Influence of higher order effects on the vortex instability of thermal boundary layer flow in a wedge shaped domain

We reconsider the onset of streamwise vortices in the thermal boundary layer flow induced by an inclined upward-facing heated semi-infinite surface placed within a Newtonian fluid. Particular emphasis is laid upon how the induced flow in the isothermal region outside the boundary layer affects the boundary layer itself at higher order, and how this, in turn, affects the stability criterion for the onset of vortices. We find that the stability criterion for thermal boundary layers in air is less susceptible to changes in external geometry than for boundary layers in water. In general, we conclude that the variation of the stability criterion with wedge angle (between the heated and the outer boundary surface) is too great for the theory to predict reliably where disturbances first begin to grow

Data supporting development and validation of liquid chromatography tandem mass spectrometry method for the quantitative determination of bile acids in feces

Measuring bile acids in feces has an important role in disease prevention, diagnosis, treatment, and can be considered a measure of health status. Therefore, the primary aim was to develop a sensitive, robust, and high throughput liquid chromatography tandem mass spectrometry method with minimal sample preparation for quantitative determination of bile acids in human feces applicable to large cohorts. Due to the chemical diversity of bile acids, their wide concentration range in feces, and the complexity of feces itself, developing a sensitive and selective analytical method for bile acids is challenging. A simple extraction method using methanol suitable for subsequent quantification by liquid chromatography tandem mass spectrometry has been reported in, “Extraction and quantitative determination of bile acids in feces” [1]. The data highlight the importance of optimization of the extraction procedure and the stability of the bile acids in feces post-extraction and prior to analysis and after several freeze-thaw cycles

GRBs on probation: testing the UHE CR paradigm with IceCube

Gamma ray burst (GRB) fireballs provide one of very few astrophysical environments where one can contemplate the acceleration of cosmic rays to energies that exceed 10^20 eV. The assumption that GRBs are the sources of the observed cosmic rays generates a calculable flux of neutrinos produced when the protons interact with fireball photons. With data taken during construction IceCube has already reached a sensitivity to observe neutrinos produced in temporal coincidence with individual GRBs provided that they are the sources of the observed extragalactic cosmic rays. We here point out that the GRB origin of cosmic rays is also challenged by the IceCube upper limit on a possible diffuse flux of cosmic neutrinos which should not be exceeded by the flux produced by all GRB over Hubble time. Our alternative approach has the advantage of directly relating the diffuse flux produced by all GRBs to measurements of the cosmic ray flux. It also generates both the neutrino flux produced by the sources and the associated cosmogenic neutrino flux in a synergetic way.Comment: 12 pages, 3 figures, matches version published in Astroparticle Physic

Design, construction and operational results of the IGBT controlled solid state modulator high voltage power supply used in the high power RF systems of the Low Energy Demonstration Accelerator of the accelerator production of tritium (APT) project

The 1700 MeV, 100 mA Accelerator Production of Tritium (APT) Proton Linac will require 244 1 MW, continuous wave RF systems. 1 MW continuous wave klystrons are used as the RF source and each klystron requires 95 kV, 17 A of beam voltage and current. The cost of the DC power supplies is the single largest percentage of the total RF system cost. Power supply reliability is crucial to overall RF system availability and AC to DC conversion efficiency affects the operating cost. The Low Energy Demonstration Accelerator (LEDA) being constructed at Los Alamos National Laboratory (LANL) will serve as the prototype and test bed for APT. The design of the RF systems used in LEDA is driven by the need to field test high efficiency systems with extremely high reliability before APT is built. The authors present a detailed description and test results of one type of advanced high voltage power supply system using Insulated Gate Bipolar Transistors (IGBTs) that has been used with the LEDA High Power RF systems. The authors also present some of the distinctive features offered by this power supply topology, including crowbarless tube protection and modular construction which allows graceful degradation of power supply operation

Multidimensional relativistic MHD simulations of Pulsar Wind Nebulae: dynamics and emission

Pulsar Wind Nebulae, and the Crab nebula in particular, are the best cosmic laboratories to investigate the dynamics of magnetized relativistic outflows and particle acceleration up to PeV energies. Multidimensional MHD modeling by means of numerical simulations has been very successful at reproducing, to the very finest details, the innermost structure of these synchrotron emitting nebulae, as observed in the X-rays. Therefore, the comparison between the simulated source and observations can be used as a powerful diagnostic tool to probe the physical conditions in pulsar winds, like their composition, magnetization, and degree of anisotropy. However, in spite of the wealth of observations and of the accuracy of current MHD models, the precise mechanisms for magnetic field dissipation and for the acceleration of the non-thermal emitting particles are mysteries still puzzling theorists to date. Here we review the methodologies of the computational approach to the modeling of Pulsar Wind Nebulae, discussing the most relevant results and the recent progresses achieved in this fascinating field of high-energy astrophysics.Comment: 29 pages review, preliminary version. To appear in the book "Modelling Nebulae" edited by D. Torres for Springer, based on the invited contributions to the workshop held in Sant Cugat (Barcelona), June 14-17, 201

Active Galaxies in the UV

In this article we present different aspects of AGN studies demonstrating the importance of the UV spectral range. Most important diagnostic lines for studying the general physical conditions as well as the metalicities in the central broad line region in AGN are emitted in the UV. The UV/FUV continuum in AGN excites not only the emission lines in the immediate surrounding but it is responsible for the ionization of the intergalactic medium in the early stages of the universe. Variability studies of the emission line profiles of AGN in the UV give us information on the structure and kinematics of the immediate surrounding of the central supermassive black hole as well as on its mass itself.Comment: 29 pages, 13 figures, Ap&SS in pres

Magnetoluminescence

Pulsar Wind Nebulae, Blazars, Gamma Ray Bursts and Magnetars all contain regions where the electromagnetic energy density greatly exceeds the plasma energy density. These sources exhibit dramatic flaring activity where the electromagnetic energy distributed over large volumes, appears to be converted efficiently into high energy particles and gamma-rays. We call this general process magnetoluminescence. Global requirements on the underlying, extreme particle acceleration processes are described and the likely importance of relativistic beaming in enhancing the observed radiation from a flare is emphasized. Recent research on fluid descriptions of unstable electromagnetic configurations are summarized and progress on the associated kinetic simulations that are needed to account for the acceleration and radiation is discussed. Future observational, simulation and experimental opportunities are briefly summarized.Comment: To appear in "Jets and Winds in Pulsar Wind Nebulae, Gamma-ray Bursts and Blazars: Physics of Extreme Energy Release" of the Space Science Reviews serie

Low-Luminosity Accretion in Black Hole X-ray Binaries and Active Galactic Nuclei

At luminosities below a few percent of Eddington, accreting black holes switch to a hard spectral state which is very different from the soft blackbody-like spectral state that is found at higher luminosities. The hard state is well-described by a two-temperature, optically thin, geometrically thick, advection-dominated accretion flow (ADAF) in which the ions are extremely hot (up to $10^{12}$ K near the black hole), the electrons are also hot ($\sim10^{9-10.5}$ K), and thermal Comptonization dominates the X-ray emission. The radiative efficiency of an ADAF decreases rapidly with decreasing mass accretion rate, becoming extremely low when a source reaches quiescence. ADAFs are expected to have strong outflows, which may explain why relativistic jets are often inferred from the radio emission of these sources. It has been suggested that most of the X-ray emission also comes from a jet, but this is less well established.Comment: To appear in "From X-ray Binaries to Quasars: Black Hole Accretion on All Mass Scales" edited by T. Maccarone, R. Fender, L. Ho, to be published as a special edition of "Astrophysics and Space Science" by Kluwe

Survival of Mycobacterium avium subspecies paratuberculosis in retail pasteurised milk

A survey of retail purchased semi-skimmed pasteurised milk (n = 368) for Mycobacterium avium subspecies paratuberculosis (MAP) was conducted between May 2014 and June 2015 across the midlands of England using the Phage-PCR assay. Overall, 10.3% of the total samples collected contained viable MAP cells, confirming that pasteurisation is not capable of fully eliminating human exposure to viable MAP through milk. Comparison of the results gained using the Phage-PCR assay with the results of surveys using either culture or direct PCR suggest that the phage-PCR assay is able to detect lower numbers of cells, resulting in an increase in the number of MAP-positive samples detected. Comparison of viable count and levels of MAP detected in bulk milk samples suggest that MAP is not primarily introduced into the milk by faecal contamination but rather are shed directly into the milk within the udder. In addition results detected an asymmetric distribution of MAP exists in the milk matrix prior to somatic cell lysis, indicating that the bacterial cells in naturally contaminated milk are clustered together and may primarily be located within somatic cells. These latter two results lead to the hypothesis that intracellular MAP within the somatic cells may be protected against heat inactivation during pasteurisation, accounting for the presence of low levels of MAP detected in retail milk

Menus for Feeding Black Holes

Black holes are the ultimate prisons of the Universe, regions of spacetime where the enormous gravity prohibits matter or even light to escape to infinity. Yet, matter falling toward the black holes may shine spectacularly, generating the strongest source of radiation. These sources provide us with astrophysical laboratories of extreme physical conditions that cannot be realized on Earth. This chapter offers a review of the basic menus for feeding matter onto black holes and discusses their observational implications.Comment: 27 pages. Accepted for publication in Space Science Reviews. Also to appear in hard cover in the Space Sciences Series of ISSI "The Physics of Accretion onto Black Holes" (Springer Publisher