PHARMACEUTICO THERAPEUTICS OF SHADBINDU THAILA - A CASE STUDY ON EFFICACY IN TIMIRA W.S.R. TO MYOPIA

Nasyakarma is one among the Panchakarma procedures in which, the medicated drugs are administered through the nasal route and is indicated specially for the treatment of Urdhwajathrugatharogas i.e., the disorders of head and neck. Prathimarsha nasya is a type of Nasya wherein the medicament is administered in smaller dosage and advisable in all age groups and conditions. Material and methods: Shadbindhu taila containing different Vatahara and Kaphahara drugs processed along with Ajakshira was prepared in the laboratory of Rasashatra and Bhaishajyakalpana of SDM college of Ayurveda, Udupi, as per the classical reference and with all precautions. Single case study was taken up in a patient diagnosed of Timira viz myopia Results and discussion: Shadbindhu taila is Tikta – katu rasa, Madhuravipaka, having Ushnathikshnaguna. It helps in decreasing the excessive secretions from the mucus membrane of nose, dryness as well as the inflammation of the nose. It is useful in strengthening the functions of eyes, growth of hair, maintaining the integrity of the teeth. A single case study was taken up to access its efficacy in Timira w.s.r. myopia and it is found to have promising results. Conclusion: Shadbindhu taila has shown improvement in the patient when used in the form of Prathimarsha nasya. Further study with larger sample size has to be done and with different stages of myopia can be done for further evaluation

Dependence of Self-Assembled Peptide Hydrogel Network Structure on Local Fibril Nanostructure

Physically cross-linked, fibrillar hydrogel networks are formed by the self-assembly of β-hairpin peptide molecules with varying degrees of strand asymmetry. The peptide registry in the self-assembled state can be used as a design element to generate fibrils with twisting, nontwisting, or laminated morphology. The mass density of the networks varies significantly, and can be directly related to the local fibrillar morphology as evidenced by small angle neutron scattering (SANS) and in situ substantiation using cryogenic transmission electron microscopy (cryo-TEM) under identical concentrations and conditions. Similarly, the density of the network is dependent on changes in the peptide concentration. Bulk rheological properties of the hydrogels can be correlated to the fibrillar nanostructure, with the stiffer, laminated fibrils forming networks with a higher G′ as compared to the flexible, singular fibrillar networks

PHYTOSYNTHESIS AND CHARACTERIZATION OF SILVER NANOPARTICLES FROM RUELLIA TUBEROSA (L.): EFFECT OF PHYSICOCHEMICAL PARAMETERS

Objective: The current study focused on synthesizing silver nanoparticles (AgNPs) using Ruellia tuberosa aqueous tuber extract (RTTE) and silver nitrate (AgNO3) solution. Methods: AgNPs were synthesized using an aqueous tuber extract of the medicinal herb R. tuberosa (L.). The existence of significant phytoconstituents involved in synthesizing the AgNPs was determined using the gas chromatography–mass spectrometry (GC–MS) study. We evaluated the physical and chemical parameters such as the effect of time, temperature, metal ion concentration, crude aqueous tuber extract concentration, and pH in the synthesis of nanoparticles. The AgNPs were characterized using ultraviolet (UV)–Vis spectroscopy, field emission scanning electron microscopy (FESEM), energy-dispersive X-ray spectroscopy (EDX), high-resolution transmission electron microscope (HRTEM), selected area electron diffraction (SAED), X-ray diffraction (XRD), and Fourier transform infrared (FTIR) techniques. Results: R. tuberosa tuber extract was rich in various phytochemical constituents which were identified by GC–MS. For biosynthesis, the optimal values were 1 mM AgNO3concentration, 0.1 mL of aqueous tuber extract, and a 40 min incubation temperature of 70°C. The existence of a characteristic surface plasmon resonance (SPR) peak at 421 nm indicated the biosynthesis of AgNPs using UV–Vis spectroscopy. At higher temperatures and alkaline pH, the development of AgNPs increased overtime and remained stable up to 4 weeks. FESEM, EDX, HRTEM, SAED, and XRD analysis revealed that most AgNPs were spherical, with an average size distribution of 34.9 nm and a crystalline phase, face-centered cubic lattice. Infrared (FTIR) spectroscopic analysis revealed that hydroxyl and amino functional groups were involved in the biosynthesis and stabilization of AgNPs. Conclusion: The synthesis of AgNPs from R. tuberosa aqueous tuber extract was a cost-effective process and environmental friendly

Association of Vitamin D Deficiency with Hypertension in Uninsured Women

Vitamin D deficiency is an epidemic in the United States. Uninsured women are at high risk due to a lower intake of vitamin D and limited sun exposure. We examined the association between vitamin D deficiency and hypertension in 96 uninsured women at a County Free Medical Clinic in urban Michigan. Questionnaires were used to obtain information about demographics, medical history including hypertension, and dietary habits. Measurements including blood pressure and serum 25(OH)D level were also collected. Prevalence of hypertension was higher in subjects with 25(OH)D less than 50nmol/l compared with others (85% vs. 27.3%, p = 0.014). For every 1 nmol/L decrease in serum 25(OH)D, there was an increase in the systolic and diastolic blood pressure by 0.20 (p =0.006) and 0.13 (p =0.003) mm of Hg respectively. These results demonstrate a high prevalence of hypertension in the vitamin D deficient, uninsured female population

A new method for secure kNN algorithm to guarantee the security of the outsourced data maintaining its searchability

Distributed computing is a promising IT framework that can make a ton out of IT resources in a profitable and versatile manner. Continuously different associations plan to move their close by information the board systems to the cloud and store and manage their item information on cloud servers. A going with challenge is the way to guarantee the security of the monetarily mystery information while keeping up the capacity to look through the information. In this paper, a security protecting information search plan is suggested that can support both the identifier-based and include based item look. Specifically, two novel rundown trees are created and encoded that can be looked without knowing the plaintext information

A Study on the Customers Perception About Advertisement of Organic Toddler Food

Purpose: This study assesses the impact of organic toddler food labelling on customer attitudes towards advertising, brand loyalty, and purchase intentions as well as consumer perceptions of healthiness and tastiness.   Theoretical Framework: These advertisements negative effects on the lower middle class are significantly more severe. Quite frequently, these food products develop snob appeal, and people from less affluent backgrounds are persuaded to buy them as dietary supplements and a means of ascension.   Design/methodology/approach: Researcher used Purposive sampling technique This study concentrates on the impact and awareness of advertisement in organic toddler foods. Both ancillary and principal data were used in this study. Researcher has taken 384 as a sample for research study which is greater than the minimum statistically accepted sample size. The data were analyzed using the SPSS_22. Pearson’s Coefficient of Correlation Chi-square   Findings: Study reveals that there is no association between demographic variables and legal consideration of advertisement. It depicts that unlike gender and age, qualification has association opinion about legal consideration of advertisement. There exists a high positive relation between attitude toward advertising of toddler organic foods and awareness about legal issues related to toddler organic foods.   Research, Practical and Social Implication: Customers should evaluate the value of advertisement and take buying decision. They should be given a clear picture on the myths and reality and identify the source and authenticity of advertisement. They should understand the legality related to advertisement.   Originality/value: The importance of health in customers food shopping decisions has increased as their interest in health-related problems has increased

Total and Edge Domination on Anti Fuzzy Line Graph

In this paper, the total dominating set, edge dominating set and domination number (TDN & EDN) for anti fuzzy line graph is computed by maxima method algorithm (MMA). This calculation is executed using strong adjacency matrix of anti fuzzy graphs and its line graph

Evaluation of erythrocyte membrane lipids and proteins in renal disorders

Background: Membrane lipids and proteins play a significant part in imparting membrane its rheological properties. These parameters are altered in diseased states. Exploring the conformational changes in renal disorders can widen our understanding of its impact on the circulatory system. This could lead to a new diagnostic parameter to study the progress of a disease.Methods: 120 blood samples collected from 30 kidney donors, 30 stage 3-4 Chronic kidney disease (CKD) patients (group 1) and 30 stage 5 CKD patients on dialysis (pre and post dialysis) (group 2) were lysed and washed to obtain erythrocyte ghost membranes. The proteins extracted from these membranes were estimated colorimetrically using Micro BCA kit. Phospholipids were separated and quantified using HPTLC. Fatty acids and cholesterol were analysed using GCMS.Results: The erythrocyte membrane protein profile showed lower values in group 2 participants than group 1 participants, but this difference was not significant. Distinct decreases in percentages of palmitic acid, myristic acid, stearic acid, dodecanoic acid, cholesterol, phosphatidylserine, phosphatidylcholine and phosphatidylethanolamine were observed in both groups, with the lowest values in patients undergoing dialysis. Sphingomyelin and linoleic acid did not show any such trend across groups.Conclusions: The data is suggestive of an altered membrane structure in participants undergoing dialysis patients than the control group. This could be because of uremic toxins in the circulatory system affecting the membrane lipids. Decreased levels of essential phospholipids can impact the functions and lifespan of the erythrocytes. This could be a reason behind anaemia seen in most patients with CKD

Potential anti-seizure activity of atorvastatin in rat models of seizure

Background: Atorvastatin belongs to the class of Hypolipidemic statins. Increasing evidence indicates that statins are neuroprotective in several conditions, including stroke, cerebral ischemia and traumatic brain injury. However, only scanty and controversial reports are available on anticonvulsant action of statins. The present study therefore aims at exploring the influence of atorvastatin on seizures as compared to standard anticonvulsants phenytoin and sodium valproate in Wistar rats.Methods: Rats were divided into 8 groups (n=6), each treated intraperitoneally (i.p) with atorvastatin, phenytoin or sodium valproate in their therapeutic equivalent doses. Their effects were evaluated on seizures induced by maximum electroshock seizure (MES) and pentylenetetrazole (PTZ). Hind limb extension (HLE) in MES model, number of seizures, duration of seizure, number of myoclonic jerks and time for onset as well as recovery from seizures in PTZ model were monitored. Statistical analysis was done using Kruskal-Wallis ANOVA and Mann-Whitney U test for significance.Results: Atorvastatin failed to protect rats against HLE in MES seizure model. However, atorvastatin significantly prolonged seizure onset time (p<0.0547), decreased seizure number (p<0.0082), seizure duration (p<0.0547) and recovery time (p<0.0040) in PTZ model indicating its potential antiepileptic activity in PTZ model.Conclusions: Atorvastatin exhibited protection against seizures only in PTZ seizure model. Hence, it could possess anti absence seizure activity. This needs to be established with further systematic animal and clinical studies

The Impact of Financial Histories on Individuals and Societies: A Laboratory Study

This paper studies how successive generations of laboratory societies organize themselves when given reports of financial transactions from previous generations. We define an increase in societal organization as a reduction in the entropy of the distribution of amounts sent and returned by successive generations of players in the Investment Game. Our entropy analysis of data from Berg, J., Dickhaut, J., and McCabe, K. (1995. Trust, Reciprocity, and Social History. Games and Economic Behavior, 10, 122-142) indicate that the provision of a financial history reduced the entropy of the amounts sent by Investors, amounts returned by Stewards, and the amounts in the joint Investor/Steward distribution. We then gathered new data over five societal generations to test the predictive power of our hypothesis that financial histories provide a basis for developing societal order. Participants in Session I (the first generation) received no financial history, whereas participants in the subsequent Sessions II-V received a report that summarized the financial history of the immediately preceding session. The amounts sent by Investors and returned by Stewards increased over the five sessions and produced greater overall societal wealth, but entropy declined significantly only in the amounts sent by Investors. The concluding section discusses the implications of our results and identifies opportunities for future research