495 research outputs found

    Gypsy-travellers/Roma and social integration: childhood, habitus and the 'we-I balance'

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    Norbert Elias provides a very useful theoretical framework for understanding long-term changes in childhood-adulthood relations at the societal level. Key processes central to this theorization include: the increasing separation of the social worlds of children and adults; the increasing distance between childhood and adulthood; the partial defunctionalisation of the family; the civilizing of parents; changes in the "we-I balance" towards the "I"; and the gradual conversion of social constraints into self-restraints. Yet variable trajectories are under-developed in Elias' work: the differing nature of these interrelated social processes for different "outsider" groups in society were not systematically addressed by him. However, this paper argues that Elias's theories on childhood do provide us with a very useful conceptual framework from which to understand these variable trajectories. It applies his theories on childhood and individualization to Gypsy-Traveller/Roma groups in Europe. The paper argues that the above processes differ markedly for many groups and, coupled with the existence of a very strong group orientation and long-term stigmatisation, are central to accounting for their relative lack of social integration. That is, differing processes of childhood and family socialisation are crucial in explaining how Gypsy-Traveller/Roma groups have maintained their own group identity and cultural continuity under intense pressures to assimilation and conformity

    On-line monitoring for operational control of water distribution networks

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    This work concerns the concept of on-line monitoring and control for water distribution networks. The problem is simple to state. It is to produce a robust scheme that can continuously provide reliable information about the state of a water network in real-time and over extended periods with the minimum of operator interaction. This thesis begins by proposing a relational database schema to store 'asset data' for a water distribution network and asserts that asset data should be used as a basis for network modelling. It presents a topology determination algorithm and a demand allocation algorithm so that a mathematical model can be maintained on-line, with operator intervention only necessary to record the change of state of non-telemetered plant items such as switch valves. In order to provide a reliable on-line model of a distribution system, an investigation has been carried out into the methods available for modelling water networks and in particular, the inherent assumptions in these practices. As a result, new methods have been produced for network element combination and for demand allocation. These methods both support the database approach and enhance the robustness of the system by increasing the range of conditions for which the resulting model is applicable. For operational control, a new technique for state estimation is proposed which combines the advantages of weighted least squares estimation with those of weighted least absolute values estimation. The proposed method is tolerant to transducer noise and to the presence of large measurement outliers. However, the method is not limited in its application to water networks and could be applied to a wide range of measurement processing problems. Lastiy, a new topology based method for processing suspect data is proposed which can determine the likely causes using identifying templates. Thus a new approach to water network monitoring is proposed via an overall framework into which the various tasks of on-line operational control can be integrated. The exercise has resulted in the production of a core software package which could realistically be used in a control room to facilitate reliable operational control of water distribution systems

    Summary report on the geology of the proposed HS2 Route (3) in the Chesham and Amersham Constituency

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    This brief open-file report summarises the information available from the British Geological Survey (BGS), a component body of the Natural Environment Research Council (NERC), on the geology, hydrogeology and potential geological hazards of the proposed HS2 Route 3 within the Chesham and Amersham Constituency, and surrounding areas. The report summarises the geology and hydrogeology of the district and highlights geological and hydrogeological considerations that may need further investigation along the route. Further review and analysis of existing data and possible field investigation would be required to confirm details of the local geology. The report was requested by Mrs Cheryl Gillan MP following a meeting with Dr Martin Smith, Head of Geology & Landscapes programme, on Monday 16th May 2011 at the offices of the Secretary of State for Wales in Whitehall

    The power of group stigmatisation: wealthy Roma, urban space and strategies of defence in post-socialist Romania

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    Recent research on Roma stigmatisation has tended to focus on the marginal socioeconomic and spatial position of Roma within European societies with poverty, persistent inequalities and sub-standard housing conditions (e.g. ghettoization) emphasised in highlighting their differential treatment. Central to such accounts are group images and stereotypes of Roma as "benefit scroungers" and/or "beggars" lacking notions of self-restraint and social responsibility. This body of research is hugely important in contributing to an understanding of the complex dynamics of marginalization and stigmatisation for poor Roma households. Yet not all Roma are characterised by poverty and economic hardship. This paper explores the neglected experiences of wealthy Roma within urban spaces in Romania. It draws on empirical evidence from interviews with Roma families, leaders and local authorities. Our analysis exposes the way in which Roma are vehemently stigmatised regardless of their economic position or housing circumstances and highlights deep, underlying sentiments towards them within wider Romanian society. We critique Wacquant's concept of territorial stigmatisation in applying it to wealthy groups outwith typical areas of relegation (e.g. Roma ghettos) within the specific urban context of post-socialist Romania. While our analysis points to the internalization of stigma, we also identify distinct defensive strategies employed by wealthy Roma in countering and avoiding stigmatisation. We suggest that a focus on the neglected spaces of wealthy Roma groups can: facilitate a more comprehensive understanding of the distinct urban power relations that shape Roma stigmatisation; reveal how this long-term process has recently been accentuated within Europe alongside a more overt populist, anti-Roma political agenda; and contribute to the development and refinement of Wacquant’s thesis

    The Opinion-Policy Nexus in Europe and the Role of Political Institutions

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    A strong link between citizen preferences and public policy is one of the key goals and criteria of democratic governance. Yet, our knowledge about the extent to which public policies on specific issues are in line with citizen preferences in Europe is limited. This article reports on the first study of the link between public opinion and public policy that covers a large and diverse sample of concrete public policy issues in 31 European democracies. The findings demonstrate a strong positive relationship and a substantial degree of congruence between public opinion and the state of public policy. Also examined is whether political institutions, including electoral systems and the horizontal and vertical division of powers, influence the opinion‐policy link. The evidence for such effects is very limited, which suggests that the same institutions might affect policy representation in countervailing ways through different mechanisms

    MTORC1 promotes T-bet phosphorylation to regulate Th1 differentiation

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    CD4+ T cells lacking the mTORC1 activator Rheb fail to secrete IFN-g under Th1 polarizing conditions. We hypothesized that this phenotype is due to defects in regulation of the canonical Th1 transcription factor T-bet at the level of protein phosphorylation downstream of mTORC1. To test this hypothesis, we employed targeted mass-spectrometry proteomic analysis-multiple reaction monitoring mass spectrometry. We used this method to detect and quantify predicted phosphopeptides derived from T-bet. By analyzing activated murine wild-type and Rheb-deficient CD4+ T cells, as well as murine CD4+ T cells activated in the presence of rapamycin, a pharmacologic inhibitor of mTORC1, we were able to identify six T-bet phosphorylation sites. Five of these are novel, and four sites are consistently dephosphorylated in both Rheb-deficient CD4+ T cells and T cells treated with rapamycin, suggesting mTORC1 signaling controls their phosphorylation. Alanine mutagenesis of each of the six phosphorylation sites was tested for the ability to impair IFN-g expression. Single phosphorylation site mutants still support induction of IFN-g expression; however, simultaneous mutation of three of the mTORC1-dependent sites results in significantly reduced IFN-g expression. The reduced activity of the triple mutant T-bet is associated with its failure to recruit chromatin remodeling complexes to the Ifng gene promoter. These results establish a novel mechanism by which mTORC1 regulates Th1 differentiation, through control of T-bet phosphorylation

    Pilot scale microwave sorting of porphyry copper ores: Part 2: pilot plant trials

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    An experimental pilot plant was constructed, commissioned and operated at a major porphyry copper mine to understand the challenges of microwave infrared thermal (MW-IRT) sorting at scale and to compare batch laboratory performance with pilot-scale continuous sortability performance. A method was developed to define the 95% confidence intervals on pilot plant operating windows from experiments on 50 to 150 fragments performed in a laboratory based replica of the pilot scale microwave treatment system. It appeared that the laboratory testing methodology predicted the sortability of the ores fairly well. For the 11 ore types and three size classes (-76.2+50.8mm, -50.8+25.4mm and -25.4+12.7mm) tested over 233 pilot plant experiments, approximately 42% of the better optimised pilot plant runs predicted copper recovery to within ±5% copper recovery and approximately 84% of the runs to within ±10%. These figures were improved to approximately 50% predicted to within ±5% and approximately 90% to within ±10% if the -25.4+12.7mm size class was omitted. It was demonstrated that laboratory testing better predicted pilot plant sorting performance and provided a narrower operating window when a larger sample size (>50 fragments) was considered due to improved representivity. It is, therefore, fully expected that better predictions would result from larger laboratory sample sizes than those tested during any future testing campaigns. To date, approximately 15,500 tonnes of ore has been processed through the pilot-scale test facility, generating significant engineering know-how and demonstrating MW-IRT sorting at a scale in the order of that required by the mining industry

    Hyaluronan fragments induce IFNβ via a novel TLR4-TRIF-TBK1-IRF3- dependent pathway

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    Background: The extracellular matrix plays a critical role in insuring tissue integrity and water homeostasis. However, breakdown products of the extracellular matrix have emerged as endogenous danger signals, designed to rapidly activate the immune system against a potential pathogen breach. Type I interferons play a critical role in the immune response against viral infections. In the lungs, hylauronan (HA) exists as a high molecular weight, biologically inert extracellular matrix component that is critical for maintaining lung function. When lung tissue is injured, HA is broken down into lower molecular weight fragments that alert the immune system to the breach in tissue integrity by activating innate immune responses. HA fragments are known to induce inflammatory gene expression via TLR-MyD88-dependent pathways. Methods. Primary peritoneal macrophages from C57BL/6 wild type, TLR4 null, TLR3 null, MyD88 null, and TRIF null mice as well as alveolar and peritoneal macrophage cell lines were stimulated with HA fragments and cytokine production was assessed by rt-PCR and ELISA. Western blot analysis for IRF3 was preformed on cell lysates from macrophages stimulate with HA fragments. Results: We demonstrate for the first time that IFNβ is induced in murine macrophages by HA fragments. We also show that HA fragments induce IFNβ using a novel pathway independent of MyD88 but dependent on TLR4 via TRIF and IRF-3. Conclusions: Overall our findings reveal a novel signaling pathway by which hyaluronan can modulate inflammation and demonstrate the ability of hyaluronan fragments to induce the expression of type I interferons in response to tissue injury even in the absence of viral infection. This is independent of the pathway of the TLR2-MyD88 used by these matrix fragments to induce inflammatory chemokines. Thus, LMW HA may be modifying the inflammatory milieu simultaneously via several pathways

    Social Network Analysis: Recent Achievements and Current Controversies

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    Network analysis has grown rapidly over the past two decades, but criticisms of the approach have increased as well This article focuses on several accomplishments and unresolved problems of the network approach In the first section. I illustrate the value of the network model in several substantive areas. focusing on studies of centrahty and power, network subgroups, and interorganizational relations I then discuss three issues over which the approach has provoked controversy the relation between network analysis and rational choice theory; the role of norms and culture, and the question of human agency I conclude with some examples of how network theorists are addressing these problemsPeer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68023/2/10.1177_000169939403700403.pd
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