Checkmate to Peace in Russia and Ukraine

This article will to answer the question Why Russia allow a military intervention in the Ukraine on the side of the Russian forces How are we to think of it How are we those that love Russia and especially cherish its peaceful and peacemaking nature going to deal with this situation morally politically A main reason for this war is in fact insufficient representation of the Russian point of view and integration of Russia by Westerns counterparts in the global order despite Russia making all efforts to join it in the last 25 years How are we to maintain the open dialogue and improve the representation of Russia after and during this military conflict The other reason for the conflict is the astounding deafness and unwillingness to compromise or simply acknowledge the Russian position and trut

The Future of the Ukrainian State and Regime: Domestic Disassociation and International Association

On the chessboard of the contemporary multipolar structure theorized by structural realism the role of the main actors in constituting the international Crisis are examined through the lens of the mirror-processes of balancing and bandwagoning It is important to situate the Crisis at its inception the creation of a Ukrainian state in 1991 of the Russian forces How are we to think of it How are we those that love Russia and especially cherish its peaceful and peacemaking nature going to deal with this situation morally politically A main reason for this war is in fact insufficient representation of the Russian point of view and integration of Russia by Westerns counterparts in the global order despite Russia making all efforts to join it in the last 25 years How are we to maintain the open dialogue and improve the representation of Russia after and during this military conflict The other reason for the conflict is the astounding deafness and unwillingness to compromise or simply acknowledge the Russian position and trut

Multi-speed solitary waves of nonlinear Schrödinger systems: theoretical and numerical analysis

International audienceWe consider a system of coupled nonlinear Schrödinger equations in one space dimension. First, we prove the existence of multi-speed solitary waves, i.e solutions to the system with each component behaving at large times as a solitary wave. Then, we investigate numerically the interaction of two solitary waves supported each on one component. Among the possible outcomes, we find elastic and inelastic interactions, collision with mass extraction and reflexion

TV Series and Social Media: Powerful Engagement Factors in Mobile Video Games

The free-to-play business model has become hegemonic in the mobile video game industry, displacing the traditional paid content model that was the norm until the appearance of manufacturers' app stores. Companies attempt to monetize these games by means of in-game micro-transactions and in-game advertising; thus, it is essential to acquire an enormous number of users because only a small percentage will ultimately make any purchases. To keep players engaged, companies typically put in place marketing and design strategies derived from behavioral telemetry, to maintain a grip on players. We propose an innovative approach, focusing our attention on the impact of having a video game based on a famous TV series. Furthermore, we analyze the effect of social networks on game metrics. The outcome indicates that developing a game based on a TV series and integrating social media with the gameplay improve and reinforce the user's activation, retention and monetization

Treatment with a New Peroxisome Proliferator-Activated Receptor Gamma Agonist, Pyridinecarboxylic Acid Derivative, Increases Angiogenesis and Reduces Inflammatory Mediators in the Heart of Trypanosoma cruzi-Infected Mice

Trypanosoma cruzi infection induces an intense inflammatory response in diverse host tissues. The immune response and the microvascular abnormalities associated with infection are crucial aspects in the generation of heart damage in Chagas disease. Upon parasite uptake, macrophages, which are involved in the clearance of infection, increase inflammatory mediators, leading to parasite killing. The exacerbation of the inflammatory response may lead to tissue damage. Peroxisome proliferator-activated receptor gamma (PPARγ) is a ligand-dependent nuclear transcription factor that exerts important antiinflammatory effects and is involved in improving endothelial functions and proangiogenic capacities. In this study, we evaluated the intermolecular interaction between PPARγ anda new synthetic PPARγ ligand, HP24, using virtual docking. Also, we showed that early treatment with HP24, decreases the expression of NOS2, a pro-inflammatory mediator, and stimulates proangiogenic mediators (vascular endothelial growth factor A, CD31, and Arginase I) both in macrophages and in the heart of T. cruzi-infected mice. Moreover, HP24 reduces the inflammatory response, cardiac fbrosis and the levels of inflammatory cytokines (TNF-α, interleukin 6) released by macrophages of T. cruzi-infected mice. We consider that PPARγ agonists might be useful as coadjuvants of the antiparasitic treatment of Chagas disease, to delay, reverse, or preclude the onset of heart damage.Fil: Penas, Federico Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; ArgentinaFil: Carta, Davide. Università di Padova; ItaliaFil: Dmytrenko, Ganna. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Mirkin, Gerardo Ariel Isidoro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; ArgentinaFil: Modenutti, Carlos Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Cevey, Ágata Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; ArgentinaFil: Rada, Maria Jimena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; ArgentinaFil: Ferlin, Maria Grazia. Università di Padova; ItaliaFil: Sales, María Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; ArgentinaFil: Goren, Nora Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Microbiología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentin

KARAKTERISTIK BAYI BARU LAHIR YANG MENGALAMI ASFIKSIA NEONATORUM DI RSUD PANEMBAHAN SENOPATI TAHUN 2021

ABSTRAK Latar Belakang: Kejadian asfiksia tertinggi di Daerah Istimewa Yogyakarta berada di kabupaten Bantul. Beberapa faktor yang menyebabkan asfiksia neonatorum pada bayi baru lahir di antaranya faktor ibu (usia ibu, preeklamsia, paritas, usia kehamilan), faktor bayi (premature, BBLR, air ketuban bercampur meconium), dan faktor persalinan (jenis persalinan). Tujuan: Untuk mengetahui karakteristik bayi baru lahir yang mengalami asfiksia neonatorum di RSUD Panembahan Senopati Bantul tahun 2021. Metode Penelitian: Penelitian deskriptif dengan rancangan cross sectional. Subjek dalam penelitian yaitu seluruh bayi baru lahir yang mengalami asfiksia neonatorum di RSUD Panembahan Senopati, Bantul pada bulan Oktober-Desember tahun 2021 sejumlah 92 bayi dan tercatat dalam rekam medis. Variabel pada penelitian ini adalah karakteristik bayi baru lahir yang mengalami asfiksia neonatorum. Pengumpulan data penelitian ini menggunakan format pengumpulan data berupa master tabel. Analisis data menggunakan analisis univariat. Hasil: Mayoritas subyek dengan ibu berusia 20-25 tahun (73,9%), ibu yang tidak mengalami preeklamsia (83,7%), paritas multipara (68,5%), ibu dengan usia kehamilan aterm (78,3%), bayi yang tidak mengalami prematur (78,3%), bayi dengan BBLN (69,6%), air ketuban tidak bercampur mekonium (71,7%), jenis persalinan tindakan (57,6%) dengan mayoritas bayi mengalami asfiksia ringan. Kesimpulan: mayoritas pada ibu usia rentang 20-25 tahun, pada ibu yang tidak mengalami preeklamsia, pada paritas multipara, pada ibu dengan usia kehamilan aterm, pada bayi yang tidak mengalami prematur, pada bayi dengan BBLN, pada air ketuban tidak bercampur mekonium, pada persalinan tindakan dengan mayoritas mengalami asfiksia ringan. Kata Kunci: Karakteristik Asfiksia, Bayi Baru Lahir, Asfiksia Neonatorum