Correlators of Wilson loops and local operators from multi-matrix models and strings in AdS

We study correlation functions of Wilson loops and local operators in a subsector of N=4 SYM which preserves two supercharges. Localization arguments allow to map the problem to a calculation in bosonic two-dimensional Yang-Mills theory. In turn, this can be reduced to computing correlators in certain Gaussian multi-matrix models. We focus on the correlation function of a Wilson loop and two local operators, and solve the corresponding three-matrix model exactly in the planar limit. We compare the strong coupling behavior to string theory in AdS_5xS^5, finding precise agreement. We pay particular attention to the case in which the local operators have large R-charge J \sim sqrt{lambda} at strong coupling.Comment: 50 pages, 9 figures. v2: minor changes, references adde

On the reflection of magnon bound states

We investigate the reflection of two-particle bound states of a free open string in the light-cone AdS_5 x S^5 string sigma model, for large angular momentum J=J_56 and ending on a D7 brane which wraps the entire AdS_5 and a maximal S^3 of S^5. We use the superspace formalism to analyse fundamental and two-particle bound states in the cases of supersymmetry-preserving and broken-supersymmetry boundaries. We find the boundary S-matrices corresponding to bound states both in the bulk and on the boundary.Comment: 35 pages, v2: few typos and ref corrected, accepted for publication in JHE

The generalized cusp in ABJ(M) N = 6 Super Chern-Simons theories

We construct a generalized cusped Wilson loop operator in N = 6 super Chern-Simons-matter theories which is locally invariant under half of the supercharges. It depends on two parameters and interpolates smoothly between the 1/2 BPS line or circle and a pair of antiparallel lines, representing a natural generalization of the quark-antiquark potential in ABJ(M) theories. For particular choices of the parameters we obtain 1/6 BPS configurations that, mapped on S^2 by a conformal transformation, realize a three-dimensional analogue of the wedge DGRT Wilson loop of N = 4. The cusp couples, in addition to the gauge and scalar fields of the theory, also to the fermions in the bifundamental representation of the U(N)xU(M) gauge group and its expectation value is expressed as the holonomy of a suitable superconnection. We discuss the definition of these observables in terms of traces and the role of the boundary conditions of fermions along the loop. We perform a complete two-loop analysis, obtaining an explicit result for the generalized cusp at the second non-trivial order, from which we read off the interaction potential between heavy 1/2 BPS particles in the ABJ(M) model. Our results open the possibility to explore in the three-dimensional case the connection between localization properties and integrability, recently advocated in D = 4.Comment: 53 pages, 10 figures, added references, this is the version appeared on JHE

The secret symmetries of the AdS/CFT reflection matrices

We find new twisted Yangian symmetries of the AdS/CFT reflection matrices for the Y=0 maximal giant graviton and D5-brane. These new symmetries originate from the known secret symmetries of the Yangian symmetry of the AdS/CFT S-matrix.Comment: 9 pages, v2: published versio

The Role of Dimensionality on the Optoelectronic Properties of Oxide and Halide Perovskites, and their Halide Derivatives

Funder: Kim and Juliana Silverman Research FellowshipFunder: Graduate Assistance in Areas of National NeedAbstract: Halide perovskite semiconductors have risen to prominence in photovoltaics and light‐emitting diodes (LEDs), but traditional oxide perovskites, which overcome the stability limitations of their halide counterparts, have also recently witnessed a rise in potential as solar absorbers. One of the many important factors underpinning these developments is an understanding of the role of dimensionality on the optoelectronic properties and, consequently, on the performance of the materials in photovoltaics and LEDs. This review article examines the role of structural and electronic dimensionality, as well as form factor, in oxide and halide perovskites, and in lead‐free alternatives to halide perovskites. Insights into how dimensionality influences the band gap, stability, charge‐carrier transport, recombination processes and defect tolerance of the materials, and the impact these parameters have on device performance are brought forward. Particular emphasis is placed on carrier/exciton‐phonon coupling, which plays a significant role in the materials considered, owing to their soft lattices and composition of heavy elements, and becomes more prominent as dimensionality is reduced. It is finished with a discussion of the implications on the classes of materials future efforts should focus on, as well as the key questions that need to be addressed

Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort

Data from epidemiological and animal model studies suggest that nutrition during pregnancy may affect the health status of subsequent generations. These transgenerational effects are now being explained by disruptions at the level of the epigenetic machinery. Besides in vitro environmental exposures, the possible impact on the reprogramming of methylation profiles at imprinted genes at a much earlier time point, such as during spermatogenesis or oogenesis, has not previously been considered. In this study, our aim was to determine associations between preconceptional obesity and DNA methylation profiles in the offspring, particularly at the differentially methylated regions (DMRs) of the imprinted Insulin-like Growth Factor 2 (IGF2) gene

Orally active antischistosomal early leads identified from the open access malaria box.

BACKGROUND: Worldwide hundreds of millions of schistosomiasis patients rely on treatment with a single drug, praziquantel. Therapeutic limitations and the threat of praziquantel resistance underline the need to discover and develop next generation drugs. METHODOLOGY: We studied the antischistosomal properties of the Medicines for Malaria Venture (MMV) malaria box containing 200 diverse drug-like and 200 probe-like compounds with confirmed in vitro activity against Plasmodium falciparum. Compounds were tested against schistosomula and adult Schistosoma mansoni in vitro. Based on in vitro performance, available pharmacokinetic profiles and toxicity data, selected compounds were investigated in vivo. PRINCIPAL FINDINGS: Promising antischistosomal activity (IC50: 1.4-9.5 µM) was observed for 34 compounds against schistosomula. Three compounds presented IC50 values between 0.8 and 1.3 µM against adult S. mansoni. Two promising early leads were identified, namely a N,N'-diarylurea and a 2,3-dianilinoquinoxaline. Treatment of S. mansoni infected mice with a single oral 400 mg/kg dose of these drugs resulted in significant worm burden reductions of 52.5% and 40.8%, respectively. CONCLUSIONS/SIGNIFICANCE: The two candidates identified by investigating the MMV malaria box are characterized by good pharmacokinetic profiles, low cytotoxic potential and easy chemistry and therefore offer an excellent starting point for antischistosomal drug discovery and development

Integrable Wilson loops

The generalized quark-antiquark potential of N=4 supersymmetric Yang-Mills theory on S^3 x R calculates the potential between a pair of heavy charged particles separated by an arbitrary angle on S^3 and also an angle in flavor space. It can be calculated by a Wilson loop following a prescribed path and couplings, or after a conformal transformation, by a cusped Wilson loop in flat space, hence also generalizing the usual concept of the cusp anomalous dimension. In AdS_5 x S^5 this is calculated by an infinite open string. I present here an open spin-chain model which calculates the spectrum of excitations of such open strings. In the dual gauge theory these are cusped Wilson loops with extra operator insertions at the cusp. The boundaries of the spin-chain introduce a non-trivial reflection phase and break the bulk symmetry down to a single copy of psu(2|2). The dependence on the two angles is captured by the two embeddings of this algebra into \psu(2|2)^2, i.e., by a global rotation. The exact answer to this problem is conjectured to be given by solutions to a set of twisted boundary thermodynamic Bethe ansatz integral equations. In particular the generalized quark-antiquark potential or cusp anomalous dimension is recovered by calculating the ground state energy of the minimal length spin-chain, with no sites. It gets contributions only from virtual particles reflecting off the boundaries. I reproduce from this calculation some known weak coupling perturtbative results.Comment: 40 pages, 11 figures; v2-some formulas corrected, results unchange

Quantum Spectral Curve at Work: From Small Spin to Strong Coupling in N=4 SYM

We apply the recently proposed quantum spectral curve technique to the study of twist operators in planar N=4 SYM theory. We focus on the small spin expansion of anomalous dimensions in the sl(2) sector and compute its first two orders exactly for any value of the 't Hooft coupling. At leading order in the spin S we reproduced Basso's slope function. The next term of order S^2 structurally resembles the Beisert-Eden-Staudacher dressing phase and takes into account wrapping contributions. This expansion contains rich information about the spectrum of local operators at strong coupling. In particular, we found a new coefficient in the strong coupling expansion of the Konishi operator dimension and confirmed several previously known terms. We also obtained several new orders of the strong coupling expansion of the BFKL pomeron intercept. As a by-product we formulated a prescription for the correct analytical continuation in S which opens a way for deriving the BFKL regime of twist two anomalous dimensions from AdS/CFT integrability.Comment: 53 pages, references added; v3: due to a typo in the coefficients C_2 and D_2 on page 29 we corrected the rational part of the strong coupling predictions in equations (1.5-6), (6.22-24), (6.27-30) and in Table

Reflection algebra, Yangian symmetry and bound-states in AdS/CFT

We present the `Heisenberg picture' of the reflection algebra by explicitly constructing the boundary Yangian symmetry of an AdS/CFT superstring which ends on a boundary with non-trivial degrees of freedom and which preserves the full bulk Lie symmetry algebra. We also consider the spectrum of bulk and boundary states and some automorphisms of the underlying algebras.Comment: 31 page, 8 figures. Updated versio