A First-Quantized Formalism for Cosmological Particle Production

We show that the amount of particle production in an arbitrary cosmological background can be determined using only the late-time positive-frequency modes. We don't refer to modes at early times, so there is no need for a Bogolubov transformation. We also show that particle production can be extracted from the Feynman propagator in an auxiliary spacetime. This provides a first-quantized formalism for computing particle production which, unlike conventional Bogolubov transformations, may be amenable to a string-theoretic generalization.Comment: 18 pages, LaTeX; v2: significantly revised for clarity; conclusions unchange

The Volume of the Past Light-Cone and the Paneitz Operator

We study a conjecture involving the invariant volume of the past light-cone from an arbitrary observation point back to a fixed initial value surface. The conjecture is that a 4th order differential operator which occurs in the theory of conformal anomalies gives $8\pi$ when acted upon the invariant volume of the past light-cone. We show that an extended version of the conjecture is valid for an arbitrary homogeneous and isotropic geometry. First order perturbation theory about flat spacetime reveals a violation of the conjecture which, however, vanishes for any vacuum solution of the Einstein equation. These results may be significant for constructing quantum gravitational observables, for quantifying the back-reaction on spacetime expansion and for alternate gravity models which feature a timelike vector field.Comment: 22 pages, no figures, 5 tables. Version 2 substantially extended to cover nonzero spatial curvature, and with simplified derivation

The stress-energy tensor for trans-Planckian cosmology

This article presents the derivation of the stress-energy tensor of a free scalar field with a general non-linear dispersion relation in curved spacetime. This dispersion relation is used as a phenomelogical description of the short distance structure of spacetime following the conventional approach of trans-Planckian modes in black hole physics and in cosmology. This stress-energy tensor is then used to discuss both the equation of state of trans-Planckian modes in cosmology and the magnitude of their backreaction during inflation. It is shown that gravitational waves of trans-Planckian momenta but subhorizon frequencies cannot account for the form of cosmic vacuum energy density observed at present, contrary to a recent claim. The backreaction effects during inflation are confirmed to be important and generic for those dispersion relations that are liable to induce changes in the power spectrum of metric fluctuations. Finally, it is shown that in pure de Sitter inflation there is no modification of the power spectrum except for a possible magnification of its overall amplitude independently of the dispersion relation.Comment: 18 pages, 2 figures. Version to appear in PRD (minor modifications

Minimal modifications of the primordial power spectrum from an adiabatic short distance cutoff

As a simple model for unknown Planck scale physics, we assume that the quantum modes responsible for producing primordial curvature perturbations during inflation are placed in their instantaneous adiabatic vacuum when their proper momentum reaches a fixed high energy scale M. The resulting power spectrum is derived and presented in a form that exhibits the amplitude and frequency of the superimposed oscillations in terms of H/M and the slow roll parameter epsilon. The amplitude of the oscillations is proportional to the third power of H/M. We argue that these small oscillations give the lower bound of the modifications of the power spectrum if the notion of free mode propagation ceases to exist above the critical energy scale M.Comment: 10 pages; matches version accepted by PR

Ten Proofs of the Generalized Second Law

Ten attempts to prove the Generalized Second Law of Thermodyanmics (GSL) are described and critiqued. Each proof provides valuable insights which should be useful for constructing future, more complete proofs. Rather than merely summarizing previous research, this review offers new perspectives, and strategies for overcoming limitations of the existing proofs. A long introductory section addresses some choices that must be made in any formulation the GSL: Should one use the Gibbs or the Boltzmann entropy? Should one use the global or the apparent horizon? Is it necessary to assume any entropy bounds? If the area has quantum fluctuations, should the GSL apply to the average area? The definition and implications of the classical, hydrodynamic, semiclassical and full quantum gravity regimes are also discussed. A lack of agreement regarding how to define the "quasi-stationary" regime is addressed by distinguishing it from the "quasi-steady" regime.Comment: 60 pages, 2 figures, 1 table. v2: corrected typos and added a footnote to match the published versio

Constraining Cut-off Physics in the Cosmic Microwave Background

We investigate the ability to constrain oscillatory features in the primordial power spectrum using current and future cosmic microwave background observations. In particular, we study the observability of an oscillation arising from imprints of physics at the cut-off energy scale. We perform a likelihood analysis on the WMAP data set, and find that the current data set constrains the amplitude of the oscillations to be less than 0.77 at 2-sigma, consistent with a power spectrum without oscillations. In addition, we investigate the fundamental limitations in the measurement of oscillation parameters by studying the constraints from a cosmic variance limited experiment. We find that such an experiment is capable of constraining the amplitude of such oscillations to be below 0.005, implying that reasonable models with cut-off energy scales Lambda>200 H_infl are unobservable through the microwave background.Comment: 16 pages, 7 figures; PRD accepted versio

Wnt signalling and cancer stem cells

[Abstract] Intracellular signalling mediated by secreted Wnt proteins is essential for the establishment of cell fates and proper tissue patterning during embryo development and for the regulation of tissue homeostasis and stem cell function in adult tissues. Aberrant activation of Wnt signalling pathways has been directly linked to the genesis of different tumours. Here, the components and molecular mechanisms implicated in the transduction of Wnt signal, along with important results supporting a central role for this signalling pathway in stem cell function regulation and carcinogenesis will be briefly reviewed.Ministerio de Ciencia e Innovación; SAF2008-0060

Theory of Cosmological Perturbations and Applications to Superstring Cosmology

The theory of cosmological perturbations is the main tool which connects theories of the early universe (based on new fundamental physics such as string theory) with cosmological observations. In these lectures, I will provide an introduction to this theory, beginning with an overview of the Newtonian theory of fluctuations, moving on to the analysis of fluctuations in the realm of classical general relativity, and culminating with a discussion of the quantum theory of cosmological perturbations. I will illustrate the formalism with applications to inflationary cosmology. I will review the basics of inflationary cosmology and discuss why - through the evolution of fluctuations - inflation may provide a way of observationally testing Planck-scale physics.Comment: Writeup of lectures delivered at the 2004 Cargese Summer School on String Theory, 49 pages, 3 figure