1,273 research outputs found
Heavy-quark mass effects in Higgs boson production at the LHC
We study the impact of heavy-quark masses in Higgs boson production through
gluon fusion at the LHC. We extend previous computations of the fully
differential cross section and of the transverse momentum spectrum of the Higgs
boson by taking into account the finite top- and bottom-quark masses up to
O(alpha_S^3). We also discuss the issues arising when the heavy-quark mass is
much smaller than the Higgs mass. Our results are implemented in updated
versions of the HNNLO and HRes numerical programs.Comment: Minor modifications, results unchanged. Discussion on uncertainties
added. Version published on JHE
Gravitational redshift of galaxies in clusters as predicted by general relativity
The theoretical framework of cosmology is mainly defined by gravity, of which
general relativity is the current model. Recent tests of general relativity
within the \Lambda Cold Dark Matter (CDM) model have found a concordance
between predictions and the observations of the growth rate and clustering of
the cosmic web. General relativity has not hitherto been tested on cosmological
scales independent of the assumptions of the \Lambda CDM model. Here we report
observation of the gravitational redshift of light coming from galaxies in
clusters at the 99 per cent confidence level, based upon archival data. The
measurement agrees with the predictions of general relativity and its
modification created to explain cosmic acceleration without the need for dark
energy (f(R) theory), but is inconsistent with alternative models designed to
avoid the presence of dark matter.Comment: Published in Nature issued on 29 September 2011. This version
includes the Letter published there as well as the Supplementary Information.
23 pages, 7 figure
Supersymmetric next-to-next-to-leading order corrections to Higgs boson production in gluon fusion
We compute the total cross section for the production of a light CP even
Higgs boson within the framework of supersymmetric QCD up to
next-to-next-to-leading order. Technical subtleties in connection to the
evaluation of three-loop Feynman integrals with many mass scales are discussed
in detail and explicit results for the counterterms of the evanescent couplings
are provided. The new results are applied to several phenomenological scenarios
which are in accordance with the recent discovery at the LHC. In a large part
of the still allowed parameter space the factor of the supersymmetric
theory is close to the one of the Standard Model. However, for the case where
one of the top squarks is light, a deviation of more than 5% in the
next-to-next-to-leading order prediction of the cross section can be observed
where at the same time the predicted Higgs boson mass has a value of about 125
GeV.Comment: 37 page
On RAF Sets and Autocatalytic Cycles in Random Reaction Networks
The emergence of autocatalytic sets of molecules seems to have played an
important role in the origin of life context. Although the possibility to
reproduce this emergence in laboratory has received considerable attention,
this is still far from being achieved. In order to unravel some key properties
enabling the emergence of structures potentially able to sustain their own
existence and growth, in this work we investigate the probability to observe
them in ensembles of random catalytic reaction networks characterized by
different structural properties. From the point of view of network topology, an
autocatalytic set have been defined either in term of strongly connected
components (SCCs) or as reflexively autocatalytic and food-generated sets
(RAFs). We observe that the average level of catalysis differently affects the
probability to observe a SCC or a RAF, highlighting the existence of a region
where the former can be observed, whereas the latter cannot. This parameter
also affects the composition of the RAF, which can be further characterized
into linear structures, autocatalysis or SCCs. Interestingly, we show that the
different network topology (uniform as opposed to power-law catalysis systems)
does not have a significantly divergent impact on SCCs and RAFs appearance,
whereas the proportion between cleavages and condensations seems instead to
play a role. A major factor that limits the probability of RAF appearance and
that may explain some of the difficulties encountered in laboratory seems to be
the presence of molecules which can accumulate without being substrate or
catalyst of any reaction.Comment: pp 113-12
A photonic quantum information interface
Quantum communication is the art of transferring quantum states, or quantum
bits of information (qubits), from one place to another. On the fundamental
side, this allows one to distribute entanglement and demonstrate quantum
nonlocality over significant distances. On the more applied side, quantum
cryptography offers, for the first time in human history, a provably secure way
to establish a confidential key between distant partners. Photons represent the
natural flying qubit carriers for quantum communication, and the presence of
telecom optical fibres makes the wavelengths of 1310 and 1550 nm particulary
suitable for distribution over long distances. However, to store and process
quantum information, qubits could be encoded into alkaline atoms that absorb
and emit at around 800 nm wavelength. Hence, future quantum information
networks made of telecom channels and alkaline memories will demand interfaces
able to achieve qubit transfers between these useful wavelengths while
preserving quantum coherence and entanglement. Here we report on a qubit
transfer between photons at 1310 and 710 nm via a nonlinear up-conversion
process with a success probability greater than 5%. In the event of a
successful qubit transfer, we observe strong two-photon interference between
the 710 nm photon and a third photon at 1550 nm, initially entangled with the
1310 nm photon, although they never directly interacted. The corresponding
fidelity is higher than 98%.Comment: 7 pages, 3 figure
Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection
Many new gene copies emerged by gene duplication in hominoids, but little is known with respect to their functional evolution. Glutamate dehydrogenase (GLUD) is an enzyme central to the glutamate and energy metabolism of the cell. In addition to the single, GLUD-encoding gene present in all mammals (GLUD1), humans and apes acquired a second GLUD gene (GLUD2) through retroduplication of GLUD1, which codes for an enzyme with unique, potentially brain-adapted properties. Here we show that whereas the GLUD1 parental protein localizes to mitochondria and the cytoplasm, GLUD2 is specifically targeted to mitochondria. Using evolutionary analysis and resurrected ancestral protein variants, we demonstrate that the enhanced mitochondrial targeting specificity of GLUD2 is due to a single positively selected glutamic acid-to-lysine substitution, which was fixed in the N-terminal mitochondrial targeting sequence (MTS) of GLUD2 soon after the duplication event in the hominoid ancestor ~18–25 million years ago. This MTS substitution arose in parallel with two crucial adaptive amino acid changes in the enzyme and likely contributed to the functional adaptation of GLUD2 to the glutamate metabolism of the hominoid brain and other tissues. We suggest that rapid, selectively driven subcellular adaptation, as exemplified by GLUD2, represents a common route underlying the emergence of new gene functions
Clinical registry of dental outcomes in head and neck cancer patients (OraRad): rationale, methods, and recruitment considerations
Background Most head and neck (H&N) cancer patients receive high-dose external beam radiation therapy (RT), often in combination with surgery and/or chemotherapy. Unfortunately, high-dose RT has significant adverse effects on the oral and maxillofacial tissues, some of which persist for the life of the patient. However, dental management of these patients is based largely on individual and expert opinion, as few studies have followed patients prospectively to determine factors that predict adverse oral sequelae. In addition, many previous studies were conducted before wide-spread adoption of intensity-modulated radiation therapy (IMRT) and concurrent chemotherapy. The objective of this multi-center study is to systematically evaluate the oral health of subjects for 2 years after commencement of RT, with the goal of identifying risk factors that predict adverse oral outcomes post-RT. Methods This is a prospective multi-center longitudinal cohort study of H&N cancer patients who receive high-dose RT with curative intent. Planned enrollment is 756 subjects at 6 primary clinical sites (and their affiliated sites) in the USA. A baseline visit is conducted prior to the beginning of RT. Follow-up visits are conducted at 6, 12, 18 and 24 months from the start of RT. The primary outcome measure is the 2-year rate of tooth loss in patients who have received at least one session of external beam RT for H&N cancer. Secondary outcome measures include the incidence of exposed intraoral bone; incidence of post-extraction complications; change in Decayed Missing and Filled Surfaces (DMFS); change in periodontal measures; change in stimulated whole salivary flow rates; change in mouth opening; topical fluoride utilization; chronic oral mucositis incidence; changes in RT-specific quality of life measures; and change in oral pain scores. Discussion This study will contribute to a better understanding of the dental complications experienced by these patients. It will also enable identification of risk factors associated with adverse outcomes such as tooth loss and osteoradionecrosis. These findings will support the development of evidence-based guidelines and inform the planning of future interventional studies, with the goal of advancing improvements in patient care and outcomes. Trial registration ClinicalTrials.gov Identifier NCT02057510 , registered 5 February 2014
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Corporate governance and national institutions: A review and emerging research agenda
We present a critique of corporate governance research grounded in agency theory and propose that cross-national comparison of corporate governance should consider how the nature and extent of agency relationships differ across different institutional contexts. Building on prior governance studies grounded in sociology and organizational theory we argue that performance outcomes of boards of directors, ownership concentration, and executive incentives may differ depending on the legal system and institutional characteristics in a specific country. Institutions may also affect the extent of complimentarity/substitution among different firm-level governance practices producing patterned variations in firm-level governance mechanisms. Our discussion suggests that researchers need to develop more holistic, institutionally embedded governance framework to analyze organizational outcomes of various governance practices
Mental health literacy and attitudes in a Swedish community sample – Investigating the role of personal experience of mental health care
<p>Abstract</p> <p>Background</p> <p>Mental ill health is a common condition in the general population, yet only about half of those with a mental disorder have treatment contact. Personal experience may affect attitudes, which in turn influence the help-seeking process. This study investigated differences in mental health literacy and attitudes among mentally healthy persons and in persons with symptoms of mental illness with and without treatment contact.</p> <p>Method</p> <p>A postal screening questionnaire was sent to a random sample of the general population aged 20–64 in the county of Skaraborg, Sweden in order to ascertain mental health status and history of treatment contact; 3538 responded (49%). Face-to-face interviews were carried out in random sub samples of mentally healthy persons (n = 128) and in mentally ill persons with (n = 125) and without (n = 105) mental health care contact. Mental health literacy and attitudes to treatment were assessed using questions based on a vignette depicting a person with depression. Past month mental disorder was diagnosed according to the Schedule for Clinical Assessment in Neuropsychiatry (SCAN).</p> <p>Results</p> <p>Two thirds failed to recognize depression in a vignette; recognition was equally poor in mentally healthy persons and in persons with symptoms of mental illness with and without treatment contact. In response to an open-ended question concerning appropriate interventions, one third suggested counselling and only one percent proposed antidepressant treatment. Again, proportions were similar in all groups. Persons with a history of mental health contact more often suggested that a GP would provide the best form of help. When presented with a list of possible interventions, those with a history of mental health contact were more positive to medical interventions such as antidepressants, hypnotics, and inpatient psychiatric treatment. When asked about the prognosis for the condition described in the vignette, persons with treatment contact were less likely to believe in full recovery without intervention; mentally ill without treatment contact were more optimistic.</p> <p>Conclusion</p> <p>Mental health literacy, specially concerning attitudes towards interventions is associated with personal history of mental health care.</p
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