Robust control for independently rotating wheelsets on a railway vehicle using practical sensors

This paper presents the development of H-infinity control strategy for the active steering of railway vehicles with independently rotating wheelsets. The primary objective of the active steering is to stabilize the wheelset and to provide a guidance control. Some fundamental problems for active steering are addressed in the study. The developed controller is able to maintain stability and good performance when parameter variations occur, in particular at the wheel-rail interface. The control is also robust against structured uncertainties that are not included in the model such as actuator dynamics. Furthermore the control design is formulated to use only practical sensors of inertial and speed measurements, as some basic measurements required for active steering such as wheel-rail lateral displacement cannot be easily and economically measured in practice

Template synthesis of dual functional porous MoS2 nanoparticles with photothermal conversion and catalytic properties

Advanced catalysis triggered by photothermal conversion effects has aroused increasing interest due to its huge potential in environmental purification. In this work, we developed a novel approach to the fast degradation of 4 nitrophenol 4 Nip using porous MoS2 nanoparticles as catalysts, which integrate the intrinsic catalytic property of MoS2 with its photothermal conversion capability. Using assembled polystyrene b poly 2 vinylpyridine block copolymers as soft templates, various MoS2 particles were prepared, which exhibited tailored morphologies e.g., pomegranate like, hollow, and open porous structures . The photothermal conversion performance of these featured particles was compared under near infrared NIR light irradiation. Intriguingly, when these porous MoS2 particles were further employed as catalysts for the reduction of 4 Nip, the reaction rate constant was increased by a factor of 1.5 under NIR illumination. We attribute this catalytic enhancement to the open porous architecture and light to heat conversion performance of the MoS2 particles. This contribution offers new opportunities for efficient photothermal assisted catalysis

Molecular dynamics simulation of the order-disorder phase transition in solid NaNO2_2

We present molecular dynamics simulations of solid NaNO$_2$ using pair potentials with the rigid-ion model. The crystal potential surface is calculated by using an \emph{a priori} method which integrates the \emph{ab initio} calculations with the Gordon-Kim electron gas theory. This approach is carefully examined by using different population analysis methods and comparing the intermolecular interactions resulting from this approach with those from the \emph{ab initio} Hartree-Fock calculations. Our numerics shows that the ferroelectric-paraelectric phase transition in solid NaNO$_2$ is triggered by rotation of the nitrite ions around the crystallographical c axis, in agreement with recent X-ray experiments [Gohda \textit{et al.}, Phys. Rev. B \textbf{63}, 14101 (2000)]. The crystal-field effects on the nitrite ion are also addressed. Remarkable internal charge-transfer effect is found.Comment: RevTeX 4.0, 11 figure

Analysis of the correlation between strength and fractal dimension of gravelly soil in debris-flow source areas

peer-reviewedParticle size distribution of gravelly soil plays a crucial role in debris flow initiation. For better understanding the mechanism of debris flow formation, two crucial mechanical property parameters of the gravelly soil are required to be studied meticulously: hydraulic conductivity and strength. With the aim of measuring the composition of the gravelly soil, 182 soil samples were taken from debris flow prone areas. With the aid of a sieve test, the particle size distribution of the samples can be obtained and analyzed. Then fractal theory was employed to compute the fractal dimension of the soil samples. By analyzing the results of sieve test (particle size distribution curves) and the results of the fractal theory calculations, the relationship between fractal dimension and particle size distribution can be explored. The results illustrate that the particle compositions of the gravelly soil tends to remain uniform as the fractal dimension increases. Moreover, as the coarse particle content increases, the fractal dimension decreases. To better understand the formation mechanism of debris flows, direct shear tests were conducted. Subsequently the experimental results were analyzed. By analysis, the following conclusions can be drawn: the soil strength decreases as the fractal dimension increases, and for soils with lower moisture content and identical dry density, a linear relationship between fractal dimension and cohesion force was identified. Moreover, cohesion force and internal friction force both decrease as the fractal dimension increases, but the internal friction angle decreases slightly while the cohesion force decreases greatly. Therefore we concluded that soil strength decreased mainly due to the reduction in cohesion force.PUBLISHEDpeer-reviewe

The Cerenkov effect revisited: from swimming ducks to zero modes in gravitational analogs

We present an interdisciplinary review of the generalized Cerenkov emission of radiation from uniformly moving sources in the different contexts of classical electromagnetism, superfluid hydrodynamics, and classical hydrodynamics. The details of each specific physical systems enter our theory via the dispersion law of the excitations. A geometrical recipe to obtain the emission patterns in both real and wavevector space from the geometrical shape of the dispersion law is discussed and applied to a number of cases of current experimental interest. Some consequences of these emission processes onto the stability of condensed-matter analogs of gravitational systems are finally illustrated.Comment: Lecture Notes at the IX SIGRAV School on "Analogue Gravity" in Como, Italy from May 16th-21th, 201

Omega-3 Index, fish consumption, use of fish oil supplements and first clinical diagnosis of central nervous system demyelination

Higher intakes of omega-3 polyunsaturated fatty acids (n3PUFAs) have been associated with lower MS risk. We aimed to test associations between the Omega-3 Index, blood levels of n3PUFAs, fish oil supplement use, and fish consumption with a first clinical diagnosis of CNS demyelination (FCD). Cases (n = 250) had a higher Omega-3 Index compared with a matched group of controls (n = 471) (average treatment effect (ATE)=0.31, p = 0.047, based on augmented inverse probability weighting). A higher percentage of cases than controls used fish oil supplements (cases=17% vs. controls=10%). We found that Omega-3 Index increased as time between FCD and study interview increased (e.g., at or below median (112 days), based on ATE, mean=5.30, 95% CI 5.08, 5.53; above median, mean=5.90, 95% CI 5.51, 6.30). Fish oil supplement use increased in a similar manner (at or below median (112 days), based on ATE, proportion=0.12, 95% CI 0.06, 0.18; above the median, proportion=0.21, 95% CI 0.14, 0.28). Our results suggest a behaviour change post FCD with increased use of fish oil supplements

Building on Progress Towards Fair Access : annual report 2019

Supplementary Table 3: Anti-epileptic drug use in patients with SYNGAP1 mutations or deletion

Risk of a first clinical diagnosis of central nervous system demyelination in relation to human herpesviruses in the context of Epstein–Barr virus

OnlinePublBackground and purpose: Epstein–Barr virus (EBV) is implicated in multiple sclerosis (MS) risk; evidence for other herpesviruses is inconsistent. Here, we test blood markers of infection with human herpesvirus 6 (HHV-6), varicella zoster virus (VZV), and cytomegalovirus (CMV) as risk factors for a first clinical diagnosis of central nervous system demyelination (FCD) in the context of markers of EBV infection. Methods: In the Ausimmune case–control study, cases had an FCD, and population controls were matched on age, sex, and study region. We quantified HHV-6- and VZVDNA load in whole blood and HHV-6, VZV, and CMV antibodies in serum. Conditional logistic regression tested associations with FCD risk, adjusting for Epstein–Barr nuclear antigen (EBNA) IgG, EBV-DNA load, and other covariates. Results: In 204 FCD cases and 215 matched controls, only HHV-6-DNA load (positive vs. negative) was associated with FCD risk (adjusted odds ratio = 2.20, 95% confidence interval = 1.08–4.46, p= 0.03). Only EBNA IgG and HHV-6-DNA positivity were retained in a predictive model of FCD risk; the combination had a stronger association than either alone. CMV-specific IgG concentration modified the association between an MS riskrelated human leucocyte antigen gene and FCD risk. Six cases and one control had very high HHV-6-DNA load (>1.0 × 106 copies/mL). Conclusions: HHV-6-DNA positivity and high load (possibly due to inherited HHV-6 chromosomal integration) were associated with increased FCD risk, particularly in association with markers of EBV infection. With growing interest in prevention/ management of MS through EBV-related pathways, there should be additional consideration of the role of HHV-6 infection.Robyn M. Lucas, Meav-Lang J. Lay, James Grant, Nicolas Cherbuin, Cheryl S. Toi, Keith Dear, Bruce V. Taylor, Dominic E. Dwyer, Ausimmune Investigator Group, Anne-Louise Ponsonb