Taking the pulse of Mars via dating of a plume-fed volcano

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. The attached file is the published version of the article

Prostaglandin signalling regulates ciliogenesis by modulating intraflagellar transport

Cilia are microtubule-based organelles that mediate signal transduction in a variety of tissues. Despite their importance, the signalling cascades that regulate cilium formation remain incompletely understood. Here we report that prostaglandin signalling affects ciliogenesis by regulating anterograde intraflagellar transport (IFT). Zebrafish leakytail (lkt) mutants show ciliogenesis defects, and the lkt locus encodes an ATP-binding cassette transporter (ABCC4). We show that Lkt/ABCC4 localizes to the cell membrane and exports prostaglandin E2 (PGE2), a function that is abrogated by the Lkt/ABCC4T804M mutant. PGE2 synthesis enzyme cyclooxygenase-1 and its receptor, EP4, which localizes to the cilium and activates the cyclic-AMP-mediated signalling cascade, are required for cilium formation and elongation. Importantly, PGE2 signalling increases anterograde but not retrograde velocity of IFT and promotes ciliogenesis in mammalian cells. These findings lead us to propose that Lkt/ABCC4-mediated PGE2 signalling acts through a ciliary G-protein-coupled receptor, EP4, to upregulate cAMP synthesis and increase anterograde IFT, thereby promoting ciliogenesis

Alteration assemblages in Martian meteorites: implications for near-surface processes

The SNC (Shergotty-Nakhla-Chassigny) meteorites have recorded interactions between martian crustal fluids and the parent igneous rocks. The resultant secondary minerals – which comprise up to 1 vol.% of the meteorites – provide information about the timing and nature of hydrous activity and atmospheric processes on Mars. We suggest that the most plausible models for secondary mineral formation involve the evaporation of low temperature (25 – 150 °C) brines. This is consistent with the simple mineralogy of these assemblages – Fe-Mg-Ca carbonates, anhydrite, gypsum, halite, clays – and the chemical fractionation of Ca-to Mg-rich carbonate in ALH84001 "rosettes". Longer-lived, and higher temperature, hydrothermal systems would have caused more silicate alteration than is seen and probably more complex mineral assemblages. Experimental and phase equilibria data on carbonate compositions similar to those present in the SNCs imply low temperatures of formation with cooling taking place over a short period of time (e.g. days). The ALH84001 carbonate also probably shows the effects of partial vapourisation and dehydration related to an impact event post-dating the initial precipitation. This shock event may have led to the formation of sulphide and some magnetite in the Fe-rich outer parts of the rosettes. Radiometric dating (K-Ar, Rb-Sr) of the secondary mineral assemblages in one of the nakhlites (Lafayette) suggests that they formed between 0 and 670 Myr, and certainly long after the crystallisation of the host igneous rocks. Crystallisation of ALH84001 carbonate took place 0.5 Gyr after the parent rock. These age ranges and the other research on these assemblages suggest that environmental conditions conducive to near-surface liquid water have been present on Mars periodically over the last 1 Gyr. This fluid activity cannot have been continuous over geological time because in that case much more silicate alteration would have taken place in the meteorite parent rocks and the soluble salts would probably not have been preserved. The secondary minerals could have been precipitated from brines with seawater-like composition, high bicarbonate contents and a weakly acidic nature. The co-existence of siderite (Fe-carbonate) and clays in the nakhlites suggests that the pCO2 level in equilibrium with the parent brine may have been 50 mbar or more. The brines could have originated as flood waters which percolated through the top few hundred meters of the crust, releasing cations from the surrounding parent rocks. The high sulphur and chlorine concentrations of the martian soil have most likely resulted from aeolian redistribution of such aqueously-deposited salts and from reaction of the martian surface with volcanic acid volatiles. The volume of carbonates in meteorites provides a minimum crustal abundance and is equivalent to 50–250 mbar of CO2 being trapped in the uppermost 200–1000 m of the martian crust. Large fractionations in 18O between igneous silicate in the meteorites and the secondary minerals (30) require formation of the latter below temperatures at which silicate-carbonate equilibration could have taken place (400°C) and have been taken to suggest low temperatures (e.g. 150°C) of precipitation from a hydrous fluid

Cosmic-Ray Exposure History of the Norton Country Enstatite Achondrite

We report measurements of cosmogenic nuclides in up to 11 bulk samples from various depths in Norton County. The activities of 36Cl, 41Ca, 26Al, and 10Be were measured by accelerator mass spectrometry; the concentrations of the stable isotopes of He, Ne, Ar, and Sm were measured by electron and thermal ionization mass spectrometry, respectively. Production rates for the nuclides were modeled using the LAHET and the Monte Carlo N-Particle codes. Assuming a one-stage irradiation of a meteoroid with a pre-atmospheric radius of approximately 50 cm, the model satisfactorily reproduces the depth profiles of 10Be, 26Al, and 53Mn (< 6%) but overestimates the 41Ca concentrations by about 20%. 3He, 21Ne, and 26Al data give a one-stage cosmic-ray exposure (CRE) age of 115 Ma. Argon-36 released at intermediate temperatures, 36Ar(n), is attributed to production by thermal neutrons. From the values of 36Ar(n), an assumed average Cl concentration of 4 ppm, and a CRE age of 115 Ma, we estimate thermal neutron fluences of 1-4 x 1016 neutrons cm-2. We infer comparable values from epsilon 149Sm and epsilon 150Sm. Values calculated from 41Ca and a CRE age of 115 Ma, 0.2-1.4 x 1016 neutrons cm-2, are lower by a factor of approximately 2.5, indicating that nearly half of the 149Sm captures occurred earlier. One possible irradiation history places the center of proto-Norton County at a depth of 88 cm in a large body for 140 Ma prior to its liberation as a meteoroid with a radius of 50 cm and further CRE for 100 Ma. © 2011, Wiley-Blackwell. The definitive version is available at www3.interscience.wiley.co

Climate Change and Peri-Urban Household Food Security—Lessons from West Taraka, Morobe Province, Papua New Guinea

Climate change has become a major concern towards the stability of global food production due to long and short-term climate related events. This paper will incorporate climate data to build on the existing data on the status of household food and nutrition security in one of Lae’s peri-urban settlement, West Taraka in Morobe Province, Papua New Guinea. Two data sets were collected: household dietary patterns and changes in food production, and socio-economic characteristics, using stratified purposive sampling for selected fifty-eight (58) households in June 2016 through household survey and informal interviews (mixed method). Results show no statistical relationships between socio-economic characteristics of the households and their Household Dietary Diversity Score and Food Consumption Score. However, a significant inverse relationship at 95% probability exists between the numbers of household members in school with the Household Food Consumption Score. This study also found a significant positive relationship at 99% level probability between household income and Food Consumption Score signaling that income was the main determinant of household food and nutritional security

Effects of experimental nitrogen fertilization on planktonic metabolism and CO₂ flux in a hypereutrophic hardwater lake

<div><p>Hardwater lakes are common in human-dominated regions of the world and often experience pollution due to agricultural and urban effluent inputs of inorganic and organic nitrogen (N). Although these lakes are landscape hotspots for CO₂ exchange and food web carbon (C) cycling, the effect of N enrichment on hardwater lake food web functioning and C cycling patterns remains unclear. Specifically, it is unknown if different eutrophication scenarios (e.g., modest non point vs. extreme point sources) yield consistent effects on auto- and heterotrophic C cycling, or how biotic responses interact with the inorganic C system to shape responses of air-water CO₂ exchange. To address this uncertainty, we induced large metabolic gradients in the plankton community of a hypereutrophic hardwater Canadian prairie lake by adding N as urea (the most widely applied agricultural fertilizer) at loading rates of 0, 1, 3, 8 or 18 mg N L^-1 week^-1 to 3240-L, <i>in-situ</i> mesocosms. Over three separate 21-day experiments, all treatments of N dramatically increased phytoplankton biomass and gross primary production (GPP) two- to six-fold, but the effects of N on autotrophs plateaued at ~3 mg N L^-1. Conversely, heterotrophic metabolism increased linearly with N fertilization over the full treatment range. In nearly all cases, N enhanced net planktonic uptake of dissolved inorganic carbon (DIC), and increased the rate of CO₂ influx, while planktonic heterotrophy and CO₂ production only occurred in the highest N treatments late in each experiment, and even in these cases, enclosures continued to in-gas CO₂. Chemical effects on CO₂ through calcite precipitation were also observed, but similarly did not change the direction of net CO₂ flux. Taken together, these results demonstrate that atmospheric exchange of CO₂ in eutrophic hardwater lakes remains sensitive to increasing N loading and eutrophication, and that even modest levels of N pollution are capable of enhancing autotrophy and CO₂ in-gassing in P-rich lake ecosystems.</p></div