1,856 research outputs found
Evaluation of Emerging Diagnostic Tools for Commercial HVAC Systems
This paper compares and evaluates the
capabilities of six emerging diagnostic tools for
commercial HVAC systems. We present a brief
description of the diagnostic tools, and then focus on
evaluating the features of the tools. We include the
following six tools in our analysis: Architectural
Energy Corporation's ENFORMA? software, Facility
Dynamics Engineering's Performance And
Continuous Re-commissioning Analysis Tool
(PACRAT), Pacific Northwest National Laboratory's
Whole Building Diagnostician (WBD), Pacific Gas
and Electric's Universal Translator, UC Berkeley's
Fan System Tools, and Silicon Energy's Enterprise
Energy Management Suite. The air-side economizer
operation is the most common diagnostic across the
tools, so this diagnostic function is evaluated in
detail. We outline the key strengths and weaknesses
of each tool, while keeping in mind the tool intent
and current extent of commercialization. Each tool
has unique features for data management and
analysis, which can be beneficial for different
applications and users
Supernova types and rates
We review the basic properties of the different supernova types identified in
the current taxonomy, with emphasis on the more recent developments. To help
orienting in the variegate zoo, the optical photometric and spectroscopic
properties of the different supernova types are presented in a number of
summary figures. We also report the latest estimates of the supernova rates and
stress the need for a dedicated effort to measure SN rates at high redshift.Comment: Invited review at the meeting: "The influence of binaries on stellar
population studies", ed. D. Vanbeveren (Brussels 21-25 Aug. 2000). 14 pages,
10 figure
Discovery of the peculiar supernova 1998bw in the error box of GRB980425
The discovery of X-ray, optical and radio afterglows of gamma-ray bursts
(GRBs) and the measurements of the distances to some of them have established
that these events come from Gpc distances and are the most powerful photon
emitters known in the Universe, with peak luminosities up to 10^52 erg/s. We
here report the discovery of an optical transient, in the BeppoSAX Wide Field
Camera error box of GRB980425, which occurred within about a day of the
gamma-ray burst. Its optical light curve, spectrum and location in a spiral arm
of the galaxy ESO 184-G82, at a redshift z = 0.0085, show that the transient is
a very luminous type Ic supernova, SN1998bw. The peculiar nature of SN1998bw is
emphasized by its extraordinary radio properties which require that the radio
emitter expand at relativistical speed. Since SN1998bw is very different from
all previously observed afterglows of GRBs, our discovery raises the
possibility that very different mechanisms may give rise to GRBs, which differ
little in their gamma-ray properties.Comment: Under press embargo at Nature (submitted June 10, 1998
Valproate, a Mood Stabilizer, Induces WFS1 Expression and Modulates Its Interaction with ER Stress Protein GRP94
Valproate is a standard treatment for bipolar disorder and a first-line mood stabilizer. The molecular mechanisms underlying its actions in bipolar disorder are unclear. It has been suggested that the action of valproate is linked to changes in gene expression and induction of endoplasmic reticulum (ER) stress-response proteins.Here we show that valproate modulates the ER stress response through the regulation of WFS1, an important component for mitigating ER stress. Therapeutic concentrations of valproate induce expression of WFS1 mRNA and activate the WFS1 promoter. In addition, WFS1 forms a complex with GRP94, an ER stress-response protein, in which valproate dose-dependently enhances its dissociation from GRP94.These results suggest that the therapeutic effects of valproate in bipolar disorder may be mediated by WFS1 expression and its dissociation from GRP94
Dusty Planetary Systems
Extensive photometric stellar surveys show that many main sequence stars show
emission at infrared and longer wavelengths that is in excess of the stellar
photosphere; this emission is thought to arise from circumstellar dust. The
presence of dust disks is confirmed by spatially resolved imaging at infrared
to millimeter wavelengths (tracing the dust thermal emission), and at optical
to near infrared wavelengths (tracing the dust scattered light). Because the
expected lifetime of these dust particles is much shorter than the age of the
stars (>10 Myr), it is inferred that this solid material not primordial, i.e.
the remaining from the placental cloud of gas and dust where the star was born,
but instead is replenished by dust-producing planetesimals. These planetesimals
are analogous to the asteroids, comets and Kuiper Belt objects (KBOs) in our
Solar system that produce the interplanetary dust that gives rise to the
zodiacal light (tracing the inner component of the Solar system debris disk).
The presence of these "debris disks" around stars with a wide range of masses,
luminosities, and metallicities, with and without binary companions, is
evidence that planetesimal formation is a robust process that can take place
under a wide range of conditions. This chapter is divided in two parts. Part I
discusses how the study of the Solar system debris disk and the study of debris
disks around other stars can help us learn about the formation, evolution and
diversity of planetary systems by shedding light on the frequency and timing of
planetesimal formation, the location and physical properties of the
planetesimals, the presence of long-period planets, and the dynamical and
collisional evolution of the system. Part II reviews the physical processes
that affect dust particles in the gas-free environment of a debris disk and
their effect on the dust particle size and spatial distribution.Comment: 68 pages, 25 figures. To be published in "Solar and Planetary
Systems" (P. Kalas and L. French, Eds.), Volume 3 of the series "Planets,
Stars and Stellar Systems" (T.D. Oswalt, Editor-in-chief), Springer 201
Long-term culture of genome-stable bipotent stem cells from adult human liver.
Despite the enormous replication potential of the human liver, there are currently no culture systems available that sustain hepatocyte replication and/or function in vitro. We have shown previously that single mouse Lgr5+ liver stem cells can be expanded as epithelial organoids in vitro and can be differentiated into functional hepatocytes in vitro and in vivo. We now describe conditions allowing long-term expansion of adult bile duct-derived bipotent progenitor cells from human liver. The expanded cells are highly stable at the chromosome and structural level, while single base changes occur at very low rates. The cells can readily be converted into functional hepatocytes in vitro and upon transplantation in vivo. Organoids from α1-antitrypsin deficiency and Alagille syndrome patients mirror the in vivo pathology. Clonal long-term expansion of primary adult liver stem cells opens up experimental avenues for disease modeling, toxicology studies, regenerative medicine, and gene therapy.This work was supported by grants to MH (EU/236954) and to HC (The United European Gastroenterology Federation
(UEGF) Research Prize 2010, EU/232814-StemCellMark and NWO/116002008). MH is
supported by The Wellcome Trust Sir Henry Dale fellowship. The Rspo cell line was kindly
provided by Dr. Calvin Kuo.This is the final published version. It first appeared at http://www.cell.com/abstract/S0092-8674%2814%2901566-9
Circumstellar disks and planets. Science cases for next-generation optical/infrared long-baseline interferometers
We present a review of the interplay between the evolution of circumstellar
disks and the formation of planets, both from the perspective of theoretical
models and dedicated observations. Based on this, we identify and discuss
fundamental questions concerning the formation and evolution of circumstellar
disks and planets which can be addressed in the near future with optical and
infrared long-baseline interferometers. Furthermore, the importance of
complementary observations with long-baseline (sub)millimeter interferometers
and high-sensitivity infrared observatories is outlined.Comment: 83 pages; Accepted for publication in "Astronomy and Astrophysics
Review"; The final publication is available at http://www.springerlink.co
Measurement of the running of the QED coupling in small-angle Bhabha scattering at LEP
Using the OPAL detector at LEP, the running of the effective QED coupling
alpha(t) is measured for space-like momentum transfer from the angular
distribution of small-angle Bhabha scattering. In an almost ideal QED
framework, with very favourable experimental conditions, we obtain:
Delta alpha(-6.07GeV^2) - Delta alpha(-1.81GeV^2) = (440 pm 58 pm 43 pm 30) X
10^-5, where the first error is statistical, the second is the experimental
systematic and the third is the theoretical uncertainty. This agrees with
current evaluations of alpha(t).The null hypothesis that alpha remains constant
within the above interval of -t is excluded with a significance above 5sigma.
Similarly, our results are inconsistent at the level of 3sigma with the
hypothesis that only leptonic loops contribute to the running. This is
currently the most significant direct measurment where the running alpha(t) is
probed differentially within the measured t range.Comment: 43 pages, 12 figures, Submitted to Euro. Phys. J.
The search for transient astrophysical neutrino emission with IceCube-DeepCore
We present the results of a search for astrophysical sources of brief transient neutrino emission using IceCube and DeepCore data acquired between 2012 May 15 and 2013 April 30. While the search methods employed in this analysis are similar to those used in previous IceCube point source searches, the data set being examined consists of a sample of predominantly sub-TeV muon-neutrinos from the Northern Sky (-5 degrees < delta < 90 degrees) obtained through a novel event selection method. This search represents a first attempt by IceCube to identify astrophysical neutrino sources in this relatively unexplored energy range. The reconstructed direction and time of arrival of neutrino events are used to search for any significant self-correlation in the data set. The data revealed no significant source of transient neutrino emission. This result has been used to construct limits at timescales ranging from roughly 1 s to 10 days for generic soft-spectra transients. We also present limits on a specific model of neutrino emission from soft jets in core-collapse supernovae
- …