ABO Blood Group Type and Susceptibility to COVID-19 Infection

Since December 2019, the SARS-CoV2 (COVID-19) pandemic has continued to extend over most of the world, infecting over four million people and causing well over 300,000 deaths so far (https://coronavirus.jhu.edu/map.html, accessed on May 14, 2020). A significant percentage of infected patients develop severe symptoms and life-threatening conditions. While COVID-19 infection can affect all ages, available evidence points to older age and pre-existing comorbidities such as hypertension, diabetes and coronary heart disease, as important risk factors related to increased mortality rates. [1-3] Moreover, recent reports from China and the U.S. have suggested that the susceptibility, and perhaps even mortality, to Covid-19 infection might be influenced by the ABO blood type. The purpose of the present minireview is to analyze the evidence published in the COVID-19 literature and to put it in the context of the existing knowledge about the association of blood group types and disease

Immunological and Hematopoietic Biotechnology Studies

The purpose of the work carried under this interchanges was to support the development of space flight biotechnology experiments in the areas of immunology and hematopoiesis to facilitate the commercial development of space. The studies involved the interaction and development of experiments with biotechnology companies for necessary ground-based studies to allow the development of flight studies. The thrust of the work was to develop experiments with the Chiron Corporation and Bioserve involving the use of interleukin-2 to modulate the effects of spaceflight on immune responses. Spaceflight has been shown to have multiple effects on immune responses (1). lnterleukin-2 is an immuno-regulator that could have potential to counter some of the alterations induced in immune responses by spaceflight (1). To test this possibility before flight, rats were suspended antiorthostatically (2) and treated with interleukin-2. Antiorthostatic suspension is a model for some of the effects of spaceflight on immune responses (2). The interleukin-2 was given to see if it could alter some of the effects of suspension. This was achieved. As a result of these studies, two flight experiments were developed and flown with the Chiron Corp. And Bioserve to determine if use of interleukin-2 could prevent or attenuate the effects of space flight on immune responses

W-NetPan: Double-U network for inter-sensor self-supervised pan-sharpening

The increasing availability of remote sensing data allows dealing with spatial-spectral limitations by means of pan-sharpening methods. However, fusing inter-sensor data poses important challenges, in terms of resolution differences, sensor-dependent deformations and ground-truth data availability, that demand more accurate pan-sharpening solutions. In response, this paper proposes a novel deep learning-based pan-sharpening model which is termed as the double-U network for self-supervised pan-sharpening (W-NetPan). In more details, the proposed architecture adopts an innovative W-shape that integrates two U-Net segments which sequentially work for spatially matching and fusing inter-sensor multi-modal data. In this way, a synergic effect is produced where the first segment resolves inter-sensor deviations while stimulating the second one to achieve a more accurate data fusion. Additionally, a joint loss formulation is proposed for effectively training the proposed model without external data supervision. The experimental comparison, conducted over four coupled Sentinel-2 and Sentinel-3 datasets, reveals the advantages of W-NetPan with respect to several of the most important state-of-the-art pan-sharpening methods available in the literature. The codes related to this paper will be available at https://github.com/rufernan/WNetPan

Post-Acute Sequelae of COVID-19 (PASC): Association with Inflammation and Autoimmunity

It has become increasingly evident that a high percentage of patients that recover from acute COVID-19 infection continue to suffer from a variety of persistent symptoms even months after viral clearance, the most common ones being fatigue, dyspnea, anosmia, dysgeusia, cognitive dysfunction, and psychological problems, including anxiety and depression. This syndrome, known as Post-acute sequelae of COVID-19 (PASC), can severely affect the life quality and represents an important health care concern. The exact causes for the symptoms observed in patients with PASC remain to be adequately characterized, but are likely to be associated with multiple factors, including residual disease and/or inflammation, organ damage, effects of hospitalization and/or prolonged ventilation, as well as effects of social isolation and stress. This mini-review discusses evidence that may link both inflammatory and auto-immune processes in the pathophysiology of PASC

Interleukin-6 and soluble interleukin-6 receptor levels in posttraumatic stress disorder : associations with lifetime diagnostic status and psychological context.

This study correlated lifetime PTSD diagnostic status with interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) levels, and tested whether these correlations are sensitive to psychological context. Midlife women attended two research visits where blood was drawn (beginning of visits) and saliva and oral mucosal transudate were collected (beginning and end of visits) to measure IL-6 and sIL-6R. Women were classified as PTSD−/− (past and current symptoms below subsyndromal levels), PTSD+/− (past symptoms at or above subsyndromal levels), or PTSD +/+ (past and current symptoms at or above subsyndromal levels). PTSD+/+ women, compared to the other women, showed more negative emotion at the beginning of the visits, higher salivary IL-6 levels at the beginning versus end of visits, and positive correlations between negative emotion, salivary IL-6, and plasma sIL-6R. Their plasma sIL-6R levels exceeded those of the PTSD+/− women. Overall, IL-6 sensitivity to anticipation and to negative emotions, and higher sIL-6R levels, differentiated persistent versus remitted PTSD

Analysis of the Local and Systemic Cytokine Response Profiles in Patients with Community-Acquired Pneumonia. Relationship with Disease Severity and Outcomes.

The goals of this study were to investigate the relationship of systemic and local cytokine responses with time to clinical stability (TCS) in patients with community-acquired pneumonia (CAP) and to develop a model to integrate multiple cytokine data into “cytokine response profiles” based on local vs. systemic and pro- vs. anti-inflammatory cytokine patterns in order to better understand their relationships with measures of CAP severity and outcomes. Forty hospitalized patients enrolled through the Community Acquired Pneumonia Inflammatory Study Group (CAPISG) were analyzed. Based on the ranked distribution of the levels of eight different pro-inflammatory cytokines and chemokines (IL-1b, IL-6, IL-8, IL-12p40, IL-17A, IFNg, TNFa and CXCL10) in plasma and sputum on hospital admission, a “pro-inflammatory cytokine score (PICS)” was defined. PICS in plasma and sputum were plotted against each other and quadrants used to define profiles based on the four possible high/low combinations. A similar approach was used to contrast sputum PICS vs. anti-inflammatory cytokines (IL-1ra and IL-10). Some of the “profiles” thus defined were found to group patients with common etiologic characteristics and/or associate with similar measures of disease severity and/or clinical outcomes, suggesting the predictive value of the use of cytokine data in CAP patients

Sheltering for safety in community women with divorce histories.

This cross-sectional study compared the prevalence of formal and informal sheltering (i.e., staying in an agency shelter, or with friends/family, respectively), and evaluated associations with abuse severity. Community women (N = 197) with divorce histories reported on lifetime intimate partner abuse, including sheltering for safety. Prevalence of informal sheltering (43%) exceeded that of formal sheltering (11%). Rates/levels of coercive control, severe violence, injury, and police involvement were comparable for women who sheltered formally or informally, and exceeded those of women who never sheltered. Sheltering histories can be identified in community samples of women with divorce histories. Informal sheltering is prevalent, and comparable to formal sheltering in terms of correlations with abuse severity

Lack of Association of the ABO Blood Group with COVID-19 risk and Severity in Hospitalized Patients in Louisville, KY

Background: The potential association of the ABO blood group with the risk of COVID-19 and its severity has attracted a lot of interest since the start of the pandemic. While a number of studies have reported an increased risk associated with blood type A and a reduced risk with type O, other studies have did not found a significant effect. This study aimed to define the prevalence of different ABO blood groups in hospitalized COVID-19 patients in the Louisville, KY area and to investigate whether an association exists between the blood group and disease severity. Methods: This was a retrospective observational study of 380 patients with SARS-CoV-2 infection hospitalized to eight of the adult hospitals in the city of Louisville. Patients were divided into four different groups according to their ABO blood type. Demographic characteristics and clinical variables, including laboratory data as well as clinical outcomes were compared. Results: Type O was the most common blood group among the hospitalized patients (51%) followed by type A (31%), B (14%) and AB (4%). The observed blood group distribution among the patients was not significantly different from the distribution expected when compared to a population of similar racial/ethnic composition. No significant associations were found between the blood group and comorbidities, inflammatory biomarkers as well as with recorded outcomes, including the mortality rate and the length of the hospital stay. Conclusions: The data from hospitalized patients in Louisville is is not consistent with the ABO blood group having a significant effect as a risk or severity factor for COVID-19, but it is representative in COVID-19 or its severityof its prevalence among different racial/ethnic populations

Valor diagnóstico de las proteí­nas uPAR en sangre para el cáncer gástrico en Guatemala

El cáncer gástrico es la neoplasia más frecuente del tubo digestivo, Guatemala posee tasas de incidencia y de mortalidad altas. La infección producida por Helicobacter pylori se ha establecido como una de las fuerzas impulsoras de la carcinogénesis gástrica y se ha determinado que la infección con cepas que expresen el factor de virulencia CagA está asociado con lesiones atróficas y precancerosas. El análisis por reacción en cadena de la polimerasa en tiempo real de biopsias del cuerpo gástrico, ha mostrado un incremento significativo de la expresión del activador del plasminógeno de tipo uroquinasa (uPA), su receptor (uPAR) y su inhibidor (PAI-I) en pacientes positivos para H. pylori. En esta investigación se planteó determinar el valor diagnóstico de las variantes uPAR en sangre como marcador del riesgo de cáncer gástrico en Guatemala, así­ como su asociación con la infección de cepas de H. pylori virulentas dentro de la población. Para ello se realizaron pruebas serológicas de H. pylori, CagA y la cuantificación de las proteí­nas uPAR a los participantes (casos y controles), evidenciándose que la prevalencia de participantes con serologí­a positiva para cepas de H. pylori virulentas asciende a 54.9% y el 18% corresponde a verdaderos negativos para H. pylori cagA negativos. Se demostró que existe diferencia significativa en las medias de las cuantificaciones de uPAR entre casos y controles. La curva ROC mostró que resulta razonable plantear que la cuantificación de uPAR es una prueba diagnóstica con capacidad aceptable de discriminar pacientes con y sin cáncer gástrico

understanding the roles of cytokines and neutrophil activity and neutrophil apoptosis in the protective versus deleterious inflammatory response in pneumonia

SummaryInflammation is a double-edged sword in the outcome of pneumonia. On the one hand, an effective and timely inflammatory response is required to eliminate the invading respiratory pathogen. On the other, a toxic and prolonged inflammatory response may result in lung injury and poor outcomes, even in those receiving advanced medical care. This review focuses on recent understanding of the dynamics of the cytokine response, neutrophil activity, and responsiveness to cytokines and neutrophil lifespan as major elements of lung inflammation resulting in favorable or poor outcomes in lung infection primarily due to pneumococcus and influenza virus. Although some progress has been made in our understanding of the molecular mechanisms of the pneumonia inflammation axis composed of cytokines modulating neutrophil activation and neutrophil apoptosis, important questions remain to be answered. The degree of neutrophil activation, generation of reactive oxygen species, and the release of granule antimicrobial peptides play a key role in microbial pathogen clearance; however, prolonged neutrophil activation may contribute to lung injury and poor outcomes in pneumonia. Molecular markers of the mechanisms regulating neutrophil survival and apoptosis may help in the identification of novel therapeutic targets to modulate inflammation by inducing timely neutrophil apoptosis. A major task is to identify the mechanisms of dysregulation in inflammation leading to toxic responses, thereby targeting a biomarker and enabling timely therapies to modulate inflammation