1,169 research outputs found

    Synthesis of toxyloxanthone B

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    A synthesis of the naturally occurring xanthone toxyloxanthone B is described, in which the key step is the regioselective addition of a methyl salicylate to a substituted benzyne followed by cyclization of the intermediate aryl anion to form the xanthone, the regiochemistry of the aryne addition being confirmed by X-ray crystallography. Subsequent introduction of the pyran ring by [3,3]-rearrangement and deprotection completed the synthesi

    Epidemiologic Study of Dental Caries Experience and Between-Meal Eating Patterns

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    The relationship between dental caries and between-meal snacks was investigated in a study of 1,486 high school students. The participants completed a questionnaire on between-meal habits and then were given dental examinations. The lack of differences in dental caries between racial and geographic groups was not related to the frequency of sucrose-containing, between-meal snacks.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66591/2/10.1177_00220345730520022501.pd

    Integrated stratigraphical study of the Rhuddanian-Aeronian (Llandovery, Silurian) boundary succession in the Rheidol Gorge, Wales:A proposed Global Stratotype Section and Point for the base of the Aeronian Stage

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    The Rheidol Gorge section, approximately 17 km east of Aberystwyth, mid Wales, exposes a ca. 20 m-thick succession of Llandovery (Silurian) strata from the upper Rhuddanian Pernerograptus revolutus Biozone through the lower Aeronian Demirastrites triangulatus Biozone and basal Neodiplograptus magnus Biozone. The section records deposition under a range of bottom-water oxygenation states. The Rhuddanian-Aeronian boundary is located 0.8 m above an abrupt lithological change from predominantly organic-poor, bioturbated `oxic' mudrocks to an interval of black, richly graptolitic `anoxic' shales. The graptolite fauna through the boundary interval, including the local lowest occurrence of D. triangulatus, allows precise correlation with other parts of the world. Graptolite assemblages indicative of separate divisions in the underlying revolutus Biozone and of the lower and upper parts of the triangulatus Biozone are also present. Chitinozoans are relatively well preserved in the section and indicate the Spinachitina maennili Biozone throughout the boundary interval, as is widely the case. The results of carbon isotope analyses from organic matter indistinctly show the weak interval of positive shift in d13C org values through the Rhuddanian-Aeronian boundary interval, as observed globally, though local or regional processes appear largely to overprint the global signal. Overall, the excellent biostratigraphical record, well-documented local and regional stratigraphical context, historical significance, as well as easy access and assured longterm preservation, mean that the Rheidol Gorge section can be proposed as a strong candidate for a new Global Stratotype Section and Point for the base of the Aeronian Stage.. Silurian, Llandovery, Rhuddanian, Aeronian, Global Stratotype Section and Point, Graptolites, Chitinozoa, Carbon Isotope

    Big Bang Nucleosynthesis with Gaussian Inhomogeneous Neutrino Degeneracy

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    We consider the effect of inhomogeneous neutrino degeneracy on Big Bang nucleosynthesis for the case where the distribution of neutrino chemical potentials is given by a Gaussian. The chemical potential fluctuations are taken to be isocurvature, so that only inhomogeneities in the electron chemical potential are relevant. Then the final element abundances are a function only of the baryon-photon ratio η\eta, the effective number of additional neutrinos ΔNν\Delta N_\nu, the mean electron neutrino degeneracy parameter ξˉ\bar \xi, and the rms fluctuation of the degeneracy parameter, σξ\sigma_\xi. We find that for fixed η\eta, ΔNν\Delta N_\nu, and ξˉ\bar \xi, the abundances of helium-4, deuterium, and lithium-7 are, in general, increasing functions of σξ\sigma_\xi. Hence, the effect of adding a Gaussian distribution for the electron neutrino degeneracy parameter is to decrease the allowed range for η\eta. We show that this result can be generalized to a wide variety of distributions for ξ\xi.Comment: 9 pages, 3 figures, added discussion of neutrino oscillations, altered presentation of figure

    The Five Factor Model of personality and evaluation of drug consumption risk

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    The problem of evaluating an individual's risk of drug consumption and misuse is highly important. An online survey methodology was employed to collect data including Big Five personality traits (NEO-FFI-R), impulsivity (BIS-11), sensation seeking (ImpSS), and demographic information. The data set contained information on the consumption of 18 central nervous system psychoactive drugs. Correlation analysis demonstrated the existence of groups of drugs with strongly correlated consumption patterns. Three correlation pleiades were identified, named by the central drug in the pleiade: ecstasy, heroin, and benzodiazepines pleiades. An exhaustive search was performed to select the most effective subset of input features and data mining methods to classify users and non-users for each drug and pleiad. A number of classification methods were employed (decision tree, random forest, kk-nearest neighbors, linear discriminant analysis, Gaussian mixture, probability density function estimation, logistic regression and na{\"i}ve Bayes) and the most effective classifier was selected for each drug. The quality of classification was surprisingly high with sensitivity and specificity (evaluated by leave-one-out cross-validation) being greater than 70\% for almost all classification tasks. The best results with sensitivity and specificity being greater than 75\% were achieved for cannabis, crack, ecstasy, legal highs, LSD, and volatile substance abuse (VSA).Comment: Significantly extended report with 67 pages, 27 tables, 21 figure

    Prox-regularity of rank constraint sets and implications for algorithms

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    We present an analysis of sets of matrices with rank less than or equal to a specified number ss. We provide a simple formula for the normal cone to such sets, and use this to show that these sets are prox-regular at all points with rank exactly equal to ss. The normal cone formula appears to be new. This allows for easy application of prior results guaranteeing local linear convergence of the fundamental alternating projection algorithm between sets, one of which is a rank constraint set. We apply this to show local linear convergence of another fundamental algorithm, approximate steepest descent. Our results apply not only to linear systems with rank constraints, as has been treated extensively in the literature, but also nonconvex systems with rank constraints.Comment: 12 pages, 24 references. Revised manuscript to appear in the Journal of Mathematical Imaging and Visio

    A distance for partially labeled trees

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    In a number of practical situations, data have structure and the relations among its component parts need to be coded with suitable data models. Trees are usually utilized for representing data for which hierarchical relations can be defined. This is the case in a number of fields like image analysis, natural language processing, protein structure, or music retrieval, to name a few. In those cases, procedures for comparing trees are very relevant. An approximate tree edit distance algorithm has been introduced for working with trees labeled only at the leaves. In this paper, it has been applied to handwritten character recognition, providing accuracies comparable to those by the most comprehensive search method, being as efficient as the fastest.This work is supported by the Spanish Ministry projects DRIMS (TIN2009-14247-C02), and Consolider Ingenio 2010 (MIPRCV, CSD2007-00018), partially supported by EU ERDF and the Pascal Network of Excellence

    Long-term perturbations due to a disturbing body in elliptic inclined orbit

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    In the current study, a double-averaged analytical model including the action of the perturbing body's inclination is developed to study third-body perturbations. The disturbing function is expanded in the form of Legendre polynomials truncated up to the second-order term, and then is averaged over the periods of the spacecraft and the perturbing body. The efficiency of the double-averaged algorithm is verified with the full elliptic restricted three-body model. Comparisons with the previous study for a lunar satellite perturbed by Earth are presented to measure the effect of the perturbing body's inclination, and illustrate that the lunar obliquity with the value 6.68\degree is important for the mean motion of a lunar satellite. The application to the Mars-Sun system is shown to prove the validity of the double-averaged model. It can be seen that the algorithm is effective to predict the long-term behavior of a high-altitude Martian spacecraft perturbed by Sun. The double-averaged model presented in this paper is also applicable to other celestial systems.Comment: 28 pages, 6 figure
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