Non-Gaussianities due to Relativistic Corrections to the Observed Galaxy Bispectrum

High-precision constraints on primordial non-Gaussianity (PNG) will significantly improve our understanding of the physics of the early universe. Among all the subtleties in using large scale structure observables to constrain PNG, accounting for relativistic corrections to the clustering statistics is particularly important for the upcoming galaxy surveys covering progressively larger fraction of the sky. We focus on relativistic projection effects due to the fact that we observe the galaxies through the light that reaches the telescope on perturbed geodesics. These projection effects can give rise to an effective $f_{\rm NL}$ that can be misinterpreted as the primordial non-Gaussianity signal and hence is a systematic to be carefully computed and accounted for in modelling of the bispectrum. We develop the technique to properly account for relativistic effects in terms of purely observable quantities, namely angles and redshifts. We give some examples by applying this approach to a subset of the contributions to the tree-level bispectrum of the observed galaxy number counts calculated within perturbation theory and estimate the corresponding non-Gaussianity parameter, $f_{\rm NL}$, for the local, equilateral and orthogonal shapes. For the local shape, we also compute the local non-Gaussianity resulting from terms obtained using the consistency relation for observed number counts. Our goal here is not to give a precise estimate of $f_{\rm NL}$ for each shape but rather we aim to provide a scheme to compute the non-Gaussian contamination due to relativistic projection effects. For the terms considered in this work, we obtain contamination of $f_{\rm NL}^{\rm loc} \sim {\mathcal O}(1)$.Comment: 31 pages, 6 figures, Typos corrected to match the published version in JCA

Ethical difficulties in clinical practice : experiences of European doctors

Background: Ethics support services are growing in Europe to help doctors in dealing with ethical difficulties. Currently, insufficient attention has been focused on the experiences of doctors who have faced ethical difficulties in these countries to provide an evidence base for the development of these services. Methods: A survey instrument was adapted to explore the types of ethical dilemma faced by European doctors, how they ranked the difficulty of these dilemmas, their satisfaction with the resolution of a recent ethically difficult case and the types of help they would consider useful. The questionnaire was translated and given to general internists in Norway, Switzerland, Italy and the UK. Results: Survey respondents (n = 656, response rate 43%) ranged in age from 28 to 82 years, and averaged 25 years in practice. Only a minority (17.6%) reported having access to ethics consultation in individual cases. The ethical difficulties most often reported as being encountered were uncertain or impaired decisionmaking capacity (94.8%), disagreement among caregivers (81.2%) and limitation of treatment at the end of life (79.3%). The frequency of most ethical difficulties varied among countries, as did the type of issue considered most difficult. The types of help most often identified as potentially useful were professional reassurance about the decision being correct (47.5%), someone capable of providing specific advice (41.1%), help in weighing outcomes (36%) and clarification of the issues (35.9%). Few of the types of help expected to be useful varied among countries. Conclusion: Cultural differences may indeed influence how doctors perceive ethical difficulties. The type of help needed, however, did not vary markedly. The general structure of ethics support services would not have to be radically altered to suit cultural variations among the surveyed countries

Poly(bromoethyl acrylate) : a reactive precursor for the synthesis of functional RAFT materials

Postpolymerization modification has become a powerful tool to create a diversity of functional materials. However, simple nucleophilic substitution reactions on halogenated monomers remains relatively unexplored. Here we report the synthesis of poly(bromoethyl acrylate) (pBEA) by reversible addition–fragmentation chain transfer (RAFT) polymerization to generate a highly reactive polymer precursor for postpolymerization nucleophilic substitution. RAFT polymerization of BEA generated well-defined homopolymers and block copolymers over a range of molecular weights. The alkylbromine-containing homopolymer and block copolymer precursors were readily substituted by a range of nucleophiles in good to excellent conversion under mild and efficient reaction conditions without the need of additional catalysts. The broad range of nucleophilic species that are compatible with this postmodification strategy enables facile synthesis of complex functionalities, from permanently charged polyanions to hydrophobic polythioethers to glycopolymers

Communication satisfaction, job satisfaction, organisational commitment and intention to leave

The retention of highly motivated, skilled and committed employees is a major concern by organisations to achieve a competitive advantage. The turnover intentions of human capital are of interest to managers, employees, and organisations today. This study explores a theoretical model of turnover intentions that included three proximal variables, job satisfaction, affective and continuance commitment, the distal variables of subordinate communication, horizontal communication, personal feedback, media quality, communication climate, supervisor communication, job-related communication, and management communication, with turnover intentions. A questionnaire was completed by 101 participants of a rental firm in New Zealand. Job satisfaction, affective commitment, continuance commitment, subordinate communication, horizontal communication, personal feedback, media quality, communication climate, supervisor communication, job-related communication, and management communication correlated with turnover intentions. The results of the mediated regression analysis indicated that job satisfaction, affective commitment, and continuance commitment are significant mediators between the eight distal (organisational communication) variables, with turnover intentions. This study highlights the necessity for managers to develop good quality relationships with their employees to improve the quality of their communication, to foster job satisfaction, affective commitment, and continuance commitment to reduce turnover intentions. The conclusion of this study discusses the practical implications for managers, and organisations and the direction for future research

No planet for HD 166435

The G0V star HD166435 has been observed by the fiber-fed spectrograph ELODIE as one of the targets in the large extra-solar planet survey that we are conducting at the Observatory of Haute-Provence. We detected coherent, low-amplitude, radial-velocity variations with a period of 3.7987days, suggesting a possible close-in planetary companion. Subsequently, we initiated a series of high-precision photometric observations to search for possible planetary transits and an additional series of CaII H and K observations to measure the level of surface magnetic activity and to look for possible rotational modulation. Surprisingly, we found the star to be photometrically variable and magnetically active. A detailed study of the phase stability of the radial-velocity signal revealed that the radial-velocity variability remains coherent only for durations of about 30days. Analysis of the time variation of the spectroscopic line profiles using line bisectors revealed a correlation between radial velocity and line-bisector orientation. All of these observations, along with a one-quarter cycle phase shift between the photometric and the radial-velocity variationss, are well explained by the presence of dark photospheric spots on HD166435. We conclude that the radial-velocity variations are not due to gravitational interaction with an orbiting planet but, instead, originate from line-profile changes stemming from star spots on the surface of the star. The quasi-coherence of the radial-velocity signal over more than two years, which allowed a fair fit with a binary model, makes the stability of this star unusual among other active stars. It suggests a stable magnetic field orientation where spots are always generated at about the same location on the surface of the star.Comment: 9 pages, 8 figures, Accepted for publication in A&

Percolation properties of 3-D multiscale pore networks: how connectivity controls soil filtration processes

Quantifying the connectivity of pore networks is a key issue not only for modelling fluid flow and solute transport in porous media but also for assessing the ability of soil ecosystems to filter bacteria, viruses and any type of living microorganisms as well inert particles which pose a contamination risk. Straining is the main mechanical component of filtration processes: it is due to size effects, when a given soil retains a conveyed entity larger than the pores through which it is attempting to pass. We postulate that the range of sizes of entities which can be trapped inside soils has to be associated with the large range of scales involved in natural soil structures and that information on the pore size distribution has to be complemented by information on a critical filtration size (CFS) delimiting the transition between percolating and non percolating regimes in multiscale pore networks. We show that the mass fractal dimensions which are classically used in soil science to quantify scaling laws in observed pore size distributions can also be used to build 3-D multiscale models of pore networks exhibiting such a critical transition. We extend to the 3-D case a new theoretical approach recently developed to address the connectivity of 2-D fractal networks (Bird and Perrier, 2009). Theoretical arguments based on renormalisation functions provide insight into multi-scale connectivity and a first estimation of CFS. Numerical experiments on 3-D prefractal media confirm the qualitative theory. These results open the way towards a new methodology to estimate soil filtration efficiency from the construction of soil structural models to be calibrated on available multiscale data

Active optical decoupling circuit for radio frequency endoluminal coil

International audienceDespite the enhanced image provided by multiple-channels array coils, an accurate exploration of bowel diseases and detailed information about the gastrointestinal wall layers are still not available. The use of endoluminal RF coil located in the region of interest could potentially allow good evaluation of tumor invasion or depth of inflammatory processes [1]. However, since metallic coaxial cables are used, patient safety is threatened due to local electric field concentration that can happen and the associated local high Specific Absorption Rate (SAR) [2]. Moreover, in this case, cable isolation and traps cannot be straightforwardly employed due to limited dimension. Signal transmission based onoptical fiber is an alternative to coaxial cables to solve definitively the electromagnetic issues. On a receiver coil, both signal transmission and decoupling have to be insured. For MR signal transmission, the electro-optical conversion has been partially validated based on electro-optic effect of some crystals [3]. In this work, an active optical decoupling circuit for endoluminal coil is presented and compared to a reference coil with regular decoupling using bias signal though coaxial cable

Tunable length of cyclic peptide–polymer conjugate self-assemblies in water

Polymers conjugated to cyclic peptides capable of forming strong hydrogen bonds can self-assemble into supramolecular bottlebrushes even in aqueous solutions. However, controlling the aggregation of these supramolecular assemblies remains an obstacle that is yet to be overcome. By introducing pH-responsive poly(dimethylamino ethyl methacrylate) (pDMAEMA) arms, the repulsive forces were tuned by adjusting the degree of protonation on the polymer arms. Neutron scattering experiments demonstrated that conjugates in an uncharged state will self-assemble into supramolecular bottlebrushes. Reducing the pH in the system led to a decrease in the number of aggregation, which was reversible by addition of base. Potentiometric titration showed a correlation between the number of aggregation and the degree of ionization of the pDMAEMA arms. Hence, a balance between the strength of the hydrogen bonds and the repulsive electrostatic interactions determines the number of aggregation and extent of self-assembly. The presented work demonstrates that conjugate self-association can be controlled by tuning the charge density on the conjugated polymer arms, paving the way for the use of responsive cyclic peptide conjugates in pharmaceutical applications

Single addition of an allyl amine monomer enables access to end-functionalized RAFT polymers via native chemical ligation

A novel method for the introduction of a single protected amine-functional monomer at the chain end of RAFT polymers has been developed. This monomer addition, in concert with native chemical ligation, facilitated the development of a simple and versatile method for the end-functionalisation of polymers with peptides