Millimagnitude Photometry for Transiting Extrasolar Planetary Candidates. V. Follow-up of 30 OGLE Transits. New Candidates

We used VLT/VIMOS images in the V band to obtain light curves of extrasolar planetary transits OGLE-TR-111 and OGLE-TR-113, and candidate planetary transits: OGLE-TR-82, OGLE-TR-86, OGLE-TR-91, OGLE-TR-106, OGLE-TR-109, OGLE-TR-110, OGLE-TR-159, OGLE-TR-167, OGLE-TR-170, OGLE-TR-171. Using difference imaging photometry, we were able to achieve millimagnitude errors in the individual data points. We present the analysis of the data and the light curves, by measuring transit amplitudes and ephemerides, and by calculating geometrical parameters for some of the systems. We observed 9 OGLE objects at the predicted transit moments. Two other transits were shifted in time by a few hours. For another seven objects we expected to observe transits during the VIMOS run, but they were not detected. The stars OGLE-TR-111 and OGLE-TR-113 are probably the only OGLE objects in the observed sample to host planets, with the other objects being very likely eclipsing binaries or multiple systems. In this paper we also report on four new transiting candidates which we have found in the data.Comment: 11 pages, 17 figures, accepted for publication in A&

Leveraging on Digital Signage Networks to Bring Connectivity IOT Devices

The number of Internet-connected devices exceeds the world’s population by more than three times and this figure is expected to be doubled within the next five years. The Internet of Things is a concept that describes this trend and outlines certain aspects of design and functionality that new devices should incorporate for a successful integration into the Internet. In this respect, Digital Signage networks traditionally used for audiovisual media, accomplish many of the characteristics of the Internet of Things devices: interoperability, mobility, scalability and ubiquity, both in terms of access and control of devices and regarding the information they generate. This paper raises the power to employ a proposed Digital Signage network as a substrate to connect other types of devices that can benefit from the advantages of this kind of networks. For that aim, the main problems for this integration are discussed, mainly those related to the bidirectional tunneling scheme used in the proposed Digital Signage solution. The effects of this tunneling approach are analyzed in scenarios with bandwidth constraints, and different solutions are proposed. Tunneling performance in mobility is improved, to increase the amount of Internet of Things devices and applications that can benefit from this type of network. El número de dispositivos conectados a Internet supera actualmente a la población mundial por más de tres veces y se espera que esta cifra se duplique en los próximos cinco años. El Internet de las Cosas es un concepto que describe esta tendencia y perfila ciertos aspectos de diseño y funcionalidad que los nuevos dispositivos deben incorporar para lograr una integración exitosa en Internet. En este sentido, las redes digital signage utilizadas tradicionalmente para los medios de comunicación audiovisual cumplen muchas de las características requeridas en el contexto del Internet de las Cosas: interoperabilidad, movilidad, escalabilidad y ubicuidad; relativas tanto al acceso y control de dispositivos como a la información que estos generan. En este trabajo se plantea el poder de emplear la red digital signage propuesta como sustrato para poder conectar otros tipos de dispositivos para que así puedan aprovechar las ventajas de estas redes. Para ese fin, se discuten los principales problemas existentes en esta integración, prestando especial atención al esquema de túnel bidireccional utilizado en la solución digital signage propuesta. Los efectos de este enfoque de tunelación se analizan en escenarios con limitaciones de ancho de banda y se proponen diferentes soluciones. Con ello se consigue mejorar el rendimiento del túnel en movilidad, facilitando la integración de más dispositivos al Internet de las Cosas al permitir que puedan integrarse en este tipo de redes

Iberian cured-ham consumption improves endothelial function in healthy subjects

Objectives: Previous studies have shown that dietary components such as oleic acid or polyphenols exert beneficial effects on endothelium. We aimed to assess the impact of regular consumption of Iberian cured-ham (ICH) on endothelial function. Design: An open-label, randomized controlled parallel study. Setting: Volunteers recruited through advertisements at a hospital in Madrid, Spain. Participants: 102 Caucasian adults (76.8% females) aged 25-55 years, and free from cardiometabolic disease. Intervention: Participants were randomized to an ICH-enriched ad libitum diet or an ad libitum diet without ICH for 6 weeks. Subjects in ICH group were randomly provided with either acorn- or mixed-fed ICH, and followed up for an additional 6-week period under their usual diet. Measurements: Clinical parameters, biomarkers of endothelial function and oxidative stress, microvascular vasodilatory response to hyperemia and arterial stiffness were measured before and after the intervention. Results: After 6 weeks, a larger decrease in PAI-1 was observed in subjects consuming ICH compared to the Control group (-6.2±17.7 vs. 0.3±1.4 ng/ml; p=0.020). Similarly, microvascular vasodilatory response to hyperemia showed a significant increase (112.4±391.7 vs. -56.0±327.9%; p=0.007). However, neither oxidative stress, hemodynamic nor clinical parameters differed significantly over the study. Additionally, after stopping ICH consumption, improvements in PAI-1 remained for 6 additional weeks with respect to baseline (p=0.006). Conclusion: The present study demonstrates, for the first time, that regular consumption of ICH improves endothelial function in healthy adults. Strategies aimed to preserve or improve the endothelial function may have implications in vascular aging beyond the prevention of the atherothrombotic disease

Elevation and cholera: an epidemiological spatial analysis of the cholera epidemic in Harare, Zimbabwe, 2008-2009

BACKGROUND: In highly populated African urban areas where access to clean water is a challenge, water source contamination is one of the most cited risk factors in a cholera epidemic. During the rainy season, where there is either no sewage disposal or working sewer system, runoff of rains follows the slopes and gets into the lower parts of towns where shallow wells could easily become contaminated by excretes. In cholera endemic areas, spatial information about topographical elevation could help to guide preventive interventions. This study aims to analyze the association between topographic elevation and the distribution of cholera cases in Harare during the cholera epidemic in 2008 and 2009. METHODS: We developed an ecological study using secondary data. First, we described attack rates by suburb and then calculated rate ratios using whole Harare as reference. We illustrated the average elevation and cholera cases by suburbs using geographical information. Finally, we estimated a generalized linear mixed model (under the assumption of a Poisson distribution) with an Empirical Bayesian approach to model the relation between the risk of cholera and the elevation in meters in Harare. We used a random intercept to allow for spatial correlation of neighboring suburbs. RESULTS: This study identifies a spatial pattern of the distribution of cholera cases in the Harare epidemic, characterized by a lower cholera risk in the highest elevation suburbs of Harare. The generalized linear mixed model showed that for each 100 meters of increase in the topographical elevation, the cholera risk was 30% lower with a rate ratio of 0.70 (95% confidence interval=0.66-0.76). Sensitivity analysis confirmed the risk reduction with an overall estimate of the rate ratio between 20% and 40%. CONCLUSION: This study highlights the importance of considering topographical elevation as a geographical and environmental risk factor in order to plan cholera preventive activities linked with water and sanitation in endemic areas. Furthermore, elevation information, among other risk factors, could help to spatially orientate cholera control interventions during an epidemic

Structural basis for the inactivation of cytosolic DNA sensing by the vaccinia virus.

Detection of cytosolic DNA is a central element of the innate immunity system against viral infection. The Ku heterodimer, a component of the NHEJ pathway of DNA repair in the nucleus, functions as DNA sensor that detects dsDNA of viruses that replicate in the cytoplasm. Vaccinia virus expresses two proteins, C4 and C16, that inactivate DNA sensing and enhance virulence. The structural basis for this is unknown. Here we determine the structure of the C16 - Ku complex using cryoEM. Ku binds dsDNA by a preformed ring but C16 sterically blocks this access route, abrogating binding to a dsDNA end and its insertion into DNA-PK, thereby averting signalling into the downstream innate immunity system. C4 replicates these activities using a domain with 54% identity to C16. Our results reveal how vaccinia virus subverts the capacity of Ku to recognize viral DNA