Inverse Geometry for Stereolithographic Manufacturing

As parts produced by stereolithography form and cure, they warp and shrink to produce Pitrts that are not quite the san~ ~ as those originally specified. This research attempts to solve the inverse geomptry problem, that is, what shape should be specified initially so that the she pe produced is the desired one. Assuming that 'the process is repeatable, we ~neasure the difference between the ideal and actua). part dimensions. A finite-element based model is built which mirrors the distortion from the ideal geometry. A "pre-deformed" geometry is then built so that it deforms to the ideal geometry under the conditions imposed on the finite element model. This pre-warped geometry is the geometry we seek.Mechanical Engineerin

Supplementing tuberculosis surveillance with automated data from health maintenance organizations.

Data collected by health maintenance organizations (HMOs), which provide care for an increasing number of persons with tuberculosis (TB), may be used to complement traditional TB surveillance. We evaluated the ability of HMO-based surveillance to contribute to overall TB reporting through the use of routinely collected automated data for approximately 350,000 HMO members. During approximately 1.5 million person-years, 45 incident cases were identified in either HMO or public health department records. Eight (18%) confirmed cases had not been identified by the public health department. The most useful screening criterion (sensitivity of 89% and predictive value positive of 30%) was dispensing of two or more TB drugs. Pharmacy dispensing information routinely collected by many HMOs appears to be a useful adjunct to traditional TB surveillance, particularly for identifying cases without positive microbiologic results that may be missed by traditional public health surveillance methods

Evidence of epigenetic changes affecting the chromatin state of the retinoic acid receptor beta2 promoter in breast cancer cells

Retinoic acid (RA)-resistance in breast cancer cells has been associated with irreversible loss of retinoic acid receptor beta, RARbeta, gene expression. Search of the causes affecting RARbeta gene activity has been oriented at identifying possible differences either at the level of one of the RARbeta promoters, RARbeta2, or at regulatory factors. We hypothesized that loss of RARbeta2 activity occurs as a result of multiple factors, including epigenetic modifications, which can pattern RARbeta2 chromatin state. Using methylation-specific PCR, we found hypermethylation at RARbeta2 in a significant proportion of both breast cancer cell lines and primary breast tumors. Treatment of cells with a methylated RARbeta2 promoter, by means of the DNA methyltransferase inhibitor 5-Aza-2'-deoxycytidine (5-Aza-CdR), led to demethylation within RARbeta2 and expression of RARbeta indicating that DNA methylation is at least one factor, contributing to RARbeta inactivity. However, identically methylated promoters can differentially respond to RA, suggesting that RARbeta2 activity may be associated to different repressive chromatin states. This supposition is supported by the finding that the more stable repressive RARbeta2 state in the RA-resistant MDA-MB-231 cell line can be alleviated by the HDAC inhibitor, trichostatin A (TSA), with restoration of RA-induced RARbeta transcription. Thus, chromatin-remodeling drugs might provide a strategy to restore RARbeta activity, and help to overcome the hurdle of RA-resistance in breast cancer

Electromagnetic Transmission of Intellectual Property Data to Protect FPGA Designs

International audienceOver the past 10 years, the designers of intellectual properties(IP) have faced increasing threats including cloning, counterfeiting, andreverse-engineering. This is now a critical issue for the microelectronicsindustry. The design of a secure, efficient, lightweight protection scheme fordesign data is a serious challenge for the hardware security community. In thiscontext, this chapter presents two ultra-lightweight transmitters using sidechannel leakage based on electromagnetic emanation to send embedded IPidentity discreetly and quickl

The First Murchison Widefield Array low-frequency radio observations of cluster scale non-thermal emission: the case of Abell 3667

We present the first Murchison Widefield Array observations of the well-known cluster of galaxies Abell 3667 (A3667) between 105 and 241 MHz. A3667 is one of the best known examples of a galaxy cluster hosting a double radio relic and has been reported to contain a faint radio halo and bridge. The origin of radio haloes, relics and bridges is still unclear, however galaxy cluster merger seems to be an important factor. We clearly detect the north-west (NW) and south-east radio relics in A3667 and find an integrated flux density at 149 MHz of 28.1 ± 1.7 and 2.4 ± 0.1 Jy, respectively, with an average spectral index, between 120 and 1400 MHz, of −0.9 ± 0.1 for both relics. We find evidence of a spatial variation in the spectral index across the NW relic steepening towards the centre of the cluster, which indicates an ageing electron population. These properties are consistent with higher frequency observations. We detect emission that could be associated with a radio halo and bridge. However, due to the presence of poorly sampled large-scale Galactic emission and blended point sources we are unable to verify the exact nature of these features

Consanguinity and reproductive health among Arabs

Consanguineous marriages have been practiced since the early existence of modern humans. Until now consanguinity is widely practiced in several global communities with variable rates depending on religion, culture, and geography. Arab populations have a long tradition of consanguinity due to socio-cultural factors. Many Arab countries display some of the highest rates of consanguineous marriages in the world, and specifically first cousin marriages which may reach 25-30% of all marriages. In some countries like Qatar, Yemen, and UAE, consanguinity rates are increasing in the current generation. Research among Arabs and worldwide has indicated that consanguinity could have an effect on some reproductive health parameters such as postnatal mortality and rates of congenital malformations. The association of consanguinity with other reproductive health parameters, such as fertility and fetal wastage, is controversial. The main impact of consanguinity, however, is an increase in the rate of homozygotes for autosomal recessive genetic disorders. Worldwide, known dominant disorders are more numerous than known recessive disorders. However, data on genetic disorders in Arab populations as extracted from the Catalogue of Transmission Genetics in Arabs (CTGA) database indicate a relative abundance of recessive disorders in the region that is clearly associated with the practice of consanguinity

Effect of acid dye processing on microstructural parameters in silk fibres

The changes in microstructural parameters in silk fibres, due to acid dye processing have been studied using wide angle X-ray scattering method. Width of the crystal distribution function has been determined by Fourier analysis of (201) reflection in these silk fibres. Volume-weighted and surface-weighted crystal sizes have been estimated and compared. (C) 1997 Elsevier Science Ltd

technical briefs A Cumulative Damage Rule Based on Successive Reduction in Fatigue Limit ' l { ** )

Proposed Cumulative Damage Model The fatigue damage accumulation at stresses below the fatigue limit of the virgin material is accounted for in the proposed damage model as long as the stress level is greater than the "instantaneous" or "reduced" fatigue limit of the material. In the proposed model, the following premises are suitably modified and extended for multilevel fatigue cycling. (i) That all constant damage lines do converge to the knee point of the S-log N curve, as proposed by Subramanyan [l]. 2 (ii) That there is a reduction in the fatigue limit of a material due to overstressing, as proposed by Brown and Work When a specimen is subjected to a stressing at level Si for ni cycles, there exists a remaining life Nn = (A r i -n{), at the stress level Si and Nn = (Ni -n 2 i), at a stress level Si, where TJ 2 I is the equivalent number of cycles required to cause the same damage at a stress level S 2 due to stressing at stress level Si for ni cycles. The value of N21 is obtained These remaining lives when replotted on S-log JV diagram would yield a "remaining life line." The material having been stressed for a cycle ratio Ci = (wi/ JVi), will also have a reduced fatigue limit. This reduced value of fatigue limit S e2 , consequent to prestressing for a cycle ratio C\ at Si level, is then [2] where (3 is a constant, based on the yield strength of the material, and Sfi is the fatigue limit of the virgin material. If the specimen is stressed further at a second level, yet another remaining S-log N curve may be obtained using equations (1) and (2). Thus, the problem of prediction of life at the last stress level in a multilevel loading spectrum is now split up into a number of "two-level" sequences of loading each one having its ow