Searching for Millisecond Pulsars: Surveys, Techniques and Prospects

Searches for millisecond pulsars (which we here loosely define as those with periods $<$ 20 ms) in the Galactic field have undergone a renaissance in the past five years. New or recently refurbished radio telescopes utilizing cooled receivers and state-of-the art digital data acquisition systems are carrying out surveys of the entire sky at a variety of radio frequencies. Targeted searches for millisecond pulsars in point sources identified by the {\it Fermi} Gamma-ray Space Telescope have proved phenomenally successful, with over 50 discoveries in the past five years. The current sample of millisecond pulsars now numbers almost 200 and, for the first time in 25 years, now outnumbers their counterparts in Galactic globular clusters. While many of these searches are motivated to find pulsars which form part of pulsar timing arrays, a wide variety of interesting systems are now being found. Following a brief overview of the millisecond pulsar phenomenon, we describe these searches and present some of the highlights of the new discoveries in the past decade. We conclude with predictions and prospects for ongoing and future surveys.Comment: 16 pages, 3 figures, accepted for publication in Classical and Quantum gravit

Effects of geometric constraints on the nuclear multifragmentation process

We include in statistical model calculations the facts that in the nuclear multifragmentation process the fragments are produced within a given volume and have a finite size. The corrections associated with these constraints affect the partition modes and, as a consequence, other observables in the process. In particular, we find that the favored fragmenting modes strongly suppress the collective flow energy, leading to much lower values compared to what is obtained from unconstrained calculations. This leads, for a given total excitation energy, to a nontrivial correlation between the breakup temperature and the collective expansion velocity. In particular we find that, under some conditions, the temperature of the fragmenting system may increase as a function of this expansion velocity, contrary to what it might be expected.Comment: 16 pages, 5 figure

Statistical multifragmentation model with discretized energy and the generalized Fermi breakup. I. Formulation of the model

The Generalized Fermi Breakup recently demonstrated to be formally equivalent to the Statistical Multifragmentation Model, if the contribution of excited states are included in the state densities of the former, is implemented. Since this treatment requires the application of the Statistical Multifragmentation Model repeatedly on the hot fragments until they have decayed to their ground states, it becomes extremely computational demanding, making its application to the systems of interest extremely difficult. Based on exact recursion formulae previously developed by Chase and Mekjian to calculate the statistical weights very efficiently, we present an implementation which is efficient enough to allow it to be applied to large systems at high excitation energies. Comparison with the GEMINI++ sequential decay code shows that the predictions obtained with our treatment are fairly similar to those obtained with this more traditional model.Comment: 8 pages, 6 figure

Free healthy breakfasts in primary schools: A cluster randomised controlled trial of a policy intervention in Wales, UK

Objective: The present study evaluated the impact of a national school programme of universal free healthy breakfast provision in Wales, UK. Design: A cluster randomised controlled trial with repeated cross-sectional design and a 12-month follow-up. Primary outcomes were breakfast skipping, breakfast diet and episodic memory. Secondary outcomes were frequency of eating breakfast at home and at school, breakfast attitudes, rest-of-day diet and class behaviour. Setting: Primary schools in nine local education authority areas. Subjects: A total of 4350 students (aged 9–11 years) at baseline and 4472 at follow-up in 111 schools. Results: Students in intervention schools reported significantly higher numbers of healthy food items consumed at breakfast and more positive attitudes towards breakfast eating at 12 months. Parents in intervention schools reported significantly higher rates of consumption of breakfast at school and correspondingly lower rates of breakfast consumption at home. No other significant differences were found. Conclusions: The intervention did not reduce breakfast skipping; rather, pupils substituted breakfast at home for breakfast at school. However, there were improvements in children’s nutritional intake at breakfast time, if not the rest of the day, and more positive attitudes to breakfast, which may have implications for life-course dietary behaviours. There was no impact on episodic memory or classroom behaviour, which may require targeting breakfast skippers

Canine liver transplantation under nva cyclosporine versus cyclosporine

The immunosuppressive qualities and other features of a new cyclosporine (CsA) analogue, Nva 2-cyclosporine (Nva 2-CsA) were examined using canine orthotopic liver allografts. The mean survival time was 11.8±9.6 (SD) days in dogs without treatment, 60.8±34.4 days with Nva 2-CsA and 65.1±33.0 days with CsA. Functional abnormalities indicating toxic side effects were not noted either with Nva 2-CsA or with CsA. Using the same oral dose, the rate of blood level rise and the amount of the rise were greater with Nva2-CsA. Histopathologically, Nva2-CsA the treatment was associated with the same degree of hydropic vocuolation in the pars recta of the proximal tubules as CsA treatment. Thus, in the dog, Nva2-CsA had identical immunosuppressive properties as CsA, with no functionally detectable toxicity affecting the liver and kidney. © 1986 by The Williams & Wilkins Co

Magnetic-Island Contraction and Particle Acceleration in Simulated Eruptive Solar Flares

The mechanism that accelerates particles to the energies required to produce the observed high-energy impulsive emission in solar flares is not well understood. Drake et al. (2006) proposed a mechanism for accelerating electrons in contracting magnetic islands formed by kinetic reconnection in multi-layered current sheets. We apply these ideas to sunward-moving flux ropes (2.5D magnetic islands) formed during fast reconnection in a simulated eruptive flare. A simple analytic model is used to calculate the energy gain of particles orbiting the field lines of the contracting magnetic islands in our ultrahigh-resolution 2.5D numerical simulation. We find that the estimated energy gains in a single island range up to a factor of five. This is higher than that found by Drake et al. for islands in the terrestrial magnetosphere and at the heliopause, due to strong plasma compression that occurs at the flare current sheet. In order to increase their energy by two orders of magnitude and plausibly account for the observed high-energy flare emission, the electrons must visit multiple contracting islands. This mechanism should produce sporadic emission because island formation is intermittent. Moreover, a large number of particles could be accelerated in each magnetohydrodynamic-scale island, which may explain the inferred rates of energetic-electron production in flares. We conclude that island contraction in the flare current sheet is a promising candidate for electron acceleration in solar eruptions.Comment: Accepted for publication in The Astrophysical Journal (2016

Adaptive evolution of molecular phenotypes

Molecular phenotypes link genomic information with organismic functions, fitness, and evolution. Quantitative traits are complex phenotypes that depend on multiple genomic loci. In this paper, we study the adaptive evolution of a quantitative trait under time-dependent selection, which arises from environmental changes or through fitness interactions with other co-evolving phenotypes. We analyze a model of trait evolution under mutations and genetic drift in a single-peak fitness seascape. The fitness peak performs a constrained random walk in the trait amplitude, which determines the time-dependent trait optimum in a given population. We derive analytical expressions for the distribution of the time-dependent trait divergence between populations and of the trait diversity within populations. Based on this solution, we develop a method to infer adaptive evolution of quantitative traits. Specifically, we show that the ratio of the average trait divergence and the diversity is a universal function of evolutionary time, which predicts the stabilizing strength and the driving rate of the fitness seascape. From an information-theoretic point of view, this function measures the macro-evolutionary entropy in a population ensemble, which determines the predictability of the evolutionary process. Our solution also quantifies two key characteristics of adapting populations: the cumulative fitness flux, which measures the total amount of adaptation, and the adaptive load, which is the fitness cost due to a population's lag behind the fitness peak.Comment: Figures are not optimally displayed in Firefo

Nuclear isotope thermometry

We discuss different aspects which could influence temperatures deduced from experimental isotopic yields in the multifragmentation process. It is shown that fluctuations due to the finite size of the system and distortions due to the decay of hot primary fragments conspire to blur the temperature determination in multifragmentation reactions. These facts suggest that caloric curves obtained through isotope thermometers, which were taken as evidence for a first-order phase transition in nuclear matter, should be investigated very carefully.Comment: 9 pages, 7 figure