1,109 research outputs found
Patient Self-Management and Tracking A European Experience
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Diffusion-Weighted MRI: Distinction of Skull Base Chordoma from Chondrosarcoma
BACKGROUND AND PURPOSE: Chordoma and chondrosarcoma of the skull base are rare tumors with overlapping presentations and anatomic imaging features but different prognoses. We hypothesized that these tumors might be distinguished by using diffusion-weighted MR imaging. MATERIALS AND METHODS: We retrospectively reviewed 19 patients with pathologically confirmed chordoma or chondrosarcoma who underwent both conventional and diffusion-weighted MR imaging. Differences in distributions of ADC were assessed by the Kruskal-Wallis test. Associations between histopathologic diagnosis and conventional MR imaging features (T2 signal intensity, contrast enhancement, and tumor location) were assessed with the Fisher exact test. RESULTS: Chondrosarcoma was associated with the highest mean ADC value (2051 ± 261 × 10−6 mm2/s) and was significantly different from classic chordoma (1474 ± 117 × 10−6 mm2/s) and poorly differentiated chordoma (875 ± 100 × 10−6 mm2/s) (P CONCLUSIONS: Diffusion-weighted MR imaging may be useful in assessing clival tumors, particularly in differentiating chordoma from chondrosarcoma. A prospective study of a larger cohort will be required to determine the value of ADC in predicting histopathologic diagnosis
Low Background Micromegas in CAST
Solar axions could be converted into x-rays inside the strong magnetic field
of an axion helioscope, triggering the detection of this elusive particle. Low
background x-ray detectors are an essential component for the sensitivity of
these searches. We report on the latest developments of the Micromegas
detectors for the CERN Axion Solar Telescope (CAST), including technological
pathfinder activities for the future International Axion Observatory (IAXO).
The use of low background techniques and the application of discrimination
algorithms based on the high granularity of the readout have led to background
levels below 10 counts/keV/cm/s, more than a factor 100 lower than
the first generation of Micromegas detectors. The best levels achieved at the
Canfranc Underground Laboratory (LSC) are as low as 10
counts/keV/cm/s, showing good prospects for the application of this
technology in IAXO. The current background model, based on underground and
surface measurements, is presented, as well as the strategies to further reduce
the background level. Finally, we will describe the R&D paths to achieve
sub-keV energy thresholds, which could broaden the physics case of axion
helioscopes.Comment: 6 pages, 3 figures, Large TPC Conference 2014, Pari
Potential for Supernova Neutrino Detection in MiniBooNE
The MiniBooNE detector at Fermilab is designed to search for oscillation appearance at and to make a
decisive test of the LSND signal. The main detector (inside a veto shield) is a
spherical volume containing 0.680 ktons of mineral oil. This inner volume,
viewed by 1280 phototubes, is primarily a \v{C}erenkov medium, as the
scintillation yield is low. The entire detector is under a 3 m earth
overburden. Though the detector is not optimized for low-energy (tens of MeV)
events, and the cosmic-ray muon rate is high (10 kHz), we show that MiniBooNE
can function as a useful supernova neutrino detector. Simple trigger-level cuts
can greatly reduce the backgrounds due to cosmic-ray muons. For a canonical
Galactic supernova at 10 kpc, about 190 supernova
events would be detected. By adding MiniBooNE to the international network of
supernova detectors, the possibility of a supernova being missed would be
reduced. Additionally, the paths of the supernova neutrinos through Earth will
be different for MiniBooNE and other detectors, thus allowing tests of
matter-affected mixing effects on the neutrino signal.Comment: Added references, version to appear in PR
Time-ordering and a generalized Magnus expansion
Both the classical time-ordering and the Magnus expansion are well-known in
the context of linear initial value problems. Motivated by the noncommutativity
between time-ordering and time derivation, and related problems raised recently
in statistical physics, we introduce a generalization of the Magnus expansion.
Whereas the classical expansion computes the logarithm of the evolution
operator of a linear differential equation, our generalization addresses the
same problem, including however directly a non-trivial initial condition. As a
by-product we recover a variant of the time ordering operation, known as
T*-ordering. Eventually, placing our results in the general context of
Rota-Baxter algebras permits us to present them in a more natural algebraic
setting. It encompasses, for example, the case where one considers linear
difference equations instead of linear differential equations
The angular distribution of the reaction
The reaction is very important for low-energy
( MeV) antineutrino experiments. In this paper we calculate
the positron angular distribution, which at low energies is slightly backward.
We show that weak magnetism and recoil corrections have a large effect on the
angular distribution, making it isotropic at about 15 MeV and slightly forward
at higher energies. We also show that the behavior of the cross section and the
angular distribution can be well-understood analytically for MeV by calculating to , where is the nucleon mass. The
correct angular distribution is useful for separating events from other reactions and detector backgrounds, as well as for
possible localization of the source (e.g., a supernova) direction. We comment
on how similar corrections appear for the lepton angular distributions in the
deuteron breakup reactions and . Finally, in the reaction , the
angular distribution of the outgoing neutrons is strongly forward-peaked,
leading to a measurable separation in positron and neutron detection points,
also potentially useful for rejecting backgrounds or locating the source
direction.Comment: 10 pages, including 5 figure
Bounds on the dipole moments of the tau-neutrino via the process in a 331 model
We obtain limits on the anomalous magnetic and electric dipole moments of the
through the reaction
and in the framework of a 331 model. We consider initial-state radiation, and
neglect and photon exchange diagrams. The results are based on the data
reported by the L3 Collaboration at LEP, and compare favorably with the limits
obtained in other models, complementing previous studies on the dipole moments.Comment: 13 pages, 4 figures, to be published in The European Physical J C.
arXiv admin note: substantial text overlap with arXiv:hep-ph/060527
Towards Practical Runtime Verification and Validation of Self-Adaptive Software Systems
International audienceSoftware validation and verification (V&V) ensures that software products satisfy user requirements and meet their expected quality attributes throughout their lifecycle. While high levels of adaptation and autonomy provide new ways for software systems to operate in highly dynamic environments, developing certifiable V&V methods for guaranteeing the achievement of self-adaptive software goals is one of the major challenges facing the entire research field. In this chapter we (i) analyze fundamental challenges and concerns for the development of V&V methods and techniques that provide certifiable trust in self-adaptive and self-managing systems; and (ii) present a proposal for including V&V operations explicitly in feedback loops for ensuring the achievement of software self-adaptation goals. Both of these contributions provide valuable starting points for V&V researchers to help advance this field
Post-ischaemic silencing of p66Shc reduces ischaemia/reperfusion brain injury and its expression correlates to clinical outcome in stroke
In light of the limited repertoire of therapeutical options available for the treatment of ischaemic stroke, the identification of novel potential targets is vital; in this respect, the present study demonstrates that the adaptor protein p66Shc holds this potential as an adjunct therapy to thrombolysis. Post-ischaemic silencing of p66Shc protein yielded beneficial effects in a mouse model of I/R brain injury underlying an interesting translational perspective for this target protein. Further, in proof-of-principle clinical experiments using PBMs, we demonstrate that p66Shc gene expression is transiently increased and that its levels correlate to short-term outcome in ischaemic stroke patients. Although these latter experiments are not directly relevant to the experiments performed in mice and in human endothelial cells, they provide novel important information about p66Shc regulation in stroke patients and set the basis for further investigations aimed at assessing the potential for p66Shc to become a novel therapeutic target as an adjunct of thrombolysis for the management of acute ischaemic strok
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