Water Supply Planning under Interdependence of Actions: Theory and Application

An ongoing water supply planning problem in the Regional Municipality of Waterloo, Ontario, Canada, is studied to select the best water supply combination, within a multiple-objective framework, when actions are interdependent. The interdependencies in the problem are described and shown to be essential features. The problem is formulated as a multiple-criteria integer program with interdependent actions. Because of the large number of potential actions and the nonconvexity of the decision space, it is quite difficult to find nondominated subsets of actions. Instead, a modified goal programming technique is suggested to identify promising subsets. The appropriateness of this technique is explained, and the lessons learned in applying it to the Waterloo water supply planning problem are described

Assessment of human errors in driving accidents; Analysis of the causes based on aberrant behaviors

Introduction: Today, mortalities and injuries due to traffic accidents have been confirmed as a global phenomenon. Meanwhile, mistakes and high risk behaviors by drivers, is the most important intervening factor in traffic accidents. This study is to analyze the causes of traffic accidents according to drivers' aberrant behaviors. Methods: This cross-sectional study was conducted on 540 taxi drivers using Manchester Driving Behaviour Questinnaire in 0-5 Likert scale. After being gathered, the data were analyzed by SPSS 11.5 using Pearson Correlation and Logistic Regression. Findings: The mean score of aberrant driving behaviors was obtained 2.06 (± 0.47) and lapse obtained the highest score and driving mistakes did the lowest. As age advanced, the rate of aberrant behaviours declined (P = 0.006). Commitment of mistakes and offences was more prevalent in ages under 30 years compared to other age ranges and lapse in the individuals over 50 years was more prevalent compared to other items. The results of logistic regression indicated that all variables of DBQ are important in predicting Iranian drivers' aberrant behaviors (P < 0.001), but intentional offences had the highest correlation. There was an inverse correlation between driving history and intentional offences and mistakes (P < 0.001). Conclusion: According to the results, it could be said that intentional offences and lapse in driving behaviors are more predictive of self-reported accidents compared to other variables. The drivers in low ages are more willing to practice aberrant behaviors due to lack of adequate skill and experience and having intrinsic excitements. By contrast, as age advances, intentional offenses declines and the rate of lapses ascends. It seems that through provision of regular, periodic training for the drivers by occupation and creating awareness, aberrant behaviors and, by extension, traffic accidents could be effectively decreased

The damping properties of the foam‑filled shaft of primary feathers of the pigeon Columba livia

The avian feather combines mechanical properties of robustness and flexibility while maintaining a low weight. Under periodic and random dynamic loading, the feathers sustain bending forces and vibrations during flight. Excessive vibrations can increase noise, energy consumption, and negatively impact flight stability. However, damping can alter the system response, and result in increased stability and reduced noise. Although the structure of feathers has already been studied, little is known about their damping properties. In particular, the link between the structure of shafts and their damping is unknown. This study aims at understanding the structure-damping relationship of the shafts. For this purpose, laser Doppler vibrometry (LDV) was used to measure the damping properties of the feather shaft in three segments selected from the base, middle, and tip. A combination of scanning electron microscopy (SEM) and micro-computed tomography (μCT) was used to investigate the gradient microstructure of the shaft. The results showed the presence of two fundamental vibration modes, when mechanically excited in the horizontal and vertical directions. It was also found that the base and middle parts of the shaft have higher damping ratios than the tip, which could be attributed to their larger foam cells, higher foam/cortex ratio, and higher percentage of foam. This study provides the first indication of graded damping properties in feathers

Developing methodology to evaluate the oral sensory features of pharmaceutical tablet coatings

Acceptability of medicines is critical for effective pharmacotherapy. The aim of this study was to investigate the oral sensory properties of tablet coatings to determine how mouthfeel can improve acceptability. A randomised double-blind study was performed in 84 adult volunteers (51% ≥55 years). Each participant received 4 placebo tablets (3 coated and 1 uncoated) to evaluate (i) ease of swallowing and (ii) palatability. Visual analogue scales (VAS) were used to capture sensory parameters. Acceptability was assessed using the following parameters: ease of swallowing; amount of water taken with the tablet; rank order of preference; roughness; adhesiveness and slipperiness. Ease of swallowing was determined to be the most sensitive measure of acceptance. The best coating was the one that was reported to be the most slippery and smooth. The presence of a coating improved ease of swallowing, mouthfeel and overall palatability. This study demonstrates that slippery coatings improve acceptability of tablets. The study also demonstrates the value of VAS to measure the sensory attributes of coated tablets

Does the Formulation of Oral Solid Dosage Forms Affect Acceptance and Adherence in Older Patients?:A Mixed Methods Systematic Review

OBJECTIVES: Age-related changes mean that the older population can encounter barriers toward taking medication orally. Further work is needed to identify the characteristics of oral solid dosage forms that will improve patient acceptance and adherence. The aim of this systematic review was to identify if and how formulation aspects of oral solid dosage forms affect acceptance and adherence in older people. DESIGN: Mixed methods systematic review using a data-based convergent synthesis design. SETTING AND PARTICIPANTS: Articles were selected if they included participants aged 60 years and older, or included health care professionals, social care professionals, and informal carers of patients aged 60 years and older. METHODS: A systematic search of the following databases was undertaken: Web of Science, MEDLINE, Scopus, and The Cochrane Databases. The search of databases was supplemented by a search of gray literature, and reference lists of included papers were manually searched. RESULTS: A total of 16 studies were included in the final synthesis. Three themes were generated from the thematic analysis: (1) dimensions, (2) palatability, and (3) appearance. The dimensions and palatability are often modified to improve swallowability by breaking tablets in half or taste masking with food. Polypharmacy can lead to patients using the appearance to identify tablets; however, this can lead to confusion when products appear similar. No study was identified that explored formulation characteristics across all 3 categories directly in the older population. CONCLUSION AND IMPLICATIONS: Manufacturers should take into account practical problems older people may encounter when considering the dimensions, palatability, and appearance of the final drug product. These characteristics should be optimized to aid visual identification and swallowability. Medical providers and pharmacists have an important role in ensuring that these patient-centric drug products are prescribed and dispensed appropriately so that patients receive the most suitable formulation

Supporting disengaged children and young people living with diabetes to self-care: a qualitative study in a socially disadvantaged and ethnically diverse urban area

OBJECTIVE: To explore how to enhance services to support the self-care of children and young people (CYP) clinically considered 'disengaged' by diabetes services. DESIGN: Qualitative study. SETTING: Two diabetes clinics in an ethnically diverse and socially disadvantaged urban area in the UK. Eligible participants were CYP living with type 1 or type 2 diabetes aged between 10 and 25 years who did not attend their last annual hospital appointment. PARTICIPANTS: 22 CYP (14 female and 8 male) aged between 10 and 19 years old took part. The sample was diverse in terms of ethnicity, age at diagnosis, family composition and presence of diabetes among other family members. DATA COLLECTION: Semistructured interviews. DATA ANALYSIS: Data were analysed thematically. RESULTS: Analysis of participant accounts confirmed the crucial importance of non-medicalised care in CYP diabetes care. A life plan was considered as important to participants as a health plan. Participants valued the holistic support provided by friends, family members and school teachers. However, they found structural barriers in their health and educational pathways as well as disparities in the quality of support at critical moments along the life course. They actively tried to maximise their well-being by balancing life priorities against diabetes priorities. Combined, these features could undermine participants engagement with health services where personal strategies were often held back or edited out of clinical appointments in fear of condemnation. CONCLUSION: We demonstrate why diabetes health teams need to appreciate the conflicting pressures experienced by CYP and to coproduce more nuanced health plans for addressing their concerns regarding identity and risk taking behaviours in the context of their life-worlds. Exploring these issues and identifying ways to better support CYP to address them more proactively should reduce disengagement and set realistic health outcomes that make best use of medical resources

Chiral Four-Wave-Mixing signals with circularly-polarized X-ray pulses

Chiral four-wave-mixing signals are calculated using the irreducible tensor formalism. Different polarization and crossing angle configurations allow to single out the magnetic dipole and the electric quadrupole interactions. Other configurations can reveal that the chiral interaction occurs at a given step within the nonlinear interaction pathways contributing to the signal. Applications are made to the study of valence excitations of S-ibuprofen by chiral Stimulated X-ray Raman signals at the Carbon K-edge and by chiral visible 2D Electronic Spectroscopy.teraction pathways contributing to the signal.Comment: 33 pages, 10 figure