Microbial phosphorus pools in a long-term organic farming system in Scott, Saskatchewan

Non-Peer ReviewedOrganic farmers across Saskatchewan face widespread phosphorus (P) shortages. Due to the lack of inputs in organic systems, organic farmers must rely on mechanisms like crop rotation and naturally-occurring arbuscular mycorrhizal fungi (AMF) for plant P supply. Crops that are not colonized by AMF (non-mycorrhizal) can decrease colonization of a following crop. An experiment was carried out to look at varying P pools in four cropping sequences under organic management, and also to determine if mustard (non-mycorrhizal) was delaying the colonization of wheat following it. Soils from the four cropping sequences were measured for inorganic P (Pi), AMF spore density (SD), phospholipid fatty acid analysis (PLFA, for AMF biomarker counts), and alkaline phosphatase activity (ALPase, related to AMF metabolic activity). Plants were measured for AMF colonization and P content and uptake of above-ground biomass. A lack of significant difference in AMF activity indicated that mustard was not depressing colonization. The combination of low Pi levels, no inputs, and crop rotation were most likely creating optimal conditions for AMF colonization

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis

Idiopathic pulmonary fibrosis (IPF) is a fatal disease that is unresponsive to current therapies and characterized by excessive collagen deposition and subsequent fibrosis. While inflammatory cytokines, including interleukin (IL)-6, are elevated in IPF, the molecular mechanisms that underlie this disease are incompletely understood, although the development of fibrosis is believed to depend on canonical transforming growth factor (TGF)-β signalling. We examined bleomycin-induced inflammation and fibrosis in mice carrying a mutation in the shared IL-6 family receptor gp130. Using genetic complementation, we directly correlate the extent of IL-6-mediated, excessive Stat3 activity with inflammatory infiltrates in the lung and the severity of fibrosis in corresponding gp130757F mice. The extent of fibrosis was attenuated in B lymphocyte-deficient gp130757F;µMT−/− compound mutant mice, but fibrosis still occurred in their Smad3−/− counterparts consistent with the capacity of excessive Stat3 activity to induce collagen 1α1 gene transcription independently of canonical TGF-β/Smad3 signalling. These findings are of therapeutic relevance, since we confirmed abundant STAT3 activation in fibrotic lungs from IPF patients and showed that genetic reduction of Stat3 protected mice from bleomycin-induced lung fibrosis

Chalcogenide glasses for photonics device applications

Chalcogenides are compounds formed predominately from one or more of the chalcogen elements; sulphur, selenium and tellurium. Although first studied over fifty years ago, interest in chalcogenide glasses has, over the past few years, increased significantly as glasses, crystals and alloys find new life in a wide range of photonic devices. This chapter begins with an overview of chalcogenide glass compositions, their purification, synthesis and fabrication. Focussing on more novel gallium lanthanum sulphide based chalcogenides, as well as reviewing more established materials such as arsenic trisulphide based glasses we then explore the purification and synthesis of these materials, along with their basic optical and thermal properties. Next the fabrication of these versatile glasses into a variety of forms; including thin films, microspheres and optical fibers is explained. This chapter ends with an overview of representative applications of these exciting optoelectronic materials

Neutrophil Extracellular Traps in COVID-19

In severe cases of coronavirus disease 2019 (COVID-19), viral pneumonia progresses to respiratory failure. Neutrophil extracellular traps (NETs) are extracellular webs of chromatin, microbicidal proteins, and oxidant enzymes that are released by neutrophils to contain infections. However, when not properly regulated, NETs have potential to propagate inflammation and microvascular thrombosis - including in the lungs of patients with acute respiratory distress syndrome. While elevated levels of blood neutrophils predict worse outcomes in COVID-19, the role of NETs has not been investigated. We now report that sera from patients with COVID-19 (n = 50 patients, n = 84 samples) have elevated levels of cell-free DNA, myeloperoxidase(MPO)-DNA, and citrullinated histone H3 (Cit-H3); the latter two are highly specific markers of NETs. Highlighting the potential clinical relevance of these findings, cell-free DNA strongly correlated with acute phase reactants including C-reactive protein, D-dimer, and lactate dehydrogenase, as well as absolute neutrophil count. MPO-DNA associated with both cell-free DNA and absolute neutrophil count, while Cit-H3 correlated with platelet levels. Importantly, both cell-free DNA and MPO-DNA were higher in hospitalized patients receiving mechanical ventilation as compared with hospitalized patients breathing room air. Finally, sera from individuals with COVID-19 triggered NET release from control neutrophils in vitro. In summary, these data reveal high levels of NETs in many patients with COVID-19, where they may contribute to cytokine release and respiratory failure. Future studies should investigate the predictive power of circulating NETs in longitudinal cohorts, and determine the extent to which NETs may be novel therapeutic targets in severe COVID-19

Laser ablation loading of a radiofrequency ion trap

The production of ions via laser ablation for the loading of radiofrequency (RF) ion traps is investigated using a nitrogen laser with a maximum pulse energy of 0.17 mJ and a peak intensity of about 250 MW/cm^2. A time-of-flight mass spectrometer is used to measure the ion yield and the distribution of the charge states. Singly charged ions of elements that are presently considered for the use in optical clocks or quantum logic applications could be produced from metallic samples at a rate of the order of magnitude 10^5 ions per pulse. A linear Paul trap was loaded with Th+ ions produced by laser ablation. An overall ion production and trapping efficiency of 10^-7 to 10^-6 was attained. For ions injected individually, a dependence of the capture probability on the phase of the RF field has been predicted. In the experiment this was not observed, presumably because of collective effects within the ablation plume.Comment: submitted to Appl. Phys. B., special issue on ion trappin

Slow Relaxation in a Constrained Ising Spin Chain: a Toy Model for Granular Compaction

We present detailed analytical studies on the zero temperature coarsening dynamics in an Ising spin chain in presence of a dynamically induced field that favors locally the `-' phase compared to the `+' phase. We show that the presence of such a local kinetic bias drives the system into a late time state with average magnetization m=-1. However the magnetization relaxes into this final value extremely slowly in an inverse logarithmic fashion. We further map this spin model exactly onto a simple lattice model of granular compaction that includes the minimal microscopic moves needed for compaction. This toy model then predicts analytically an inverse logarithmic law for the growth of density of granular particles, as seen in recent experiments and thereby provides a new mechanism for the inverse logarithmic relaxation. Our analysis utilizes an independent interval approximation for the particle and the hole clusters and is argued to be exact at late times (supported also by numerical simulations).Comment: 9 pages RevTeX, 1 figures (.eps

Stationary distributions for diffusions with inert drift

Consider reflecting Brownian motion in a bounded domain in $${\mathbb R^d}$$ that acquires drift in proportion to the amount of local time spent on the boundary of the domain. We show that the stationary distribution for the joint law of the position of the reflecting Brownian motion and the value of the drift vector has a product form. Moreover, the first component is uniformly distributed on the domain, and the second component has a Gaussian distribution. We also consider more general reflecting diffusions with inert drift as well as processes where the drift is given in terms of the gradient of a potential

Compaction of Rods: Relaxation and Ordering in Vibrated, Anisotropic Granular Material

We report on experiments to measure the temporal and spatial evolution of packing arrangements of anisotropic, cylindrical granular material, using high-resolution capacitive monitoring. In these experiments, the particle configurations start from an initially disordered, low-packing-fraction state and under vertical vibrations evolve to a dense, highly ordered, nematic state in which the long particle axes align with the vertical tube walls. We find that the orientational ordering process is reflected in a characteristic, steep rise in the local packing fraction. At any given height inside the packing, the ordering is initiated at the container walls and proceeds inward. We explore the evolution of the local as well as the height-averaged packing fraction as a function of vibration parameters and compare our results to relaxation experiments conducted on spherically shaped granular materials.Comment: 9 pages incl. 7 figure

Overcoming the Impasse in Modern Economics

This document is the Accepted Manuscript version of the following article: Francesca Gagliardi, and David Gindis, 'Overcoming the Impasse in Modern Economics', Competition and Change, Vol. 15 (4): 336-42, November 2011, doi: 10.1179/102452911X13135903675732. Published by SAGE.Peer reviewe