299 research outputs found
T-Branes and Monodromy
We introduce T-branes, or "triangular branes," which are novel non-abelian
bound states of branes characterized by the condition that on some loci, their
matrix of normal deformations, or Higgs field, is upper triangular. These
configurations refine the notion of monodromic branes which have recently
played a key role in F-theory phenomenology. We show how localized matter
living on complex codimension one subspaces emerge, and explain how to compute
their Yukawa couplings, which are localized in complex codimension two. Not
only do T-branes clarify what is meant by brane monodromy, they also open up a
vast array of new possibilities both for phenomenological constructions and for
purely theoretical applications. We show that for a general T-brane, the
eigenvalues of the Higgs field can fail to capture the spectrum of localized
modes. In particular, this provides a method for evading some constraints on
F-theory GUTs which have assumed that the spectral equation for the Higgs field
completely determines a local model.Comment: 110 pages, 5 figure
Social marketing and healthy eating : Findings from young people in Greece
This document is the Accepted Manuscript version. The final publication is available at Springer via http://dx.doi.org/10.1007/s12208-013-0112-xGreece has high rates of obesity and non-communicable diseases owing to poor dietary choices. This research provides lessons for social marketing to tackle the severe nutrition-related problems in this country by obtaining insight into the eating behaviour of young adults aged 18–23. Also, the main behavioural theories used to inform the research are critically discussed. The research was conducted in Athens. Nine focus groups with young adults from eight educational institutions were conducted and fifty-nine participants’ views towards eating habits, healthy eating and the factors that affect their food choices were explored. The study found that the participants adopted unhealthier nutritional habits after enrolment. Motivations for healthy eating were good health, appearance and psychological consequences, while barriers included lack of time, fast-food availability and taste, peer pressure, lack of knowledge and lack of family support. Participants reported lack of supportive environments when deciding on food choices. Based on the findings, recommendations about the development of the basic 4Ps of the marketing mix, as well as of a fifth P, for Policy are proposedPeer reviewe
Occult hepatitis B virus infection: diagnosis, implications and management?
Occult hepatitis B virus (HBV) infection is generally defined as the detection of HBV-DNA in the serum or liver tissue of patients who test negative for hepatitis B surface antigen. In most cases, occult HBV infection is related to low level HBV infection with subdetectable levels of HBsAg and not infection with HBV variants that cannot express S proteins or produce S proteins with aberrant epitopes that are not detected by conventional serological assays. Prevalence of occult HBV infection is related to the overall prevalence of HBV infection in that country, being more common in persons with prior exposure to HBV. Occult HBV infection has been found in a substantial proportion of patients with cirrhosis and hepatocellular carcinoma but other causes of liver disease are frequently present. Future studies should focus on delineating the pathogenic role of occult HBV infection and the basis for failure to detect circulating hepatitis B surface antigen.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75344/1/j.1440-1746.2004.03657.x.pd
Flux and Instanton Effects in Local F-theory Models and Hierarchical Fermion Masses
We study the deformation induced by fluxes and instanton effects on Yukawa
couplings involving 7-brane intersections in local F-theory constructions. In
the absence of non-perturbative effects, holomorphic Yukawa couplings do not
depend on open string fluxes. On the other hand instanton effects (or gaugino
condensation on distant 7-branes) do induce corrections to the Yukawas. The
leading order effect may also be captured by the presence of closed string
(1,2) IASD fluxes, which give rise to a non-commutative structure. We check
that even in the presence of these non-perturbative effects the holomorphic
Yukawas remain independent of magnetic fluxes. Although fermion mass
hierarchies may be obtained from these non-perturbative effects, they would
give identical Yukawa couplings for D-quark and Lepton masses in SU(5) F-theory
GUT's, in contradiction with experiment. We point out that this problem may be
solved by appropriately normalizing the wavefunctions. We show in a simple toy
model how the presence of hypercharge flux may then be responsible for the
difference between D-quarks and Lepton masses in local SU(5) GUT's.Comment: 84 pages, 1 figure. v2: minor corrections and references adde
Evidence for F(uzz) Theory
We show that in the decoupling limit of an F-theory compactification, the
internal directions of the seven-branes must wrap a non-commutative four-cycle
S. We introduce a general method for obtaining fuzzy geometric spaces via toric
geometry, and develop tools for engineering four-dimensional GUT models from
this non-commutative setup. We obtain the chiral matter content and Yukawa
couplings, and show that the theory has a finite Kaluza-Klein spectrum. The
value of 1/alpha_(GUT) is predicted to be equal to the number of fuzzy points
on the internal four-cycle S. This relation puts a non-trivial restriction on
the space of gauge theories that can arise as a limit of F-theory. By viewing
the seven-brane as tiled by D3-branes sitting at the N fuzzy points of the
geometry, we argue that this theory admits a holographic dual description in
the large N limit. We also entertain the possibility of constructing string
models with large fuzzy extra dimensions, but with a high scale for quantum
gravity.Comment: v2: 66 pages, 3 figures, references and clarifications adde
Surprisingly Simple Spectra
The large N limit of the anomalous dimensions of operators in
super Yang-Mills theory described by restricted Schur polynomials, are studied.
We focus on operators labeled by Young diagrams that have two columns (both
long) so that the classical dimension of these operators is O(N). At large N
these two column operators mix with each other but are decoupled from operators
with columns. The planar approximation does not capture the large N
dynamics. For operators built with 2, 3 or 4 impurities the dilatation operator
is explicitly evaluated. In all three cases, in a certain limit, the dilatation
operator is a lattice version of a second derivative, with the lattice emerging
from the Young diagram itself. The one loop dilatation operator is diagonalized
numerically. All eigenvalues are an integer multiple of and there
are interesting degeneracies in the spectrum. The spectrum we obtain for the
one loop anomalous dimension operator is reproduced by a collection of harmonic
oscillators. This equivalence to harmonic oscillators generalizes giant
graviton results known for the BPS sector and further implies that the
Hamiltonian defined by the one loop large dilatation operator is
integrable. This is an example of an integrable dilatation operator, obtained
by summing both planar and non-planar diagrams.Comment: 34 page
EEG alterations during treatment with olanzapine
The aim of this naturalistic observational study was to investigate EEG alterations in patients under olanzapine treatment with a special regard to olanzapine dose and plasma concentration. Twenty-two in-patients of a psychiatric university ward with the monodiagnosis of paranoid schizophrenia (ICD-10: F20.0), who received a monotherapy of olanzapine were included in this study. All patients had a normal alpha-EEG before drug therapy, and did not suffer from brain-organic dysfunctions, as verified by clinical examination and cMRI scans. EEG and olanzapine plasma levels were determined under steady-state conditions (between 18 and 22 days after begin of treatment). In 9 patients (40.9%), pathological EEG changes (one with spike-waves) consecutive to olanzapine treatment were observed. The dose of olanzapine was significantly higher in patients with changes of the EEG than in patients without changes (24.4 mg/day (SD: 8.1) vs. 12.7 mg/day (SD: 4.8); T = −4.3, df = 21, P < 0.001). In patients with EEG changes, the blood plasma concentration of olanzapine (45.6 μg/l (SD: 30.9) vs. 26.3 μg/l (SD: 21.6) tended to be also higher. The sensitivity of olanzapine dosage to predict EEG changes was 66.7%, the specificity 100% (Youden-index: 0.67). EEG abnormalities during olanzapine treatment are common. These are significantly dose dependent. Thus, EEG control recordings should be mandatory during olanzapine treatment with special emphasis on dosages exceeding 20 mg per day, although keeping in mind that EEGs have only a limited predictive power regarding future epileptic seizures
The perturbative partition function of supersymmetric 5D Yang-Mills theory with matter on the five-sphere
Based on the construction by Hosomichi, Seong and Terashima we consider N=1
supersymmetric 5D Yang-Mills theory with matter on a five-sphere with radius r.
This theory can be thought of as a deformation of the theory in flat space with
deformation parameter r and this deformation preserves 8 supercharges. We
calculate the full perturbative partition function as a function of r/g^2,
where g is the Yang-Mills coupling, and the answer is given in terms of a
matrix model. We perform the calculation using localization techniques. We also
argue that in the large N-limit of this deformed 5D Yang-Mills theory this
matrix model provides the leading contribution to the partition function and
the rest is exponentially suppressed.Comment: 34 pages; v2: typos fixed, matches published version; v3: factor
correcte
Different significance between intratumoral and peritumoral lymphatic vessel density in gastric cancer: a retrospective study of 123 cases
<p>Abstract</p> <p>Background</p> <p>Patients with gastric cancer in China have worse outcome and poorer prognosis. Tumor-induced lymphangiogenesis plays a crucial role in metastasis and tumor progression. The intratumoral and peritumoral lymphatics were supposed to have different biological effects. Three major growth factors, vascular endothelial growth factor- (VEGF)-A, VEGF-C and VEGF-D, are involved in the activation process via their receptors (VEGFRs). The purpose of current study is to investigate the significant difference between intratumoral and peritumoral lymphatic vessel density (LVD) in gastric cancer and their correlations with lymphangiogenetic growth factors.</p> <p>Methods</p> <p>Intratumoral LVD (I-LVD) and peritumoral LVD (P-LVD) of 123 patients with primary gastric cancer were assessed after staining with D2-40, and confirmed by double staining with D2-40/CD34. Proliferative activity of lymphatics endothelium was evaluated by double staining with D2-40/Ki-67. The associations were analyzed between I-LVD/P-LVD and the expression level of VEGF-A, VEGF-C, VEGF-D and the receptor VEGFR-3, which was measured by immunohistochemistry (IHC). The correlations of I-LVD and P-LVD with patient prognosis were also valued.</p> <p>Results</p> <p>(1) The peritumoral lymphatics (PTLs) were relatively enlarged with dilated lumen compared with the intratumoral lymphatics (ITLs). Increased P-LVD was significantly higher than I-LVD (<it>P </it>< 0.05). (2) P-LVD was found significantly associated with lymph node metastasis (LNM) (<it>P </it>< 0.001), lymphatic vessel invasion (LVI) (<it>P </it>< 0.001), VEGF-C (<it>P </it>= 0.003), VEGF-D expression level (<it>P </it>= 0.005) and VEGFR-3 expression level (<it>P </it>< 0.001) in peritumoral tissues, despite no significant association was found between above variants with I-LVD. However, increased I-LVD was demonstrated to be associated with decreased tumor volume (<it>P </it>< 0.001). Neither I-LVD nor P-LVD was correlated with VEGF-A expression (<it>P </it>> 0.05). (3) Proliferative activity of lymphatics endothelium was observed in PTLs, in spite of ITLs. (4) Increased P-LVD, but not I-LVD, was indicated to be an independent risk factor for lymph node metastasis by multivariate logistic regression analysis, and was related to worse disease-free survival and overall survival.</p> <p>Conclusions</p> <p>PTLs play roles in gastric cancer progression. Increased P-LVD, but not I-LVD, was significantly associated with VEGF-C/-D/VEGFR-3 system, and could be an independent risk factor for lymph node metastasis and a prognostic factor in gastric cancer.</p
The Molecular Epidemiology and Evolution of Murray Valley Encephalitis Virus: Recent Emergence of Distinct Sub-lineages of the Dominant Genotype 1
© 2015 Williams et al. Background: Recent increased activity of the mosquito-borne Murray Valley encephalitis virus (MVEV) in Australia has renewed concerns regarding its potential to spread and cause disease. Methodology/Principal Findings: To better understand the genetic relationships between earlier and more recent circulating strains, patterns of virus movement, as well as the molecular basis of MVEV evolution, complete pre-membrane (prM) and Envelope (Env) genes were sequenced from sixty-six MVEV strains from different regions of the Australasian region, isolated over a sixty year period (1951–2011). Phylogenetic analyses indicated that, of the four recognized genotypes, only G1 and G2 are contemporary. G1 viruses were dominant over the sampling period and found across the known geographic range of MVEV. Two distinct sub-lineages of G1 were observed (1A and 1B). Although G1B strains have been isolated from across mainland Australia, Australian G1A strains have not been detected outside northwest Australia. Similarly, G2 is comprised of only Western Australian isolates from mosquitoes, suggesting G1B and G2 viruses have geographic or ecological restrictions. No evidence of recombination was found and a single amino acid substitution in the Env protein (S332G) was found to be under positive selection, while several others were found to be under directional evolution. Evolutionary analyses indicated that extant genotypes of MVEV began to diverge from a common ancestor approximately 200 years ago. G2 was the first genotype to diverge, followed by G3 and G4, and finally G1, from which subtypes G1A and G1B diverged between 1964 and 1994. Conclusions/Significance: The results of this study provides new insights into the genetic diversity and evolution of MVEV. The demonstration of co-circulation of all contemporary genetic lineages of MVEV in northwestern Australia, supports the contention that this region is the enzootic focus for this virus
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