UNDERSTANDING THE ROLE OF SOCIAL PRESENCE IN CROWDFUNDING: EVIDENCE FROM LEADING U.S. AND GERMAN PLATFORMS

As a novel opportunity to acquire capital from the masses, crowdfunding has attracted great attention in academia and practice. So far, little is known about the factors that promote the success of crowdfunding projects, however. In this paper, we examine in how far the social presence perceived on a project’s website influences the success of the respective crowdfunding project. Based on a data-driven analysis of 2.000 project websites from the largest crowdfunding platforms in the U.S. and Germany, we show that the perceived social presence has a significant influence on the success of crowdfunding projects. The obtained results indicate that using socially rich pictures and a socially rich description in the project presentation positively affects the success of a crowdfunding project. A socially rich profile page of the founder(s) in contrast appears to have a rather limited effect. The success of crowdfunding projects seems to be dependent on the participation behavior of the founder, however. Our results indicate that having backed other projects positively influences the success of one’s own initiative. The number of answered comments might have a negative effect on the success of the initiative, though

Is it necessary to stabilize every fracture in patients with serial rib fractures in blunt force trauma?

INTRODUCTION: Management of traumatic rib fractures is subject of controversial discussions. Rib fractures are common, especially after traffic accidents and falls. There is no consensus on whether and how many rib fractures need reconstruction. Not every rib fracture needs to be stabilized, but conservative treatment by internal splinting and analgesia is not effective for all patients. Deformities of the chest wall with reduced thoracic volume and restrictive ventilation disorders must be avoided. Intraoperative assessment of fractures and chest stability plays a central role. MATERIAL AND METHODS: From 07/2016 to 07/2021, a total of 121 chest wall stabilizations were performed (m:f = 2:1, age 65 ± 14.5 a). Indications for surgery were the following criteria: (1) palpatory instability of the chest wall, (2) dislocated fracture endings, (3) concomitant injuries, (4) uncontrollable pain symptoms. In all patients, a computed tomography scan of the thorax was performed before the osteosynthetic treatment to assess dislocation of the fracture endings and possible concomitant injuries of intrathoracic organs. RESULTS: Video-assisted thoracoscopy was performed in all patients. Hemothorax and concomitant injuries of the lung, diaphragm and mediastinum could be assessed. This was followed by an intraoperative assessment of the rib fractures, in particular penetration of fracture endings and resulting instability and deformity. Relevant fractures could be identified and subsequent incisions for rib osteosynthesis precisely defined. 6.3 (±2.7) rib fractures were detected, but 2.4 (±1.2) ribs treated osteosynthetically. Bilateral rib fractures were present in 26 patients (21.5%). Post-operative bleeding occurred in seven patients (5.8%), a breakage of the osteosynthetic material in two patients (1.7%). DISCUSSION: Intraoperative assessment of relevant fractures and dislocation is the decisive criterium for osteosynthesis. Thoracoscopy is mandatory for this purpose – also to identify accompanying injuries. Not every fracture has to be approached osteosynthetically. Even with serial rib fractures or multiple fractures in a single rib, the thoracic contour can be restored by stabilizing only relevant fractures. Intraoperative palpation can adequately assess the stability and thus the result of the osteosynthesis. Even after surgical treatment of thoracic trauma, adequate analgesia and respiratory therapy are important to the healing process

Accurate Transponder Calibrations with the Novel Three-Transponder Method

Transponders are, besides trihedral corner reflectors, the most commonly used measurement standards in radiometric SAR calibration. They allow signal recording for the reconstruction of the azimuth pattern of the SAR system, adjustments of the backscattering matrix for polarimetric applications, and radar cross sections (RCSs) which are potentially much larger than those of passive point targets. These advantages led DLR to develop, manufacture, and install three new, accurate C-band “Kalibri” transponders in South Germany, which are now being used for the calibration and monitoring of the Copernicus Sentinel-1A satellite. Before the transponders could be used as radiometric measurement standards, they needed to be calibrated themselves. In an effort to find the most accurate RCS calibration approach for the given transponder design, several existing methods were compared [1], and a new, potentially highly accurate method, devised which exploits the specific design of the Kalibri transponders [2]. The new “three-transponder method” is similar in principle to the known “three-antenna method”, but is based on the radar equation instead of the Friis transmission formula. The approach exploits the fact that modern transponders like the “Kalibri” device can also be operated as radars because of the integrated digital sub-system (which is needed to implement a digital delay line and incorporates an AD and DA converter). To conduct a complete measurement, three transponders and three measurements (with one transponder pair each) are required; refined measurement schemas are also possible. In comparison to existing methods, no additional radiometric measurement standard is needed, which so far has been one of the limiting factors in accomplishing lower calibration uncertainties. Measurement traceability is achieved by tracing a comparatively simple length measurement back to a national realization of the meter. Such a length measurements can be performed with high accuracy. The presentation will include the setup and the measurement results of a first demonstration measurement campaign. Despite remaining challenges in the practical implementation, the uncertainty analysis shows that the method is a good candidate for highly accurate transponder RCS calibrations in the future

Highly Accurate Radar Cross Section and Transfer Function Measurement of a Digital Calibration Transponder without Known Reference - Part I: Measurement & Results

Active Radar Calibrators (ARC), also called calibration transponders, are often used as reference targets for absolute radiometric calibration of radar systems due to their large achievable Radar Cross Section (RCS). But before using a transponder as a reference target, the hardware has to be calibrated itself. A novel method, called three-transponder-method, was proposed some years ago and allows for RCS calibration of digital transponders without using any RCS target as reference. In this paper, this technique is further refined and applied to a setup utilizing only one digital transponder. The accurate measurement design is described and a novel, elaborated data processing scheme is developed to minimize remaining noise and clutter effects in the data. A comprehensive error analysis will be presented in the second part of this paper

Absolute Radiometric Calibration of Broadband X-Band Transponders

Spaceborne synthetic aperture radar (SAR) systems are often used for earth observation capable for acquiring accurate high-resolution data. In order to ensure the quality of these SAR data, the SAR system has to be calibrated first. For this purpose active targets with well-known backscatter properties, called transponders, serve as an external reference. The enhancement of the operational bandwidth up to 1.2 GHz of future civil SAR systems requires the development of appropriate broadband transponders and their accurate calibration. In order to be well prepared for these missions, DLR has been developed a broadband X-Band transponder and an innovative technique for the frequency-dependent determination of the transponder’s radar cross section (RCS) which promises an accurate measurement over the full transponder bandwidth. In this paper the calibration of a broadband transponder according to this new approach is described including the analysis of corresponding measurements. The derived results are verified with a second independent calibration method and finally evaluated

Lignin-based polyurethane materials

Four technical lignins (Alcell, Indulin AT, Sarkanda and Curan 27-11P) were used as macromonomers in the synthesis of polyurethane materials following two global approaches. In the first one Alcell and Indulin AT lignins were used directly as co-monomers in combination with a linear polycaprolactone (PCL) in order to produce polyurethane elastomers where lignin content varied between 10 and 25% (w/w) with respect to polyol mixture (PCL+lignin). The thermomechanical properties of the resulting materials were determined by dynamical mechanical analysis (DMA), differential scanning calorimetry (DSC) and swelling tests. In lignin-based elastomers Indulin AT showed to be more efficiently incorporated in the polyurethane network compared with Alcell lignin. Elastomers prepared with Indulin AT lignin exhibited a cross-linking density and storage modulus (rubbery plateau) higher than those of Alcell lignin-based counterpart and a lower soluble fraction. For both Alcell and Indulin AT based elastomers the glass transition temperature increased and extended over a wide temperature range with the increase of lignin content. The second approach consisted of producing rigid polyurethane foams (RPU) using ligninbased polyols obtained after chemical modification by an oxypropylation procedure. Two polyol formulations (20/80 and 30/70, in what concerns the weight ratios between lignin and propylene oxide, PO), were used in RPU formulations and their content varied from 0 to 100% (w/w with respect to a commercial polyol, used as a reference). The resulting RPU foams were characterized in terms of density, mechanical properties, conductivity and morphology. The prepared RPU foams with lignin-based polyols presented properties, very similar to those obtained from conventional commercial polyols. RPU foams prepared with 30/70 polyols exhibited improved properties comparatively to those arising from 20/80 formulations. Exceptions were however detected in RPU foams prepared with all Sarkanda lignin based polyols and Curan 27-11P 30/70 formulation, which were found to be inadequate for RPU formulation

Novel risk stratification algorithm for estimating the risk of death in patients with relapsed multiple myeloma: external validation in a retrospective chart review.

OBJECTIVES AND DESIGN: A novel risk stratification algorithm estimating risk of death in patients with relapsed multiple myeloma starting second-line treatment was recently developed using multivariable Cox regression of data from a Czech registry. It uses 16 parameters routinely collected in medical practice to stratify patients into four distinct risk groups in terms of survival expectation. To provide insight into generalisability of the risk stratification algorithm, the study aimed to validate the risk stratification algorithm using real-world data from specifically designed retrospective chart audits from three European countries. PARTICIPANTS AND SETTING: Physicians collected data from 998 patients (France, 386; Germany, 344; UK, 268) and applied the risk stratification algorithm. METHODS: The performance of the Cox regression model for predicting risk of death was assessed by Nagelkerke's R2, goodness of fit and the C-index. The risk stratification algorithm's ability to discriminate overall survival across four risk groups was evaluated using Kaplan-Meier curves and HRs. RESULTS: Consistent with the Czech registry, the stratification performance of the risk stratification algorithm demonstrated clear differentiation in risk of death between the four groups. As risk groups increased, risk of death doubled. The C-index was 0.715 (95% CI 0.690 to 0.734). CONCLUSIONS: Validation of the novel risk stratification algorithm in an independent 'real-world' dataset demonstrated that it stratifies patients in four subgroups according to survival expectation

Comprehensive genomic analysis of refractory multiple myeloma reveals a complex mutational landscape associated with drug resistance and novel therapeutic vulnerabilities

The outcomes of patients with multiple myeloma (MM) refractory to immunomodulatory agents (IMiDs) and proteasome inhibitors (PIs) remain poor. In this study, we performed whole genome and transcriptome sequencing of 39 heavily pretreated relapsed/refractory MM (RRMM) patients to identify mechanisms of resistance and potential therapeutic targets. We observed a high mutational load and indications of increased genomic instability. Recurrently mutated genes in RRMM, which had not been previously reported or only observed at a lower frequency in newly diagnosed MM, included NRAS, BRAF, TP53, SLC4A7, MLLT4, EWSR1, HCFC2, and COPS3. We found multiple genomic regions with bi-allelic events affecting tumor suppressor genes and demonstrated a significant adverse impact of bi-allelic TP53 alterations on survival. With regard to potentially resistance conferring mutations, recurrently mutated gene networks included genes with relevance for PI and IMiD activity; the latter particularly affecting members of the Cereblon and the COP9 signalosome complex. We observed a major impact of signatures associated with exposure to melphalan or impaired DNA double-strand break homologous recombination repair in RRMM. The latter coincided with mutations in genes associated with PARP inhibitor sensitivity in 49% of RRMM patients; a finding with potential therapeutic implications. In conclusion, this comprehensive genomic characterization revealed a complex mutational and structural landscape in RRMM and highlights potential implications for therapeutic strategies

Acute megakaryoblastic leukaemia shows high frequency of chromosome 1q aberrations and dismal outcome

Acute megakaryoblastic leukaemia (AMKL) is associated with poor prognosis. Limited information is available on its cytogenetics, molecular genetics and clinical outcome. We performed genetic analyses, evaluated prognostic factors and the value of allogeneic haematopoietic stem cell transplantation (allo-HSCT) in a homogenous adult AMKL patient cohort. We retrospectively analysed 38 adult patients with AMKL (median age: 58 years, range: 21–80). Most received intensive treatment in AML Cooperative Group (AMLCG) trials between 2001 and 2016. Cytogenetic data showed an accumulation of adverse risk markers according to ELN 2017 and an unexpected high frequency of structural aberrations on chromosome arm 1q (33%). Most frequently, mutations occurred in TET2 (23%), TP53 (23%), JAK2 (19%), PTPN11 (19%) and RUNX1 (15%). Complete remission rate in 33 patients receiving intensive chemotherapy was 33% and median overall survival (OS) was 33 weeks (95% CI: 21–45). Patients undergoing allo-HSCT (n = 14) had a superior median OS (68 weeks; 95% CI: 11–126) and relapse-free survival (RFS) of 27 weeks (95% CI: 4–50), although cumulative incidence of relapse after allo-HSCT was high (62%). The prognosis of AMKL is determined by adverse genetic risk factors and therapy resistance. So far allo-HSCT is the only potentially curative treatment option in this dismal AML subgroup