The relative frequency of odontogenic tumors : a study of 376 cases in a Brazilian population

Odontogenic tumors (OTs) are rare lesions, exclusive of the jaws, that are derived from epithelial and/or ectomesenchymal elements of the tooth-forming apparatus. Their biological behavior is heterogeneous, including hamartomatous tissue proliferation, benign nonaggressive and aggressive neoplasms, and malignant tumors with metastatic capacity. The aim of this study was to describe the relative frequency of odontogenic tumors in a Brazilian population. In addition, a review of the literature identified studies on odontogenic tumors that follow the 2005 World Health Organization. A total of 376 cases of odontogenic tumors from an oral pathology service were reviewed about age, gender, anatomic site and histologic diagnosis. Keratocystic odontogenic tumors (31.6%) were the most common, followed by ameloblastoma (28.5%), and odontoma (22.6%). The mean age was 32.2 years, and more than half the patients (52.1%) were in the second and third decades of life. The male to female ratio was 1:1.37, with a maxilla to mandible ratio of 1:2.08. The variation in relative frequency of tumors observed among the several series, including the present study, is probably due in part to cultural differences between geographic areas but also to the study design

Multiple brown tumours of tertiary hyperparathyroidism in a renal transplant recipient: : a case report

Tertiary Hyperparathyroidism (HPT) is an uncommon condition that affects patients with secondary HPT after a successful kidney transplant. Bone alterations are the main consequences of this endocrine condition, including the development of an osteolytic lesion called brown tumour. This paper reports an unusual case of multiple brown tumours located in the maxilla and mandible in a 58-year-old renal transplant recipient, with tertiary HPT. Incisional biopsies were performed and, in both samples, the histopathological diagnoses were giant cell lesions. Due to these diagnoses, the medical history of chronic renal failure, and high levels of serum calcium and PTH, lesions were diagnosed as multiple brown tumours of tertiary HPT. The lesions showed regression within the two months following a total parathyroidectomy. Minimal local interventions were established to make an early diagnosis and to treat these lesions. The diagnosis of primary oral lesions was very important in order to demonstrate the relevance of interdisciplinary activity and the inclusion of dentists as part of organ transplant units

Oral lipomas in a Brazilian population : a 10-year study and analysis of 450 cases reported in the literature

Objectives: Lipomas are common benign mesenchymal neoplasms that rarely occur in the oral cavity and correspond to less than 4.4% of all benign oral soft tissue tumors. This study describes the clinical, radiological and histological features of cases of oral lipomas seen over a period of 10 years and compared the findings with those reported in the literature. Study Design: All cases of oral lipomas seen between 1999 and 2009 were retrieved from the archives of the Stomatology Division of the Federal University of Ceará, Brazil. Age, gender, tumor location, clinical findings, duration, histological subtypes, and treatment outcome were recorded. In addition, the English-language literature was searched for studies published between 1966 and 2009. Results: Ten patients (6 women and 4 men) were enrolled in this study. The mean age was 53.4 years (range: 21-73 years). The specific sites involved were the oral mucosa (n=5), vestibule (n=3), gingiva (n=1), and retromolar region (n=1). The mean size of the tumors was 1.94 cm (range 1.0 to 3.0 cm). Radiographically, only one case appeared as a radiolucent area on occlusal film. Microscopically, 4 cases were classified as simple lipoma, 4 as fibrolipoma, 1 as myxoid lipoma, and 1 as angiolipoma. The duration of the tumors ranged from 2 to 84 months, with a mean duration of 30.4 months. All cases were treated by simple surgical excision and there was no recurrence after a mean post-treatment period of 34.5 months. The findings were compared with 450 cases of oral lipomas reported in the literature. Conclusions: Lipomas continue to be an uncommon neoplasm of the oral cavity. Radiography is a valuable tool due to the possible occurrence of bone involvement. Surgical excision is the treatment of choice and recurrence is not expected

Intralesional corticosteroid injections in the treatment of central giant cell lesions of the jaws: a meta-analytic study

Objective: The aim of this study was to evaluate the response of treatment of central giant cell lesion to intral - esional corticosteroid injections. Study Design: Review of articles indexed in PubMed on the topic between the years 1988 and 2011, and develop - ment of a descriptive meta-analysis of the results. Results: Sample of 41 patients primarily treated with intralesional corticosteroid injections was obtained, with a male female ratio of 1:0.95, being 23 aggressive and 18 non-aggressive central giant cell lesions. Triamcinolone acetonide and triamcinolone hexacetonide were the drugs used, and 78.0% cases were considered as good result, 14.6% were considered as moderate response and 7.3% were considered as negative result to treatment. Consider - ing the aggressiveness, 88.9% of non-aggressive lesions presented a good response to treatment, in aggressive central giant cell lesions, 69.6% presented a good response to intralesional corticosteroid injections. Conclusion: In view of the results analyzed, intralesional corticosteroid injections could be considered as first treat - ment option for central giant cell lesion

Intralesional corticosteroid injections in the treatment of central giant cell lesions of the jaws

Objective: The aim of this study was to evaluate the response of treatment of central giant cell lesion to intralesional corticosteroid injections. Study Design: Review of articles indexed in PubMed on the topic between the years 1988 and 2011, and development of a descriptive meta-analysis of the results. Results: Sample of 41 patients primarily treated with intralesional corticosteroid injections was obtained, with a male female ratio of 1:0.95, being 23 aggressive and 18 non-aggressive central giant cell lesions. Triamcinolone acetonide and triamcinolone hexacetonide were the drugs used, and 78.0% cases were considered as good result, 14.6% were considered as moderate response and 7.3% were considered as negative result to treatment. Considering the aggressiveness, 88.9% of non-aggressive lesions presented a good response to treatment, in aggressive central giant cell lesions, 69.6% presented a good response to intralesional corticosteroid injections. Conclusion: In view of the results analyzed, intralesional corticosteroid injections could be considered as first treatment option for central giant cell lesion

Oral granular cell tumor: a study of twelve cases in a Brazilian population

Objectives: Analyze clinic and epidemiological aspects of all Oral Granular cell tumor (GCT) during a 5-year period in a Brazilian population. Study design: clinical and treatment outcome data of patients with oral GCT seen at the Division of Stomatology, School of Dentistry, Federal University of Ceara, Brazil, between January 2001 and December 2005 were reviewed. Results: during the analyzed period, 6231 oral lesions were collected from files of different anatomo-pathology laboratories situated in the state of Ceara, Brazil. Of all cases, only 12 of GCT were diagnosed. The lesion was more common in female patients, with a mean age of 40.8 years, occurring mainly in tongue. Conclusion: Oral GCT is a rare and infrequent lesion in this population, and affects more female in the third, fourth a fifth decade of life. Clinical significance: Although it is a rare occurrence in the oral cavity, the clinician must know about its occurrence and should include GCT in the differential diagnose of certain lesions especially when situated in tongu

Oral Granulocytic Sarcoma: a case report

Granulocytic sarcoma (GS) is a localized infiltrate of immature granulocytes in an extramedullary site. This lesion is most frequently associated with leukemia, but can occur associated with others myeloproliferative disorders.GS can affect virtually any part of the body, but lesions in the oral cavity are rare, with only 37 cases described.Case Description: We present a rare case of GS in a 23-year-old female, with a prior history of acute myeloid leukemia, presenting with a solitary mandibular swelling in the region of the erupting 3rd lower left molar. After biopsy, conventional immunohistochemical stains were positive for CD45 (hematological marker) and myeloid markers, such as myeloperoxidase, and CD68, demonstrating myeloid lineage with monocytic cells differentiation, suggesting the diagnosis of GS associated to Acute Myeloid Leukemia (AML-M5).Clinical implication: Although GS is a rare tumor in oral cavity, and its diagnosis is usually difficult, the clinician must know about its existence to make differential diagnosis

Percepção do estudante de medicina acerca da realização de quizzes na metodologia pbl de ensino / Medicine student perception about quizzing in pbl teaching methodology

Durante os últimos anos ocorreram grandes mudanças no método de ensino médico especialmente devido ao desenvolvimento da metodologia de ensino chamada de PBL e com o desenvolvimento e incorporação de novas tecnologias no contexto educacional moderno. Dentre dessas tecnologias o uso de smartphones e de redes sociais se destaca, visto que esses recursos permitem um contato mais lúdico entre a parte discente e docente.Nesse contexto, objetivou-se compreender a percepção de estudantes de medicina acerca da introdução de quizzes como metodologia inovadora de ensino para anatomia, patologia e radiologia. A pesquisa teve como proposta um método transversal, observacional, descritivo e quantitativo, avaliando por meio de um questionário criado pelos monitores acerca da opinião de 74 alunos de medicina do 4° semestre da Universidade de Fortaleza.Percebeu-se progressiva adesão dos alunos ao longo dos 3 quizzes com mais pontos positivos do que negativos em relação à ajuda no aprendizado. Conferindo, portanto, uma boa opção de metodologia interativa, pois é embasada por mídias digitais (fotos, vídeos) atrelada a perguntas e respostas, sendo um fator adicional de estudo para os estudantes no tocante as disciplinas

Avaliação da importância dos monitores no processo ensino-aprendizagem no laboratório morfofuncional IV / Evaluation of the importance of monitors in the teaching-learning process in the morphofunctional laboratory IV

A monitoria é um espaço de aprendizagem proporcionado aos estudantes. Sua finalidade é aperfeiçoar o processo de formação profissional e promover a melhoria da qualidade de ensino, criando condições para o aprofundamento teórico e o desenvolvimento de habilidades relacionadas à atividade docente do monitor. Os programas de monitoria têm que proporcionar aos graduandos a possibilidade de otimizar o seu potencial acadêmico, auxiliando-os na formação profissional. Baseado nesse princípio, será avaliada a eficácia desse método de ensino por meio de questões enfocando temáticas de anatomia, patologia e radiologia dentro da ótica do Laboratório Morfofuncional IV aplicadas antes e após o teste cognitivo do módulo. Espera-se um melhor resultado nas questões pós teste cognitivo devido maior esclarecimento do conteúdo pelos monitores