Facilities management and its importance in the research: preliminary analysis of the FMVZ-USP experience

Facilitie puede ser entendida como un conjunto de servicios y valores que auxilia y hace ais fácil alguna acción. Para que el servicio entregado por la facilitie cumpla sus objetivos de calidad, optimización de tiempo y de espacio, así como reducción de costo, es necesario que sea bien gestionada. El crecimiento de estas instalaciones en el medio académico ha aumentado vertiginosamente, permitiendo que el acceso a determinados equipos e informaciones sea ampliado. Es el caso del Centro Avanzado en Diagnóstico por imagen (CADI), una plataforma de la Facultad de Medicina Veterinaria y Zootecnia (FMVZ) de la USP que cuenta con diversos equipos de imagen sofisticados y que están agrupados en diferentes lugares de la FMVZ. Entre estos equipos, se pueden citar los microscopios, que están presentes en el edificio de la Anatomía (llamado Facilitie FMVZ / USP). En este contexto, el trabajo tuvo como objetivo hacer un análisis descriptivo, cualitativo y cuantitativo de los registros realizados por los usuarios de la Facilitie FMVZ / USP. Para cumplir este objetivo, se aplicó un cuestionario para los usuarios de Facilitie, conteniendo 14 preguntas que engloban el perfil del usuario, los equipos más utilizados y frecuencia de uso, la funcionalidad de la programación y la importancia del Centro en la investigación. En total, 42 usuarios respondieron el cuestionario, mostrando que la mayoría de ellos era del sexo femenino; alumnos de postgrado de la propia FMVZ; que la mayoría ya había utilizado el laboratorio diez o más veces; que la programación para la utilización de la Central se da de forma rápida y clara; y que la existencia del laboratorio es esencial para sus investigaciones. Además de los usuarios saber la importancia de Facilitie en sus investigaciones, muchos resultados positivos fueron generados en la Central, tales como artículos científicos, proyectos académicos y atención a grupos de investigación, contribuyendo para el mayor desarrollo de la Universidad.La facilité peut être comprise comme un ensemble de services et de valeurs  qui  aident  et  facilitent  certaines  actions.  Pour  que  le  service fourni  par  le  facilitie  réponde  à  ses  objectifs  d'optimisation  de  la qualité, du temps et de l'espace, ainsi que de réduction des coûts, il doit être bien géré. La croissance de ces installations dans le monde universitaire a explosé, ce qui a permis d'élargir l'accès à certains équipements  et  informations.  C'est  le  cas  du  centre  avancé d'imagerie  diagnostique  (CADI),  une  plate-forme  de  la  faculté  de médecine vétérinaire  et de zootechnie (FMVZ) de l'USP, dotée de plusieurs  équipements  d'imagerie  sophistiqués  et  regroupés  dans différents emplacements de la FMVZ. Parmi ces dispositifs, on peut citer  les  microscopes  présentsdans  le  bâtiment  Anatomy  (appelé Facilitie  FMVZ  /  USP).  Dans  ce  contexte,  les  travaux  visaient  à effectuer  une  analyse  descriptive,  qualitative  et  quantitative  des enregistrements effectués par les utilisateurs de Facilitie FMVZ / USP. Pour répondre à cetobjectif, un questionnaire a été appliqué aux utilisateurs  de  Facilitie.  Il  comportait  14  questions,  notamment  le profil de l'utilisateur, l'équipement le plus fréquemment utilisé et la fréquence  d'utilisation,  la  fonctionnalité  de  planification  et l'importance  du  système  central  dans  la  recherche.  Au  total,  42 utilisateurs ont répondu au questionnaire, indiquant que la plupart d'entre eux étaient des femmes; étudiants de troisième cycle de la FMVZ; que la plupart avaient déjà utilisé le laboratoire dix fois  ou plus;  que  le  calendrier  d'utilisation  de  la  centrale  est  donné rapidement  et  clairement;  et  que  l'existence  du  laboratoire  est essentielle  pour  leurs  recherches.  Outre  le  fait  que  les  utilisateurs connaissaient  l’importance  de  Facilitie  dans  leurs  recherches,  de nombreux résultats positifs ont été générés dans la centrale, tels que des articles scientifiques, des projets universitaires et la participation à  des  groupes  de  recherche,  contribuant  au  développement  plus poussé de l’Université.Facilitie pode ser compreendida como um conjunto de serviços e valores que auxilia e torna mais fácil alguma ação. Para que o serviço entregue pela facilitie cumpra os seus objetivos de qualidade, otimização de tempo e de espaço, assim como redução de custo, é necessário que ela seja bem gerida. O crescimento dessas facilities no meio acadêmico tem aumentado vertiginosamente, permitindo que o acesso a determinados equipamentos e informações seja ampliado. É o caso do Centro Avançado em Diagnóstico por Imagem (CADI), uma plataforma da Faculdade de Medicina Veterinária e Zootecnia (FMVZ) da USP que conta com diversos equipamentos de imagem sofisticados e que estão agrupados em diferentes locais da FMVZ. Dentre esses equipamentos, podem ser citados os microscópios, que estão presentes no prédio da Anatomia (chamado de Facilitie FMVZ/USP). Nesse contexto, o trabalho objetivou-se a fazer uma análise descritiva, qualitativa e quantitativa dos cadastramentos realizados pelos usuários da Facilitie FMVZ/USP. Para cumprir esse objetivo, foi aplicado um questionário para os usuários da Facilitie, contendo 14 perguntas que englobavam o perfil do usuário, os equipamentos mais utilizados e frequência de uso, a funcionalidade do agendamento e a importância da Central na pesquisa. Ao todo, 42 usuários responderam o questionário, mostrando que a maioria deles era do sexo feminino; alunos de pós-graduação da própria FMVZ; que a maioria já tinha utilizado o laboratório dez ou mais vezes; que o agendamento para utilização da Central se da de forma rápida e clara; e que a existência do laboratório é essencial para suas pesquisas. Além dos usuários saberem a importância da Facilitie nas suas pesquisas, muitos resultados positivos foram gerados na Central, tais como artigos científicos, projetos acadêmicos e atendimento a grupos de pesquisa, contribuindo para o maior desenvolvimento da Universidade.Facilitie can be understood as a set of services and values that assists and makes some action easier. In order for the service delivered by the facilitie to meet its objectives of quality, time and space optimization, as well as cost reduction, it must be well managed. The growth of these facilities in academia has skyrocketed, allowing access to certain equipment and information to be expanded. This is the case of the Advanced Center for Diagnostic Imaging (CADI), a platform of the Faculty of Veterinary Medicine and Animal Science (FMVZ) of USP that has several sophisticated imaging equipment and are grouped in different FMVZ locations. Among these devices, microscopes can be mentioned, which are present in the Anatomy building (called Facilitie FMVZ/USP). In this context, the aim of the research was making a descriptive, qualitative and quantitative analysis of the registrations made by Facilitie FMVZ/USP users. To fulfill this objective, a questionnaire was applied to Facilitie users, containing 14 questions that included the user profile, the most frequently used equipment and frequency of use, the scheduling functionality and the importance of the Central in the research. In all, 42 users answered the questionnaire, showing that most of them were female; postgraduate students of the FMVZ; that most had already used the laboratory ten or more times; that the scheduling for use of the Central is given quickly and clearly; and that the existence of the laboratory is essential for their research. In addition to the users knowing the importance of CADI in their research, many positive results were generated in the Central, such as scientific articles, academic projects and attendance to research groups, contributing to the greater development of the University

Dental manifestations in bariatric patients: review of literature

The rate of bariatric surgery has significantly risen in the past decade as an increasing prevalence of extreme obesity can be observed. Although bariatric surgery is an effective therapeutic modality for extreme obesity, it is associated with risk factors affecting also oral health. Based on an overview of the current literature, this paper presents a summary of dental manifestations in bariatric patients. Bariatric surgeries are associated with an increased risk for gastro-esophageal reflux which in turn might account for the higher amount of carious and erosive lesions observed in bariatric patients. As a result, also dentin hypersensitivity might be observed more frequently. The current data indicate that recommended postsurgical meal patterns and gastric reflux might increase the risk for dental lesions, particularly in the presence of other risk factors, such as consumption of sweet-tasting foods and acidic beverages. Further research is needed to evaluate the correlation of bariatric surgery and the development of dental diseases

Dental manifestations in bariatric patients: review of literature

The rate of bariatric surgery has significantly risen in the past decade as an increasing prevalence of extreme obesity can be observed. Although bariatric surgery is an effective therapeutic modality for extreme obesity, it is associated with risk factors affecting also oral health. Based on an overview of the current literature, this paper presents a summary of dental manifestations in bariatric patients. Bariatric surgeries are associated with an increased risk for gastro-esophageal reflux which in turn might account for the higher amount of carious and erosive lesions observed in bariatric patients. As a result, also dentin hypersensitivity might be observed more frequently. The current data indicate that recommended postsurgical meal patterns and gastric reflux might increase the risk for dental lesions, particularly in the presence of other risk factors, such as consumption of sweet-tasting foods and acidic beverages. Further research is needed to evaluate the correlation of bariatric surgery and the development of dental diseases

Recovering lead from cupel waste generated in gold analysis by Pb-Fire assay.

Because of its precision and accuracy, Pb-Fire assay is the most employed method for gold analysis in geological materials. At the second stage of the method, namely cupellation, lead is oxidized to PbO which is absorbed by the cupel, leading to metallic gold as a tiny bend at the bottom of the recipient. After cupellation, cupel becomes highly contaminated with lead, making its disposal a serious risk of environmental contamination. In the present work, a leaching process for removing lead from cupel waste is proposed, which allowed for removing 96% of PbO by weight. After a precipitation step, 92.0% of lead was recovered from leachates in the form of PbSO4. Lead in the solid wastes left by the extraction was above the limit established by Brazilian legislation and these were classified as non-hazardous. Finally, secondary effluents generated after the precipitation step presented lead content more than twenty times lower than that of leachates from cupel waste. Tons of cupel waste are annually generated from gold analysis by Pb-Fire assay. Thus, the proposed method can contribute to prevent the discharge of high amounts of lead into the environment. Also, recovery of lead can help to partially meet the industrial demand for lead compounds

Preliminary studies of the cytotoxicity and photoprotective properties of Benzophenone and Lactone derivatives.

A Radia??o solar ultravioleta(RUV) pode induzir efeitos ? pele devidos a sua a??o direta ou indireta, por meio da gera??o de radicais livres. Esses efeitos podem provocar diversas les?es na pele humana como o c?ncer de pele. Como medida de prote??o da pele contra os efeitos da radia??o solar pode-se citar o uso de protetores solares, produtos t?picos adicionados de filtros solares UV sint?ticos com propriedades de absor??o e reflex?o de raios solares.Um fotoprotetor org?nico ideal deve proteger a pele contra os raios UVB (290-320 nm) e UVA (320-400 nm), possuir um fator de prote??o solar (FPS) seguro, ser fotoest?vel e n?o ser fotot?xico. Este trabalho objetiva em estudos preliminares de fotoprote??o dos derivados das Benzofenonas e Lactonas. Os produtos obtidos foram sintetizados e caracterizados por t?cnicas espectrosc?picas usuais e foram submetidos a ensaios de viabilidade celular frente ao MTT e determina??o do valor de prote??o solar (FPS) in vitro pelo m?todo espectrofotom?trico UV/VIS. Os espectros de IV, RMN de 1 H e RMN de 13C mostraram bandas e sinais em conformidades com as estruturas propostas para os compostos estudados. Os compostos 1 e2 apresentaram um FPS proporcional ? concentra??o analisada, ou seja, quanto maior a concentra??o, maior ? o Fator de Prote??o, por?m o composto 3 apresentou fator prote??o menor em concentra??es mais elevadas. No estudo de viabilidade celular, os compostos 1 e 2 n?o foram citot?xicos nas concentra??es avaliadas neste trabalho.Ultraviolet solar radiation can generate free radicals that damage skin and cause skin lesions or skin cancer. Sunscreens are a protective measure against the effects of solar radiation that protects the skin by absorbing or reflecting solar rays. Ideally, the sunscreen should protect the skin against UVB (290-320 nm) and UVA (320-400 nm) rays, be photostable and non-toxic. This work describes a preliminary study on the SPF of a benzophenone and a lactone derivative. The synthesized compounds were characterized by spectroscopic techniques, submitted to cell viability assays against MTT and SPF determined in vitro by UV/VIS spectroscopy measurements. The spectroscopic data was in agreement with the proposed structures of the compounds studied. The SPF was proportional to concentration, and in one case, the sun protection factor was lower at higher concentrations. The benzophenone derivatives were evaluated for toxicity by a cell viability study, and found to be non-cytotoxic at the tested concentrations

Preparation and characterization of a quercetin-tetraethyl ether-based photoprotective nanoemulsion.

Although Quercetin absorbs in the UVA/UVB electromagnetic region, it is limited for applications as a UV filter due to its low lipophilicity and capacity to penetrate the epidermis. In order to overcome this limitation, we synthetized and evaluated the photo protective properties of a derivative obtained from Quercetin. The derivative was prepared by alkylation of Quercetin with iodoethane and characterized by IR and NMR spectroscopy. The in vitro Solar Protection Factor was determined by the Mansur method and the cytotoxicity was evaluated using hepatocellular cell (Hep G2) cells. Finally, Quercetin and the corresponding derivative were incorporated in nanoemulsions. Nanoemulsions with particles sizes between 53 and 73 nm were obtained, and polydispersity indexes were around 0.1, indicating good homogeneity of the nanoemulsion particles. The cell viability study for the Quercetin derivative indicated a very low cytotoxicity profile. The chemical modification of Quercetin resulted in a promising compound with improved properties desirable for skin penetration and incorporation into sunscreen formulations

Baccharis trimera (Carqueja) Improves metabolic and redox status in an experimental model of type 1 diabetes.

Diabetes mellitus is a metabolic disorder that causes severe complications due to the increased oxidative stress induced by disease. Many plants are popularly used in the treatment of diabetes, e.g., Baccharis trimera (carqueja). The aim of this study was to explore the potential application of the B. trimera hydroethanolic extract in preventing redox stress induced by diabetes and its hypoglycemic properties. Experiments were conducted with 48 female rats, divided into 6 groups, named C (control), C600 (control + extract 600 mg/kg), C1200 (control + extract 1200 mg/kg), D (diabetic), D600 (diabetic + 600 mg/kg), and D1200 (diabetic + 1200 mg/kg). Type 1 diabetes was induced with alloxan, and the animals presented hyperglycemia and reduction in insulin and body weight. After seven days of experimentation, the nontreated diabetic group showed changes in biochemical parameters (urea, triacylglycerol, alanine aminotransferase, and aspartate aminotransferase) and increased carbonyl protein levels. Regarding the antioxidant enzymes, an increase in superoxide dismutase activity was observed but in comparison a decrease in catalase and glutathione peroxidase activity was noted which suggests that diabetic rats suffered redox stress. In addition, the mRNA of superoxide dismutase, catalase, and glutathione peroxidase enzymes were altered. Treatment of diabetic rats with B. trimera extract resulted in an improved glycemic profile and liver function, decreased oxidative damage, and altered the expression of mRNA of the antioxidants enzymes. These results together suggest that B. trimera hydroethanolic extract has a protective effect against diabetes

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Educomunicação e suas áreas de intervenção: Novos paradigmas para o diálogo intercultural

oai:omp.abpeducom.org.br:publicationFormat/1O material aqui divulgado representa, em essência, a contribuição do VII Encontro Brasileiro de Educomunicação ao V Global MIL Week, da UNESCO, ocorrido na ECA/USP, entre 3 e 5 de novembro de 2016. Estamos diante de um conjunto de 104 papers executivos, com uma média de entre 7 e 10 páginas, cada um. Com este rico e abundante material, chegamos ao sétimo e-book publicado pela ABPEducom, em seus seis primeiros anos de existência. A especificidade desta obra é a de trazer as “Áreas de Intervenção” do campo da Educomunicação, colocando-as a serviço de uma meta essencial ao agir educomunicativo: o diálogo intercultural, trabalhado na linha do tema geral do evento internacional: Media and Information Literacy: New Paradigms for Intercultural Dialogue