1,449 research outputs found
Neutrophil gelatinase-associated lipocalin: its response to hypoxia and association with acute mountain sickness.
Acute Mountain Sickness (AMS) is a common clinical challenge at high altitude (HA). A point-of-care biochemical marker for AMS could have widespread utility. Neutrophil gelatinase-associated lipocalin (NGAL) rises in response to renal injury, inflammation and oxidative stress. We investigated whether NGAL rises with HA and if this rise was related to AMS, hypoxia or exercise. NGAL was assayed in a cohort (n = 22) undertaking 6 hours exercise at near sea-level (SL); a cohort (n = 14) during 3 hours of normobaric hypoxia (FiO2 11.6%) and on two trekking expeditions (n = 52) to over 5000 m. NGAL did not change with exercise at SL or following normobaric hypoxia. During the trekking expeditions NGAL levels (ng/ml, mean ± sd, range) rose significantly (P < 0.001) from 68 ± 14 (60-102) at 1300 m to 183 ± 107 (65-519); 143 ± 66 (60-315) and 150 ± 71 (60-357) at 3400 m, 4270 m and 5150 m respectively. At 5150 m there was a significant difference in NGAL between those with severe AMS (n = 7), mild AMS (n = 16) or no AMS (n = 23): 201 ± 34 versus 171 ± 19 versus 124 ± 12 respectively (P = 0.009 for severe versus no AMS; P = 0.026 for mild versus no AMS). In summary, NGAL rises in response to prolonged hypobaric hypoxia and demonstrates a relationship to the presence and severity of AMS
PSS32 Impact of dry eye on everyday life (Ideel) - Symptom bother: Estimating cut-off scores for dry eye severity groups
The aims of the study were to estimate score ranges associated with dry eye severity based on the Impact of Dry Eye on Everyday Life (IDEEL) Symptom Bother (SB) domain, and to evaluate the overall performance of the SB domain
The connection between stellar mass, age and quenching timescale in massive quiescent galaxies at
We present a spectro-photometric study of a mass-complete sample of quiescent
galaxies at with
drawn from the
VANDELS survey, exploring the relationship between stellar mass, age and
star-formation history. Within our sample of 114 galaxies, we derive a
stellar-mass vs stellar-age relation with a slope of Gyr
per decade in stellar mass. When combined with recent literature results, we
find evidence that the slope of this relation remains consistent over the
redshift interval . The galaxies within the VANDELS quiescent display a
wide range of star-formation histories, with a mean star-formation timescale of
Gyr and a mean quenching timescale of Gyr. We also
find a large scatter in the quenching timescales of the VANDELS quiescent
galaxies, in agreement with previous evidence that galaxies at cease
star formation via multiple mechanisms. We then focus on the oldest galaxies in
our sample, finding that the number density of galaxies that quenched before with stellar masses is . Although
uncertain, this estimate is in good agreement with the latest observational
results at , tentatively suggesting that neither rejuvenation nor merger
events are playing a major role in the evolution of the oldest massive
quiescent galaxies within the redshift interval .Comment: Accepted for publication in MNRAS, 11 pages, 6 figure
Dopamine D_2-receptor activation elicits akinesia, rigidity, catalepsy, and tremor in mice expressing hypersensitive 4 nicotinic receptors via a cholinergic-dependent mechanism
Recent studies suggest that high-affinity neuronal nicotinic acetylcholine receptors (nAChRs) containing α4 and β2 subunits (α4β2*) functionally interact with G-protein-coupled dopamine (DA) D_2 receptors in basal ganglia. We hypothesized that if a functional interaction between these receptors exists, then mice expressing an M2 point mutation (Leu9'Ala) rendering 4 nAChRs hypersensitive to ACh may exhibit altered sensitivity to a D_2-receptor agonist. When challenged with the D_(2)R agonist, quinpirole (0.5–10 mg/kg), Leu9'Ala mice, but not wild-type (WT) littermates, developed severe, reversible motor impairment characterized by rigidity, catalepsy, akinesia, and tremor. While striatal DA tissue content, baseline release, and quinpirole-induced DA depletion did not differ between Leu9'Ala and WT mice, quinpirole dramatically increased activity of cholinergic striatal interneurons only in mutant animals, as measured by increased c-Fos expression in choline acetyltransferase (ChAT)-positive interneurons. Highlighting the importance of the cholinergic system in this mouse model, inhibiting the effects of ACh by blocking muscarinic receptors, or by selectively activating hypersensitive nAChRs with nicotine, rescued motor symptoms. This novel mouse model mimics the imbalance between striatal DA/ACh function associated with severe motor impairment in disorders such as Parkinson’s disease, and the data suggest that a D_(2)R–α4*-nAChR functional interaction regulates cholinergic interneuron activity.—Zhao-Shea, R., Cohen, B. N., Just, H., McClure-Begley, T., Whiteaker, P., Grady, S. R., Salminen, O., Gardner, P. D., Lester, H. A., Tapper, A. R. Dopamine D2-receptor activation elicits akinesia, rigidity, catalepsy, and tremor in mice expressing hypersensitive α4 nicotinic receptors via a cholinergic-dependent mechanism
Surface relaxation and ferromagnetism of Rh(001)
The significant discrepancy between first-principles calculations and
experimental analyses for the relaxation of the (001) surface of rhodium has
been a puzzle for some years. In this paper we present density functional
theory calculations using the local-density approximation and the generalized
gradient approximation of the exchange-correlation functional. We investigate
the thermal expansion of the surface and the possibility of surface magnetism.
The results throw light on several, hitherto overlooked, aspects of metal
surfaces. We find, that, when the free energy is considered, density-functional
theory provides results in good agreement with experiments.Comment: 6 pages, 4 figures, submitted to Phys. Rev. Lett. (April 28, 1996
Strained tetragonal states and Bain paths in metals
Paths of tetragonal states between two phases of a material, such as bcc and
fcc, are called Bain paths. Two simple Bain paths can be defined in terms of
special imposed stresses, one of which applies directly to strained epitaxial
films. Each path goes far into the range of nonlinear elasticity and reaches a
range of structural parameters in which the structure is inherently unstable.
In this paper we identify and analyze the general properties of these paths by
density functional theory. Special examples include vanadium, cobalt and
copper, and the epitaxial path is used to identify an epitaxial film as related
uniquely to a bulk phase.Comment: RevTeX, 4 pages, 4 figures, submitted to Phys. Rev. Let
Meanings of epilepsy in its sociocultural context and implications for stigma: Findings from ethnographic studies in local communities in China and Vietnam
We investigated beliefs about the causes, course, and treatment of epilepsy and its impact on quality of life (QOL) in key target groups, using “mini-ethnographies” involving 141 in-depth interviews and 12 focus groups in China, and 84 in-depth interviews and 16 focus groups in Vietnam. Data were analyzed thematically, using a qualitative data analysis package. In both countries, beliefs about causes and triggers of epilepsy and seizures were a complex interweaving of Western, traditional, and folk medicine concepts. Epilepsy was understood to be chronic, not curable, but controllable, and was seen as enormously socially disruptive, with wide-ranging impact on QOL. Our findings suggest a more “embodied” and benign set of theories about epilepsy than in some other cultural contexts; nonetheless, people with epilepsy are still seen as having low social value and face social rejection. By exploring meanings attached to epilepsy in these two cultural contexts, we have clarified reasons behind previously documented negative attitudes and foci for future intervention studies
Evidence for the emergence of dust-free stellar populations at z > 10
We present an analysis of the UV continuum slopes for a sample of
galaxy candidates at . Focusing primarily on a new
sample of galaxies at selected from arcmin of public JWST imaging data across independent datasets,
we investigate the evolution of in the galaxy population at . In
the redshift range , we find evidence for a relationship between
and , such that galaxies with brighter UV luminosities
display redder UV slopes, with . A comparison with literature studies down to suggests that a
relation has been in place from at least , with a
slope that does not evolve strongly with redshift, but with an evolving
normalisation such that galaxies at higher redshifts become bluer at fixed
. We find a significant trend between and redshift, with
the inverse-variance weighted mean value evolving from at to at . Based on a comparison with stellar population models, we find that at
the average UV continuum slope is consistent with the intrinsic blue
limit of `dust-free' stellar populations .
These results suggest that the moderately dust-reddened galaxy population at was essentially dust free at . The extremely blue galaxies
being uncovered at place important constraints on the dust content of
early galaxies, and imply that the already observed galaxy population is likely
supplying an ionizing photon budget capable of maintaining ionized IGM
fractions of per cent at .Comment: 16 pages, 12 figures, submitted to MNRA
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