In-Situ Thickness Measurement of Die Silicon Using Voltage Imaging for Hardware Assurance

Hardware assurance of electronics is a challenging task and is of great interest to the government and the electronics industry. Physical inspection-based methods such as reverse engineering (RE) and Trojan scanning (TS) play an important role in hardware assurance. Therefore, there is a growing demand for automation in RE and TS. Many state-of-the-art physical inspection methods incorporate an iterative imaging and delayering workflow. In practice, uniform delayering can be challenging if the thickness of the initial layer of material is non-uniform. Moreover, this non-uniformity can reoccur at any stage during delayering and must be corrected. Therefore, it is critical to evaluate the thickness of the layers to be removed in a real-time fashion. Our proposed method uses electron beam voltage imaging, image processing, and Monte Carlo simulation to measure the thickness of remaining silicon to guide a uniform delayering processComment: 5 pages, 10 figures, Government Microcircuit Applications & Critical Technology Conference (GOMACTech) 202

Experimental Validation of Microwave Tomographywith the DBIM-TwIST Algorithm for Brain StrokeDetection and Classification

We present an initial experimental validation of a microwave tomography (MWT) prototype for brain stroke detection and classification using the distorted Born iterative method, two-step iterative shrinkage thresholding (DBIM-TwIST) algorithm. The validation study consists of first preparing and characterizing gel phantoms which mimic the structure and the dielectric properties of a simplified brain model with a haemorrhagic or ischemic stroke target. Then, we measure the S-parameters of the phantoms in our experimental prototype and process the scattered signals from 0.5 to 2.5 GHz using the DBIM-TwIST algorithm to estimate the dielectric properties of the reconstruction domain. Ourresultsdemonstratethatweareabletodetectthestroketargetinscenarios where the initial guess of the inverse problem is only an approximation of the true experimental phantom. Moreover, the prototype can differentiate between haemorrhagic and ischemic strokes based on the estimation of their dielectric properties

Differential mitochondrial roles for α-synuclein in DRP1-dependent fission and PINK1/Parkin-mediated oxidation

Mitochondria are highly dynamic organelles with strict quality control processes that maintain cellular homeostasis. Within axons, coordinated cycles of fission-fusion mediated by dynamin related GTPase protein (DRP1) and mitofusins (MFN), together with regulated motility of healthy mitochondria anterogradely and damaged/oxidized mitochondria retrogradely, control mitochondrial shape, distribution and size. Disruption of this tight regulation has been linked to aberrant oxidative stress and mitochondrial dysfunction causing mitochondrial disease and neurodegeneration. Although pharmacological induction of Parkinson’s disease (PD) in humans/animals with toxins or in mice overexpressing α-synuclein (α-syn) exhibited mitochondrial dysfunction and oxidative stress, mice lacking α-syn showed resistance to mitochondrial toxins; yet, how α-syn influences mitochondrial dynamics and turnover is unclear. Here, we isolate the mechanistic role of α-syn in mitochondrial homeostasis in vivo in a humanized Drosophila model of Parkinson’s disease (PD). We show that excess α-syn causes fragmented mitochondria, which persists with either truncation of the C-terminus (α-syn1–120) or deletion of the NAC region (α-synΔNAC). Using in vivo oxidation reporters Mito-roGFP2-ORP1/GRX1 and MitoTimer, we found that α-syn-mediated fragments were oxidized/damaged, but α-syn1–120-induced fragments were healthy, suggesting that the C-terminus is required for oxidation. α-syn-mediated oxidized fragments showed biased retrograde motility, but α-syn1–120-mediated healthy fragments did not, demonstrating that the C-terminus likely mediates the retrograde motility of oxidized mitochondria. Depletion/inhibition or excess DRP1-rescued α-syn-mediated fragmentation, oxidation, and the biased retrograde motility, indicating that DRP1-mediated fragmentation is likely upstream of oxidation and motility changes. Further, excess PINK/Parkin, two PD-associated proteins that function to coordinate mitochondrial turnover via induction of selective mitophagy, rescued α-syn-mediated membrane depolarization, oxidation and cell death in a C-terminus-dependent manner, suggesting a functional interaction between α-syn and PINK/Parkin. Taken together, our findings identify distinct roles for α-syn in mitochondrial homeostasis, highlighting a previously unknown pathogenic pathway for the initiation of PD.Fil: Krzystek, Thomas J.. State University of New York; Estados UnidosFil: Banerjee, Rupkatha. State University of New York; Estados UnidosFil: Thurston, Layne. State University of New York; Estados UnidosFil: Huang, JianQiao. State University of New York; Estados UnidosFil: Swinter, Kelsey. State University of New York; Estados UnidosFil: Rahman, Saad Navid. State University of New York; Estados UnidosFil: Falzone, Tomas Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; ArgentinaFil: Gunawardena, Shermali. State University of New York; Estados Unido

Potent antibacterial activity of MXene–functionalized graphene nanocomposites

Two dimensional (2D) nanomaterials display properties with significant biological utility (e.g., antimicrobial activity). In this study, MXene–functionalized graphene (FG) nanocomposites with Ti3C2Tx in varying ratios (FG : Ti3C2Tx, 25 : 75%, 50 : 50%, and 75 : 25%) were prepared and characterized via scanning electron microscopy, scanning electron microscopy-energy dispersive X-ray (SEM-EDX), high-resolution transmission electron microscopy (HRTEM), and zeta potential analysis. Their cytotoxicity was assessed using immortalized human keratinocytes (HaCaT) cells at three different timepoints, and antibacterial activity was assessed using Gram-positive Methicillin resistant Staphylococcus aureus, MRSA, and Gram-negative neuro-pathogenic Escherichia coli K1 (E. coli K1) in vitro. The nanomaterials and composites displayed potent antibacterial effects against both types of bacteria and low cytotoxicity against HaCaT cells at 200 μg mL−1, which is promising for their utilization for biomedical applications

Insight into the investigation of diamond nanoparticles suspended therminol 55 nanofluids on concentrated photovoltaic/thermal solar collector

Nanofluids are identified as advanced working fluids in the solar energy conversion field with superior heat transfer characteristics. This research work introduces carbon-based diamond nanomaterial and Therminol®55 oil-based nanofluids for implementation in a concentrated photovoltaic/thermal (CPV/T) solar collector. This study focuses on the experimental formulation, characterization of properties, and performance evaluation of the nanofluid-based CPV/T system. Thermo-physical (thermal conductivity, viscosity, and rheology), optical (UV-vis and FT-IR), and stability (Zeta potential) properties of the formulated nanofluids are characterized at 0.001–0.1 wt.% concentrations of dispersed particles using experimental assessment. The maximum photo-thermal energy conversion efficiency of the base fluid is improved by 120.80% at 0.1 wt.%. The thermal conductivity of pure oil is increased by adding the nanomaterial. The highest enhancement of 73.39% is observed for the TH-55/DP nanofluid. Furthermore, dynamic viscosity decreased dramatically across the temperature range studied (20–100 °C), and the nanofluid exhibited dominant Newtonian flow behavior, with viscosity remaining nearly constant up to a shear rate of 100 s−1. Numerical simulations of the nanofluid-operated CPV/T collector have disclosed substantial improvements. At a concentrated solar irradiance of 5000 W/m2 and an optimal flow rate of 3 L/min, the highest thermal and electrical energy conversion efficiency enhancements are found to be 11 and 1.8%, respectively

The Role of Janus Kinase/STAT3 Pathway in Hematologic Malignancies With an Emphasis on Epigenetics

The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway has been known to be involved in cell growth, cellular differentiation processes development, immune cell survival, and hematopoietic system development. As an important member of the STAT family, STAT3 participates as a major regulator of cellular development and differentiation-associated genes. Prolonged and persistent STAT3 activation has been reported to be associated with tumor cell survival, proliferation, and invasion. Therefore, the JAK-STAT pathway can be a potential target for drug development to treat human cancers, e.g., hematological malignancies. Although STAT3 upregulation has been reported in hematopoietic cancers, protein-level STAT3 mutations have also been reported in invasive leukemias/lymphomas. The principal role of STAT3 in tumor cell growth clarifies the importance of approaches that downregulate this molecule. Epigenetic modifications are a major regulatory mechanism controlling the activity and function of STAT3. So far, several compounds have been developed to target epigenetic regulatory enzymes in blood malignancies. Here, we discuss the current knowledge about STAT3 abnormalities and carcinogenic functions in hematopoietic cancers, novel STAT3 inhibitors, the role of epigenetic mechanisms in STAT3 regulation, and targeted therapies, by focusing on STAT3-related epigenetic modifications

ToSHI - Towards Secure Heterogeneous Integration: Security Risks, Threat Assessment, and Assurance

The semiconductor industry is entering a new age in which device scaling and cost reduction will no longer follow the decades-long pattern. Packing more transistors on a monolithic IC at each node becomes more difficult and expensive. Companies in the semiconductor industry are increasingly seeking technological solutions to close the gap and enhance cost-performance while providing more functionality through integration. Putting all of the operations on a single chip (known as a system on a chip, or SoC) presents several issues, including increased prices and greater design complexity. Heterogeneous integration (HI), which uses advanced packaging technology to merge components that might be designed and manufactured independently using the best process technology, is an attractive alternative. However, although the industry is motivated to move towards HI, many design and security challenges must be addressed. This paper presents a three-tier security approach for secure heterogeneous integration by investigating supply chain security risks, threats, and vulnerabilities at the chiplet, interposer, and system-in-package levels. Furthermore, various possible trust validation methods and attack mitigation were proposed for every level of heterogeneous integration. Finally, we shared our vision as a roadmap toward developing security solutions for a secure heterogeneous integration

Secure Physical Design

An integrated circuit is subject to a number of attacks including information leakage, side-channel attacks, fault-injection, malicious change, reverse engineering, and piracy. Majority of these attacks take advantage of physical placement and routing of cells and interconnects. Several measures have already been proposed to deal with security issues of the high level functional design and logic synthesis. However, to ensure end-to-end trustworthy IC design flow, it is necessary to have security sign-off during physical design flow. This paper presents a secure physical design roadmap to enable end-to-end trustworthy IC design flow. The paper also discusses utilization of AI/ML to establish security at the layout level. Major research challenges in obtaining a secure physical design are also discussed