843 research outputs found
Towards Analyzing Semantic Robustness of Deep Neural Networks
Despite the impressive performance of Deep Neural Networks (DNNs) on various
vision tasks, they still exhibit erroneous high sensitivity toward semantic
primitives (e.g. object pose). We propose a theoretically grounded analysis for
DNN robustness in the semantic space. We qualitatively analyze different DNNs'
semantic robustness by visualizing the DNN global behavior as semantic maps and
observe interesting behavior of some DNNs. Since generating these semantic maps
does not scale well with the dimensionality of the semantic space, we develop a
bottom-up approach to detect robust regions of DNNs. To achieve this, we
formalize the problem of finding robust semantic regions of the network as
optimizing integral bounds and we develop expressions for update directions of
the region bounds. We use our developed formulations to quantitatively evaluate
the semantic robustness of different popular network architectures. We show
through extensive experimentation that several networks, while trained on the
same dataset and enjoying comparable accuracy, do not necessarily perform
similarly in semantic robustness. For example, InceptionV3 is more accurate
despite being less semantically robust than ResNet50. We hope that this tool
will serve as a milestone towards understanding the semantic robustness of
DNNs.Comment: Presented at European conference on computer vision (ECCV 2020)
Workshop on Adversarial Robustness in the Real World (
https://eccv20-adv-workshop.github.io/ ) [best paper award]. The code is
available at https://github.com/ajhamdi/semantic-robustnes
Stress dependent thermal pressurization of a fluid-saturated rock
Temperature increase in saturated porous materials under undrained conditions
leads to thermal pressurization of the pore fluid due to the discrepancy
between the thermal expansion coefficients of the pore fluid and of the solid
matrix. This increase in the pore fluid pressure induces a reduction of the
effective mean stress and can lead to shear failure or hydraulic fracturing.
The equations governing the phenomenon of thermal pressurization are presented
and this phenomenon is studied experimentally for a saturated granular rock in
an undrained heating test under constant isotropic stress. Careful analysis of
the effect of mechanical and thermal deformation of the drainage and pressure
measurement system is performed and a correction of the measured pore pressure
is introduced. The test results are modelled using a non-linear
thermo-poro-elastic constitutive model of the granular rock with emphasis on
the stress-dependent character of the rock compressibility. The effects of
stress and temperature on thermal pressurization observed in the tests are
correctly reproduced by the model
Image analysis of cutaneous melanoma histology: a systematic review and meta-analysis
The current subjective histopathological assessment of cutaneous melanoma is challenging. The application of image analysis algorithms to histological images may facilitate improvements in workflow and prognostication. To date, several individual algorithms applied to melanoma histological images have been reported with variations in approach and reported accuracies. Histological digital images can be created using a camera mounted on a light microscope, or through whole slide image (WSI) generation using a whole slide scanner. Before any such tool could be integrated into clinical workflow, the accuracy of the technology should be carefully evaluated and summarised. Therefore, the objective of this review was to evaluate the accuracy of existing image analysis algorithms applied to digital histological images of cutaneous melanoma. Database searching of PubMed and Embase from inception to 11th March 2022 was conducted alongside citation checking and examining reports from organisations. All studies reporting accuracy of any image analysis applied to histological images of cutaneous melanoma, were included. The reference standard was any histological assessment of haematoxylin and eosin-stained slides and/or immunohistochemical staining. Citations were independently deduplicated and screened by two review authors and disagreements were resolved through discussion. The data was extracted concerning study demographics; type of image analysis; type of reference standard; conditions included and test statistics to construct 2βΓβ2 tables. Data was extracted in accordance with our protocol and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses-Diagnostic Test Accuracy (PRISMA-DTA) Statement. A bivariate random-effects meta-analysis was used to estimate summary sensitivities and specificities with 95% confidence intervals (CI). Assessment of methodological quality was conducted using a tailored version of the Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool. The primary outcome was the pooled sensitivity and specificity of image analysis applied to cutaneous melanoma histological images. Sixteen studies were included in the systematic review, representing 4,888 specimens. Six studies were included in the meta-analysis. The mean sensitivity and specificity of automated image analysis algorithms applied to melanoma histological images was 90% (CI 82%, 95%) and 92% (CI 79%, 97%), respectively. Based on limited and heterogeneous data, image analysis appears to offer high accuracy when applied to histological images of cutaneous melanoma. However, given the early exploratory nature of these studies, further development work is necessary to improve their performance
Discovering a junction tree behind a Markov network by a greedy algorithm
In an earlier paper we introduced a special kind of k-width junction tree,
called k-th order t-cherry junction tree in order to approximate a joint
probability distribution. The approximation is the best if the Kullback-Leibler
divergence between the true joint probability distribution and the
approximating one is minimal. Finding the best approximating k-width junction
tree is NP-complete if k>2. In our earlier paper we also proved that the best
approximating k-width junction tree can be embedded into a k-th order t-cherry
junction tree. We introduce a greedy algorithm resulting very good
approximations in reasonable computing time.
In this paper we prove that if the Markov network underlying fullfills some
requirements then our greedy algorithm is able to find the true probability
distribution or its best approximation in the family of the k-th order t-cherry
tree probability distributions. Our algorithm uses just the k-th order marginal
probability distributions as input.
We compare the results of the greedy algorithm proposed in this paper with
the greedy algorithm proposed by Malvestuto in 1991.Comment: The paper was presented at VOCAL 2010 in Veszprem, Hungar
Influence of chromophores on quarternary structure of phycobiliproteins from the cyanobacterium, Mastigocladus laminosus
Chromophores of C-phycocyanin and phycoerythrΞΏ-cyanin have been chemically modified by reduction to
rubins , bleaching , photoisomerization , or perturbation
with bulky substituents. Pigments containing modified
chromophores, or hybrids containing modified and unmodified chromophores in individual protomers have been prepared. All modifications inhibit the association of the
(aΓ)-protomers of these pigments to higher aggregates. The
results demonstrate a pronounced effect of the state of
the chromophores on biliprotein quaternary structure. It
may be important in phycobi1isome assembly , and also in
the dual function of biliproteins as (i) antenna pigments
for photosynthesis and (ii) reaction centers for photomor-phogenesis
Ancient hydrothermal seafloor deposits in Eridania basin on Mars
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the articleβs Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the articleβs Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/ licenses/by/4.0/. The file attached is the Published/publisherβs pdf version of the article
Use of Combined Hartree-Fock-Roothaan Theory in Evaluation of Lowest States of K [Ar]4s^0 3d^1 and Cr+ [Ar]4s^0 3d^5 Isoelectronic Series Over Noninteger n-Slater Type Orbitals
By the use of integer and noninteger n-Slater Type Orbitals in combined
Hartree-Fock-Roothaan method, self consistent field calculations of orbital and
lowest states energies have been performed for the isoelectronic series of open
shell systems K [Ar]4s^0 3d^1 2(D) (Z=19-30) and Cr+ [Ar] 4s^0 3d^5 6(S)
(Z=24-30). The results of calculations for the orbital and total energies
obtained from the use of minimal basis sets of integer- and noninteger n-Slater
Type Orbitals are given in tables. The results are compared with the
extended-basis Hartree-Fock computations. The orbital and total energies are in
good agreement with those presented in the literature. The results are
accurately and considerably can be useful in the application of
non-relativistic and relativistic combined Hartree-Fock-Roothaan approach for
heavy atomic systems.Comment: 11 pages, 6 tables, 2 figures. submitte
Frequency stabilization in nonlinear micromechanical oscillators
Mechanical oscillators are present in almost every electronic device. They mainly consist of a resonating element providing an oscillating output with a specific frequency. Their ability to maintain a determined frequency in a specified period of time is the most important parameter limiting their implementation. Historically, quartz crystals have almost exclusively been used as the resonating element, but micromechanical resonators are increasingly being considered to replace them. These resonators are easier to miniaturize and allow for monolithic integration with electronics. However, as their dimensions shrink to the microscale, most mechanical resonators exhibit nonlinearities that considerably degrade the frequency stability of the oscillator. Here we demonstrate that, by coupling two different vibrational modes through an internal resonance, it is possible to stabilize the oscillation frequency of nonlinear self-sustaining micromechanical resonators. Our findings provide a new strategy for engineering low-frequency noise oscillators capitalizing on the intrinsic nonlinear phenomena of micromechanical resonators.Fil: Antonio, Dario. Argonne National Laboratory. Center for Nanoscale Materials; Estados Unidos. Consejo Nacional de Investigaciones CientΓficas y TΓ©cnicas; ArgentinaFil: Zanette, Damian Horacio. ComisiΓ³n Nacional de EnergΓa AtΓ³mica. Gerencia del Area de InvestigaciΓ³n y Aplicaciones No Nucleares. Gerencia de FΓsica (centro AtΓ³mico Bariloche); Argentina. Consejo Nacional de Investigaciones CientΓficas y TΓ©cnicas; ArgentinaFil: LΓ³pez, Daniel . Argonne National Laboratory. Center for Nanoscale Materials; Estados Unido
The Effect of Epstein-Barr Virus Latent Membrane Protein 2 Expression on the Kinetics of Early B Cell Infection
Infection of human B cells with wild-type Epstein-Barr virus (EBV) in vitro leads to activation and proliferation that result in efficient production of lymphoblastoid cell lines (LCLs). Latent Membrane Protein 2 (LMP2) is expressed early after infection and previous research has suggested a possible role in this process. Therefore, we generated recombinant EBV with knockouts of either or both protein isoforms, LMP2A and LMP2B (Ξ2A, Ξ2B, Ξ2A/Ξ2B) to study the effect of LMP2 in early B cell infection. Infection of B cells with Ξ2A and Ξ2A/Ξ2B viruses led to a marked decrease in activation and proliferation relative to wild-type (wt) viruses, and resulted in higher percentages of apoptotic B cells. Ξ2B virus infection showed activation levels comparable to wt, but fewer numbers of proliferating B cells. Early B cell infection with wt, Ξ2A and Ξ2B viruses did not result in changes in latent gene expression, with the exception of elevated LMP2B transcript in Ξ2A virus infection. Infection with Ξ2A and Ξ2B viruses did not affect viral latency, determined by changes in LMP1/Zebra expression following BCR stimulation. However, BCR stimulation of Ξ2A/Ξ2B cells resulted in decreased LMP1 expression, which suggests loss of stability in viral latency. Long-term outgrowth assays revealed that LMP2A, but not LMP2B, is critical for efficient long-term growth of B cells in vitro. The lowest levels of activation, proliferation, and LCL formation were observed when both isoforms were deleted. These results suggest that LMP2A appears to be critical for efficient activation, proliferation and survival of EBV-infected B cells at early times after infection, which impacts the efficient long-term growth of B cells in culture. In contrast, LMP2B did not appear to play a significant role in these processes, and long-term growth of infected B cells was not affected by the absence of this protein. Β© 2013 Wasil et al
PRNP variation in UK sporadic and variant Creutzfeldt Jakob disease highlights genetic risk factors and a novel non-synonymous polymorphism
<p>Abstract</p> <p>Background</p> <p>Genetic analysis of the human prion protein gene (<it>PRNP</it>) in suspect cases of Creutzfeldt-Jakob disease (CJD) is necessary for accurate diagnosis and case classification. Previous publications on the genetic variation at the <it>PRNP </it>locus have highlighted the presence of numerous polymorphisms, in addition to the well recognised one at codon 129, with significant variability between geographically distinct populations. It is therefore of interest to consider their influence on susceptibility or the clinico-pathological disease phenotype. This study aimed to characterise the frequency and effect of <it>PRNP </it>open reading frame polymorphisms other than codon 129 in both disease and control samples sourced from the United Kingdom population.</p> <p>Methods</p> <p>DNA was extracted from blood samples and genetic data obtained by full sequence analysis of the prion protein gene or by restriction fragment length polymorphism analysis using restriction enzymes specific to the gene polymorphism under investigation.</p> <p>Results</p> <p>147 of 166 confirmed cases of variant CJD (vCJD) in the UK have had <it>PRNP </it>codon 129 genotyping and all are methionine homozygous at codon 129; 118 have had full <it>PRNP </it>gene sequencing. Of the latter, 5 cases have shown other polymorphic loci: at codon 219 (2, 1.69%), at codon 202 (2, 1.69%), and a 24 bp deletion in the octapeptide repeat region (1, 0.85%). E219K and D202D were not found in sporadic CJD (sCJD) cases and therefore may represent genetic risk factors for vCJD.</p> <p>Genetic analysis of 309 confirmed UK sCJD patients showed codon 129 genotype frequencies of MM: 59.5% (n = 184), MV: 21.4% (n = 66), and VV: 19.1% (n = 59). Thirteen (4.2%) had the A117A polymorphism, one of which also had the P68P polymorphism, four (1.3%) had a 24 bp deletion, and a single patient had a novel missense variation at codon 167. As the phenotype of this latter case is similar to sCJD and in the absence of a family history of CJD, it is unknown whether this is a form of genetic CJD, or simply a neutral polymorphism.</p> <p>Conclusions</p> <p>This analysis of <it>PRNP </it>genetic variation in UK CJD patients is the first to show a comprehensive comparison with healthy individuals (n = 970) from the same population, who were genotyped for the three most common variations (codon 129, codon 117, and 24 bp deletion). These latter two genetic variations were equally frequent in UK sCJD or vCJD cases and a normal (healthy blood donor) UK population.</p
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