First measurements of OH-C exchange and temperature-dependent partitioning of OH and halogens in the system apatite - silicate melt

We present the first integrated study of carbonate, hydroxyl, fluoride, and chloride ion partitioning in the apatite-melt system. We determined volatile partitioning behavior between apatite and silicate melt for both haplobasaltic andesite and trachyte bulk compositions at 0.5–1 GPa and 1250°C using the piston-cylinder apparatus. All volatile species were analyzed directly in both apatite and glass using secondary ion mass spectrometry (SIMS) and electron probe microanalysis. Distribution coefficients for OH-halogen exchange are similar to those from previous studies, and together with literature data, reveal a significant log-linear relationship with temperature, while the effects of pressure and melt composition are minimal. Meanwhile, halogen-free experiments generate very high C contents (up to 5000 ppm) in apatite. Stoichiometry calculations and infrared spectra indicate that this C is mainly incorporated onto the channel volatile site together with hydroxyl. In halogen-bearing experiments, apatite crystals contain significantly lower C (≤500 ppm), which may be partly incorporated onto the phosphate site while the channel volatile site is filled by OH+F+Cl+C. Our experiments give the first constraints on H2O-CO2 exchange between apatite and silicate melt, with a KD of 0.355 ± 0.05 for the trachyte and 0.629 ± 0.08 for the haplobasaltic andesite. The new constraints on the temperature-dependence of partitioning will enable quantitative modeling of apatite-volatile exchange in igneous systems, while this new partitioning data and method for direct, in situ analysis of C in apatite mark a significant advance that will permit future studies of magmatic C and other volatiles. This has a broad range of potential applications including magmatic differentiation, fractionation, and degassing; quantification of volatile budgets in extraterrestrial and deep earth environments; and mineralization processes

The generalized non-conservative model of a 1-planet system - revisited

We study the long-term dynamics of a planetary system composed of a star and a planet. Both bodies are considered as extended, non-spherical, rotating objects. There are no assumptions made on the relative angles between the orbital angular momentum and the spin vectors of the bodies. Thus, we analyze full, spatial model of the planetary system. Both objects are assumed to be deformed due to their own rotations, as well as due to the mutual tidal interactions. The general relativity corrections are considered in terms of the post-Newtonian approximation. Besides the conservative contributions to the perturbing forces, there are also taken into account non-conservative effects, i.e., the dissipation of the mechanical energy. This dissipation is a result of the tidal perturbation on the velocity field in the internal zones with non-zero turbulent viscosity (convective zones). Our main goal is to derive the equations of the orbital motion as well as the equations governing time-evolution of the spin vectors (angular velocities). We derive the Lagrangian equations of the second kind for systems which do not conserve the mechanical energy. Next, the equations of motion are averaged out over all fast angles with respect to time-scales characteristic for conservative perturbations. The final equations of motion are then used to study the dynamics of the non-conservative model over time scales of the order of the age of the star. We analyze the final state of the system as a function of the initial conditions. Equilibria states of the averaged system are finally discussed.Comment: 37 pages, 13 figures, accepted to Celestial Mechanics and Dynamical Astronom

Hydrogen incorporation and charge balance in natural zircon

The water and trace element contents of natural igneous zircons were determined to constrain the mechanism of hydrogen incorporation. The low radiation-damage zircons were derived from Fe–Ti oxide gabbros from the Vema Fracture Zone (11°N, Mid-Atlantic Ridge). They contain up to 1212 ppmw H2O, 1.9 wt.% Y2O3 and 0.6 wt.% P2O5 and are generally strongly zoned. REE + Y are partially charge-balanced by P (Y, REE3+ + P5+ = Zr4+ + Si4+), but a large REE excess is present. On an atomic basis, this excess is closely approximated by the amount of H present in the zircons. We therefore conclude that H is incorporated by a charge-balance mechanism (H+ + REE3+ = Zr4+). This interpretation is consistent with FTIR data of the Vema zircons, which shows a strongly polarised main absorption band at ca. 3100 cm−1, similar to experimentally grown Lu-doped hydrous zircon. The size of this 3100 cm−1 band scales with H and REE contents. Apart from a small overlapping band at 3200 cm−1, no other absorption bands are visible, indicating that a hydrogrossular-type exchange mechanism does not appear to be operating in these zircons. Because of charge-balanced uptake of H, P and REE in zircon, the partitioning of these elements into zircon is dependent on each of their concentrations. For instance, DREEzrc/melt increases with increasing H and P contents of the melt, whereas DHzrc/melt increases with increasing REE content but decreases with increasing P content. In addition, H–P–REE systematics of sector zoning indicate kinetic effects may play an important role. Hence, using H in zircon to determine the water content of melts is problematic, and REE partitioning studies need to take into account P and H2O contents of the melt

A fully integrated GIS-based model of particulate waste distribution from marine fish-cage sites

Modern Geographical Information System (GIS) offers a powerful modelling environment capable of handling large databases. It is a very suitable environment in which to develop a suite of tools designed for environmental management of aquaculture sites, including carrying capacity prediction, land–water interactions and multi-site effects. One such tool, presented here, is a fully integrated and validated particulate fish waste dispersion module which uses mass balance to estimate waste input and takes account of variable bathymetry and variable settling velocity for feed and faecal components. The model also incorporates the effect of cage movement on waste dispersion, the first such model to do so. When tidal range was low (1.67 m), the maximum movement of a 22 m diameter circular cage was 10.1 m and 7.7 m easting and northing, respectively. Highest deposition from particulate fish waste is under the cage and incorporation of cage movement increased the effective area under a cage by 72%. This reduced peak deposition measurements by up to 32% and reduced the average modelled feed and faecal settlement at the cage centre by 23% and 11%, respectively. The model was validated by comparing model predictions with observed deposition measured using sediment traps during three 2-week field trips at a fish farm on the west coast of Scotland. The mean ratio of observed to predicted waste deposition at 5–25 m from the cage centre ranged from 0.9 to 1.06, whilst under the cage the model over-predicts deposition (observed/predicted=2.21). Although far-field data was seen to be comparable the near-field discrepancies resulted in variable overall accuracy in the model. The overall accuracy based on August 2001 data was ±50.9%, on February 2002, ±72.8% and on April 2002, ±50.6%. Summarizing the data resulted in an overall average predictive accuracy of ±58.1%. © 2006 Elsevier B.V. All rights reserved

Mouse Chromosome 11

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46996/1/335_2004_Article_BF00648429.pd

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Background: In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation. Methods: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those trial participants with hypoxia (oxygen saturation <92% on air or requiring oxygen therapy) and evidence of systemic inflammation (C-reactive protein ≥75 mg/L) were eligible for random assignment in a 1:1 ratio to usual standard of care alone versus usual standard of care plus tocilizumab at a dose of 400 mg–800 mg (depending on weight) given intravenously. A second dose could be given 12–24 h later if the patient's condition had not improved. The primary outcome was 28-day mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN (50189673) and ClinicalTrials.gov (NCT04381936). Findings: Between April 23, 2020, and Jan 24, 2021, 4116 adults of 21 550 patients enrolled into the RECOVERY trial were included in the assessment of tocilizumab, including 3385 (82%) patients receiving systemic corticosteroids. Overall, 621 (31%) of the 2022 patients allocated tocilizumab and 729 (35%) of the 2094 patients allocated to usual care died within 28 days (rate ratio 0·85; 95% CI 0·76–0·94; p=0·0028). Consistent results were seen in all prespecified subgroups of patients, including those receiving systemic corticosteroids. Patients allocated to tocilizumab were more likely to be discharged from hospital within 28 days (57% vs 50%; rate ratio 1·22; 1·12–1·33; p<0·0001). Among those not receiving invasive mechanical ventilation at baseline, patients allocated tocilizumab were less likely to reach the composite endpoint of invasive mechanical ventilation or death (35% vs 42%; risk ratio 0·84; 95% CI 0·77–0·92; p<0·0001). Interpretation: In hospitalised COVID-19 patients with hypoxia and systemic inflammation, tocilizumab improved survival and other clinical outcomes. These benefits were seen regardless of the amount of respiratory support and were additional to the benefits of systemic corticosteroids. Funding: UK Research and Innovation (Medical Research Council) and National Institute of Health Research

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

Background: Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19. Methods: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. Eligible and consenting patients were randomly assigned (1:1) to receive either usual care alone (usual care group) or usual care plus high-titre convalescent plasma (convalescent plasma group). The primary outcome was 28-day mortality, analysed on an intention-to-treat basis. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings: Between May 28, 2020, and Jan 15, 2021, 11558 (71%) of 16287 patients enrolled in RECOVERY were eligible to receive convalescent plasma and were assigned to either the convalescent plasma group or the usual care group. There was no significant difference in 28-day mortality between the two groups: 1399 (24%) of 5795 patients in the convalescent plasma group and 1408 (24%) of 5763 patients in the usual care group died within 28 days (rate ratio 1·00, 95% CI 0·93–1·07; p=0·95). The 28-day mortality rate ratio was similar in all prespecified subgroups of patients, including in those patients without detectable SARS-CoV-2 antibodies at randomisation. Allocation to convalescent plasma had no significant effect on the proportion of patients discharged from hospital within 28 days (3832 [66%] patients in the convalescent plasma group vs 3822 [66%] patients in the usual care group; rate ratio 0·99, 95% CI 0·94–1·03; p=0·57). Among those not on invasive mechanical ventilation at randomisation, there was no significant difference in the proportion of patients meeting the composite endpoint of progression to invasive mechanical ventilation or death (1568 [29%] of 5493 patients in the convalescent plasma group vs 1568 [29%] of 5448 patients in the usual care group; rate ratio 0·99, 95% CI 0·93–1·05; p=0·79). Interpretation: In patients hospitalised with COVID-19, high-titre convalescent plasma did not improve survival or other prespecified clinical outcomes. Funding: UK Research and Innovation (Medical Research Council) and National Institute of Health Research

Trace elements and Li isotope systematics in Zabargad peridotites: evidence of ancient subduction processes in the Red Sea mantle

Mantle peridotites exposed on Zabargad Island in the Red Sea (Egypt) record a range of features, most of which have been attributed to recent rifting events associated with the opening of this proto-oceanic basin. However, both the trace element data and Li isotope systematics presented here suggest an alternative hypothesis for some of these features, implicating them in the more ancient subduction zone processes that operated in the region during the Pan-African orogeny (700–600 Ma). High Li contents and other trace element characteristics of the exceptionally fresh spinel-lherzolites show they have been metasomatised by a hydrous fluid, but measured δ7Li values of around +4.9 are within the range reported for fresh MORB (+1.5 to +6.5) and OIB (+2.5 to +5.8). This suggests that these lherzolites and the metasomatic agent introducing the elevated Li contents are similar to typical upper mantle in terms of Li isotopes. In contrast, extensive modal metasomatism of these lherzolites to give as much as 20% of green pargasitic amphibole, is associated with the influx of melt or fluid with a relatively heavy δ7Li signature. As such heavy values are typical of the low-temperature weathering processes observed in altered oceanic crust (AOC), we propose that this metasomatic event involves the release of Li from a dehydrating, subducted slab, consistent with the tectonic setting during the Pan-African. Pyroxenite veins that cross-cut the peridotites and a lower crustal meta-basalt in tectonic contact not only display a similar, heavy AOC Li component, but also the trace element patterns characteristic of a slab release fluid, as observed in modern island arc basalts (IAB). In contrast, one of the IAB signature pyroxenites has a negative δ7Li value (−4.1‰) that would require a different fluid source. We speculate that this could represent a later stage of fluid release, subsequent to the earlier dehydration processes that have preferentially removed 7Li from the AOC. This study appears to indicate the presence of AOC signatures in a paleo-subduction zone mantle wedge, a feature that is predicted, but remains elusive in modern basalts collected from arc environments

Ar and K partitioning between clinopyroxene and silicate melt to 8 GPa

The relative incompatibility of Ar and K are fundamental parameters in understanding the degassing history of the mantle. Clinopyroxene is the main host for K in most of the upper mantle, playing an important role in controlling the K/Ar ratio of residual mantle and the subsequent time-integrated evolution of 40Ar/36Ar ratios. Clinopyroxene also contributes to the bulk Ar partition coefficient that controls the Ar degassing rate during mantle melting. The partitioning of Ar and K between clinopyroxene and quenched silicate melt has been experimentally determined from 1 to 8 GPa for the bulk compositions Ab80Di20 (80 mol% albite-20 mol% diopside) and Ab20Di80 with an ultraviolet laser ablation microprobe (UVLAMP) technique for Ar analysis and the ion microprobe for K. Data for Kr (UVLAMP) and Rb (ion probe) have also been determined to evaluate the role of crystal lattice sites in controlling partitioning. By excluding crystal analyses that show evidence of glass contamination, we find relatively constant Ar partition coefficients (DAr) of 2.6 × 10−4 to 3.9 × 10−4 for the Ab80Di20 system at pressures from 2 to 8 GPa. In the Ab20Di80 system, DAr shows similar low values of 7.0 × 10−5 and 3.0 × 10−4 at 1 to 3 GPa. All these values are several orders of magnitude lower than previous measurements on separated crystal-glass pairs. DK is 10 to 50 times greater than DRb for all experiments, and both elements follow parallel trends with increasing pressure, although these trends are significantly different in each system studied. The DK values for clinopyroxene are at least an order of magnitude greater than DAr under all conditions investigated here, but DAr appears to show more consistent behavior between the two systems than K or Rb. The partitioning behavior of K and Rb can be explained in terms of combined pressure, temperature, and crystal chemistry effects that result in changes for the size of the clinopyroxene M2 site. In the Ab20Di80 system, where clinopyroxene is diopside rich at all pressures, DK and DRb increase with pressure (and temperature) in an analogous fashion to the well-documented behavior of Na. For the Ab80Di20 system, the jadeite content of the clinopyroxene increases from 22 to 75 mol% with pressure resulting in a contraction of the M2 site. This has the effect of discriminating against the large K+ and Rb+ ions, thereby countering the effect of increasing pressure. As a consequence DK and DRb do not increase with pressure in this system. In contrast to the alkalis (Na, K, and Rb), DKr values are similar to DAr despite a large difference in atomic radius. This lack of discrimination (and the constant DAr over a range of crystal compositions) is also consistent with incorporation of these heavier noble gases at crystal lattice sites and a predicted consequence of their neutrality or “zero charge.” Combined with published DAr values for olivine, our results confirm that magma generation is an efficient mechanism for the removal of Ar from the uppermost 200 km of the mantle, and that K/Ar ratios in the residuum are controlled by the amount of clinopyroxene. Generally, Ar is more compatible than K during mantle melting because DAr for olivine is similar to DK for clinopyroxene. As a result, residual mantle that has experienced variable amounts of melt extraction may show considerable variability in time-integrated 36Ar/40Ar