1,210 research outputs found
Trial factors for the look elsewhere effect in high energy physics
When searching for a new resonance somewhere in a possible mass range, the
significance of observing a local excess of events must take into account the
probability of observing such an excess anywhere in the range. This is the so
called "look elsewhere effect". The effect can be quantified in terms of a
trial factor, which is the ratio between the probability of observing the
excess at some fixed mass point, to the probability of observing it anywhere in
the range. We propose a simple and fast procedure for estimating the trial
factor, based on earlier results by Davies. We show that asymptotically, the
trial factor grows linearly with the (fixed mass) significance
"Dark energy" in the Local Void
The unexpected discovery of the accelerated cosmic expansion in 1998 has
filled the Universe with the embarrassing presence of an unidentified "dark
energy", or cosmological constant, devoid of any physical meaning. While this
standard cosmology seems to work well at the global level, improved knowledge
of the kinematics and other properties of our extragalactic neighborhood
indicates the need for a better theory. We investigate whether the recently
suggested repulsive-gravity scenario can account for some of the features that
are unexplained by the standard model. Through simple dynamical considerations,
we find that the Local Void could host an amount of antimatter
() roughly equivalent to the mass of a typical
supercluster, thus restoring the matter-antimatter symmetry. The antigravity
field produced by this "dark repulsor" can explain the anomalous motion of the
Local Sheet away from the Local Void, as well as several other properties of
nearby galaxies that seem to require void evacuation and structure formation
much faster than expected from the standard model. At the global cosmological
level, gravitational repulsion from antimatter hidden in voids can provide more
than enough potential energy to drive both the cosmic expansion and its
acceleration, with no need for an initial "explosion" and dark energy.
Moreover, the discrete distribution of these dark repulsors, in contrast to the
uniformly permeating dark energy, can also explain dark flows and other
recently observed excessive inhomogeneities and anisotropies of the Universe.Comment: 6 pages, accepted as a Letter to the Editor by Astrophysics and Space
Scienc
Physics in the Real Universe: Time and Spacetime
The Block Universe idea, representing spacetime as a fixed whole, suggests
the flow of time is an illusion: the entire universe just is, with no special
meaning attached to the present time. This view is however based on
time-reversible microphysical laws and does not represent macro-physical
behaviour and the development of emergent complex systems, including life,
which do indeed exist in the real universe. When these are taken into account,
the unchanging block universe view of spacetime is best replaced by an evolving
block universe which extends as time evolves, with the potential of the future
continually becoming the certainty of the past. However this time evolution is
not related to any preferred surfaces in spacetime; rather it is associated
with the evolution of proper time along families of world linesComment: 28 pages, including 9 Figures. Major revision in response to referee
comment
Rapid destruction of protoplanetary discs due to external photoevaporation in star-forming regions
We analyse N-body simulations of star-forming regions to investigate the effects of external far- and extreme-ultraviolet photoevaporation from massive stars on protoplanetary discs. By varying the initial conditions of simulated star-forming regions, such as the spatial distribution, net bulk motion (virial ratio), and density, we investigate which parameters most affect the rate at which discs are dispersed due to external photoevaporation. We find that disc dispersal due to external photoevaporation is faster in highly substructured star-forming regions than in smooth and centrally concentrated regions. Subvirial star-forming regions undergoing collapse also show higher rates of disc dispersal than regions that are in virial equilibrium or are expanding. In moderately dense (∼100 M⊙ pc−3) regions, half of all protoplanetary discs with radii ≥100 au are photoevaporated within 1 Myr, three times faster than is currently suggested by observational studies. Discs in lower density star-forming regions (∼10 M⊙ pc−3) survive for longer, but half are still dispersed on short time-scales (∼2 Myr). This demonstrates that the initial conditions of the star-forming regions will greatly impact the evolution and lifetime of protoplanetary discs. These results also imply that either gas giant planet formation is extremely rapid and occurs before the gas component of discs is  evaporated, or gas giants only form in low-density star-forming regions where no massive stars are present to photoevaporate gas from protoplanetary discs
Structural characterization suggests models for monomeric and dimeric forms of full-length ezrin
Ezrin is a member of the ERM (ezrin–radixin–moesin) family of proteins that have been conserved through metazoan evolution. These proteins have dormant and active forms, where the latter links the actin cytoskeleton to membranes. ERM proteins have three domains: an N-terminal FERM [band Four-point-one (4.1) ERM] domain comprising three subdomains (F1, F2, and F3); a helical domain; and a C-terminal actin-binding domain. In the dormant form, FERM and C-terminal domains form a stable complex. We have determined crystal structures of the active FERM domain and the dormant FERM:C-terminal domain complex of human ezrin. We observe a bistable array of phenylalanine residues in the core of subdomain F3 that is mobile in the active form and locked in the dormant form. As subdomain F3 is pivotal in binding membrane proteins and phospholipids, these transitions may facilitate activation and signaling. Full-length ezrin forms stable monomers and dimers. We used small-angle X-ray scattering to determine the solution structures of these species. As expected, the monomer shows a globular domain with a protruding helical coiled coil. The dimer shows an elongated dumbbell structure that is twice as long as the monomer. By aligning ERM sequences spanning metazoan evolution, we show that the central helical region is conserved, preserving the heptad repeat. Using this, we have built a dimer model where each monomer forms half of an elongated antiparallel coiled coil with domain-swapped FERM:C-terminal domain complexes at each end. The model suggests that ERM dimers may bind to actin in a parallel fashion
Vitamin D deficiency in traumatic brain injury and its relationship with severity of injury and quality of life: a prospective, observational study
This single-centre prospective observational study aims to describe the prevalence of vitamin D deficiency (VDD) in the traumatic brain injury (TBI) population and identify any relationship between vitamin D and severity of head injury or quality of life.
124 TBI patients had serum vitamin D (25-OHD) levels measured at the local post-TBI endocrine screening clinic over 20 months. Quality of Life after Brain Injury (QOLIBRI) questionnaires were completed by the patient concurrently. A multivariate regressional analysis was performed, controlling for age, season, ethnicity, time since injury, TBI severity and gender.
34% (n=42) of the cohort were vitamin D deficient (25-OHD <25nmol/L) with a further 23% (n=29) having insufficient levels (25-OHD 25-50nmol/L). Vitamin D was significantly lower in severe TBI compared to mild TBI (n=95, p=0.03, CI 95% -23.60 to -1.21, mean effect size 12.40 nmol/L). There was a trend for self-reported quality of life to be better in patients with optimum vitamin D levels compared to patients with deficient vitamin D levels, controlling for severity of injury (n=81, p=0.05, CI 95% -0.07 to 21.27).
This is the first study to identify a significant relationship between vitamin D levels and severity of head injury. Clinicians should actively screen for and treat VDD in head injured patients to reduce the risk of further morbidity such as osteomalacia and cardiovascular disease. Future research should establish the natural history of vitamin D levels following TBI to identify at which stage VDD develops and whether vitamin D replacement could have a beneficial effect on recovery and quality of life
Remarks on 't Hooft's Brick Wall Model
A semi-classical reasoning leads to the non-commutativity of the space and
time coordinates near the horizon of Schwarzschild black hole. This
non-commutativity in turn provides a mechanism to interpret the brick wall
thickness hypothesis in 't Hooft's brick wall model as well as the boundary
condition imposed for the field considered. For concreteness, we consider a
noncommutative scalar field model near the horizon and derive the effective
metric via the equation of motion of noncommutative scalar field. This metric
displays a new horizon in addition to the original one associated with the
Schwarzschild black hole. The infinite red-shifting of the scalar field on the
new horizon determines the range of the noncommutativ space and explains the
relevant boundary condition for the field. This range enables us to calculate
the entropy of black hole as proportional to the area of its original horizon
along the same line as in 't Hooft's model, and the thickness of the brick wall
is found to be proportional to the thermal average of the noncommutative
space-time range. The Hawking temperature has been derived in this formalism.
The study here represents an attempt to reveal some physics beyond the brick
wall model.Comment: RevTeX, 5 pages, no figure
Information measures and classicality in quantum mechanics
We study information measures in quantu mechanics, with particular emphasis
on providing a quantification of the notions of classicality and
predictability. Our primary tool is the Shannon - Wehrl entropy I. We give a
precise criterion for phase space classicality and argue that in view of this
a) I provides a measure of the degree of deviation from classicality for closed
system b) I - S (S the von Neumann entropy) plays the same role in open systems
We examine particular examples in non-relativistic quantum mechanics. Finally,
(this being one of our main motivations) we comment on field classicalisation
on early universe cosmology.Comment: 35 pages, LATE
Glassy Phase Transition and Stability in Black Holes
Black hole thermodynamics, confined to the semi-classical regime, cannot
address the thermodynamic stability of a black hole in flat space. Here we show
that inclusion of correction beyond the semi-classical approximation makes a
black hole thermodynamically stable. This stability is reached through a phase
transition. By using Ehrenfest's scheme we further prove that this is a glassy
phase transition with a Prigogine-Defay ratio close to 3. This value is well
placed within the desired bound (2 to 5) for a glassy phase transition. Thus
our analysis indicates a very close connection between the phase transition
phenomena of a black hole and glass forming systems. Finally, we discuss the
robustness of our results by considering different normalisations for the
correction term.Comment: v3, minor changes over v2, references added, LaTeX-2e, 18 pages, 3 ps
figures, to appear in Eour. Phys. Jour.
Arrow of time in a recollapsing quantum universe
We show that the Wheeler-DeWitt equation with a consistent boundary condition
is only compatible with an arrow of time that formally reverses in a
recollapsing universe. Consistency of these opposite arrows is facilitated by
quantum effects in the region of the classical turning point. Since
gravitational time dilation diverges at horizons, collapsing matter must then
start re-expanding ``anticausally" (controlled by the reversed arrow) before
horizons or singularities can form. We also discuss the meaning of the
time-asymmetric expression used in the definition of ``consistent histories".
We finally emphasize that there is no mass inflation nor any information loss
paradox in this scenario.Comment: Many conceptual clarifications include
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