Caring for Substance Exposed Newborns

As part of the mini-symposium entitled Pregnant and Parenting Mothers with History of Opiate Addiction, this presentation describes innovations in care for substance exposed newborns while highlighting the gaps in services antepartum and post hospital discharge

ANTIOXIDANT, CYTOTOXICITY, AND STABILITY EVALUATION OF GINKGO BILOBA EXTRACT-BASED MICROEMULSIONS FOR ENHANCED THERAPEUTIC ACTIVITY

Objective: This study is aimed to evaluate the antioxidant (AO) potential, cytotoxicity, and stability of preformulated Ginkgo biloba standard extractmicroemulsion (GBME), to investigate if, it retains the therapeutic potential of EGB761 and remains safe and stable for a longer period.Method and Results: GBME has shown enhanced AO (85.2±0.78%, IC50=31.3±0.45 μg/ml) in comparison to EGB761 (74.1±0.51%,IC50=49.4±0.05 μg/ml) using 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assay. Similarly, 2,2-diphenyl-1-picryl-hydrazyl-hydrate(DPPH) assay has also shown that AO for GBME (94.6±0.04%, IC50=11.4±1.03 μg/ml) was higher than EGB761 (78.6±1.20%, IC50=34.6±0.81 μg/ml).Further, IC50 value of antiradical unit of GBME was much lesser (ABTS=14.3±1.05 μg/ml and DPPH=17.03±1.8 μg/ml) in comparison to EGB761(ABTS=34.1±1.62 μg/ml and DPPH=37.5±0.08 μg/ml). Equivalently, both, hydrogen peroxide scavenging activity, and nitric oxide activity wereappreciably higher for GBME than the pure extract. The in vitro cytotoxicity assessment showed that GBME is quite safe (98.68±0.76% cell viability) incomparison to EGB761 (83.29±1.02%). Thereafter, these samples were tested for stability by evaluating their AO activity along with high-performanceliquid chromatography analysis, for the major phytocompounds, after 1 year, and results suggested that AO of GBME remained stable while comparingwith the freshly prepared GBME, whereas AO of EGB761 reduced significantly as compared to freshly taken EGB761 extract implying the degradationof phytocompounds supporting decrease in AO activity.Conclusion: Therefore, the observed results suggest that GBME maintained AO and scavenging activity along with enhanced shelf life with no observedtoxicity, which can be explored further for its potential therapeutic implications in various oxidative stress-induced central nervous system disorders

A Review of Spam Filtering and Measures of Antispam

Spam is commonly defined as unsolicited email messages, and the goal of spam categorization is to distinguish between spam and legitimate email messages. Our main aim is classification of spam mail and solving various problem is related to web space. So we discuss the measuring parameter which are helpful for reduce the spam or junk mail. In this paper, we describe procedure that  can help eliminate unsolicited commercial e-mail, viruses, Trojans, and worms, as well as frauds perpetrated electronically and other undesired and troublesome e-mail.so this research is helpful for best classification and categorization method of email spam detection. Keywords: spam, anti spam factor

Evaluation of the ecological state of the major streams located in Doon valley using diatoms as indicators

Biological communities reflect overall ecological integrity (i.e. chemical, physical and biological integrity). Since the diatom species exhibit variation in tolerances to physical and chemical change in water, they are excellent indicators changes in their environment. Based on the dominant categories for each characteristic, the ecological state of the stream can be determined. This study evaluates the ecological state of the streams in Doon Valley. The diatom samples collected at regular monthly intervals from the twelve streams located in the eastern and western Doon were treated with acid-peroxide and mounted in Naphrax for species count at x1500. About 250-300 valves of diatom species were counted and Van Dam ecologic values were computed by OMNIDIA ver. 5.3. pH was alkaliphilous (4), salinity - fresh brackish (2) and oxygenation - continuously high (1) for most of the streams. Saprobity and trophic status was largely ?-mesosaprobous (2) and eutraphentic (5), respectively. The Leclercq index also shows non-existent (<10%) to low (10-20%) organic pollution, degradation (IDSE=3.5-3.0) and moderate anthropogenic eutrophication (20.1-45%) in most of the streams attributed to urbanization stress (62 MLD sewage). The water quality based on indices; IBD (Indice biologique diatomèes), IPS (Indice de polluo-sensibilite) and TDI (Trophic Diatom Index) showed the moderate water quality in the streams of the Valley. Like EU Water Framework Directive 2000/60/EC (WFD) India should also have the objective to ensure ecosystem integrity through bio-assessment and not just mere pollution control

A Clinical Study in the management of Garbhini Pandu with Draksha Ghrita w.s.r. to Iron Deficiency Anaemia in Pregnancy

Background: Pregnancy is a beautiful phase because it gives a woman the joy and fulfilment which comes from bringing a new life in to the world. It is a state, where there is progressive anatomical, physiological and biochemical change not only confined to the genital organs but also to all the system of body. In underdeveloped countries due to nutrient deficiency anaemia has become major contributing factor for mortality and morbidity. In Pregnancy if anaemia is not treated in time may lead to complications like Preterm labor, Low birth weight, Infection, PPH, Growth retardation, Pregnancy Anaemia cause high maternal and pre-nantal, morbidity and mortality. Objective: This study was carried out to know the efficacy of Draksha Ghrita in Garbhini Pandu (Anaemia in Pregnancy). Methods: A Randomized clinical study of two groups consisting of 15 patients each in control and trial group. Group A was administered with Draksha Ghrita in the dose of 15ml BD with hot water before food daily for the period of 60 days. Group B was administered with Dadimadi Ghrita, 15ml BD with hot water before food daily for the period of 60 days. Results: The study revealed a substantial efficacy of Draksha Ghrita in Garbhini Pandu (Anaemia in Pregnancy) with respect to subjective parameters and also with objective parameter. Draksha Ghrita has got a vital role in the pregnancy which has shown successful result in symptomatic relief. Conclusion: The drug is proved to be safe, easily available and cost effective and no adverse effect has seen

Flow equations in commercial gas piping system

There are various types of flow equations in commercial gas piping system and this thesis will covered about the comparison of Cox and Pole‟s method. FORTRAN 90 software was used to validate the manual calculation of both equations and a comparative study was made. The analytical solutions of the resulting differential equations are obtained in the form of Cox and Pole‟s equations. The equations give functional relationship between flow rate, inlet pressure and outlet pressure, as well as pressure drop at any given length. The effect of pressure drop per segment on gas flow rate is presented. Both of the equation was calculated manually from the commercial area gas piping route and the syntax generated from the equations were compiled and executed in F90 with no errors. The Cox‟s method was found more economically with smaller pipe size but allowable pressure drop in each section, compared to Pole‟s method. The equations considerably enhance gas pipeline design in terms of both ease of usage and accuracy. A simple computer program in FORTRAN 90 is developed to handle these calculations

Otorhinolaryngological myiasis: the problem and its presentations in the weak and forgotten

Introduction: Myiasis is common in tropical regions, but now increasing incidence is seen in the west due to international travel. Otorhinolaryngological myiasis is uncommon and is seen in diabetics, alcoholics or patients unable in self-care.Objectives: To study presentations of otorhinolaryngological myiasis, identify associated risk factors and species of flies causing myiasis.Methods: Clinical findings and co-morbidities of 67 myiasis cases were noted. Maggots were identified, manually removed, and patients were managed with topical treatment, systemic ivermectin and antibiotics.Findings: Thirty-three nasal myiasis, 13 aural myiasis and 5 patients with oral myiasis were noted. Seven patients with head neck wounds myiasis and nine patients of tracheostome myiasis were recorded.Discussion: Warm humid climate of tropical regions is a major concern along with co-existing conditions like poor sanitation, alcoholism, psychiatric diseases and neuropathies. Hesitancy is seen in attendants and health care professionals to deal with myiasis.Conclusion: Awareness about risk factors is important in avoiding myiasis along with prompt treatment which reduces morbidity. Tracheostome myiasis is an under-documented entity rather than a rare presentation.Keywords: Myiasis, Ivermectin, screwworm, Chrysomya bezziana, Musca domestica, Lucilia sericata.Funding: Non

Managing dub with progesterone - locally or orally which is a better option?

Background: The levonorgestrel intrauterine system (LNG-IUS) is a safe and effective form of contraception used by millions of people worldwide. Other than this, it has many non-contraceptive benefits-treatments for dysfunctional uterine bleeding (DUB), fibroid uterus, endometriosis and endometrial hyperplasia.Methods: A prospective longitudinal comparative study was carried out at department of obstetrics and gynaecology S.N. Medical College, Agra, Uttar Pradesh, India including 100 women of 20-45 years of age group (comparable in all aspects), with DUB. All cases were subjected to detailed history, examination and baseline investigations- Hemoglobin (Hb), endometrial aspiration, histopathology and ultrasound pelvis (along with endometrial thickness) and PBAC scoring before starting the treatment. Then cases were randomly allocated in two equal groups. In group A LNG-IUS was inserted. In group B cases were prescribed oral medroxy progesterone acetate 10 mg bd from 5th and 25th day of menstrual cycle. Cases were followed at 1 month, 3 months and 6 months after starting treatment. At each follow-up visit primary outcome in terms of subjective assessment by patient, PBAC scores and secondary outcome as Hb levels and side-effects were recorded.Results: Reduction in PBAC Scores, improvement in Hb and reduction in endometrial thickness were seen with both treatment modalities but results were significantly (p <0.0001) better with LNG-IUS group as compared to MPA. LNG-IUS was found to be more effective in endometrial hyperplasia and proliferative type of endometrium.Conclusions: LNG-IUS is a good alternative to oral progesterone therapy for patients of DUB

Material Study of Co2CrAl Heusler Alloy Magnetic Thin Film and Co2CrAl/n-Si Schottky Junction Device

The structural, optical, magnetic, and electrical properties of Co2CrAl Heusler alloy magnetic thin films grown on n-type silicon (100) substrate (n-Si) and glass substrate were studied. The films were deposited using DC magnetron sputtering. X-ray diffraction (XRD) analysis confirmed the polycrystalline nature of the films. The effect of grain size on transmittance was investigated. Magnetic measurements revealed the presence of magnetic ordering in the films. Partial densities of states (PDOS) of the Co2CrAl were calculated by density functional theory (DFT) methods using the Vienna Ab initio Simulation Package (VASP). Co2CrAl thin film deposited over a silicon substrate was investigated for I-V characteristics. The electrical behaviour confirmed the existence of a Co2CrAl/n-Si Schottky contact, which suggests a spin injection phenomenon from Co2CrAl to n-Si by tunnelling through the lowered Schottky barrier

Field Efficacy of Different Insecticides Against Fall Armyworm (Spodoptera frugiperda J.E. Smith) in Spring Maize (Zea mays L.)

An experiment was conducted from February to June 2022 to determine the effectiveness of different insecticides in controlling fall armyworm (Spodoptera frugiperda: FA) under field conditions. The experiment followed a randomized complete block design (RCBD) with 5 treatments and 4 replications. Insecticides were applied three times at 7-day intervals. The treatments included: T1 - untreated or control (water spray), T2 - Cypermethrin 5% + Chlorpyriphos 50% EC, T3 - Chlorantraniliprole 18.5% SC, T4 - Emamectin Benzoate 5% SG, and T5 - Spinetoram 11.7% SC. Data were collected for the number of live larvae, damage to the top four leaves and whorls, and yield attributes. The results showed that the lowest FA infestation was observed in the plots treated with Chlorantraniliprole 18.5% SC, while the highest infestation was observed in the control group. The highest yield (7.52 t/ha) was obtained from the Emamectin Benzoate treatment, while the lowest yield (5.74 t/ha) was recorded in the control group. Among the different control measures, spraying Chlorantraniliprole 18.5% SC at 7-day intervals was found to be the most effective method to control FA in spring maize variety TX-369, achieving 100% efficacy. These results provide valuable guidance to growers in selecting effective insecticides for FA control. This study addresses the challenge of FA management in maize crops while aligning with multiple Sustainable Development Goals (SDGs)