341 research outputs found
White matter microstructural development and cognitive ability in the first 2 years of life
White matter (WM) integrity has been related to cognitive ability in adults and children, but it remains largely unknown how WM maturation in early life supports emergent cognition. The associations between tract-based measures of fractional anisotropy (FA) and axial and radial diffusivity (AD, RD) shortly after birth, at age 1, and at age 2 and cognitive measures at 1 and 2 years were investigated in 447 healthy infants. We found that generally higher FA and lower AD and RD across many WM tracts in the first year of life were associated with better performance on measures of general cognitive ability, motor, language, and visual reception skills at ages 1 and 2, suggesting an important role for the overall organization, myelination, and microstructural properties of fiber pathways in emergent cognition. RD in particular was consistently related to ability, and protracted development of RD from ages 1 to 2 years in several tracts was associated with higher cognitive scores and better language performance, suggesting prolonged plasticity may confer cognitive benefits during the second year of life. However, we also found that cognition at age 2 was weakly associated with WM properties across infancy in comparison to child and demographic factors including gestational age and maternal education. Our findings suggest that early postnatal WM integrity across the brain is important for infant cognition, though its role in cognitive development should be considered alongside child and demographic factors
Extension of geodesic algebras to continuous genus
Using the Penner--Fock parameterization for Teichmuller spaces of Riemann
surfaces with holes, we construct the string-like free-field representation of
the Poisson and quantum algebras of geodesic functions in the continuous-genus
limit. The mapping class group acts naturally in the obtained representation.Comment: 16 pages, submitted to Lett.Math.Phy
Cortical Structure and Cognition in Infants and Toddlers
Cortical structure has been consistently related to cognitive abilities in children and adults, yet we know little about how the cortex develops to support emergent cognition in infancy and toddlerhood when cortical thickness (CT) and surface area (SA) are maturing rapidly. In this report, we assessed how regional and global measures of CT and SA in a sample (N = 487) of healthy neonates, 1-year-olds, and 2-year-olds related to motor, language, visual reception, and general cognitive ability. We report novel findings that thicker cortices at ages 1 and 2 and larger SA at birth, age 1, and age 2 confer a cognitive advantage in infancy and toddlerhood. While several expected brain-cognition relationships were observed, overlapping cortical regions were also implicated across cognitive domains, suggesting that infancy marks a period of plasticity and refinement in cortical structure to support burgeoning motor, language, and cognitive abilities. CT may be a particularly important morphological indicator of ability, but its impact on cognition is relatively weak when compared with gestational age and maternal education. Findings suggest that prenatal and early postnatal cortical developments are important for cognition in infants and toddlers but should be considered in relation to other child and demographic factors
Gut microbiome and brain functional connectivity in infants-a preliminary study focusing on the amygdala
Recently, there has been a surge of interest in the possibility that microbial communities inhabiting the human gut could affect cognitive development and increase risk for mental illness via the “microbiome-gut-brain axis.” Infancy likely represents a critical period for the establishment of these relationships, as it is the most dynamic stage of postnatal brain development and a key period in the maturation of the microbiome. Indeed, recent reports indicate that characteristics of the infant gut microbiome are associated with both temperament and cognitive performance. The neural circuits underlying these relationships have not yet been delineated. To address this gap, resting-state fMRI scans were acquired from 39 1-year-old human infants who had provided fecal samples for identification and relative quantification of bacterial taxa. Measures of alpha diversity were generated and tested for associations with measures of functional connectivity. Primary analyses focused on the amygdala as manipulation of the gut microbiota in animal models alters the structure and neurochemistry of this brain region. Secondary analyses explored functional connectivity of nine canonical resting-state functional networks. Alpha diversity was significantly associated with functional connectivity between the amygdala and thalamus and between the anterior cingulate cortex and anterior insula. These regions play an important role in processing/responding to threat. Alpha diversity was also associated with functional connectivity between the supplementary motor area (SMA, representing the sensorimotor network) and the inferior parietal lobule (IPL). Importantly, SMA-IPL connectivity also related to cognitive outcomes at 2 years of age, suggesting a potential pathway linking gut microbiome diversity and cognitive outcomes during infancy. These results provide exciting new insights into the gut-brain axis during early human development and should stimulate further studies into whether microbiome-associated changes in brain circuitry influence later risk for psychopathology
Dissecting the sugarcane expressed sequence tag (SUCEST) database: unraveling flower-specific genes
There are almost 260,000 independent clones sequenced from the 5? end in the Sugarcane Expressed Sequence Tag (SUCEST) database, which have been obtained from 37 cDNA libraries prepared from different tissues. This large number of expressed sequence tags (ESTs) provides an opportunity, unprecedented in plants, to perform ?digital differential screening? on selected cDNA libraries. In general, the frequency of a particular EST correlates with transcript accumulation in the tissues from which the cDNA libraries were constructed, so it is possible to compare the whole transcriptome from different tissues using computer-assisted analysis of an EST database. In our research we analyzed sugarcane ESTs according to tissue expression and identified more than 1,000 putative flower-specific genes. The fact that using this technique we were able to identify sugarcane homologues of several genes previously described as pollen-specific justifies this method of assessing tissue specificity. In addition, ESTs similar to genes specific to reproductive organs were detected e.g. a sugarcane gene encoding a meiotic protein essential for assembly of the synaptonemal complex and normal synapsis. This approach also allowed the identification of many flower-specific anonymous sequences that are good candidates for being novel genes involved in plant reproduction. This paper describes the analysis of the gene expression levels of 24 EST clusters during flower development using a ?digital northern blot? constructed from direct EST counts made on the non-normalized sugarcane cDNA libraries.Existem quase 260.000 clones independentes, seqĂĽenciados a partir da extremidade 5?, no banco de dados do SUCEST (Sugarcane Expressed Sequence Tag), os quais foram obtidos a partir de 37 bibliotecas de cDNA preparadas de diferentes tecidos. Este grande nĂşmero de etiquetas de sequĂŞncias expressas (ESTs) fornece uma oportunidade, sem precedentes em plantas, de realizar um ?digital differential screening? em bibliotecas de cDNA selecionadas. Geralmente, a frequĂŞncia de um determinado EST está correlacionada ao acĂşmulo de transcritos nos tecidos dos quais as bibliotecas de cDNA foram construĂdas, e desta forma, Ă© possĂvel comparar o transcriptoma completo de diferentes tecidos, usando uma análise computacional de um banco de dados de ESTs. Em nossa pesquisa, analisamos os ESTs de cana-de-açúcar de acordo com sua expressĂŁo tecidual e identificamos mais de 1.000 putativos genes especĂficos de flor. O fato de que usando esta tĂ©cnica fomos capazes de identificar homolĂłgos em cana-de-açúcar, de vários genes previamente descritos como especĂficos de pĂłlen, sustenta este mĂ©todo de estimar especificidade tecidual. AlĂ©m disto, ESTs com similaridade a genes especĂficos de ĂłrgĂŁos reprodutivos foram revelados, como por exemplo, o gene que codifica uma proteĂna meiĂłtica essencial para a montagem do complexo sinaptonĂŞmico e sinapse normal. Esta abordagem tambĂ©m permitiu a identificação de muitas sequĂŞncias anĂ´nimas, especĂficas de flor, que sĂŁo boas candidatas para novos genes envolvidos com a reprodução de plantas. Este trabalho descreve a análise dos nĂveis de expressĂŁo gĂŞnica de 24 clusters de ESTs, durante o desenvolvimento floral, usando um ?northern blot digital? construĂdo a partir da contagem direta dos ESTs das bibliotecas nĂŁo-normalizadas de cDNAs de cana-de-açúcar.7784Fundação de Amparo Ă Pesquisa do Estado de SĂŁo Paulo (FAPESP)Conselho Nacional de Desenvolvimento CientĂfico e TecnolĂłgico (CNPq
Altered Brain Structure in Infants with Turner Syndrome
Turner syndrome (TS) is a genetic disorder affecting approximately 1:2000 live-born females. It results from partial or complete X monosomy and is associated with a range of clinical issues including a unique cognitive profile and increased risk for certain behavioral problems. Structural neuroimaging studies in adolescents, adults, and older children with TS have revealed altered neuroanatomy but are unable to identify when in development differences arise. In addition, older children and adults have often been exposed to years of growth hormone and/or exogenous estrogen therapy with potential implications for neurodevelopment. The study presented here is the first to test whether brain structure is altered in infants with TS. Twenty-six infants with TS received high-resolution structural MRI scans of the brain at 1 year of age and were compared to 47 typically developing female and 39 typically developing male infants. Results indicate that the typical neuroanatomical profile seen in older individuals with TS, characterized by decreased gray matter volumes in premotor, somatosensory, and parietal-occipital cortex, is already present at 1 year of age, suggesting a stable phenotype with origins in the prenatal or early postnatal period
Composite Fermion Description of Correlated Electrons in Quantum Dots: Low Zeeman Energy Limit
We study the applicability of composite fermion theory to electrons in
two-dimensional parabolically-confined quantum dots in a strong perpendicular
magnetic field in the limit of low Zeeman energy. The non-interacting composite
fermion spectrum correctly specifies the primary features of this system.
Additional features are relatively small, indicating that the residual
interaction between the composite fermions is weak. \footnote{Published in
Phys. Rev. B {\bf 52}, 2798 (1995).}Comment: 15 pages, 7 postscript figure
Topological Defects, Orientational Order, and Depinning of the Electron Solid in a Random Potential
We report on the results of molecular dynamics simulation (MD) studies of the
classical two-dimensional electron crystal in the presence disorder. Our study
is motivated by recent experiments on this system in modulation doped
semiconductor systems in very strong magnetic fields, where the magnetic length
is much smaller than the average interelectron spacing , as well as by
recent studies of electrons on the surface of helium. We investigate the low
temperature state of this system using a simulated annealing method. We find
that the low temperature state of the system always has isolated dislocations,
even at the weakest disorder levels investigated. We also find evidence for a
transition from a hexatic glass to an isotropic glass as the disorder is
increased. The former is characterized by quasi-long range orientational order,
and the absence of disclination defects in the low temperature state, and the
latter by short range orientational order and the presence of these defects.
The threshold electric field is also studied as a function of the disorder
strength, and is shown to have a characteristic signature of the transition.
Finally, the qualitative behavior of the electron flow in the depinned state is
shown to change continuously from an elastic flow to a channel-like, plastic
flow as the disorder strength is increased.Comment: 31 pages, RevTex 3.0, 15 figures upon request, accepted for
publication in Phys. Rev. B., HAF94MD
Quinoxaline 1,4-di-N-oxide and the Potential for Treating Tuberculosis
New drugs active against drug-resistant tuberculosis are urgently needed to extend the range of TB treatment options to cover drug resistant infections. Quinoxaline derivatives show very interesting biological properties (antibacterial, antiviral, anticancer, antifungal, antihelmintic, insecticidal) and evaluation of their medicinal chemistry is still in progress. In this review we report the properties and the recent developments of quinoxaline 1,4-di-N-oxide derivatives as potential anti-tuberculosis agents. Specific agents are reviewed that have excellent antitubercular drug properties, are active on drug resistant strains and non-replicating mycobacteria. The properties of select analogs that have in vivo activity in the low dose aerosol infection model in mice will be reviewed
The induction of behavioural sensitization is associated with cocaine-induced structural plasticity in the core (but not shell) of the nucleus accumbens
Repeated exposure to cocaine increases the density of dendritic spines on medium spiny neurons in the nucleus accumbens (Acb) and pyramidal cells in the medial prefrontal cortex (mPFC). To determine if this is associated with the development of psychomotor sensitization, rats were given daily i.p. injections of 15 mg/kg of cocaine (or saline) for 8 days, either in their home cage (which failed to induce significant psychomotor sensitization) or in a distinct and relatively novel test cage (which induced robust psychomotor sensitization). Their brains were obtained 2 weeks after the last injection and processed for Golgi–Cox staining. In the Acb core (AcbC) cocaine treatment increased spine density only in the group that developed psychomotor sensitization (i.e. in the Novel but not Home group), and there was a significant positive correlation between the degree of psychomotor sensitization and spine density. In the Acb shell (AcbS) cocaine increased spine density to the same extent in both groups; i.e. independent of psychomotor sensitization. In the mPFC cocaine increased spine density in both groups, but to a significantly greater extent in the Novel group. Furthermore, when rats were treated at Home with a higher dose of cocaine (30 mg/kg), cocaine now induced psychomotor sensitization in this context, and also increased spine density in the AcbC. Thus, the context in which cocaine is experienced influences its ability to reorganize patterns of synaptic connectivity in the Acb and mPFC, and the induction of psychomotor sensitization is associated with structural plasticity in the AcbC and mPFC, but not the AcbS.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73532/1/j.1460-9568.2004.03612.x.pd
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