Aerodynamic characteristics of a hypersonic research airplane concept having a 70 deg swept double-delta wing at Mach number 0.2

A wind-tunnel of the static longitudinal, lateral and directional stability characteristics of a hypersonic research airplane concept having a 70 deg swept double-delta wing was conducted in the Langley low-turbulence pressure tunnel. The configuration variables included wing planform, tip fins, center fin, and scramjet engine modules. A mach number of 0.2 was investigated over a Reynolds number (based on fuselage length) range of 2,200,000 to 19.75 x 1,000,000 (with a majority of tests at 10.0 x 1,000,000. Tests were conducted through an angle-of-attack range from about -2 deg to 34 deg at angles of sideslip of 0 deg to 5 deg, and at elevon deflection of 0 deg, -5 deg, -10 deg, -15 deg, and -20 deg. The drag coefficient of the integrated scramjet engine appears relatively constant with Reynolds number at the test Mach number of 0.2. Mild pitch-up was exhibited by the models equipped with tip fins. The forward delta, a highly swept forward portion of the wing, was destabilizing. The center fin model has a higher trimmed maximum lift-drag ratio and a wider trim lift and angle-of-attack range than the tip fin model. Both the tip fin models and center fin models exhibited positive dihedral effect and positive directional stability. Roll control was positive for the tip fin model, but yaw due to roll control was unfavorable

Low-speed aerodynamic characteristics of a hypersonic research airplane concept having a 70 deg swept delta wing

An experimental investigation of the low-speed static longitudinal, lateral and directional stability characteristics of a hypersonic research airplane concept having a 70 deg swept delta wing was conducted in a low-speed tunnel with a 12-foot (3.66 meter) octagonal test section. Aircraft component variations included: (1) fuselage shape modifications, (2) tip fins, (3) center vertical fin, (4) wing camber, and (5) wing planform. This investigation was conducted at a dynamic pressure of 262.4 Pa (5.48 psf), a Mach number of 0.06, and a Reynolds number of 2.24 million, based on body length. Tests were conducted through an angle-of-attack range of 0 deg to 30 deg with elevon deflections from +5.0 deg to minus 30.0 deg. The complete configuration exhibited positive static longitudinal, lateral and directional stability up to angles of attack of at least 20 deg and was trimmable to lift coefficients of at least 0.70 with elevon deflections of minus 30 deg

Aerodynamic characteristics of a hypersonic research airplane concept having a 70 degree swept double delta wing at Mach numbers from 1.50 to 2.86

An experimental investigation of the static longitudinal, lateral, and directional stability characteristics of a hypersonic research airplane concept having a 70 deg swept double-delta wing was conducted in the Langley unitary plan wind tunnel. The configuration variables included wing planform, tip fins, center fin, and scramjet engine modules. The investigation was conducted at Mach numbers from 1.50 to 2.86 and at a constant Reynolds number, based on fuselage length, of 3,330,000. Tests were conducted through an angle-of-attack range from about -4 deg to 24 deg with angles of sideslip of 0 deg and 3 deg and at elevon deflections of 0, -10, and -20 deg. The complete configuration was trimmable up to angles of attack of about 22 deg with the exception of regions at low angles of attack where positive elevon deflections should provide trim capability. The angle-of-attack range for which static longitudinal stability also exists was reduced at the higher Mach numbers due to the tendency of the complete configuration to pitch up at the higher angles of attack. The complete configuration was statically stable directionally up to trimmed angles of attack of at least 20 deg for all Mach numbers M with the exception of a region near 4 deg at M = 2.86 and exhibited positive effective dihedral at all positive trimmed angles of attack

Experimental low-speed and calculated high-speed aerodynamic characteristics of a hypersonic research airplane concept having a 65 deg swept delta wing

An experimental wind-tunnel investigation has been carried out to determine the static longitudinal, lateral, and directional stability and control characteristics of a model of a large-body, delta-wing hypersonic research airplane concept at low speed. This investigation was conducted at a dynamic pressure of 239.4 Pa (5 psf) and a Reynolds number, based on fuselage length, of 2 million. The configuration variables included vertical fins, engine modules, canards, and a canopy. The aerodynamic results of a computer study at Mach numbers of 3 to 12 are presented

Error analysis of the quartic nodal expansion method for slab geometry

This paper presents an analysis of the quartic polynomial Nodal Expansion Method (NEM) for one-dimensional neutron diffusion calculations. As part of an ongoing effort to develop an adaptive mesh refinement strategy for use in state-of-the-art nodal kinetics codes, we derive a priori error bounds on the computed solution for uniform meshes and validate them using a simple test problem. Predicted error bounds are found to be greater than computed maximum absolute errors by no more than a factor of six allowing mesh size selection to reflect desired accuracy. We also quantify the rapid convergence in the NEM computed solution as a function of mesh size

Linear Stochastic Models of Nonlinear Dynamical Systems

We investigate in this work the validity of linear stochastic models for nonlinear dynamical systems. We exploit as our basic tool a previously proposed Rayleigh-Ritz approximation for the effective action of nonlinear dynamical systems started from random initial conditions. The present paper discusses only the case where the PDF-Ansatz employed in the variational calculation is ``Markovian'', i.e. is determined completely by the present values of the moment-averages. In this case we show that the Rayleigh-Ritz effective action of the complete set of moment-functions that are employed in the closure has a quadratic part which is always formally an Onsager-Machlup action. Thus, subject to satisfaction of the requisite realizability conditions on the noise covariance, a linear Langevin model will exist which reproduces exactly the joint 2-time correlations of the moment-functions. We compare our method with the closely related formalism of principal oscillation patterns (POP), which, in the approach of C. Penland, is a method to derive such a linear Langevin model empirically from time-series data for the moment-functions. The predictive capability of the POP analysis, compared with the Rayleigh-Ritz result, is limited to the regime of small fluctuations around the most probable future pattern. Finally, we shall discuss a thermodynamics of statistical moments which should hold for all dynamical systems with stable invariant probability measures and which follows within the Rayleigh-Ritz formalism.Comment: 36 pages, 5 figures, seceq.sty for sequential numbering of equations by sectio

High fidelity hypothermic preservation of primary tissues in organ transplant preservative for single cell transcriptome analysis

Background: High-fidelity preservation strategies for primary tissues are in great demand in the single cell RNAseq community. A reliable method would greatly expand the scope of feasible multi-site collaborations and maximize the utilization of technical expertise. When choosing a method, standardizability and fidelity are important factors to consider due to the susceptibility of single-cell RNAseq analysis to technical noise. Existing approaches such as cryopreservation and chemical fixation are less than ideal for failing to satisfy either or both of these standards. Results: Here we propose a new strategy that leverages preservation schemes developed for organ transplantation. We evaluated the strategy by storing intact mouse kidneys in organ transplant preservative solution at hypothermic temperature for up to 4 days (6 h, 1, 2, 3, and 4 days), and comparing the quality of preserved and fresh samples using FACS and single cell RNAseq. We demonstrate that the strategy effectively maintained cell viability, transcriptome integrity, cell population heterogeneity, and transcriptome landscape stability for samples after up to 3 days of preservation. The strategy also facilitated the definition of the diverse spectrum of kidney resident immune cells, to our knowledge the first time at single cell resolution. Conclusions: Hypothermic storage of intact primary tissues in organ transplant preservative maintains the quality and stability of the transcriptome of cells for single cell RNAseq analysis. The strategy is readily generalizable to primary specimens from other tissue types for single cell RNAseq analysis

Prediction and validation of exenatide risk marker effects on progression of renal disease:Insights from EXSCEL

Aim To assess whether the previously developed multivariable risk prediction framework (PRE score) could predict the renal effects observed in the EXSCEL cardiovascular outcomes trial using short-term changes in cardio-renal risk markers. Materials and Methods Changes from baseline to 6 months in HbA1c, systolic blood pressure (SBP), body mass index (BMI), haemoglobin, total cholesterol, and new micro- or macroalbuminuria were evaluated. The renal outcomes were defined as a composite of a sustained 30% or 40% decline in estimated glomerular filtration rate (eGFR) or end-stage renal disease (ESRD). Relationships between risk markers and long-term renal outcomes were determined in patients with type 2 diabetes from the ALTITUDE study using multivariable Cox regression analysis, and then applied to short-term changes in risk markers observed in EXSCEL to predict the exenatide-induced impact on renal outcomes. Results Compared with placebo, mean HbA1c, BMI, SBP and total cholesterol were lower at 6 months with exenatide, as was the incidence of new microalbuminuria. The PRE score predicted a relative risk reduction for the 30% eGFR decline + ESRD endpoint of 11.3% (HR 0.89; 95% CI 0.83-0.94), compared with 12.7% (HR 0.87; 0.77-0.99) observed risk reduction. For the 40% eGFR decline + ESRD endpoint, the predicted and observed risk reductions were 11.0% (HR 0.89; 0.82-0.97) and 13.7% (HR 0.86, 0.72-1.04), respectively. Conclusions Integrating short-term risk marker changes into a multivariable risk score predicted the magnitude of renal risk reduction observed in EXSCEL

Performance of a 500 watt Nd:GGG zigzag slab oscillator

Realization of practical multi-kilowatt Nd:garnet lasers will require the scale-up of crystal dimensions as well as more powerful pumping sources. A high average power zigzag slab crystal amplifier testing facility has been established at LLNL which employs two 100 kW{sub e} vortex stabilized arc lamps, cooled reflectors and a cooled, spectrally filtered, crystal slab mounting fixture. The operational characteristics of the first crystal laser to be tested in this setup, a Nd:GGG zigzag oscillator, are presented. A Nd:GGG crystal of dimensions 18 {times} 7 {times} 0.5 cm{sup 3}, doped at 2 {times} 10{sup 20} cm{sup {minus}3} Nd{sup 3+} atomic density, was pumped by up to 40 kW of filtered argon line emission. A small-signal single pass gain (losses excluded) of 1.09 was measured with a probe laser when the DC input to the lamps was 43 kW{sub e}. Our power supply was then modified to operate in a pulsed mode and provided one to three milliseconds pulses at 120 Hz. An average optical output power of 490 watts was obtained at a lamp input power of 93 kW{sub e} in an unoptimized resonator. The laser output power declined after a few tens of seconds since the slab tips were not properly cooled. A birdhouse specular lamp reflector and a contoured diffuse reflector were tested; in both cases the pump illuminated crystal surface was smaller than the total crystal face area. Fluorescence imaging of the zigzag amplifier's output aperture registered a smoother, more uniform pumping profile when the diffuse reflector was used. Uniformity of pumping results in decreased resonator loss and yields higher laser output power. Thermo-optic distortions observed in these preliminary tests are analyzed with the aid of computer simulations of the thermal fields, stresses, and surface displacements of our crystal slab. 3 refs., 12 figs