Robots that can adapt like animals

As robots leave the controlled environments of factories to autonomously function in more complex, natural environments, they will have to respond to the inevitable fact that they will become damaged. However, while animals can quickly adapt to a wide variety of injuries, current robots cannot "think outside the box" to find a compensatory behavior when damaged: they are limited to their pre-specified self-sensing abilities, can diagnose only anticipated failure modes, and require a pre-programmed contingency plan for every type of potential damage, an impracticality for complex robots. Here we introduce an intelligent trial and error algorithm that allows robots to adapt to damage in less than two minutes, without requiring self-diagnosis or pre-specified contingency plans. Before deployment, a robot exploits a novel algorithm to create a detailed map of the space of high-performing behaviors: This map represents the robot's intuitions about what behaviors it can perform and their value. If the robot is damaged, it uses these intuitions to guide a trial-and-error learning algorithm that conducts intelligent experiments to rapidly discover a compensatory behavior that works in spite of the damage. Experiments reveal successful adaptations for a legged robot injured in five different ways, including damaged, broken, and missing legs, and for a robotic arm with joints broken in 14 different ways. This new technique will enable more robust, effective, autonomous robots, and suggests principles that animals may use to adapt to injury

Altered Neurocircuitry in the Dopamine Transporter Knockout Mouse Brain

The plasma membrane transporters for the monoamine neurotransmitters dopamine, serotonin, and norepinephrine modulate the dynamics of these monoamine neurotransmitters. Thus, activity of these transporters has significant consequences for monoamine activity throughout the brain and for a number of neurological and psychiatric disorders. Gene knockout (KO) mice that reduce or eliminate expression of each of these monoamine transporters have provided a wealth of new information about the function of these proteins at molecular, physiological and behavioral levels. In the present work we use the unique properties of magnetic resonance imaging (MRI) to probe the effects of altered dopaminergic dynamics on meso-scale neuronal circuitry and overall brain morphology, since changes at these levels of organization might help to account for some of the extensive pharmacological and behavioral differences observed in dopamine transporter (DAT) KO mice. Despite the smaller size of these animals, voxel-wise statistical comparison of high resolution structural MR images indicated little morphological change as a consequence of DAT KO. Likewise, proton magnetic resonance spectra recorded in the striatum indicated no significant changes in detectable metabolite concentrations between DAT KO and wild-type (WT) mice. In contrast, alterations in the circuitry from the prefrontal cortex to the mesocortical limbic system, an important brain component intimately tied to function of mesolimbic/mesocortical dopamine reward pathways, were revealed by manganese-enhanced MRI (MEMRI). Analysis of co-registered MEMRI images taken over the 26 hours after introduction of Mn^(2+) into the prefrontal cortex indicated that DAT KO mice have a truncated Mn^(2+) distribution within this circuitry with little accumulation beyond the thalamus or contralateral to the injection site. By contrast, WT littermates exhibit Mn^(2+) transport into more posterior midbrain nuclei and contralateral mesolimbic structures at 26 hr post-injection. Thus, DAT KO mice appear, at this level of anatomic resolution, to have preserved cortico-striatal-thalamic connectivity but diminished robustness of reward-modulating circuitry distal to the thalamus. This is in contradistinction to the state of this circuitry in serotonin transporter KO mice where we observed more robust connectivity in more posterior brain regions using methods identical to those employed here

Alzheimer's disease markers in the aged sheep (Ovis aries)

This study reports the identification and characterization of markers of Alzheimer's disease (AD) in aged sheep (Ovis aries) as a preliminary step toward making a genetically modified large animal model of AD. Importantly, the sequences of key proteins involved in AD pathogenesis are highly conserved between sheep and human. The processing of the amyloid-β (Aβ) protein is conserved between sheep and human, and sheep Aβ1–42/Aβ1–40 ratios in cerebrospinal fluid (CSF) are also very similar to human. In addition, total tau and neurofilament light levels in CSF are comparable with those found in human. The presence of neurofibrillary tangles in aged sheep brain has previously been established; here, we report for the first time that plaques, the other pathologic hallmark of AD, are also present in the aged sheep brain. In summary, the biological machinery to generate the key neuropathologic features of AD is conserved between the human and sheep, making the sheep a good candidate for future genetic manipulation to accelerate the condition for use in pathophysiological discovery and therapeutic testing

Statin Therapy in Metabolic Syndrome and Hypertension Post-JUPITER: What is the Value of CRP?

Much evidence supports a pivotal role for inflammation in atherosclerosis. C-reactive protein (CRP), the prototypic marker of inflammation in humans, is a cardiovascular risk marker and may also promote atherogenesis. CRP levels are increased in metabolic syndrome and hypertension and confer increased risk of cardiovascular events in patients in these subgroups. Statins have been shown to lower low-density lipoproteins and CRP independently, and reduce cardiovascular events in subjects with and without metabolic syndrome and hypertension. In this review, we focus on the results from the primary prevention statin trial, Justification for the Use of statins in Primary prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER), which showed reductions in LDL, CRP, and cardiovascular events. Post-JUPITER, the new guidelines will now need to consider recommending high-sensitivity CRP testing to intermediate-risk metabolic syndrome patients and those with hypertension and intermediate risk so that we can better identify candidates at greater risk and reduce cardiovascular burden in these subjects with statin therapy

Water Policies and Conflict Resolution of Public Participation Decision-Making Processes Using Prioritized Ordered Weighted Averaging (OWA) Operators

[EN] There is a growing interest in environmental policies about how to implement public participation engagement in the context of water resources management. This paper presents a robust methodology, based on ordered weighted averaging (OWA) operators, to conflict resolution decision-making problems under uncertain environments due to both information and stakeholders' preferences. The methodology allows integrating heterogeneous interests of the general public and stakeholders on account of their different degree of acceptance or preference and level of influence or power regarding the measures and policies to be adopted, and also of their level of involvement (i.e., information supply, consultation and active involvement). These considerations lead to different environmental and socio-economic outcomes, and levels of stakeholders' satisfaction. The methodology establishes a prioritization relationship over the stakeholders. The individual stakeholders' preferences are aggregated through their associated weights, which depend on the satisfaction of the higher priority decision maker. The methodology ranks the optimal management strategies to maximize the stakeholders' satisfaction. It has been successfully applied to a real case study, providing greater fairness, transparency, social equity and consensus among actors. Furthermore, it provides support to environmental policies, such as the EU Water Framework Directive (WFD), improving integrated water management while covering a wide range of objectives, management alternatives and stakeholders.Llopis Albert, C.; Merigó-Lindahl, JM.; Liao, H.; Xu, Y.; Grima-Olmedo, J.; Grima-Olmedo, C. (2018). Water Policies and Conflict Resolution of Public Participation Decision-Making Processes Using Prioritized Ordered Weighted Averaging (OWA) Operators. Water Resources Management. 32(2):497-510. https://doi.org/10.1007/s11269-017-1823-2S497510322Amin GR, Sadeghi H (2010) Application of prioritized aggregation operators in preference voting. Int J Intell Syst 25(10):1027–1034Chen TY (2014) A prioritized aggregation operator-based approach to multiple criteria decision making using interval-valued intuitionistic fuzzy sets: A comparative perspective. Inf Sci 281:97–112Chen LH, Xu ZS (2014) A prioritized aggregation operator based on the OWA operator and prioritized measures. J Intell Fuzzy Syst 27:1297–1307Chen LH, Xu ZS, Yu XH (2014a) Prioritized measure-guided aggregation operators. IEEE Trans Fuzzy Syst 22:1127–1138Chen LH, Xu ZS, Yu XH (2014b) Weakly prioritized measure aggregation in prioritized multicriteria decision making. Int J Intell Syst 29:439–461CHJ (2016). Júcar river basin authority http://www.chj.es/CHS (2016). Segura river basin authority http://www.chsegura.es/Dong JY, Wan SP (2016) A new method for prioritized multi-criteria group decision making with triangular intuitionistic fuzzy numbers. J Intell Fuzzy Syst 30:1719–1733EC (2000). Directive 2000/60/EC of the European Parliament and of the Council of October 23 2000 Establishing a Framework for Community Action in the Field of Water Policy. Official Journal of the European Communities, L327/1eL327/72 22.12.2000Jackson S, Tan P-L, Nolan S (2012) Tools to enhance public participation and confidence in the development of the Howard East aquifer water plan, Northern Territory. J Hydrol 474:22–28Jin FF, Ni ZW, Chen HY (2016) Note on “Hesitant fuzzy prioritized operators and their application to multiple attribute decision making”. Knowl-Based Syst 96:115–119Kentel E, Aral MM (2007) Fuzzy Multiobjective Decision-Making Approach for Groundwater Resources Management. J Hydrol Eng 12(2):206–217. https://doi.org/10.1061/(ASCE)1084-0699(2007)12:2(206).Kirchherr J, Charles KJ, Walton MJ (2016) Multi-causal pathways of public opposition to dam project in Asia: A fuzzy set qualitative comparative analysis (fsQCA). Glob Environ Chang 41:33–45. https://doi.org/10.1016/j.gloenvcha.2016.08.001Llopis-Albert C, Pulido-Velazquez D (2015) Using MODFLOW code to approach transient hydraulic head with a sharp-interface solution. Hydrol Process 29(8):2052–2064. https://doi.org/10.1002/hyp.10354Llopis-Albert C, Palacios-Marqués D, Soto-Acosta P (2015) Decision-making and stakeholders constructive participation in environmental projects. J Bus Res 68:1641–1644. https://doi.org/10.1016/j.jbusres.2015.02.010Llopis-Albert C, Merigó JM, Xu Y, Huchang L (2017) Improving regional climate projections by prioritized aggregation via ordered weighted averaging operators. Environ Eng Sci. https://doi.org/10.1089/ees.2016.0546Maia R (2017) The WFD Implementation in the European Member States. Water Resour Manag 31(10):3043–3060. https://doi.org/10.1007/s11269-017-1723-5Malczewski J, Chapman T, Flegel C, Walters D, Shrubsole D, Healy MA (2003) GIS - multicriteria evaluation with ordered weighted averaging (OWA): case study of developing watershed management strategies. Environ Plan A 35:1769–1784. https://doi.org/10.1068/a35156Merigó JM, Casanovas M (2011) The uncertain generalized owa operator and its application to financial decision making. Int J Inf Technol Decis Mak 10(2):211–230Merigó JM, Yager RR (2013) Generalized moving averages, distance measures and OWA operators. Int J Uncertain, Fuzziness Knowl-Based Syst 21(4):533–559Merigó JM, Palacios-Marqués D, Ribeiro-Navarrete B (2015) Aggregation systems for sales forecasting. J Bus Res 68:2299–2304Mesiar R, Stupnanová A, Yager RR (2015) Generalizations of OWA Operators. IEEE Trans Fuzzy Syst 23(6):2154–2162O’Hagan M (1988) Aggregating Template Rule Antecedents in Real-time Expert Systems with Fuzzy Set Logic. In: Proceedings of 22nd annual IEEE Asilomar Conference on Signals. IEEE and Maple Press, Pacific Grove, Systems and Computers, pp 681–689Rahmani MA, Zarghami M (2013) A new approach to combine climate change projections by ordered weighting averaging operator; applications to northwestern provinces of Iran. Glob Planet Chang 102:41–50Ran LG, Wei GW (2015) Uncertain prioritized operators and their application to multiple attribute group decision making. Technol Econ Dev Econ 21:118–139Ruiz-Villaverde, A., García-Rubio, M.A. (2017). Public Participation in European Water Management: from Theory to Practice. Water Resour Manag 31(8), 2479–2495. https://doi.org/10.1007/s11269-016-1355-1Sadiq R, Tesfamariam S (2007) Probability density functions based weights for ordered weighted averaging (OWA) operators: An example of water quality indices. Eur J Oper Res 182:1350–1368Sadiq R, Rodríguez MJ, Tesfamariam S (2010) Integrating indicators for performance assessment of small water utilities using ordered weighted averaging (OWA) operators. Expert Syst Appl 37:4881–4891Verma R, Sharma B (2016) Prioritized information fusion method for triangular fuzzy information and its application to multiple attribute decision making. Int J Uncertain, Fuzziness Knowl-Based Syst 24:265–290Wang HM, Xu YJ, Merigó JM (2014) Prioritized aggregation for non-homogeneous group decision making in water resource management. Econ Comput Econ Cybern Stud Res 48(1):247–258Wei GW (2012) Hesitant fuzzy prioritized operators. Knowl-Based Syst 31:176–182Wei CP, Tang XJ (2012) Generalized prioritized aggregation operators. Int J Intell Syst 27:578–589Xu ZS (2005) An Overview of Methods for Determining OWA Weights. Int J Intell Syst 20:843–865Yager RR (1988) On ordered weighted averaging aggregation operators in multi-criteria decision making, IEEE Transactions on Systems. Man Cybern B 18(1988):183–190Yager RR (2008) Prioritized Aggregation Operators. Int J Approx Reason 48:263–274Yan H-B, Huynh V-N, Nakamori Y, Murai T (2011) On prioritized weighted aggregation in multi-criteria decision making. Expert Syst Appl 38(1):812–823Ye J (2014) Prioritized aggregation operators of trapezoidal intuitionistic fuzzy sets and their application to multicriteria decision-making. Neural Comput & Applic 25:1447–1454Yu XH, Xu ZS, Liu SS (2013) Prioritized multi-criteria decision making based on preference relations. Comput Ind Eng 66:104–115Zadeh LA (1983) A Computational Approach to Fuzzy Quantifiers in Natural Languages. Comput Math Appl 9:149–184Zarghami M, Szidarovszky F (2009) Revising the OWA operator for multi criteria decision making problems under uncertainty. Eur J Oper Res 198:259–265Zarghami M, Ardakanian R, Memariani A, Szidarovszky F (2008) Extended OWA Operator for Group Decision Making on Water Resources Projects. J Water Resour Plan Manag 134(3):266–275. https://doi.org/10.1061/(ASCE)0733-9496(2008)134:3(266)Zarghami M, Szidarovszky F, Ardakanian R (2009) Multi-attribute decision making on inter-basin water transfer projects. Transaction E. Ind Eng 16(1):73–80Zhao XF, Li QX, Wei GW (2014) Some prioritized aggregating operators with linguistic information and their application to multiple attribute group decision making. J Intell Fuzzy Syst 26:1619–1630Zhao N, Xu ZS, Ren ZL (2016) On typical hesitant fuzzy prioritized “or” operator in multi-attribute decision making. Int J Intell Syst 31:73–100Zhou LY, Lin R, Zhao XF, Wei GW (2013) Uncertain linguistic prioritized aggregation operators and their application to multiple attribute group decision making. Int J Uncertain, Fuzziness Knowl-Based Syst 21:603–627Zhou LG, Merigó JM, Chen HY, Liu JP (2016) The optimal group continuous logarithm compatibility measure for interval multiplicative preference relations based on the COWGA operator. Inf Sci 328:250–26

An experimental study of cathodic protection for chloride contaminated reinforced concrete

Cathodic protection (CP) is being increasingly used on reinforced concrete structures to protect steel reinforcing bars from corrosion in aggressive conditions. Due to the complexity of environmental conditions, the design specifications in national and international standards are still open to discussion to achieve both sufficient and efficient protection for reinforced concrete structures in engineering practices. This paper reports an experimental research to investigate the influence of chloride content on concrete resistivity, rebar corrosion rate and the performance of CP operation using different current densities. It aims to understand the correlation between the chloride content and concrete resistivity together with the CP current requirement, and to investigate the precision of the CP design criteria in standards

A high-performance 8 nV/root Hz 8-channel wearable and wireless system for real-time monitoring of bioelectrical signals

Background: It is widely accepted by the scientific community that bioelectrical signals, which can be used for the identification of neurophysiological biomarkers indicative of a diseased or pathological state, could direct patient treatment towards more effective therapeutic strategies. However, the design and realisation of an instrument that can precisely record weak bioelectrical signals in the presence of strong interference stemming from a noisy clinical environment is one of the most difficult challenges associated with the strategy of monitoring bioelectrical signals for diagnostic purposes. Moreover, since patients often have to cope with the problem of limited mobility being connected to bulky and mains-powered instruments, there is a growing demand for small-sized, high-performance and ambulatory biopotential acquisition systems in the Intensive Care Unit (ICU) and in High-dependency wards. Finally, to the best of our knowledge, there are no commercial, small, battery-powered, wearable and wireless recording-only instruments that claim the capability of recording electrocorticographic (ECoG) signals. Methods: To address this problem, we designed and developed a low-noise (8 nV/√Hz), eight-channel, battery-powered, wearable and wireless instrument (55 × 80 mm2). The performance of the realised instrument was assessed by conducting both ex vivo and in vivo experiments. Results: To provide ex vivo proof-of-function, a wide variety of high-quality bioelectrical signal recordings are reported, including electroencephalographic (EEG), electromyographic (EMG), electrocardiographic (ECG), acceleration signals, and muscle fasciculations. Low-noise in vivo recordings of weak local field potentials (LFPs), which were wirelessly acquired in real time using segmented deep brain stimulation (DBS) electrodes implanted in the thalamus of a non-human primate, are also presented. Conclusions: The combination of desirable features and capabilities of this instrument, namely its small size (~one business card), its enhanced recording capabilities, its increased processing capabilities, its manufacturability (since it was designed using discrete off-the-shelf components), the wide bandwidth it offers (0.5 – 500 Hz) and the plurality of bioelectrical signals it can precisely record, render it a versatile and reliable tool to be utilized in a wide range of applications and environments

Optical Coherence Tomography in the UK Biobank Study – Rapid Automated Analysis of Retinal Thickness for Large Population-Based Studies

Purpose: To describe an approach to the use of optical coherence tomography (OCT) imaging in large, population-based studies, including methods for OCT image acquisition, storage, and the remote, rapid, automated analysis of retinal thickness. Methods: In UK Biobank, OCT images were acquired between 2009 and 2010 using a commercially available “spectral domain” OCT device (3D OCT-1000, Topcon). Images were obtained using a raster scan protocol, 6 mm x 6 mm in area, and consisting of 128 B-scans. OCT image sets were stored on UK Biobank servers in a central repository, adjacent to high performance computers. Rapid, automated analysis of retinal thickness was performed using custom image segmentation software developed by the Topcon Advanced Biomedical Imaging Laboratory (TABIL). This software employs dual-scale gradient information to allow for automated segmentation of nine intraretinal boundaries in a rapid fashion. Results: 67,321 participants (134,642 eyes) in UK Biobank underwent OCT imaging of both eyes as part of the ocular module. 134,611 images were successfully processed with 31 images failing segmentation analysis due to corrupted OCT files or withdrawal of subject consent for UKBB study participation. Average time taken to call up an image from the database and complete segmentation analysis was approximately 120 seconds per data set per login, and analysis of the entire dataset was completed in approximately 28 days. Conclusions: We report an approach to the rapid, automated measurement of retinal thickness from nearly 140,000 OCT image sets from the UK Biobank. In the near future, these measurements will be publically available for utilization by researchers around the world, and thus for correlation with the wealth of other data collected in UK Biobank. The automated analysis approaches we describe may be of utility for future large population-based epidemiological studies, clinical trials, and screening programs that employ OCT imaging

Local Translation in Primary Afferent Fibers Regulates Nociception

Recent studies have demonstrated the importance of local protein synthesis for neuronal plasticity. In particular, local mRNA translation through the mammalian target of rapamycin (mTOR) has been shown to play a key role in regulating dendrite excitability and modulating long-term synaptic plasticity associated with learning and memory. There is also increased evidence to suggest that intact adult mammalian axons have a functional requirement for local protein synthesis in vivo. Here we show that the translational machinery is present in some myelinated sensory fibers and that active mTOR-dependent pathways participate in maintaining the sensitivity of a subpopulation of fast-conducting nociceptors in vivo. Phosphorylated mTOR together with other downstream components of the translational machinery were localized to a subset of myelinated sensory fibers in rat cutaneous tissue. We then showed with electromyographic studies that the mTOR inhibitor rapamycin reduced the sensitivity of a population of myelinated nociceptors known to be important for the increased mechanical sensitivity that follows injury. Behavioural studies confirmed that local treatment with rapamycin significantly attenuated persistent pain that follows tissue injury, but not acute pain. Specifically, we found that rapamycin blunted the heightened response to mechanical stimulation that develops around a site of injury and reduced the long-term mechanical hypersensitivity that follows partial peripheral nerve damage - a widely used model of chronic pain. Our results show that the sensitivity of a subset of sensory fibers is maintained by ongoing mTOR-mediated local protein synthesis and uncover a novel target for the control of long-term pain states