Front Microbiol

Chromosomal rearrangements (CR) such as translocations, duplications and inversions play a decisive role in the adaptation of microorganisms to specific environments. In enological strains, CR involving the promoter region of the gene lead to a higher sulfite tolerance by enhancing the SO efflux. To date, three different associated CR events have been described, including translocations XV-t-XVI and VIII-t-XVI and inversion inv-XVI. In the present study, we developed a multiplex PCR method ( checkup) that allows a rapid characterization of these three chromosomal configurations in a single experiment. Nearly 600 strains collected from fermented grape juice were genotyped by microsatellite markers. We demonstrated that alleles of the promoter are differently distributed according to the wine environment (cellar versus vineyard) and the nature of the grape juice. Moreover, rearranged promoters are significantly enriched among commercial starters. In addition, the analysis of nearly isogenic strains collected in wine related environments demonstrated that the inheritance of these CR shapes the genetic diversity of clonal populations. Finally, the link between the nature of promoter and the tolerance to sulfite was statistically validated in natural grape juice containing various SO concentrations. The checkup is therefore a convenient new tool for addressing population genetics questions and for selecting yeast strains by using molecular markers

Analysis of Outcomes in Ischemic vs Nonischemic Cardiomyopathy in Patients With Atrial Fibrillation A Report From the GARFIELD-AF Registry

IMPORTANCE Congestive heart failure (CHF) is commonly associated with nonvalvular atrial fibrillation (AF), and their combination may affect treatment strategies and outcomes

Investigating the nature of the K∗0(700) state with π±K0S correlations at the LHC

The first measurements of femtoscopic correlations with the particle pair combinations π±K0S in pp collisions at s√=13 TeV at the Large Hadron Collider (LHC) are reported by the ALICE experiment. Using the femtoscopic approach, it is shown that it is possible to study the elusive K∗0(700) particle that has been considered a tetraquark candidate for over forty years. Boson source parameters and final-state interaction parameters are extracted by fitting a model assuming a Gaussian source to the experimentally measured two-particle correlation functions. The final-state interaction is modeled through a resonant scattering amplitude, defined in terms of a mass and a coupling parameter, decaying into a π±K0S pair. The extracted mass and Breit-Wigner width, derived from the coupling parameter, of the final-state interaction are found to be consistent with previous measurements of the K∗0(700). The small value and increasing behavior of the correlation strength with increasing source size support the hypothesis that the K∗0(700) is a four-quark state, i.e. a tetraquark state. This latter trend is also confirmed via a simple geometric model that assumes a tetraquark structure of the K∗0(700) resonance

Investigating the nature of the K0∗(700)^*_0(700) state with π±\pi^\pmKS0^0_{\rm S} correlations at the LHC

International audienceThe first measurements of femtoscopic correlations with the particle pair combinations $\pi^\pm$K$^0_{\rm S}$ in pp collisions at $\sqrt{s}=13$ TeV at the Large Hadron Collider (LHC) are reported by the ALICE experiment. Using the femtoscopic approach, it is shown that it is possible to study the elusive K$^*_0(700)$ particle that has been considered a tetraquark candidate for over forty years. Boson source parameters and final-state interaction parameters are extracted by fitting a model assuming a Gaussian source to the experimentally measured two-particle correlation functions. The final-state interaction is modeled through a resonant scattering amplitude, defined in terms of a mass and a coupling parameter, decaying into a $\pi^\pm$K$^0_{\rm S}$ pair. The extracted mass and Breit-Wigner width, derived from the coupling parameter, of the final-state interaction are found to be consistent with previous measurements of the K$^*_0(700)$. The small value and increasing behavior of the correlation strength with increasing source size support the hypothesis that the K$^*_0(700)$ is a four-quark state, i.e. a tetraquark state. This latter trend is also confirmed via a simple geometric model that assumes a tetraquark structure of the K$^*_0(700)$ resonance

Investigating the nature of the K0∗^*_0(700) state with π±\pi^\pmKS0^0_{\rm S} correlations at the LHC

The first measurements of femtoscopic correlations with the particle pair combinations $\pi^\pm$K$^0_{\rm S}$ in pp collisions at $\sqrt{s}=13$ TeV at the Large Hadron Collider (LHC) are reported by the ALICE experiment. Using the femtoscopic approach, it is shown that it is possible to study the elusive K$^*_0(700)$ particle that has been considered a tetraquark candidate for over forty years. Boson source parameters and final-state interaction parameters are extracted by fitting a model assuming a Gaussian source to the experimentally measured two-particle correlation functions. The final-state interaction is modeled through a resonant scattering amplitude, defined in terms of a mass and a coupling parameter, decaying into a $\pi^\pm$K$^0_{\rm S}$ pair. The extracted mass and Breit--Wigner width, derived from the coupling parameter, of the final-state interaction are found to be consistent with previous measurements of the K$^*_0(700)$. The small value and increasing behavior of the correlation strength with increasing source size support the hypothesis that the K$^*_0(700)$ is a four-quark state, i.e. a tetraquark state. This latter trend is also confirmed via a simple geometric model that assumes a tetraquark structure of the K$^*_0(700)$ resonance.The first measurements of femtoscopic correlations with the particle pair combinations $\pi^\pm$K$^0_{\rm S}$ in pp collisions at $\sqrt{s}=13$ TeV at the Large Hadron Collider (LHC) are reported by the ALICE experiment. Using the femtoscopic approach, it is shown that it is possible to study the elusive K$^*_0(700)$ particle that has been considered a tetraquark candidate for over forty years. Boson source parameters and final-state interaction parameters are extracted by fitting a model assuming a Gaussian source to the experimentally measured two-particle correlation functions. The final-state interaction is modeled through a resonant scattering amplitude, defined in terms of a mass and a coupling parameter, decaying into a $\pi^\pm$K$^0_{\rm S}$ pair. The extracted mass and Breit-Wigner width, derived from the coupling parameter, of the final-state interaction are found to be consistent with previous measurements of the K$^*_0(700)$. The small value and increasing behavior of the correlation strength with increasing source size support the hypothesis that the K$^*_0(700)$ is a four-quark state, i.e. a tetraquark state. This latter trend is also confirmed via a simple geometric model that assumes a tetraquark structure of the K$^*_0(700)$ resonance

Investigating the nature of the K0∗(700)^*_0(700) state with π±\pi^\pmKS0^0_{\rm S} correlations at the LHC

International audienceThe first measurements of femtoscopic correlations with the particle pair combinations $\pi^\pm$K$^0_{\rm S}$ in pp collisions at $\sqrt{s}=13$ TeV at the Large Hadron Collider (LHC) are reported by the ALICE experiment. Using the femtoscopic approach, it is shown that it is possible to study the elusive K$^*_0(700)$ particle that has been considered a tetraquark candidate for over forty years. Boson source parameters and final-state interaction parameters are extracted by fitting a model assuming a Gaussian source to the experimentally measured two-particle correlation functions. The final-state interaction is modeled through a resonant scattering amplitude, defined in terms of a mass and a coupling parameter, decaying into a $\pi^\pm$K$^0_{\rm S}$ pair. The extracted mass and Breit-Wigner width, derived from the coupling parameter, of the final-state interaction are found to be consistent with previous measurements of the K$^*_0(700)$. The small value and increasing behavior of the correlation strength with increasing source size support the hypothesis that the K$^*_0(700)$ is a four-quark state, i.e. a tetraquark state. This latter trend is also confirmed via a simple geometric model that assumes a tetraquark structure of the K$^*_0(700)$ resonance

Investigating the nature of the K0∗(700)^*_0(700) state with π±\pi^\pmKS0^0_{\rm S} correlations at the LHC

International audienceThe first measurements of femtoscopic correlations with the particle pair combinations $\pi^\pm$K$^0_{\rm S}$ in pp collisions at $\sqrt{s}=13$ TeV at the Large Hadron Collider (LHC) are reported by the ALICE experiment. Using the femtoscopic approach, it is shown that it is possible to study the elusive K$^*_0(700)$ particle that has been considered a tetraquark candidate for over forty years. Boson source parameters and final-state interaction parameters are extracted by fitting a model assuming a Gaussian source to the experimentally measured two-particle correlation functions. The final-state interaction is modeled through a resonant scattering amplitude, defined in terms of a mass and a coupling parameter, decaying into a $\pi^\pm$K$^0_{\rm S}$ pair. The extracted mass and Breit-Wigner width, derived from the coupling parameter, of the final-state interaction are found to be consistent with previous measurements of the K$^*_0(700)$. The small value and increasing behavior of the correlation strength with increasing source size support the hypothesis that the K$^*_0(700)$ is a four-quark state, i.e. a tetraquark state. This latter trend is also confirmed via a simple geometric model that assumes a tetraquark structure of the K$^*_0(700)$ resonance

Investigating the nature of the K0∗(700)^*_0(700) state with π±\pi^\pmKS0^0_{\rm S} correlations at the LHC

International audienceThe first measurements of femtoscopic correlations with the particle pair combinations $\pi^\pm$K$^0_{\rm S}$ in pp collisions at $\sqrt{s}=13$ TeV at the Large Hadron Collider (LHC) are reported by the ALICE experiment. Using the femtoscopic approach, it is shown that it is possible to study the elusive K$^*_0(700)$ particle that has been considered a tetraquark candidate for over forty years. Boson source parameters and final-state interaction parameters are extracted by fitting a model assuming a Gaussian source to the experimentally measured two-particle correlation functions. The final-state interaction is modeled through a resonant scattering amplitude, defined in terms of a mass and a coupling parameter, decaying into a $\pi^\pm$K$^0_{\rm S}$ pair. The extracted mass and Breit-Wigner width, derived from the coupling parameter, of the final-state interaction are found to be consistent with previous measurements of the K$^*_0(700)$. The small value and increasing behavior of the correlation strength with increasing source size support the hypothesis that the K$^*_0(700)$ is a four-quark state, i.e. a tetraquark state. This latter trend is also confirmed via a simple geometric model that assumes a tetraquark structure of the K$^*_0(700)$ resonance

Measurements of the groomed jet radius and momentum splitting fraction with the soft drop and dynamical grooming algorithms in pp collisions at √s = 5.02 TeV

This article presents measurements of the groomed jet radius and momentum splitting fraction in pp collisions at s√=5.02 TeV with the ALICE detector at the Large Hadron Collider. Inclusive charged-particle jets are reconstructed at midrapidity using the anti-kT algorithm for transverse momentum 60<pchjetT<80 GeV/c. We report results using two different grooming algorithms: soft drop and, for the first time, dynamical grooming. For each grooming algorithm, a variety of grooming settings are used in order to explore the impact of collinear radiation on these jet substructure observables. These results are compared to perturbative calculations that include resummation of large logarithms at all orders in the strong coupling constant. We find good agreement of the theoretical predictions with the data for all grooming settings considered

Measurement of the production of charm jets tagged with D0 mesons in pp collisions at √s = 5.02 and 13 TeV

The measurement of the production of charm jets, identified by the presence of a D0 meson in the jet constituents, is presented in proton-proton collisions at centre-of-mass energies of s√ = 5.02 and 13 TeV with the ALICE detector at the CERN LHC. The D0 mesons were reconstructed from their hadronic decay D0→K−π+ and the respective charge conjugate. Jets were reconstructed from D0-meson candidates and charged particles using the anti-kT algorithm, in the jet transverse momentum range 5<pT;chjet<50 GeV/c, pseudorapidity |ηjet|<0.9−R, and with the jet resolution parameters R = 0.2, 0.4, 0.6. The distribution of the jet momentum fraction carried by a D0 meson along the jet axis (zch||) was measured in the range 0.4<zch||<1.0 in four ranges of the jet transverse momentum. Comparisons of results for different collision energies and jet resolution parameters are also presented. The measurements are compared to predictions from Monte Carlo event generators based on leading-order and next-to-leading-order perturbative quantum chromodynamics calculations. A generally good description of the main features of the data is obtained in spite of a few discrepancies at low pT;chjet. Measurements were also done for R=0.3 at s√ = 5.02 TeV and are shown along with their comparisons to theoretical predictions in an appendix to this paper