367 research outputs found
Maturity-associated considerations for training load, injury risk, and physical performance within youth soccer: One size does not fit all
Biological maturation can be defined as the timing and tempo of progress to achieve a mature state. The estimation of age of peak height velocity (PHV) or percentage of final estimated adult stature attainment (%EASA) is typically used to inform the training process in young athletes. In youth soccer, maturity-related changes in anthropometric and physical fitness characteristics are diverse among individuals, particularly around PHV. During this time, players are also at an increased risk of sustaining an overuse or growth-related injury. As a result, the implementation of training interventions can be challenging. The purpose of this review is to (1) highlight and discuss many of the methods that can be used to estimate maturation in the applied setting and (2) discuss the implications of manipulating training load around PHV on physical development and injury risk. We also have provided key stakeholders with a practical online tool for estimating player maturation status (see online supplementary maturity estimation tool(s)). Whilst estimating maturity using predictive equations is useful in guiding the training process, practitioners should be aware of its limitations. To increase the accuracy and usefulness of data, it is also vital that sports scientists implement reliable testing protocols at predetermined time-points
Foot Bone in Vivo: Its Center of Mass and Centroid of Shape
This paper studies foot bone geometrical shape and its mass distribution and
establishes an assessment method of bone strength. Using spiral CT scanning,
with an accuracy of sub-millimeter, we analyze the data of 384 pieces of foot
bones in vivo and investigate the relationship between the bone's external
shape and internal structure. This analysis is explored on the bases of the
bone's center of mass and its centroid of shape. We observe the phenomenon of
superposition of center of mass and centroid of shape fairly precisely,
indicating a possible appearance of biomechanical organism. We investigate two
aspects of the geometrical shape, (i) distance between compact bone's centroid
of shape and that of the bone and (ii) the mean radius of the same density bone
issue relative to the bone's centroid of shape. These quantities are used to
interpret the influence of different physical exercises imposed on bone
strength, thereby contributing to an alternate assessment technique to bone
strength.Comment: 9 pages, 4 figure
Extending colonic mucosal microbiome analysis - Assessment of colonic lavage as a proxy for endoscopic colonic biopsies
This study was supported through GI Research funds and MRC Grant Ref: MR/M00533X/1 to GH.Peer reviewedPublisher PD
Engineering of quantum dot photon sources via electro-elastic fields
The possibility to generate and manipulate non-classical light using the
tools of mature semiconductor technology carries great promise for the
implementation of quantum communication science. This is indeed one of the main
driving forces behind ongoing research on the study of semiconductor quantum
dots. Often referred to as artificial atoms, quantum dots can generate single
and entangled photons on demand and, unlike their natural counterpart, can be
easily integrated into well-established optoelectronic devices. However, the
inherent random nature of the quantum dot growth processes results in a lack of
control of their emission properties. This represents a major roadblock towards
the exploitation of these quantum emitters in the foreseen applications. This
chapter describes a novel class of quantum dot devices that uses the combined
action of strain and electric fields to reshape the emission properties of
single quantum dots. The resulting electro-elastic fields allow for control of
emission and binding energies, charge states, and energy level splittings and
are suitable to correct for the quantum dot structural asymmetries that usually
prevent these semiconductor nanostructures from emitting polarization-entangled
photons. Key experiments in this field are presented and future directions are
discussed.Comment: to appear as a book chapter in a compilation "Engineering the
Atom-Photon Interaction" published by Springer in 2015, edited by A.
Predojevic and M. W. Mitchel
Appointing Women to Boards: Is There a Cultural Bias?
Companies that are serious about corporate governance and business ethics are turning their attention to gender diversity at the most senior levels of business (Institute of Business Ethics, Business Ethics Briefing 21:1, 2011). Board gender diversity has been the subject of several studies carried out by international organizations such as Catalyst (Increasing gender diversity on boards: Current index of formal approaches, 2012), the World Economic Forum (Hausmann et al., The global gender gap report, 2010), and the European Board Diversity Analysis (Is it getting easier to find women on European boards? 2010). They all lead to reports confirming the overall relatively low proportion of women on boards and the slow pace at which more women are being appointed. Furthermore, the proportion of women on corporate boards varies much across countries. Based on institutional theory, this study hypothesizes and tests whether this variation can be attributed to differences in cultural settings across countries. Our analysis of the representation of women on boards for 32 countries during 2010 reveals that two cultural characteristics are indeed associated with the observed differences. We use the cultural dimensions proposed by Hofstede (Culture’s consequences: International differences in work-related values, 1980) to measure this construct. Results show that countries which have the greatest tolerance for inequalities in the distribution of power and those that tend to value the role of men generally exhibit lower representations of women on boards
Generation and control of polarization-entangled photons from GaAs island quantum dots by an electric field
Semiconductor quantum dots are potential sources for generating polarization-entangled photons efficiently. The main prerequisite for such generation based on biexciton–exciton cascaded emission is to control the exciton fine-structure splitting. Among various techniques investigated for this purpose, an electric field is a promising means to facilitate the integration into optoelectronic devices. Here we demonstrate the generation of polarization-entangled photons from single GaAs quantum dots by an electric field. In contrast to previous studies, which were limited to In(Ga)As quantum dots, GaAs island quantum dots formed by a thickness fluctuation were used because they exhibit a larger oscillator strength and emit light with a shorter wavelength. A forward voltage was applied to a Schottky diode to control the fine-structure splitting. We observed a decrease and suppression in the fine-structure splitting of the studied single quantum dot with the field, which enabled us to generate polarization-entangled photons with a high fidelity of 0.72±0.05
Neuronal circuitry for pain processing in the dorsal horn
Neurons in the spinal dorsal horn process sensory information, which is then transmitted to several brain regions, including those responsible for pain perception. The dorsal horn provides numerous potential targets for the development of novel analgesics and is thought to undergo changes that contribute to the exaggerated pain felt after nerve injury and inflammation. Despite its obvious importance, we still know little about the neuronal circuits that process sensory information, mainly because of the heterogeneity of the various neuronal components that make up these circuits. Recent studies have begun to shed light on the neuronal organization and circuitry of this complex region
Hybrid external fixation for neglected fractures of the distal radius: results after one year
Intracellular insulin in human tumors: examples and implications
Insulin is one of the major metabolic hormones regulating glucose homeostasis in the organism and a key growth factor for normal and neoplastic cells. Work conducted primarily over the past 3 decades has unravelled the presence of insulin in human breast cancer tissues and, more recently, in human non-small cell lung carcinomas (NSCLC). These findings have suggested that intracellular insulin is involved in the development of these highly prevalent human tumors. A potential mechanism for such involvement is insulin's binding and inactivation of the retinoblastoma tumor suppressor protein (RB) which in turn is likely controlled by insulin-degrading enzyme (IDE). This model and its supporting data are collectively covered in this survey in order to provide further insight into insulin-driven oncogenesis and its reversal through future anticancer therapeutics
Picodroplet partitioned whole genome amplification of low biomass samples preserves genomic diversity for metagenomic analysis
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