SEASAT B orbit synthesis

Addition were made to Battelle's Interactive Graphics Orbit Selection (IGOS) program; IGOS was exercised via telephone lines from JPL, and candidate SEASAT orbits were analyzed by Battelle. The additions to the program enable clear understanding of the implications of a specific orbit to the diverse desires of the SEASAT user community

The emotional contagion in children with autism spectrum disorder

Studies of the last decade have demonstrated that children with Autism Spectrum Disorder (ASD) showed difficulties in language, social and relational areas, but they had also impairment in the mechanisms of embodied simulation, namely the imitative behaviors that allow the body to give an experiential meaning to own and other’s emotions. The identification of this specific emotional response in ASD children, also defined as emotional contagion, allows to move the therapeutic focus from reducing the behavioral symptomatic expressions of the child to promoting the expression of his ability of emotional regulation. The aim of this study was to investigate the presence of emotional contagion in 53 ASD children aged between 22 and 66 months, through the Test of emotional contagion and verify the presence of compromised emotional contagion areas. Our findings have shown that the severity of the disorder is closely related to the inability of the child to respond to the emotional stimuli, regardless from cognitive abilities, and that emotion to which children responded most frequently was happiness, while the one who responded less was anger

From the emotional integration to the cognitive construction: the developmental approach of Turtle Project in children with autism spectrum disorder

Background: Children with autism spectrum disorder show a deficit in neurobiological processes. This deficit hinders the development of intentional behavior and appropriate problem-solving, leading the child to implement repetitive and stereotyped behaviors and to have difficulties in reciprocal interactions, empathy and in the development of a theory of mind. The objective of this research is to verify the effectiveness of a relationship-based approach on the positive evolution of autistic symptoms. Method: A sample of 80 children with autism spectrum disorder was monitored during the first four years of therapy, through a clinical diagnostic assessment at the time of intake and then in two follow-up. Results: The results showed that through the Autism Diagnostic Observation Schedule it is possible to assess the socio-relational key elements on which the therapy is based. There was evidence, in fact, of significant improvements after two and four years of therapy, both for children with severe autistic symptoms and for those in autistic spectrum. Conclusions: Socio-relational aspects represent the primary element on which work in therapy with autistic children and can be considered as indicators of a positive evolution and prognosis that will produce improvements even in the cognitive are

Fluctuations of a Greenlandic tidewater glacier driven by changes in atmospheric forcing : observations and modelling of Kangiata Nunaata Sermia, 1859–present

Acknowledgements. The authors wish to thank Stephen Price, Mauri Pelto, and the anonymous reviewer for their reviews and comments that helped to improve the manuscript. RACMO2.1 data were provided by Jan van Angelen and Michiel van den Broeke, IMAU, Utrecht University. MAR v3.2 data used for runoff calculations were provided by Xavier Fettweis, Department of Geography, University of Liège. The photogrammetric DEM used in Figs. 1 and 3 was provided by Kurt H. Kjær, Centre for GeoGenetics, University of Copenhagen. This research was financially supported by J. M. Lea’s PhD funding, NERC grant number NE/I528742/1. Support for F. M. Nick was provided through the Conoco-Phillips/Lundin Northern Area Program CRIOS project (Calving Rates and Impact on Sea Level).Peer reviewedPublisher PD

Effectiveness evaluation of STOL transport operations

A short-takeoff and landing (STOL) systems simulation model has been developed and implemented in a computer code (known as STOL OPS) which permits evaluation of the operation of a STOL aircraft and its avionics in a commercial airline operating environment. STOL OPS concentrated on the avionics functions of navigation, guidance, control, communication, hazard aviodance, and systems management. External world factors influencing the operation of the STOL aircraft include each airport and its geometry, air traffic at each airport, air traffic control equipment and procedures, weather (including winds and visibility), and the flight path between each airport served by the route. The development of the STOL OPS program provides NASA a set of computer programs which can be used for detailed analysis of a STOL aircraft and its avionics and permit establishment of system requirements as a function of airline mission performance goals

Magnetars' Giant Flares: the case of SGR 1806-20

We first review on the peculiar characteristics of the bursting and flaring activity of the Soft Gamma-ray Repeaters and Anomalous X-ray Pulsars. We then report on the properties of the SGR 1806-20's Giant Flare occurred on 2004 December 27th, with particular interest on the pre and post flare intensity/hardness correlated variability. We show that these findings are consistent with the picture of a twisted internal magnetic field which stresses the star solid crust that finally cracks causing the giant flare (and the observed torsional oscillations). This crustal fracturing is accompanied by a simplification of the external magnetic field with a (partial) untwisting of the magnetosphere.Comment: 6 pages, 2 figures; accepted for publication in the Chinese Journal for Astronomy and Astrophysics (Vulcano conference - 2005

Methylglyoxal-dependent glycative stress and deregulation of SIRT1 functional network in the ovary of PCOS mice

Advanced glycation end-products (AGEs) are involved in the pathogenesis and consequences of polycystic ovary syndrome (PCOS), a complex metabolic disorder associated with female infertility. The most powerful AGE precursor is methylglyoxal (MG), a byproduct of glycolysis, that is detoxified by the glyoxalase system. By using a PCOS mouse model induced by administration of dehydroepiandrosterone (DHEA), we investigated whether MG-dependent glycative stress contributes to ovarian PCOS phenotype and explored changes in the Sirtuin 1 (SIRT1) functional network regulating mitochondrial functions and cell survival. In addition to anovulation and reduced oocyte quality, DHEA ovaries revealed altered collagen deposition, increased vascularization, lipid droplets accumulation and altered steroidogenesis. Here we observed increased intraovarian MG-AGE levels in association with enhanced expression of receptor for AGEs (RAGEs) and deregulation of the glyoxalase system, hallmarks of glycative stress. Moreover, DHEA mice exhibited enhanced ovarian expression of SIRT1 along with increased protein levels of SIRT3 and superoxide dismutase 2 (SOD2), and decreased peroxisome proliferator-activated receptor gamma co-activator 1 alpha (PGC1 alpha), mitochondrial transcriptional factor A (mtTFA) and translocase of outer mitochondrial membrane 20 (TOMM20). Finally, the presence of autophagy protein markers and increased AMP-activated protein kinase (AMPK) suggested the involvement of SIRT1/AMPK axis in autophagy activation. Overall, present findings demonstrate that MG-dependent glycative stress is involved in ovarian dysfunctions associated to PCOS and support the hypothesis of a SIRT1-dependent adaptive response

Small-area deprivation index does not improve the capability of multisource comorbidity score in mortality prediction

BackgroundThe stratification of the general population according to health needs allows to provide better-tailored services. A simple score called Multisource Comorbidity Score (MCS) has been developed and validated for predicting several outcomes. The aim of this study was to evaluate whether the ability of MCS in predicting 1-year mortality improves by incorporating socioeconomic data (as measured by a deprivation index). MethodsBeneficiaries of the Italian National Health Service who in the index year (2018) were aged 50-85 years and were resident in the Sicily region for at least 2 years were identified. For each individual, the MCS was calculated according to his/her clinical profile, and the deprivation index of the census unit level of the individual's residence was collected. Frailty models were fitted to assess the relationship between the indexes (MCS and deprivation index) and 1-year mortality. Akaike information criterion and Bayesian information criterion statistics were used to compare the goodness of fit of the model that included only MCS and the model that also contained the deprivation index. The models were further compared by means of the area under the receiver operating characteristic curve (AUC). ResultsThe final cohort included 1,062,221 individuals, with a mortality rate of 15.6 deaths per 1,000 person-years. Both MCS and deprivation index were positively associated with mortality.The goodness of fit statistics of the two models were very similar. For MCS only and MCS plus deprivation index models, Akaike information criterion were 17,013 and 17,038, respectively, whereas Bayesian information criterion were 16,997 and 17,000, respectively. The AUC values were 0.78 for both models. ConclusionThe present study shows that socioeconomic features as measured by the deprivation index did not improve the capability of MCS in predicting 1-year risk of death. Future studies are needed to investigate other sources of data to enhance the risk stratification of populations

Large Binocular Telescope observations of PSR J2043+2740

We present the results of deep optical imaging of the radio/$\gamma$-ray pulsar PSR J2043+2740, obtained with the Large Binocular Telescope (LBT). With a characteristic age of 1.2 Myr, PSR J2043+2740 is one of the oldest (non recycled) pulsars detected in $\gamma$-rays, although with still a quite high rotational energy reservoir ($\dot{E}_{\rm rot} = 5.6 \times 10^{34}$ erg s$^{-1}$). The presumably close distance (a few hundred pc), suggested by the hydrogen column density ($N_{\rm H} \lesssim 3.6 \times 10^{20}$ cm$^{-2}$), would make it a viable target for deep optical observations, never attempted until now. We observed the pulsar with the Large Binocular Camera of the LBT. The only object (V=25.44$\pm$0.05) detected within ~3" from the pulsar radio coordinates is unrelated to it. PSR J2043+2740 is, thus, undetected down to V~26.6 (3-$\sigma$), the deepest limit on its optical emission. We discuss the implications of this result on the pulsar emission properties.Comment: 4 pages, 3 figures, accepted for publication on MNRA

Observations of three young gamma-ray pulsars with the Gran Telescopio Canarias

We report the analysis of the first deep optical observations of three isolated $\gamma$-ray pulsars detected by the {\em Fermi Gamma-ray Space Telescope}: the radio-loud PSR\, J0248+6021 and PSR\, J0631+1036, and the radio-quiet PSR\, J0633+0632. The latter has also been detected in the X rays. The pulsars are very similar in their spin-down age ($\tau \sim$40--60 kyrs), spin-down energy ($\dot{E} \sim10^{35}$ erg s$^{-1}$), and dipolar surface magnetic field ($B \sim 3$--$5\times10^{12}$ G). These pulsars are promising targets for multi-wavelength observations, since they have been already detected in $\gamma$ rays and in radio or X-rays. None of them has been detected yet in the optical band. We observed the three pulsar fields in 2014 with the Spanish 10.4m Gran Telescopio Canarias (GTC). We could not find any candidate optical counterpart to the three pulsars close to their most recent radio or {\em Chandra} positions down to $3 \sigma$ limits of $g'\sim27.3$, $g'\sim27$, $g'\sim27.3$ for PSR\, J0248+6021, J0631+1036, and J0633+0632, respectively. From the inferred optical upper limits and estimated distance and interstellar extinction, we derived limits on the pulsar optical luminosity. We also searched for the X-ray counterpart to PSR\, J0248+6021 with \chan\ but we did not detect the pulsar down to a 3$\sigma$ flux limit of $5 \times 10^{-14}$ erg cm$^{-2}$ s$^{-1}$ (0.3--10 keV). For all these pulsars, we compared the optical flux upper limits with the extrapolations in the optical domain of the $\gamma$-ray spectra and compared their multi-wavelength properties with those of other $\gamma$-ray pulsars of comparable age.Comment: 12 pages, 5 figures, accepted for publication in MNRA