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Fiber Beam Analysis of Reinforced Concrete Members with Cyclic Constitutive and Material Laws
This paper presents a non-linear Timoshenko beam element with axial, bending, and shear force interaction for nonlinear analysis of reinforced concrete structures. The structural material tangent stiffness matrix, which relates the increments of load to corresponding increments of displacement, is properly formulated. Appropriate simplified cyclic uniaxial constitutive laws are developed for cracked concrete in compression and tension. The model also includes the softening effect of the concrete due to lateral tensile strain. To establish the validity of the proposed model, correlation studies with experimentally-tested concrete specimens have been conducted
Deep Video Generation, Prediction and Completion of Human Action Sequences
Current deep learning results on video generation are limited while there are
only a few first results on video prediction and no relevant significant
results on video completion. This is due to the severe ill-posedness inherent
in these three problems. In this paper, we focus on human action videos, and
propose a general, two-stage deep framework to generate human action videos
with no constraints or arbitrary number of constraints, which uniformly address
the three problems: video generation given no input frames, video prediction
given the first few frames, and video completion given the first and last
frames. To make the problem tractable, in the first stage we train a deep
generative model that generates a human pose sequence from random noise. In the
second stage, a skeleton-to-image network is trained, which is used to generate
a human action video given the complete human pose sequence generated in the
first stage. By introducing the two-stage strategy, we sidestep the original
ill-posed problems while producing for the first time high-quality video
generation/prediction/completion results of much longer duration. We present
quantitative and qualitative evaluation to show that our two-stage approach
outperforms state-of-the-art methods in video generation, prediction and video
completion. Our video result demonstration can be viewed at
https://iamacewhite.github.io/supp/index.htmlComment: Under review for CVPR 2018. Haoye and Chunyan have equal contributio
Implicitly Constrained Semi-Supervised Least Squares Classification
We introduce a novel semi-supervised version of the least squares classifier.
This implicitly constrained least squares (ICLS) classifier minimizes the
squared loss on the labeled data among the set of parameters implied by all
possible labelings of the unlabeled data. Unlike other discriminative
semi-supervised methods, our approach does not introduce explicit additional
assumptions into the objective function, but leverages implicit assumptions
already present in the choice of the supervised least squares classifier. We
show this approach can be formulated as a quadratic programming problem and its
solution can be found using a simple gradient descent procedure. We prove that,
in a certain way, our method never leads to performance worse than the
supervised classifier. Experimental results corroborate this theoretical result
in the multidimensional case on benchmark datasets, also in terms of the error
rate.Comment: 12 pages, 2 figures, 1 table. The Fourteenth International Symposium
on Intelligent Data Analysis (2015), Saint-Etienne, Franc
CAPL: an efficient association software package using family and case-control data and accounting for population stratification
Apparent non-canonical trans-splicing is generated by reverse transcriptase in vitro
Trans-splicing, the in vivo joining of two RNA molecules, is well characterized in several groups of simple organisms but was long thought absent from fungi, plants and mammals. However, recent bioinformatic analyses of expressed sequence tag (EST) databases suggested widespread trans-splicing in mammals^1-2^. Splicing, including the characterised trans-splicing systems, involves conserved sequences at the splice junctions. Our analysis of a yeast non-coding RNA revealed that around 30% of the products of reverse transcription lacked an internal region of 117 nt, suggesting that the RNA was spliced. The junction sequences lacked canonical splice-sites but were flanked by direct repeats, and further analyses indicated that the apparent splicing actually arose because reverse transcriptase can switch templates during transcription^3^. Many newly identified, apparently trans-spliced, RNAs lacked canonical splice sites but were flanked by short regions of homology, leading us to question their authenticity. Here we report that all reported categories of non-canonical splicing could be replicated using an in vitro reverse transcription system with highly purified RNA substrates. We observed the reproducible occurrence of ostensible trans-splicing, exon shuffling and sense-antisense fusions. The latter generate apparent antisense non-coding RNAs, which are also reported to be abundant in humans^4^. Different reverse transcriptases can generate different products of template switching, providing a simple diagnostic. Many reported examples of splicing in the absence of canonical splicing signals may be artefacts of cDNA preparation
Manipulating infrared photons using plasmons in transparent graphene superlattices
Superlattices are artificial periodic nanostructures which can control the
flow of electrons. Their operation typically relies on the periodic modulation
of the electric potential in the direction of electron wave propagation. Here
we demonstrate transparent graphene superlattices which can manipulate infrared
photons utilizing the collective oscillations of carriers, i.e., plasmons of
the ensemble of multiple graphene layers. The superlattice is formed by
depositing alternating wafer-scale graphene sheets and thin insulating layers,
followed by patterning them all together into 3-dimensional
photonic-crystal-like structures. We demonstrate experimentally that the
collective oscillation of Dirac fermions in such graphene superlattices is
unambiguously nonclassical: compared to doping single layer graphene,
distributing carriers into multiple graphene layers strongly enhances the
plasmonic resonance frequency and magnitude, which is fundamentally different
from that in a conventional semiconductor superlattice. This property allows us
to construct widely tunable far-infrared notch filters with 8.2 dB rejection
ratio and terahertz linear polarizers with 9.5 dB extinction ratio, using a
superlattice with merely five graphene atomic layers. Moreover, an unpatterned
superlattice shields up to 97.5% of the electromagnetic radiations below 1.2
terahertz. This demonstration also opens an avenue for the realization of other
transparent mid- and far-infrared photonic devices such as detectors,
modulators, and 3-dimensional meta-material systems.Comment: under revie
Transmission characteristics of EM wave in a finite thickness plasma
One of the key factors for solving the problems of re-entry communication interruption is electromagnetic (EM) wave transmission characteristics in a plasma. Theoretical and experimental studies were carried out on specific transmission characteristics for different plasma sheath characteristic under thin sheath condition in re-entry state. The paper presents systematic studies on the variations of wave attenuation characteristics versus plasma sheath thickness L, collision frequency ν, electron density ne and wave working frequency f in a φ 800mm high temperature shock tube. In experiments, L is set to 4 cm and 38 cm. ν is 2 GHz and 15 GHz. ne is from 1×10^10 cm−3 to 1×10^13 cm−3, and f is set to 2, 5, 10, 14.6 GHz, respectively. Meanwhile, Wentzel–Kramers–Brillouin (WKB) and finite-difference time-domain (FDTD) methods are adopted to carry out theoretical simulation for comparison with experimental results. It is found that when L is much larger than EM wavelength λ (thick sheath) and ν is large, the theoretical result is in good agreement with experimental one, when sheath thickness L is much larger than λ, while ν is relatively small, two theoretical results are obviously different from the experimental ones. It means that the existing theoretical model can not fully describe the contribution of ν. Furthermore, when L and λ are of the same order of magnitude (thin sheath), the experimental result is much smaller than the theoretical values, which indicates that the current model can not properly describe the thin sheath effect on EM attenuation characteristics
An Anti-Human ICAM-1 Antibody Inhibits Rhinovirus-Induced Exacerbations of Lung Inflammation
Human rhinoviruses (HRV) cause the majority of common colds and acute exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Effective therapies are urgently needed, but no licensed treatments or vaccines currently exist. Of the 100 identified serotypes, ∼90% bind domain 1 of human intercellular adhesion molecule-1 (ICAM-1) as their cellular receptor, making this an attractive target for development of therapies; however, ICAM-1 domain 1 is also required for host defence and regulation of cell trafficking, principally via its major ligand LFA-1. Using a mouse anti-human ICAM-1 antibody (14C11) that specifically binds domain 1 of human ICAM-1, we show that 14C11 administered topically or systemically prevented entry of two major groups of rhinoviruses, HRV16 and HRV14, and reduced cellular inflammation, pro-inflammatory cytokine induction and virus load in vivo. 14C11 also reduced cellular inflammation and Th2 cytokine/chemokine production in a model of major group HRV-induced asthma exacerbation. Interestingly, 14C11 did not prevent cell adhesion via human ICAM-1/LFA-1 interactions in vitro, suggesting the epitope targeted by 14C11 was specific for viral entry. Thus a human ICAM-1 domain-1-specific antibody can prevent major group HRV entry and induction of airway inflammation in vivo
Wall roughness induces asymptotic ultimate turbulence
Turbulence is omnipresent in Nature and technology, governing the transport
of heat, mass, and momentum on multiple scales. For real-world applications of
wall-bounded turbulence, the underlying surfaces are virtually always rough;
yet characterizing and understanding the effects of wall roughness for
turbulence remains a challenge, especially for rotating and thermally driven
turbulence. By combining extensive experiments and numerical simulations, here,
taking as example the paradigmatic Taylor-Couette system (the closed flow
between two independently rotating coaxial cylinders), we show how wall
roughness greatly enhances the overall transport properties and the
corresponding scaling exponents. If only one of the walls is rough, we reveal
that the bulk velocity is slaved to the rough side, due to the much stronger
coupling to that wall by the detaching flow structures. If both walls are
rough, the viscosity dependence is thoroughly eliminated in the boundary layers
and we thus achieve asymptotic ultimate turbulence, i.e. the upper limit of
transport, whose existence had been predicted by Robert Kraichnan in 1962
(Phys. Fluids {\bf 5}, 1374 (1962)) and in which the scalings laws can be
extrapolated to arbitrarily large Reynolds numbers
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