27 research outputs found
CDK5 Is Essential for Soluble Amyloid β-Induced Degradation of GKAP and Remodeling of the Synaptic Actin Cytoskeleton
- Author
- AC Paula-Lima
- AD El-Husseini
- AY Hung
- AY Hung
- B Calabrese
- B O'Nuallain
- BA Samuels
- D Edbauer
- DP Seeburg
- E Kim
- EM Snyder
- F Bao
- F Gardoni
- F Gnad
- F Kamenetz
- F Roselli
- F Roselli
- FG De Felice
- FG De Felice
- Francesco Roselli
- G Bitan
- G Bitan
- G Bitan
- G Sabio
- GM Shankar
- GM Shankar
- H Decker
- H Decker
- H Hsieh
- H Kawabe
- I Navarro-LĂ©rida
- I Yao
- J Riedl
- JC Cruz
- JC Obenauer
- JC Trinidad
- JC Trinidad
- JC Tu
- JG Valtschanoff
- JJ Palop
- JM Welch
- JP Lopes
- K Cambon
- K Hirao
- KO Lai
- L Bongiorno-Borbone
- L Heredia
- LF Lue
- M Colledge
- M Futter
- M Nikolic
- M Sheng
- M Takeuchi
- M Tirard
- M Wogulis
- MA Morabito
- MW Salter
- Osborne F. X. Almeida
- P Steiner
- Paolo Livrea
- PN Lacor
- PN Lacor
- Q Wang
- QL Ma
- R Medeiros
- RD Prediger
- RD Terry
- RM Koffie
- RY Tweedie-Cullen
- S Humbert
- S Knafo
- S Naisbitt
- S Naisbitt
- S Okabe
- Sergio T. Ferreira
- TL Spires-Jones
- W Wang
- W Wei
- WB Stine Jr
- WY Fu
- Y Kim
- Y Wen
- Y Wen
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
The early stages of Alzheimer's disease are marked by synaptic dysfunction and loss. This process results from the disassembly and degradation of synaptic components, in particular of scaffolding proteins that compose the post-synaptic density (PSD), namely PSD95, Homer and Shank. Here we investigated in rat frontal cortex dissociated culture the mechanisms involved in the downregulation of GKAP (SAPAP1), which links the PSD95 complex to the Shank complex and cytoskeletal structures within the PSD. We show that Aβ causes the rapid loss of GKAP from synapses through a pathway that critically requires cdk5 activity, and is set in motion by NMDAR activity and Ca2+ influx. We show that GKAP is a direct substrate of cdk5 and that its phosphorylation results in polyubiquitination and proteasomal degradation of GKAP and remodeling (collapse) of the synaptic actin cytoskeleton; the latter effect is abolished in neurons expressing GKAP mutants that are resistant to phosphorylation by cdk5. Given that cdk5 also regulates degradation of PSD95, these results underscore the central position of cdk5 in mediating Aβ-induced PSD disassembly and synapse loss
PROTEIN SPLICING ELEMENTS AND PLANTS: From Transgene Containment to Protein Purification
- Publication venue
- 'Annual Reviews'
- Publication date
- Field of study
A Simple Parallel Analytical Method of Prenatal Screening
- Author
- Publication venue
- 'S. Karger AG'
- Publication date
- Field of study
Kinetic Controlled Tag-Catcher Interactions for Directed Covalent Protein Assembly
- Author
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Wolf phase tomography (WPT) of transparent structures using partially coherent illumination
- Author
- A Depeursinge
- A KuĹ›
- A Leblanc-Hotte
- B Bhaduri
- B Rappaz
- D Paganin
- DH Ryu
- E Wolf
- F Charrière
- F Macias-Garza
- F Merola
- FE Robles
- G Popescu
- GA Dunn
- H Subramanian
- HD Wang
- HG Davies
- IY Yanina
- K Kim
- KG Phillips
- KR Lee
- L Mandel
- M Chen
- M Habaza
- M Habaza
- M SchĂĽrmann
- M Takabayashi
- ME Kandel
- MG Shan
- N Lue
- N Lue
- P Giannios
- P Memmolo
- PY Liu
- QN Zhang
- R Barer
- RK Bista
- RY Zhu
- S Uttam
- SA Gerber
- T Kim
- TH Nguyen
- V B.
- W Choi
- X Chen
- X Chen
- X Chen
- XJ Liang
- Y Cotte
- Y Park
- YK Park
- Z Wang
- Z Wang
- Z Wang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Cephalopod-inspired optical engineering of human cells
- Author
- A Bhandiwad
- A Weber
- AR Spur
- AR Tao
- B Rappaz
- CF Bohren
- CL Curl
- D Froesch
- DG DeMartini
- DG DeMartini
- DG DeMartini
- DM Chudakov
- DS Richardson
- EA Susaki
- H Zhao
- HG Wells
- JM Guayasamin
- KL Naughton.
- KT Tokuyasu
- L Phan
- L Phan
- L Phan
- LM Mäthger
- LM Mäthger
- N Lue
- P Thomas
- PY Liu
- R Levenson
- RA Cloney
- RM Kramer
- RS Rajan
- RT Hanlon
- RY Tsien
- S Johnsen
- S Johnsen
- S Zylinski
- T Yamauchi
- W Choi
- W Liou
- WJ Crookes
- YK Park
- Z Guan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Traceless and Site-specific Attachment of Proteins onto Solid Supports
- Author
- A Girish
- A Juillerat
- B Schweitzer
- C Gauchet
- CD Hodneland
- CJ Noren
- CL Cheung
- CL Cheung
- CM Niemeyer
- CM Yam
- E Phizicky
- FB Perler
- G MacBeath
- G Wu
- G Zheng
- GB Sigal
- GY Liu
- H Zhu
- H Zhu
- J Ptacek
- J Shi
- JA Camarero
- JA Camarero
- JP Tam
- Julio A. Camarero
- KB Lee
- LJ Holt
- M Saleemuddin
- M Schnolzer
- ML Lesaicherre
- ML Lesaicherre
- N Nath
- NH Thomson
- P Arenkov
- P Peluso
- PC Lin
- PE Dawson
- PF Predki
- R Barry
- RY Lue
- SW Lee
- T Cha
- TW Muir
- Y Kwon
- Y Kwon
- Youngeun Kwon
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Electroweak parameters of the z0 resonance and the standard model
- Author
- Abbaneo D
- ABREU P
- Adam W
- Adami F
- ADEVA B
- Adriani O
- Adye T
- Aguilar-Benitez M
- Ajaltouni Z
- Akbari H
- Akesson T
- Albanese JP
- Alcaraz J
- Alekseev GD
- Alemany R
- Alexander G
- Allen P
- Allison J
- Allport PP
- Almehed S
- Aloisio A
- Alted F
- Altoon B
- Alverson G
- Alviggi MG
- Alvsvaag SJ
- Amaldi U
- Amendolia SR
- An Q
- Anassontzis EG
- Anderhub H
- Anderson AL
- Anderson KJ
- Andreev VP
- Angelov T
- Antilogus P
- Antonelli A
- Antonov L
- Antreasyan D
- Apel WD
- Apollinari G
- Arce P
- Arcelli S
- Arefev A
- Armitage JC
- Ashman JG
- Ashton P
- Asman B
- Astbury A
- Astier P
- Atwood WB
- Aubert JJ
- Augustin JE
- Augustinus A
- Axen D
- Azemoon T
- Aziz T
- Azuelos G
- Baba PVKS
- Badier J
- Bagliesi G
- Bagnaia P
- Bahan GA
- Baillon P
- Baines JTM
- Bakken JA
- Baksay L
- Baldini R
- Ball AH
- Ball RC
- Bambade P
- Banerjee S
- Banks J
- Bao J
- Barao F
- Barberio E
- Barbiellini G
- Barczewski T
- Bardadin-Otwinowska M
- Bardin DY
- Barker GJ
- Barlow RJ
- Baroncelli A
- Barone L
- Barring O
- Bartl W
- Bates MJ
- Batignani G
- Batley JR
- Battaglia M
- Baubillier M
- Bauerdick LAT
- Bay A
- Beaudoin G
- Beck A
- Becker J
- Becker U
- Becket H
- Becks KH
- Beeston CJ
- Begalli M
- Behnke T
- Behrens J
- Beilliere P
- Beingessner S
- Belk AT
- Bell KW
- Bella G
- Bellantoni L
- Belokopytov YA
- Belokopytov YA
- Beltran P
- Beltran P
- Benchouk C
- Bencivenni G
- Bencze GL
- Benedic D
- Benedic D
- Benlloch JM
- Benlloch JM
- Berdugo J
- Berges P
- Berggren M
- Berggren M
- Bernard V
- Bertin V
- Bertrand D
- Bertrand D
- Bertucci B
- Betev BL
- Betheke S
- Beuselinck R
- Biagi SF
- Biagi SF
- Bianchi F
- Bianchi F
- Bibby JH
- Bibby JH
- Biebel O
- Biland A
- Bilenky SM
- Bilenky SM
- Billoir P
- Billoir P
- Binder U
- Binnie DM
- Bird F
- Bizzarri R
- Bjarne J
- Blaising JJ
- Bloch D
- Bloch-Devaux B
- Bloemeke P
- Blondel A
- Bloodworth IJ
- Blucher E
- Blum W
- Blumenfeld B
- Blyth S
- Bobbink GJ
- Bocciolini M
- Bock P
- Boeck RK
- Boehm A
- Bogolubov PN
- Bologna G
- Bolognese T
- Bonapart M
- Bonesini M
- Bonissent A
- Bonivento W
- Bonneaud G
- Bonvicini G
- Booth CN
- Booth PSL
- Boratav M
- Borgeaud P
- Borgia B
- Borisov G
- Borner H
- Bosch HM
- Bosio C
- Bosisio L
- Bossi F
- Botner O
- Botterill DR
- Bottigli U
- Boucrot J
- Boudreau J
- Bougerolle S
- Bouquet B
- Bourilkov D
- Bourotte J
- Bourquin M
- Boutigny D
- Bouwens BT
- Bowdery CK
- Boyle O
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- Brabson B
- Bradaschia C
- Braems F
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- Branchini P
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- Brandl B
- Brandt S
- Branson JG
- Braun O
- Brenner RA
- Breuker H
- Bricman C
- Brient JC
- Brock IC
- Brodbeck TJ
- Brown D
- Brown RCA
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- Brummer N
- Brun R
- Brunet JM
- Bruyant F
- Bugge L
- Buijs A
- Buisson C
- Bujak A
- Buran T
- Burckhart HJ
- Burger JD
- Burkhardt H
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- Burnett TH
- Burq JP
- Busenitz J
- Buttar C
- Buytaert J
- Caccia M
- Cai XD
- Callot O
- Calvi M
- Camacho-Rozas AJ
- Cameron W
- Campagne JE
- Campana P
- Campion A
- Camporesi T
- Canale V
- Candlin DJ
- Cao F
- Capell M
- Capiluppi P
- Capon G
- Carbonara F
- Cardenal F
- Carminati P
- Carnegie RK
- Carney R
- Carpinelli M
- Carroll L
- Carter AA
- Carter JM
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- Cartwright S
- Caso C
- Castelli E
- Castillo-Gimenez MV
- Catacci AM
- Catanesi MG
- Cattai A
- Cattaneo M
- Cattaneo P
- Cavallo FR
- Cerrada M
- Cerrito L
- Cerutti F
- Cesaroni F
- Chang CY
- Chang YH
- Chapkin MM
- Charlton DG
- Charpentier P
- Chaturvedi UK
- Checchia P
- Chelkov GA
- Chemarin M
- Chen A
- Chen C
- Chen GM
- Chen HF
- Chen HS
- Chen M
- Chen ML
- Chen WY
- Chen X
- Chen X
- Chevalier L
- Chiarella V
- Chiefari G
- Chien CY
- Chikilev OG
- Chliapnikov PV
- Chollet F
- Chorowicz V
- Chrin JTM
- Cinabro D
- Ciocci MA
- Cirio R
- Civinini C
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- Clift RW
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- Cohn HO
- Coignet G
- Colas P
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- Combley F
- Commichau V
- Conboy JE
- Conforto G
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- Contreras JL
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- Corden M
- Cordier A
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- Couch M
- Couchot F
- Coupland M
- Courvoisier D
- Cowan G
- Cowen DF
- Crawley HB
- Creanza D
- Crennell DJ
- Crespo JM
- Crijns F
- Criscuolo P
- Crosetti G
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- Crozon M
- Cuevas-Maestro J
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- Cui XY
- Czellar S
- D'Alessandro R
- D'Almagne B
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- Dagoret S
- Dahl-Jensen E
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- Dauncey PD
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- De Fez Laso MDM
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- de Notaristefani F
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- DECAMP D
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- Dinsdale M
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- Drevermann H
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- Duchesneau D
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- Edgecock TR
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- Efthymiopoulos I
- Ekelof TJC
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- Eppling FJ
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- Extermann P
- Fabbretti R
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- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/1992
- Field of study
Contains fulltext :
124399.pdf (publisher's version ) (Open Access
Baculovirus-based gene silencing of Humanin for the treatment of pituitary tumors
- Author
- Adriana Seilicovich
- Antonela S. Asad
- B Zapala
- Camila Zuccato
- E Eriksson
- Gabriela Jaita
- J Ferraris
- J Ferraris
- K Yen
- KE Makkonen
- KJ Livak
- LS Lambeth
- M Candolfi
- M Candolfi
- M Matsuoka
- Marianela Candolfi
- MarĂa Florencia Gottardo
- MatĂas L. Pidre
- Mercedes Imsen
- MF Gottardo
- MF Gottardo
- ML Pidre
- MP Gillam
- N Mottaghi-Dastjerdi
- O Snove Jr
- P Cohen
- P Surampudi
- PJ Paddison
- RJ Benveniste
- RS Felberbaum
- RY Osamura
- S Haase
- S Melmed
- S Melmed
- T Niikura
- T Niikura
- T Niikura
- TW Kwang
- VĂctor Romanowski
- WY Luo
- Y Hashimoto
- Y Hashimoto
- Y Jia
- Y Lue
- YC Hu
- YH Je
- Z Gong
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Three important components in the regeneration of the cavernous nerve: brain-derived neurotrophic factor, vascular endothelial growth factor and the JAK/STAT signaling pathway
- Author
- Akira S
- Apfel SC
- Arbiser JL
- Bakircioglu ME
- Barde YA
- Bariohay B
- Bella AJ
- Bella AJ
- Bella AJ
- Burnett AL
- Catalona WJ
- Chen H
- Chen KC
- Coffer P
- Darnell JE
- Ernsberger U
- Fiore M
- Frostick SP
- Gallo G
- Hai-Yang Zhang
- Hou J
- Hsieh PS
- Huang EJ
- Ihle JN
- Ip NY
- Jacobson NG
- Jin KL
- Kaplan DR
- Kermer P
- Kisseleva T
- Lai SY
- Lee MC
- Levy DE
- Lin CS
- Lin G
- Lin G
- Lin G
- Lin G
- Liu RY
- Melen K
- Meyer T
- Mitsui T
- O'Shea JJ
- Ogata T
- Oppenheim RW
- Quelle FW
- Rahbar R
- Roorda BD
- Schaefer TS
- Sendtner M
- Sheu JY
- Sondell M
- Symes A
- Symes A
- Tom F Lue
- Wakao H
- Wang Z
- Wilks AF
- Xu JJ
- Xun-Bo Jin
- Yamamoto K
- Yan Q
- Zhong Z
- Zhong Z
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study