Effect of age, sex and gender on pain sensitivity: A narrative review

© 2017 Eltumi And Tashani. Introduction: An increasing body of literature on sex and gender differences in pain sensitivity has been accumulated in recent years. There is also evidence from epidemiological research that painful conditions are more prevalent in older people. The aim of this narrative review is to critically appraise the relevant literature investigating the presence of age and sex differences in clinical and experimental pain conditions. Methods: A scoping search of the literature identifying relevant peer reviewed articles was conducted on May 2016. Information and evidence from the key articles were narratively described and data was quantitatively synthesised to identify gaps of knowledge in the research literature concerning age and sex differences in pain responses. Results: This critical appraisal of the literature suggests that the results of the experimental and clinical studies regarding age and sex differences in pain contain some contradictions as far as age differences in pain are concerned. While data from the clinical studies are more consistent and seem to point towards the fact that chronic pain prevalence increases in the elderly findings from the experimental studies on the other hand were inconsistent, with pain threshold increasing with age in some studies and decreasing with age in others. Conclusion: There is a need for further research using the latest advanced quantitative sensory testing protocols to measure the function of small nerve fibres that are involved in nociception and pain sensitivity across the human life span. Implications: Findings from these studies should feed into and inform evidence emerging from other types of studies (e.g. brain imaging technique and psychometrics) suggesting that pain in the older humans may have unique characteristics that affect how old patients respond to intervention

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

ZTF SN Ia DR2: The secondary maximum in Type Ia supernovae

International audienceType Ia supernova (SN Ia) light curves have a secondary maximum that exists in the $r$, $i$, and near-infrared filters. The secondary maximum is relatively weak in the $r$ band, but holds the advantage that it is accessible, even at high redshift. We used Gaussian Process fitting to parameterise the light curves of 893 SNe Ia from the Zwicky Transient Facility's (ZTF) second data release (DR2), and we were able to extract information about the timing and strength of the secondary maximum. We found $>5\sigma$ correlations between the light curve decline rate ($\Delta m_{15}(g)$) and the timing and strength of the secondary maximum in the $r$ band. Whilst the timing of the secondary maximum in the $i$ band also correlates with $\Delta m_{15}(g)$, the strength of the secondary maximum in the $i$ band shows significant scatter as a function of $\Delta m_{15}(g)$. We found that the transparency timescales of 97 per cent of our sample are consistent with double detonation models, and that SNe Ia with small transparency timescales ($<$ 32 d) reside predominantly in locally red environments. We measured the total ejected mass for the normal SNe Ia in our sample using two methods, and both were consistent with medians of $1.3\ \pm \ 0.3$ and $1.2\ \pm\ 0.2$ solar masses. We find that the strength of the secondary maximum is a better standardisation parameter than the SALT light curve stretch ($x_1$). Finally, we identified a spectral feature in the $r$ band as Fe II, which strengthens during the onset of the secondary maximum. The same feature begins to strengthen at $<$ 3 d post maximum light in 91bg-like SNe. Finally, the correlation between $x_1$ and the strength of the secondary maximum was best fit with a broken line, with a split at $x_1^0\ =\ -0.5\ \pm\ 0.2$, suggestive of the existence of two populations of SNe Ia

ZTF SN Ia DR2: The secondary maximum in Type Ia supernovae

International audienceType Ia supernova (SN Ia) light curves have a secondary maximum that exists in the $r$, $i$, and near-infrared filters. The secondary maximum is relatively weak in the $r$ band, but holds the advantage that it is accessible, even at high redshift. We used Gaussian Process fitting to parameterise the light curves of 893 SNe Ia from the Zwicky Transient Facility's (ZTF) second data release (DR2), and we were able to extract information about the timing and strength of the secondary maximum. We found $>5\sigma$ correlations between the light curve decline rate ($\Delta m_{15}(g)$) and the timing and strength of the secondary maximum in the $r$ band. Whilst the timing of the secondary maximum in the $i$ band also correlates with $\Delta m_{15}(g)$, the strength of the secondary maximum in the $i$ band shows significant scatter as a function of $\Delta m_{15}(g)$. We found that the transparency timescales of 97 per cent of our sample are consistent with double detonation models, and that SNe Ia with small transparency timescales ($<$ 32 d) reside predominantly in locally red environments. We measured the total ejected mass for the normal SNe Ia in our sample using two methods, and both were consistent with medians of $1.3\ \pm \ 0.3$ and $1.2\ \pm\ 0.2$ solar masses. We find that the strength of the secondary maximum is a better standardisation parameter than the SALT light curve stretch ($x_1$). Finally, we identified a spectral feature in the $r$ band as Fe II, which strengthens during the onset of the secondary maximum. The same feature begins to strengthen at $<$ 3 d post maximum light in 91bg-like SNe. Finally, the correlation between $x_1$ and the strength of the secondary maximum was best fit with a broken line, with a split at $x_1^0\ =\ -0.5\ \pm\ 0.2$, suggestive of the existence of two populations of SNe Ia

ZTF SN Ia DR2: Simulations and volume limited sample

International audienceType Ia supernovae (SNe Ia) constitute an historical probe to derive cosmological parameters through the fit of the Hubble-Lemaître diagram, i.e. SN Ia distance modulus versus their redshift. In the era of precision cosmology, realistic simulation of SNe Ia for any survey entering in an Hubble-Lemaître diagram is a key tool to address observational systematics, like Malmquist bias. As the distance modulus of SNe Ia is derived from the fit of their light-curves, a robust simulation framework is required. In this paper, we present the performances of the simulation framework skysurvey to reproduce the the Zwicky Transient Facility (ZTF) SN Ia DR2 covering the first phase of ZTF running from April 2018 up to December 2020. The ZTF SN Ia DR2 sample correspond to almost 3000 classified SNe Ia of cosmological quality. First, a targeted simulation of the ZTF SN Ia DR2 was carried on to check the validity of the framework after some fine tuning of the observing conditions and instrument performance. Then, a realistic simulation has been run using observing ZTF logs and ZTF SN Ia DR2 selection criteria on simulated light-curves to demonstrate the ability of the simulation framework to match the ZTF SN Ia DR2 sample. Furthermore a redshift dependency of SALT2 light-curve parameters (stretch and colour) was conducted to deduce a volume limited sample, i.e. an unbiased SNe Ia sample, characterized with $z_{lim} \leq 0.06$. This volume limited sample of about 1000 SNe Ia is unique to carry on new analysis on standardization procedure with a precision never reached (those analysis are presented in companion papers)

ZTF SN Ia DR2: Simulations and volume limited sample

International audienceType Ia supernovae (SNe Ia) constitute an historical probe to derive cosmological parameters through the fit of the Hubble-Lemaître diagram, i.e. SN Ia distance modulus versus their redshift. In the era of precision cosmology, realistic simulation of SNe Ia for any survey entering in an Hubble-Lemaître diagram is a key tool to address observational systematics, like Malmquist bias. As the distance modulus of SNe Ia is derived from the fit of their light-curves, a robust simulation framework is required. In this paper, we present the performances of the simulation framework skysurvey to reproduce the the Zwicky Transient Facility (ZTF) SN Ia DR2 covering the first phase of ZTF running from April 2018 up to December 2020. The ZTF SN Ia DR2 sample correspond to almost 3000 classified SNe Ia of cosmological quality. First, a targeted simulation of the ZTF SN Ia DR2 was carried on to check the validity of the framework after some fine tuning of the observing conditions and instrument performance. Then, a realistic simulation has been run using observing ZTF logs and ZTF SN Ia DR2 selection criteria on simulated light-curves to demonstrate the ability of the simulation framework to match the ZTF SN Ia DR2 sample. Furthermore a redshift dependency of SALT2 light-curve parameters (stretch and colour) was conducted to deduce a volume limited sample, i.e. an unbiased SNe Ia sample, characterized with $z_{lim} \leq 0.06$. This volume limited sample of about 1000 SNe Ia is unique to carry on new analysis on standardization procedure with a precision never reached (those analysis are presented in companion papers)

ZTF SN Ia DR2: Impact of the galaxy cluster environment on the stretch distribution of Type Ia supernovae

International audienceUnderstanding the impact of the astrophysical environment on Type Ia supernova (SN Ia) properties is crucial to minimize systematic uncertainties in cosmological analyses based on this probe. We investigate the dependence of the SN Ia SALT2.4 light-curve stretch on the distance from their nearest galaxy cluster to study a potential effect of the intracluster medium (ICM) environment on SN Ia intrinsic properties. We use the largest SN Ia sample to date and cross-match it with existing X-ray, Sunyaev-Zel'dovich, and optical cluster catalogs in order to study the dependence between stretch and distance to the nearest detected cluster from each SN Ia. We model the underlying stretch distribution with a Gaussian mixture with relative amplitudes that depend on redshift and cluster-centric distance. We find a significant improvement of the fit quality of the stretch distribution if we include the distance-dependant term in the model with a variation of the Akaike information criterion $\rm{\Delta AIC} = -10.2$. Because of the known correlation between galaxy age and distance from cluster center, this supports previous evidence that the age of the stellar population is the underlying driver of the bimodial shape of the SN Ia stretch distribution. We further compute the evolution of the fraction of quenched galaxies as a function of distance with respect to cluster center from our best-fit model of the SNe Ia stretch distribution and compare it to previous results obtained from $H\alpha$ line measurements, optical broadband photometry, and simulations. We find our estimate to be compatible with these results. The results of this work indicate that SNe Ia searches at high redshift targeted towards clusters to maximize detection probability should be considered with caution as the stretch distribution of the detected sample would be strongly biased towards the old sub-population of SNe Ia

ZTF SN Ia DR2: Impact of the galaxy cluster environment on the stretch distribution of Type Ia supernovae

International audienceUnderstanding the impact of the astrophysical environment on Type Ia supernova (SN Ia) properties is crucial to minimize systematic uncertainties in cosmological analyses based on this probe. We investigate the dependence of the SN Ia SALT2.4 light-curve stretch on the distance from their nearest galaxy cluster to study a potential effect of the intracluster medium (ICM) environment on SN Ia intrinsic properties. We use the largest SN Ia sample to date and cross-match it with existing X-ray, Sunyaev-Zel'dovich, and optical cluster catalogs in order to study the dependence between stretch and distance to the nearest detected cluster from each SN Ia. We model the underlying stretch distribution with a Gaussian mixture with relative amplitudes that depend on redshift and cluster-centric distance. We find a significant improvement of the fit quality of the stretch distribution if we include the distance-dependant term in the model with a variation of the Akaike information criterion $\rm{\Delta AIC} = -10.2$. Because of the known correlation between galaxy age and distance from cluster center, this supports previous evidence that the age of the stellar population is the underlying driver of the bimodial shape of the SN Ia stretch distribution. We further compute the evolution of the fraction of quenched galaxies as a function of distance with respect to cluster center from our best-fit model of the SNe Ia stretch distribution and compare it to previous results obtained from $H\alpha$ line measurements, optical broadband photometry, and simulations. We find our estimate to be compatible with these results. The results of this work indicate that SNe Ia searches at high redshift targeted towards clusters to maximize detection probability should be considered with caution as the stretch distribution of the detected sample would be strongly biased towards the old sub-population of SNe Ia