. These values change to 2.46%, 4.98%, and 8.54% for a pitch = 5 mm and 1.62%, 3.52%, and 4.78% for a pitch = 2.5 mm, when compared to flow without magnetic field in the respective geometries. When two sources are placed at x = 7.5 mm and 15 mm, there is an decrease of 19.02%, 31.3%, and 50.34% in the pressure drop when the magnetic fields of 1200 G, 1500 G and 2000 G are applied when the pitch = 10 mm. These values change to 4.18%, 9.52%, and 16.52% for a pitch = 5 mm and 3.08%, 6.88%, and 14.88% for a pitch = 2.5 mm. Hence, with the increase in the magnetic field, there is a decrease in pressure drop for both the cases and the pitches. This trend is valid only at lower magnetic field strength, because the decrease in the pressure drop dominates over the increase in pressure drop due to turbulence.This work was funded by the Deanship of Scientific Research, Vice Presidency for Graduate Studies and Scientific Research, King Faisal University, Saudi Arabia (Project No. GRANT331). The authors also acknowledge the financial support received for the research project entitled “Performance Improvement of Solar Thermal Systems using Magnetic Nanofluids” funded by the Department of Science and Technology (DST), Govt. of India under India-South Africa Joint Science and Technology Research Collaboration vide Sanction no.: DST/INT/South Africa/P-08/2021 dtd. 16 September 2021

Multicomponent Domino Synthesis, Anticancer Activity and Molecular Modeling Simulation of Complex Dispirooxindolopyrrolidines

A series of spirooxindolopyrrolidine fused N -styrylpiperidone heterocyclic hybrids has been synthesized in excellent yield via a domino multicomponent protocol that involves one-pot three component 1,3-dipolar cycloaddition and concomitant enamine reactions performed in an inexpensive ionic liquid, namely 1-butyl-3-methylimidazolium bromide ([bmim]Br). Compounds thus synthesized were evaluated for their cytotoxicity against U-937 tumor cells. Interestingly; compounds 5i and 5m exhibited a better cytotoxicity than the anticancer drug bleomycin. In ddition; the effect of the synthesized compounds on the nuclear morphology of U937 FaDu cells revealed that treatment with compounds 5a–m led to their apoptotic cell death

NetPath: a public resource of curated signal transduction pathways

NetPath, a novel community resource of curated human signaling pathways is presented and its utility demonstrated using immune signaling data

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts