Synthesis and antibacterial studies of lanthanide (III) complexes with aminopromazine

New complexes of lanthanide(III) nitrates with aminopromazine, having the general formula Ln(AP)(2)(NO3)(2)]NO3 (Ln = La, Cc, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu and AP = aminopromazine) have been synthesised. The complexes have been screened far antibacterial activities

Curriculum and Learning for Climate Action

Curriculum and Learning for Climate Action offers researchers, practitioners, donors, and decisionmakers insights into entry points for education systems change needed to reorient human society’s relationship with our planetary systems.; Readership: All interested in Sustainability, International Education, Environmental Education will find this book useful. This includes researchers, students, policy makers, global practitioners, as well as think tanks, and donors

Curriculum and Learning for Climate Action

Curriculum and Learning for Climate Action offers researchers, practitioners, donors, and decisionmakers insights into entry points for education systems change needed to reorient human society’s relationship with our planetary systems.; Readership: All interested in Sustainability, International Education, Environmental Education will find this book useful. This includes researchers, students, policy makers, global practitioners, as well as think tanks, and donors

DESIGN, DOCKING AND SYNTHESIS OF NOVEL BROMO ISATIN INCORPORATED ISOXAZOLE DERIVATIVES AS VEGFR-2 INHIBITORS

Objective: To design, synthesize, in vitro Vascular Endothelial Growth Factor Receptor (VEGFR-2) assay, antiproliferative activity an Absorption, Distribution, Metabolism, Excretion and Toxicity (ADMET) studies of some novel bromoisatin incorporated isoxazole derivatives. Methods: Designed compounds were synthesized by the condensation of different 3-aryl-5-methylisoxazole-4-carbohydrazides (5a-h) with 5-bromoisatin to give the target molecules. To predict the affinity and activity of the ligand molecule the docking program GOLD 3.1 was employed to generate different bioactive binding poses of designing molecules at the active site of protein VEGFR-2. All the synthesized compounds were characterized based on the spectral and elemental analysis data. Antiproliferative activity performed against Human Umbilical vein endothelial cells (HUVEC cell line). Results: All the synthesized compounds showed the characteristic peaks in FTIR,1H, C[13]NMR and Mass spectral analysis. In molecular docking, all the synthesized compounds (6a-j) exhibited high fitness scores with minimum three bonding interaction with the active site VEGFR-2 kinase. In in-vitro, VEGFR-2 kinase assay, compounds 6a, 6b, 6d and 6e exhibited more than 70% inhibition at a single dose concentration of 5μM. In antiproliferative assay against HUVEC cell lines, compounds 6d and 6e exhibited potent activity with IC50 values in nanomolar concentrations. ADMET results of 6a, 6b, 6d and 6e are quite promising with least hepatotoxicity and good bioavailability. Conclusion: The derivatives were synthesized in quantitative yields. New derivatives posses antiproliferative activity, least hepatotoxicity and good bioavailability

A Study on Prevalence of Hyponatremia and Its Outcome on Mortality in Acute Coronary Syndrome in Non-Diabetic Patients

BACKGROUND: Coronary artery disease is the world’s most important cause of death. It is the most common cause of mortality and morbidity in the world. Electrolyte imbalance is common in hospitalized patients, especially in patients with heart failure. Hyponatremia is also common after myocardial infarction and clinical improvement is accompanied by a rise in plasma sodium concentration. Hyponatremia is defined as plasma sodium concentration of <135 mEq/L. Hyponatremia is relevant to heart failure, liver cirrhosis and stroke but prognostic value of serum sodium levels in patients with acute coronary syndrome are still unclear. So many studies with systematic analysis was done to assess the prognosis of hyponatremia in acute coronary syndrome. Hyponatremia was significantly associated with the increased risks of all causes of mortality and morbidity compared to normonatremia patients with acute coronary syndrome. AIMS AND OBJECTIVES: The aims and objective of this study is to study the prevalence of hyponatremia in acute coronary syndrome and to determine the mortality outcome of hyponatremia in acute coronary syndrome. MATERIALS AND METHODS: This study is a prospective based study conducted in Government Vellore Medical College for a period of one year from Sep’2018 to Aug’2019, in 100 patients who were admitted as inpatients in intensive coronary care unit. RESULTS: Among the 100 patients in my study, hyponatremia was a major factor for mortality. Out of 100 patients in my study, 7 patients had hyponatremia at discharge. Among the 7 patients, 4 patients with hyponatremia had a significant mortality. The other 3 patients death was due to other complications like CCF, VT and pulmonary embolism. CONCLUSION: The conclusion of the study explains the prevalence of hyponatremia is more common among the older age people and this hyponatremia is a single prognostic indicator in patients with acute coronary syndrome. hyponatremia can cause both short term and long term mortality in acute coronary syndrome

Assessment of the Awareness among Diabetic Patients of Their Risk for Oral Disease as Complication Associated With Diabetics

AIM: To assess the awareness of diabetic patients of their risk for oral disease as complication associated with diabetics. INTRODUCTION: Diabetes mellitus is a metabolic disorder characterized by hyperglycemia due to defective secretion or activity of insulin. Type II diabetes is a common disorder with concomitant oral manifestation that impacts dental care Evidence shows that many patients are unaware about effects of diabetes mellitus on oral health. &nbsp;METHODOLOGY: A cross sectional descriptive survey was conducted among adult dental patients attending a tertiary care hospital of Bangalore city. A total of 172 patients were included in the study. The tool used to conduct the survey was a close-ended self-administered 14-item questionnaire. Self-rate oral health was assessed using a 4 point scale as good, average, bad and don’t know. RESULT: A total of 172 subjects, among them 120 (69.7%) were males and 52 (30.3%) were females. Among 172 subjects, 87(50%) were aware that diabetics are more prone to oral diseases .91(52%) of the study subjects did not know that diabetes effects gingiva.91(52%) of individuals knew diabetes causes delay in wound healing. 81% of the subjects, self-rated their mouth as good. CONCLUSION: Diabetic patients are less aware of their risk for dental diseases. Thus, it is necessary for dental professionals and related government agencies to promote awareness of the relationship between diabetes mellitus and oral health in order to prevent harmful complications on oral healt

A Suggestive Diagnostic Technique For Early Identification Of Acyanotic Heart Disorders From Infant’s Cry

Congenital Heart Defects (CHD) are the critical heart disorders that can be observed at the birth stage of the infants. These are classified mainly into two, Cyanotic and Acyanotic. The present paper concentrates on the Acyanotic heart disorders. Acyanotic heart disorder cannot be observed on external checkup, whereas bluish skin is the indication for the infant affected with Cyanotic disorder. Acyanotic heart disorder can only be diagnosed using chest X-Ray, ECG, Echocardiogram, Cardiac Catheterization and MRI of the Heart. The present work aims at estimating the fundamental frequency (pitch) and the vocal tract resonant frequencies (formants) from the cry signal of the infants. The pitch frequency and formant frequencies are estimated using frequency domain (Cepstrum) and Linear Prediction Code (LPC) methods. The results show that the fundamental frequency of the cry signal was between 600Hz-800Hz for the infants with Acyanotic heart disorders. This fundamental frequency helps in identifying Acyanotic heart disorders at an early stage

Fe Substituted SrTiO3 as Visible Light Active Photosensitive Material for Solar-Hydrogen Generation

Perovskite SrTiO3 and Fe Substituted SrTiO3 were prepared by solid-state reaction route as visible light active photosensitive materials for solar-hydrogen generation applications. Powder X-ray diffraction pattern confirms the formation of crystalline perovskite SrTiO3 phase at sintering temperature of 1273 K. The pattern of Fe substituted SrTiO3 exhibits number of peaks with splits and less crystalline indicating a lower symmetry structure upon substation at Sr and Ti sites. Crystallinity and crystallite size also finds decrease with increased Fe substitution. The band gap of SrTiO3 obtained by DR UV-Vis absorbance analysis at various sintering temperature approaches the theoretical value 3.06 eV. However, on Fe substitution the band gap is reduced to ~ 2.0-2.5 eV suggesting the materials can extend its absorption to the visible range also. FT-IR spectra confirmed that the Fe substituted SrTiO3 is similar to that of pure phase with bands corresponding to the hydroxyl and carboxyl groups. Since the substituted materials show reduced band gap, these materials can be utilized for photosensitive solar-hydrogen generation

Secukinumab sustains improvement in signs and symptoms of psoriatic arthritis: 2 year results from the phase 3 FUTURE 2 study

Objectives. To assess long-term efficacy, safety and tolerability of secukinumab up to 104 weeks in patients with active PsA. Methods. Patients with PsA (n = 397) were randomized to s.c. secukinumab 300, 150 or 75 mg or placebo at baseline, weeks 1, 2, 3 and 4 and every 4 weeks thereafter. Placebo-treated patients were re-randomized to receive secukinumab 300 or 150 mg s.c. from week 16 (placebo non-responders) or week 24 (placebo responders). Exploratory endpoints at week 104 included 20, 50 and 70% improvement in ACR criteria (ACR20, 50, 70); 75 and 90% improvement in the Psoriasis Area Severity Index, 28-joint DAS with CRP, presence of dactylitis and enthesitis and other patient-reported outcomes. For binary variables, missing values were imputed; continuous variables were analysed by a mixed-effects model for repeated measures. Results. A total of 86/100 (86%), 76/100 (76%) and 65/99 (66%) patients in the secukinumab 300, 150 and 75 mg groups, respectively, completed 104 weeks. At week 104, ACR20 response rates after multiple imputation in the 300, 150 and 75 mg groups were 69.4, 64.4 and 50.3%, respectively. Sustained clinical improvements were observed through week 104 with secukinumab across other clinically important domains of PsA. Responses were sustained through week 104 regardless of prior anti-TNF-a use. Over the entire treatment period the incidence, type and severity of adverse events were consistent with those reported previously. Conclusion. Secukinumab provided sustained improvements in signs and symptoms and multiple clinical domains in patients of active PsA through 2 years of therapy. Secukinumab was well tolerated, with a safety profile consistent with that reported previously. Trial registration: ClinicalTrials.gov (https://clinicaltrials.gov), NCT0175263

Synthesis of novel 2-substituted benzimidazole derivatives as potential anti microbial agents

In the present study, a novel series of 2-substituted benzimidazole derivatives were synthesized and characterized by means of IR, 1H-NMR, 13C- NMR, mass spectral and elemental analysis. The compounds were screened for antibacterial (Staphylococcus aureus ATCC9144,  Staphylococcus epidermidis ATCC 155, klebsiella pneumoniae ATCC 29665 and Esherichia coli ATCC 25922) and antifungal (Candida albicans ATCC 2091 and Aspergillus niger ATCC 9029) activities. The Minimum Inhibitory Concentrations was determined by agar streak dilution method. 1-(4-(1H-benzo[d]imidazol-2-yl)phenyl)-3-chloro-4-(4-nitro phenyl)azetidin-2-one (3a) was found to exhibit the most potent in vitro antimicrobial activity with MIC of 15, 17, 19, 9, 11 and 15 μg/mL against E.coli, K.pneumoniae, S.aureus, S.epidermidis, C.albicans and A.niger respectively. All the other compounds exhibited moderate activity against the bacterial and fungal organism tested