Efektivitas Model Pembelajaran Course Review Horay Terhadap Hasil Belajar Siswa Mata Pelajaran Ekonomi

This study aims to determine the application of Model Learning Course Review horay Against Student Learning Outcomes In Subjects Economy Class X SMAN 1 Teluk Keramat Kabupaten Sambas. The method used was a quasi-experimental methods (Quasy experiments).The study population was a tenth grade students who are 80 members, namely the class XA and XD SMAN 1 Teluk Keramat Kabupaten Sambas academic year 2012/2013. XA class consists of 40 students be given the experimental class and Review Course horay learning models, while the XD class numbered 40 students made ??the grade given control and conventional learning. The average score of students using learning model horay Review Course for 74.62 higher than the average score of the students using the conventional learning model for 67.75. Based on the test results of independent sample t test significance value <0.05 (0.04 <0.05), then Ho is rejected and Ha accepted. So it can be concluded that there are differences in learning outcomes between the experimental class students with classroom control

Pengaruh Kecerdasan Emosional terhadap Perilaku Konsumsi Siswa di SMA

This thesis aims to find out how the influence of emotional intelligence on the consumer behavior of students in SMA Hidayatul Muhsinin Kubu Raya Regency Academic Year 2013/2014. The methos used is associative method with the form of causal relationship research. With a population of 111 students and a total sample of 84 students by using proportional random sampling technique. The data collection technique used are direct communication technique, indirect communication technique and document technique with the data collecting tools such as interview guideline, questionnaire and document. Based on the data analysis, there is the influence of emotional intelligence on the consumer behavior, the rate of the influence is 31,5 %. The emotional intelligence level of students in SMA Hidayatul Muhsinin Kubu Raya Regency in good category with a percentage of 65,5 % whereas the rate of consumer behavior of students in SMA Hidayatul Muhsinin Kubu Raya Regency in good category with a percentage of 58,3 %

Performance Analysis of Local Phsiciatry Hospital Abepura Using a Balanced Scorecard

Background: Balanced Scorecard represent a development from way of measurement of organizational efficacy in company by integrating some measurement technique or assessment of performance separated. Phsiciatry hospital Abepura during the time have never been conducted by measurement of performance with scorecard balanced method, where measurement of performance is which during the time used, that is measurement from performance aspect which pursuant to standard specified by government cannot depict hospital performance as a whole Target of research: How phsiciatric Hospital Abepura by performance measured by using Balanced Scorecard year 2015-2016. Materials and Method : Type Research is case study that is by analysing company data is laterthen measured by performance pursuant to four in perpective that is is in perpective of patient, in perpective of finance, in perpective of in perpective and internal business process of growth and study. Population is phsiciatry hospital abepura staf as much 58 sampel and 100 patient people. Data approach usedquestioner and analysed by univariat. Result of research : Performance pursuant to is in perpective of patient in Phsiciatry hospital Abepura about patient retention assessed less with degradation 36,81%, owning good kemampuna in patient mengakuisisi with improvement 36,80%, while satisfaction of patient still not yet optimal with score enough satisfy/ good enoughly.In perpective performance of finance measured with growth of earnings NPM good with improvement 4,69% which is conducted Phsiciatry hospital Abepuraso happened efficiency 2.599,991%and good effectiveness although happened degradation 9,58%. in perpective Performance of internal business process, category BOR to be assessed according to standard (60-85%) but happened degradation, ALOS in good category according to standard [among/between] &lt; 6 week. Performance Phsiciatry hospital Abepura pursuant to is in perpective of study and growth, where secretory officer retention experience of improvement 19,33% with unfavourable value, training [of] good officer happened improvement 29,31%. good Officer productivity happened profit improvement operate for Rp.13.570.401. satisfaction of officer in good enough category

Neuroacanthocytosis associated with a defect of the 4.1R membrane protein

BACKGROUND: Neuroacanthocytosis (NA) denotes a heterogeneous group of diseases that are characterized by nervous system abnormalities in association with acanthocytosis in the patients' blood. The 4.1R protein of the erythrocyte membrane is critical for the membrane-associated cytoskeleton structure and in central neurons it regulates the stabilization of AMPA receptors on the neuronal surface at the postsynaptic density. We report clinical, biochemical, and genetic features in four patients from four unrelated families with NA in order to explain the cause of morphological abnormalities and the relationship with neurodegenerative processes. CASE PRESENTATION: All patients were characterised by atypical NA with a novel alteration of the erythrocyte membrane: a 4.1R protein deficiency. The 4.1R protein content was significantly lower in patients (3.40 ± 0.42) than in controls (4.41 ± 0.40, P < 0.0001), reflecting weakened interactions of the cytoskeleton with the membrane. In patients IV:1 (RM23), IV:3 (RM15), and IV:6 (RM16) the 4.1 deficiency seemed to affect the horizontal interactions of spectrin and an impairment of the dimer self-association into tetramers was detected. In patient IV:1 (RM16) the 4.1 deficiency seemed to affect the skeletal attachment to membrane and the protein band 3 was partially reduced. CONCLUSION: A decreased expression pattern of the 4.1R protein was observed in the erythrocytes from patients with atypical NA, which might reflect the expression pattern in the central nervous system, especially basal ganglia, and might lead to dysfunction of AMPA-mediated glutamate transmission

Real-life data on potential drug-druginteractions in patients with chronic hepatitis C viral infection undergoing antiviral therapy with interferon-free DAAs in the PITER Cohort Study

Background There are few real-life data on the potential drug-drug interactions (DDIs) between anti-HCV direct-acting antivirals (DAAs) and the comedications used. Aim To assess the potential DDIs of DAAs in HCV-infected outpatients, according to the severity of liver disease and comedication used in a prospective multicentric study. Methods Data from patients in 15 clinical centers who had started a DAA regimen and were receiving comedications during March 2015 to March 2016 were prospectively evaluated. The DDIs for each regimen and comedication were assigned according to HepC Drug Interactions (www.hep-druginteractions.org) Results Of the 449 patients evaluated, 86 had mild liver disease and 363 had moderate-to-severe disease. The use of a single comedication was more frequent among patients with mild liver disease (p = 0.03), whereas utilization of more than three drugs among those with moderate- to-severe disease (p = 0.05). Of the 142 comedications used in 86 patients with mild disease, 27 (20%) may require dose adjustment/closer monitoring, none was contraindicated. Of the 322 comedications used in 363 patients with moderate-to-severe liver disease, 82 (25%) were classified with potential DDIs that required only monitoring and dose adjustments; 10 (3%) were contraindicated in severe liver disease. In patients with mild liver disease 30% (26/86) used at least one drug with a potential DDI whereas of the 363 patients with moderate-to-severe liver disease, 161 (44%) were at risk for one or more DDI. Conclusions Based on these results, we can estimate that 30 - 44% of patients undergoing DAA and taking comedications are at risk of a clinically significant DDI. This data indicates the need for increased awareness of potential DDI during DAA therapy, especially in patients with moderate- to-severe liver disease. For several drugs, the recommendation related to the DDI changes from "dose adjustment/closer monitoring", in mild to moderate liver disease, to "the use is contraindicated" in severe liver disease

Sustained seizure freedom with adjunctive brivaracetam in patients with focal onset seizures

The maintenance of seizure control over time is a clinical priority in patients with epilepsy. The aim of this study was to assess the sustained seizure frequency reduction with adjunctive brivaracetam (BRV) in real-world practice. Patients with focal epilepsy prescribed add-on BRV were identified. Study outcomes included sustained seizure freedom and sustained seizure response, defined as a 100% and a ≥50% reduction in baseline seizure frequency that continued without interruption and without BRV withdrawal through the 12-month follow-up. Nine hundred ninety-four patients with a median age of 45 (interquartile range = 32–56) years were included. During the 1-year study period, sustained seizure freedom was achieved by 142 (14.3%) patients, of whom 72 (50.7%) were seizure-free from Day 1 of BRV treatment. Sustained seizure freedom was maintained for ≥6, ≥9, and 12&nbsp;months by 14.3%, 11.9%, and 7.2% of patients from the study cohort. Sustained seizure response was reached by 383 (38.5%) patients; 236 of 383 (61.6%) achieved sustained ≥50% reduction in seizure frequency by Day 1, 94 of 383 (24.5%) by Month 4, and 53 of 383 (13.8%) by Month 7 up to Month 12. Adjunctive BRV was associated with sustained seizure frequency reduction from the first day of treatment in a subset of patients with uncontrolled focal epilepsy

Adjunctive Brivaracetam in Focal Epilepsy: Real-World Evidence from the BRIVAracetam add-on First Italian netwoRk STudy (BRIVAFIRST)

Background: In randomized controlled trials, add-on brivaracetam (BRV) reduced seizure frequency in patients with drug-resistant focal epilepsy. Studies performed in a naturalistic setting are a useful complement to characterize the drug profile. Objective: This multicentre study assessed the effectiveness and tolerability of adjunctive BRV in a large population of patients with focal epilepsy in the context of real-world clinical practice. Methods: The BRIVAFIRST (BRIVAracetam add-on First Italian netwoRk STudy) was a retrospective, multicentre study including adult patients prescribed adjunctive BRV. Patients with focal epilepsy and 12-month follow-up were considered. Main outcomes included the rates of seizure‐freedom, seizure response (≥&nbsp;50% reduction in baseline seizure frequency), and treatment discontinuation. The incidence of adverse events (AEs) was also considered. Analyses by levetiracetam (LEV) status and concomitant use of strong enzyme-inducing antiseizure medications (EiASMs) and sodium channel blockers (SCBs) were performed. Results: A total of 1029 patients with a median age of 45&nbsp;years (33–56) was included. At 12 months, 169 (16.4%) patients were seizure-free and 383 (37.2%) were seizure responders. The rate of seizure freedom was 22.3% in LEV-naive patients, 7.1% in patients with prior LEV use and discontinuation due to insufficient efficacy, and 31.2% in patients with prior LEV use and discontinuation due to AEs (p&nbsp;&lt;&nbsp;0.001); the corresponding values for ≥&nbsp;50% seizure frequency reduction were 47.9%, 29.7%, and 42.8% (p&nbsp;&lt;&nbsp;0.001). There were no statistically significant differences in seizure freedom and seizure response rates by use of strong EiASMs. The rates of seizure freedom (20.0% vs. 16.6%; p&nbsp;=&nbsp;0.341) and seizure response (39.7% vs. 26.9%; p&nbsp;=&nbsp;0.006) were higher in patients receiving SCBs than those not receiving SCBs; 265 (25.8%) patients discontinued BRV. AEs were reported by 30.1% of patients, and were less common in patients treated with BRV and concomitant SCBs than those not treated with SCBs (28.9% vs. 39.8%; p&nbsp;=&nbsp;0.017). Conclusion: The BRIVAFIRST provided real-world evidence on the effectiveness of BRV in patients with focal epilepsy irrespective of LEV history and concomitant ASMs, and suggested favourable therapeutic combinations

Neuromechanical response of the upper body to unexpected perturbations during gait initiation in young and older adults

Background: Control of upper body motion deteriorates with ageing leading to impaired ability to preserve balance during gait, but little is known on the contribution of the upper body to preserve balance in response to unexpected perturbations during locomotor transitions, such as gait initiation. Aim: To investigate differences between young and older adults in the ability to modify the trunk kinematics and muscle activity following unexpected waist lateral perturbations during gait initiation. Methods: Ten young (25 ± 2 years) and ten older adults (73 ± 5 years) initiated locomotion from stance while a lateral pull was randomly applied to the pelvis. Two force plates were used to define the feet centre-of-pressure displacement. Angular displacement of the trunk in the frontal plane was obtained through motion analysis. Surface electromyography of cervical and thoracic erector spinae muscles was recorded bilaterally. Results: A lower trunk lateral bending towards the stance leg side in the preparatory phase of gait initiation was observed in older participants following perturbation. Right thoracic muscle activity was increased in response to the perturbation during the initial phase of gait initiation in young (+ 68%) but not in older participants (+ 7%). Conclusions: The age-related reduction in trunk movement could indicate a more rigid behaviour of the upper body employed by older compared to young individuals in response to unexpected perturbations preceding the initiation of stepping. Older adults’ delayed activation of thoracic muscles could suggest impaired reactive mechanisms that may potentially lead to a fall in the early stages of the gait initiation

Automated power management system design for grid-tied residential units

The purpose of this project is to implement an automated power management system for a grid-tied residential unit that is able to automatically switch between different sources of power based on the power being drawn by the load. Traditional systems are categorized as off-grid, which means the residential unit is not connected to the grid and draws power from the system, or as on-grid, which means the residential unit is connected to both the grid and the system. Due to the cost of installing a solar power system to a residential unit becoming more economical, more and more people and have started to adopt this system. However, the cost of installing a system is still a substantial amount. A power management system added on top of the solar power system will help in maximizing the investment spent for energy. The researchers designed the system using an Arduino Mega microcontroller. The microcontroller was programmed using Arduino Integrated Development Environment. The designed system was tested for fixed periods of time during the day and in the evening. Electrical appliances with different power ratings were used as load during the testing. The appliances were operational for fixed periods which allowed the researchers to observe the behavior of the power management system. The implemented project was able to acquire measurement readings from the battery power source, utility power source, and the load. The system computed the power being drawn by the load and was able to switch between the batteries and utility power depending on the power being drawn by the load. The system also regularly saved measurement readings to a log file