2,005 research outputs found
Kinetostatic Analysis and Solution Classification of a Planar Tensegrity Mechanism
Tensegrity mechanisms have several interesting properties that make them
suitable for a number of applications. Their analysis is generally challenging
because the static equilibrium conditions often result in complex equations. A
class of planar one-degree-of-freedom (dof) tensegrity mechanisms with three
linear springs is analyzed in detail in this paper. The kinetostatic equations
are derived and solved under several loading and geometric conditions. It is
shown that these mechanisms exhibit up to six equilibrium configurations, of
which one or two are stable. Discriminant varieties and cylindrical algebraic
decomposition combined with Groebner base elimination are used to classify
solutions as function of the input parameters.Comment: 7th IFToMM International Workshop on Computational Kinematics, May
2017, Poitiers, France. 201
The amoebal MAP kinase response to Legionella pneumophila is regulated by DupA
SummaryThe amoeba Dictyostelium discoideum can support replication of Legionella pneumophila. Here we identify the dupA gene, encoding a putative tyrosine kinase/dual-specificity phosphatase, in a screen for D. discoideum mutants altered in allowing L. pneumophila intracellular replication. Inactivation of dupA resulted in depressed L. pneumophila growth and sustained hyperphosphorylation of the amoebal MAP kinase ERK1, consistent with loss of a phosphatase activity. Bacterial challenge of wild-type amoebae induced dupA expression and resulted in transiently increased ERK1 phosphorylation, suggesting that dupA and ERK1 are part of a response to bacteria. Indeed, over 500 of the genes misregulated in the dupA− mutant were regulated in response to L. pneumophila infection, including some thought to have immune-like functions. MAP kinase phosphatases are known to be highly upregulated in macrophages challenged with L. pneumophila. Thus, DupA may regulate a MAP kinase response to bacteria that is conserved from amoebae to mammals
Childhood and the politics of scale: Descaling children's geographies?
This is the post-print version of the final published paper that is available from the link below. Copyright @ 2008 SAGE Publications.The past decade has witnessed a resurgence of interest in the geographies of children's lives, and particularly in engaging the voices and activities of young people in geographical research. Much of this growing body of scholarship is characterized by a very parochial locus of interest — the neighbourhood, playground, shopping mall or journey to school. In this paper I explore some of the roots of children's geographies' preoccupation with the micro-scale and argue that it limits the relevance of research, both politically and to other areas of geography. In order to widen the scope of children's geographies, some scholars have engaged with developments in the theorization of scale. I present these arguments but also point to their limitations. As an alternative, I propose that the notion of a flat ontology might help overcome some difficulties around scalar thinking, and provide a useful means of conceptualizing sociospatiality in material and non-hierarchical terms. Bringing together flat ontology and work in children's geographies on embodied subjectivity, I argue that it is important to examine the nature and limits of children's spaces of perception and action. While these spaces are not simply `local', they seldom afford children opportunities to comment on, or intervene in, the events, processes and decisions that shape their own lives. The implications for the substance and method of children's geographies and for geographical work on scale are considered
Gamma ray monitoring of a AGN and galactic black hole candidates by the Compton Gamma Ray Observatory
The Compton Gamma-Ray Observatory's Burst and Transient Source Experiment (BATSE) has a powerful capability to provide nearly uninterrupted monitoring in the 25 keV-10 MeV range of both active galactic nuclei (AGN) and galactic black hole candidates (GBHC) such as Cygnus X-1, using the occultation of cosmic sources by the Earth. Since the Crab is detected by the BATSE Large Area Detectors with roughly 25(sigma) significance in the 15-125 keV range in a single rise or set, a variation by a factor of two of a source having one-tenth the strength of Cygnus X-1 should be detectable within a day. Methods of modeling the background are discussed which will increase the accuracy, sensitivity, and reliability of the results beyond those obtainable from a linear background fit with a single rise or set discontinuity
The Most Luminous z~9-10 Galaxy Candidates yet Found: The Luminosity Function, Cosmic Star-Formation Rate, and the First Mass Density Estimate at 500 Myr
[abridged] We present the discovery of four surprisingly bright (H_160 ~ 26 -
27 mag AB) galaxy candidates at z~9-10 in the complete HST CANDELS WFC3/IR
GOODS-N imaging data, doubling the number of z~10 galaxy candidates that are
known, just ~500 Myr after the Big Bang. Two similarly bright sources are also
detected in a systematic re-analysis of the GOODS-S data set. Three of the four
galaxies in GOODS-N are significantly detected at 4.5-6.2sigma in the very deep
Spitzer/IRAC 4.5 micron data, as is one of the GOODS-S candidates. Furthermore,
the brightest of our candidates (at z=10.2+-0.4) is robustly detected also at
3.6 micron (6.9sigma), revealing a flat UV spectral energy distribution with a
slope beta=-2.0+-0.2, consistent with demonstrated trends with luminosity at
high redshift. The abundance of such luminous candidates suggests that the
luminosity function evolves more significantly in phi_* than in L_* at z>~8
with a higher number density of bright sources than previously expected.
Despite the discovery of these luminous candidates, the cosmic star formation
rate density for galaxies with SFR >0.7 M_sun/yr shows an order-of-magnitude
increase in only 170 Myr from z ~ 10 to z ~ 8, consistent with previous
results. Based on the IRAC detections, we derive galaxy stellar masses at z~10,
finding that these luminous objects are typically 10^9 M_sun. The cosmic
stellar mass density at z~10 is log10 rho_* = 4.7^+0.5_-0.8 M_sun Mpc^-3 for
galaxies brighter than M_UV~-18. The remarkable brightness, and hence
luminosity, of these z~9-10 candidates highlights the opportunity for deep
spectroscopy to determine their redshift and nature, demonstrates the value of
additional search fields covering a wider area to understand star-formation in
the very early universe, and highlights the opportunities for JWST to map the
buildup of galaxies at redshifts much earlier than z~10.Comment: 20 pages, 12 figures, changed to match resubmitted version to Ap
Exploring the Impact of Galaxy Interactions over Seven Billion Years with CAS
We explore galaxy assembly over the last seven billion years by
characterizing "normal" galaxies along the Hubble sequence, against strongly
disturbed merging/interacting galaxies with the widely used CAS system of
concentration (C), asymmetry (A), and 'clumpiness' (S) parameters, as well as
visual classification. We analyze Hubble Space Telescope (HST) ACS images of
~4000 intermediate and high mass (> 10^9 solar masses) galaxies from the GEMS
survey, one of the largest HST surveys conducted to date in two filters. We
explore the effectiveness of the CAS criteria [A>S and A>~0.35] in separating
normal and strongly disturbed galaxies at different redshifts, and quantify the
recovery and contamination rate. We also compare the average star formation
rate and the cosmic star formation rate density as a function of redshift
between normal and interacting systems identified by CAS.Comment: ASP conference proceedings of 2007 Bash Symposium. Latex with
asp2006.sty. 4 pages, 4 figure
Visual activism and social justice: using visual methods to make young people’s complex lives visible across ‘public’ and ‘private’ spaces
Much critical social justice research, including work employing visual methods, focuses on young people’s use of public spaces leaving domestic spaces relatively unexplored. Such research tacitly maintains modernist notions of the public/private distinction in which the private sphere is considered less relevant to concerns of social justice. However, UK crime and social justice policy has increasingly intervened in the home lives of the poorest British families. Further, such policies have been legitimated by drawing on (or not contesting) media imagery that constructs these family lives almost entirely negatively, obscuring their complexity. Drawing on childhood studies research, and a project that employed visual methods to explore belonging among young people in foster, kinship or residential care, this paper examines participants’ often fragile efforts to find or forge places in which they could feel at ‘home’ and imagine a future. In so doing, it invites visual activists to reconsider their understanding of public and private spaces in order to contest prevalent unsympathetic policy representations of poorer young people’s lives, to focus greater attention on their need for support, and to extend imaginations of their futures
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