1,116 research outputs found
The bright optical afterglow of the nearby gamma-ray burst of 29 March 2003
Many past studies of cosmological gamma-ray bursts (GRBs) have been limited
because of the large distance to typical GRBs, resulting in faint afterglows.
There has long been a recognition that a nearby GRB would shed light on the
origin of these mysterious cosmic explosions, as well as the physics of their
fireballs. However, GRBs nearer than z=0.2 are extremely rare, with an
estimated rate of localisation of one every decade. Here, we report the
discovery of bright optical afterglow emission from GRB 030329. Our prompt
dissemination and the brilliance of the afterglow resulted in extensive
followup (more than 65 telescopes) from radio through X-ray bands, as well as
measurement of the redshift, z=0.169. The gamma-ray and afterglow properties of
GRB 030329 are similar to those of cosmological GRBs (after accounting for the
small distance), making this the nearest known cosmological GRB. Observations
have already securely identified the progenitor as a massive star that exploded
as a supernova, and we anticipate futher revelations of the GRB phenomenon from
studies of this source.Comment: 13 pages, 4 figures. Original tex
Single intraoperative intravenous Co-Amoxiclav versus postoperative full oral course in prevention of postadenotonsillectomy morbidity: a randomised clinical trial
<p>Abstract</p> <p>Background</p> <p>Adenotonsillectomy results in postoperative morbidity which otolaryngologists attempt to reduce by use of antibiotics. The regimes used as quite varied with some opting for a full oral course postoperatively while others prefer prophylactic doses. This randomised clinical trial done in Kenyatta National Hospital, Kenya had the aim of comparing the efficacy of Co-Amoxiclav given as a single intravenous dose with a full oral course in the prevention of post adenotonsillectomy morbidity.</p> <p>Methods</p> <p>126 patients below 12 years scheduled to undergo adenotonsillectomy were randomised into two groups. 63 were given a single intravenous dose of Enhancin [Co-Amoxiclav] at induction while the remaining half received a five days oral course of the same postoperatively. All received oral Pacimol [Paracetamol] in the postoperative period. Analysis was done and comparison made between the two groups with regards to pain, fever and diet tolerated in the postoperative period with a follow up period of seven days.</p> <p>Results</p> <p>There was no statistical significant difference between the two groups with regards to postoperative pain, fever and diet tolerated. All had a P-value > 0.2. Postoperative pain was highest in the first postoperative day and reduced progressively to the lowest level on the 7<sup>th </sup>postoperative day. As pain reduced, patients were able to tolerate a more solid diet with all but 6 tolerating their usual diet. 4 patients developed fever in the 1<sup>st </sup>postoperative day which did not progress to the next day. One patient had fever on the 4<sup>th </sup>and 7<sup>th </sup>postoperative day and was admitted in the paediatrics' ward with a chest infection. All these patients with history of fever were in the group that was on oral postoperative Co-Amoxiclav.</p> <p>Conclusion</p> <p>A single intraoperative dose of Co-Amoxiclav given intravenously at induction was found to be just as effective as a full oral course of the same given postoperatively in the prevention of post adenotonsillectomy morbidity. The prophylactic dose is favoured over the later as it is cheaper, ensures compliance and relieves off the need for refrigeration of the oral suspension as not all have access to refrigeration in low economy countries as ours.</p> <p>Trial registration</p> <p>ClinicalTrials.gov: <a href="http://www.clinicaltrials.gov/ct2/show/NCT01267942">NCT01267942</a></p
A Relativistic Type Ibc Supernova Without a Detected Gamma-ray Burst
Long duration gamma-ray bursts (GRBs) mark the explosive death of some
massive stars and are a rare sub-class of Type Ibc supernovae (SNe Ibc). They
are distinguished by the production of an energetic and collimated relativistic
outflow powered by a central engine (an accreting black hole or neutron star).
Observationally, this outflow is manifested in the pulse of gamma-rays and a
long-lived radio afterglow. To date, central engine-driven SNe have been
discovered exclusively through their gamma-ray emission, yet it is expected
that a larger population goes undetected due to limited satellite sensitivity
or beaming of the collimated emission away from our line-of-sight. In this
framework, the recovery of undetected GRBs may be possible through radio
searches for SNe Ibc with relativistic outflows. Here we report the discovery
of luminous radio emission from the seemingly ordinary Type Ibc SN 2009bb,
which requires a substantial relativistic outflow powered by a central engine.
The lack of a coincident GRB makes SN 2009bb the first engine-driven SN
discovered without a detected gamma-ray signal. A comparison with our extensive
radio survey of SNe Ibc reveals that the fraction harboring central engines is
low, ~1 percent, measured independently from, but consistent with, the inferred
rate of nearby GRBs. Our study demonstrates that upcoming optical and radio
surveys will soon rival gamma-ray satellites in pinpointing the nearest
engine-driven SNe. A similar result for a different supernova is reported
independently.Comment: To appear in Nature on Jan 28 2010. Embargoed for discussion in the
press until 13:00 US Eastern Time on Jan 27 (Accepted version, 27 pages,
Manuscript and Suppl. Info.
Hydrogen-poor superluminous stellar explosions
Supernovae (SNe) are stellar explosions driven by gravitational or
thermonuclear energy, observed as electromagnetic radiation emitted over weeks
or more. In all known SNe, this radiation comes from internal energy deposited
in the outflowing ejecta by either radioactive decay of freshly-synthesized
elements (typically 56Ni), stored heat deposited by the explosion shock in the
envelope of a supergiant star, or interaction between the SN debris and
slowly-moving, hydrogen-rich circumstellar material. Here we report on a new
class of luminous SNe whose observed properties cannot be explained by any of
these known processes. These include four new SNe we have discovered, and two
previously unexplained events (SN 2005ap; SCP 06F6) that we can now identify as
members. These SNe are all ~10 times brighter than SNe Ia, do not show any
trace of hydrogen, emit significant ultra-violet (UV) flux for extended periods
of time, and have late-time decay rates which are inconsistent with
radioactivity. Our data require that the observed radiation is emitted by
hydrogen-free material distributed over a large radius (~10^15 cm) and
expanding at high velocities (>10^4 km s^-1). These long-lived, UV-luminous
events can be observed out to redshifts z>4 and offer an excellent opportunity
to study star formation in, and the interstellar medium of, primitive distant
galaxies.Comment: Accepted to Nature. Press embargoed until 2011 June 8, 18:00 U
What do -ray bursts look like?
There have been great and rapid progresses in the field of -ray
bursts (denoted as GRBs) since BeppoSAX and other telescopes discovered their
afterglows in 1997. Here, we will first give a brief review on the
observational facts of GRBs and direct understanding from these facts, which
lead to the standard fireball model. The dynamical evolution of the fireball is
discussed, especially a generic model is proposed to describe the whole
dynamical evolution of GRB remnant from highly radiative to adiabatic, and from
ultra-relativistic to non-relativistic phase. Then, Various deviations from the
standard model are discussed to give new information about GRBs and their
environment. In order to relax the energy crisis, the beaming effects and their
possible observational evidences are also discussed in GRB's radiations.Comment: 10 pages, Latex. Invited talk at the Pacific Rim Conference on
Stellar Astrophysics, Hong Kong, China, Aug. 199
Relativistic ejecta from XRF 060218 and the rate of cosmic explosions
Over the last decade, long-duration gamma-ray bursts (GRBs) including the
subclass of X-ray flashes (XRFs) have been revealed to be a rare variety of
Type Ibc supernova (SN). While all these events result from the death of
massive stars, the electromagnetic luminosities of GRBs and XRFs exceed those
of ordinary Type Ibc SNe by many orders of magnitude. The essential physical
process that causes a dying star to produce a GRB or XRF, and not just an SN,
remains the crucial open question. Here we present radio and X-ray observations
of XRF 060218 (associated with SN 2006aj), the second nearest GRB identified
to-date, which allow us to measure its total energy and place it in the larger
context of cosmic explosions. We show that this event is 100 times less
energetic but ten times more common than cosmological GRBs. Moreover, it is
distinguished from ordinary Type Ibc SNe by the presence of 10^48 erg coupled
to mildly-relativistic ejecta, along with a central engine (an accretion-fed,
rapidly rotating compact source) which produces X-rays for weeks after the
explosion. This suggests that the production of relativistic ejecta is the key
physical distinction between GRBs/XRFs and ordinary SNe, while the nature of
the central engine (black hole or magnetar) may distinguish typical bursts from
low-luminosity, spherical events like XRF 060218.Comment: To appear in Nature on August 31 2006 (15 pages, 3 figures, 1 table,
including Supplementary Information
On the solution of Fredholm integral equations based on spline quasi-interpolating projectors
Altered Insulin Receptor Signalling and β-Cell Cycle Dynamics in Type 2 Diabetes Mellitus
Insulin resistance, reduced β-cell mass, and hyperglucagonemia are consistent features in type 2 diabetes mellitus (T2DM). We used pancreas and islets from humans with T2DM to examine the regulation of insulin signaling and cell-cycle control of islet cells. We observed reduced β-cell mass and increased α-cell mass in the Type 2 diabetic pancreas. Confocal microscopy, real-time PCR and western blotting analyses revealed increased expression of PCNA and down-regulation of p27-Kip1 and altered expression of insulin receptors, insulin receptor substrate-2 and phosphorylated BAD. To investigate the mechanisms underlying these findings, we examined a mouse model of insulin resistance in β-cells – which also exhibits reduced β-cell mass, the β-cell-specific insulin receptor knockout (βIRKO). Freshly isolated islets and β-cell lines derived from βIRKO mice exhibited poor cell-cycle progression, nuclear restriction of FoxO1 and reduced expression of cell-cycle proteins favoring growth arrest. Re-expression of insulin receptors in βIRKO β-cells reversed the defects and promoted cell cycle progression and proliferation implying a role for insulin-signaling in β-cell growth. These data provide evidence that human β- and α-cells can enter the cell-cycle, but proliferation of β-cells in T2DM fails due to G1-to-S phase arrest secondary to defective insulin signaling. Activation of insulin signaling, FoxO1 and proteins in β-cell-cycle progression are attractive therapeutic targets to enhance β-cell regeneration in the treatment of T2DM
Cognitive behaviour therapy versus counselling intervention for anxiety in young people with high-functioning autism spectrum disorders: a pilot randomised controlled trial
The use of cognitive-behavioural therapy (CBT) as a treatment for children and adolescents with autism spectrum disorder (ASD) has been explored in a number of trials. Whilst CBT appears superior to no treatment or treatment as usual, few studies have assessed CBT against a control group receiving an alternative therapy.
Our randomised controlled trial compared use of CBT against person-centred counselling for anxiety in 36 young people with ASD, ages 12–18. Outcome measures included parent- teacher- and self-reports of anxiety and social disability.
Whilst each therapy produced improvements inparticipants, neither therapy was superior to the other to a significant degree on any measure. This is consistent with findings for adults
Galactic and Extragalactic Samples of Supernova Remnants: How They Are Identified and What They Tell Us
Supernova remnants (SNRs) arise from the interaction between the ejecta of a
supernova (SN) explosion and the surrounding circumstellar and interstellar
medium. Some SNRs, mostly nearby SNRs, can be studied in great detail. However,
to understand SNRs as a whole, large samples of SNRs must be assembled and
studied. Here, we describe the radio, optical, and X-ray techniques which have
been used to identify and characterize almost 300 Galactic SNRs and more than
1200 extragalactic SNRs. We then discuss which types of SNRs are being found
and which are not. We examine the degree to which the luminosity functions,
surface-brightness distributions and multi-wavelength comparisons of the
samples can be interpreted to determine the class properties of SNRs and
describe efforts to establish the type of SN explosion associated with a SNR.
We conclude that in order to better understand the class properties of SNRs, it
is more important to study (and obtain additional data on) the SNRs in galaxies
with extant samples at multiple wavelength bands than it is to obtain samples
of SNRs in other galaxiesComment: Final 2016 draft of a chapter in "Handbook of Supernovae" edited by
Athem W. Alsabti and Paul Murdin. Final version available at
https://doi.org/10.1007/978-3-319-20794-0_90-
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